Brain resting-state activity in patients with vision loss due to visual system damage
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Transcript of Brain resting-state activity in patients with vision loss due to visual system damage
Ongoing brain activity in patientswith visual system damage
Michał BolaInstitute of Medical Psychology
Otto-von-Guericke University of Magdeburg
Introduction
Perception:
-bottom-up and top-down proces
-modulated by instantenous brain state
Hanslmayr et al., 2007; van Dijk et al., 2008; Weisz et al., 2014
EEG – synchronous activityof cortical circuits
Aim of the study:
to characterize visual cortex activity at rest and relate it to perception
Sample:
19 patients with pre-chiasmatic visual system damage (lesion in adulthood; partial vision loss)
13 age-matched control subjects
Methods:
Resting state eyes-closed EEG recorded (30 channels)
Alpha band activity divided into low alpha (alpha I; 7-11Hz) and high alpha (alpha II; 11-14Hz).
Hypotheses:
1. Spontaneous cortical synchronization is impaired in patients
2. Stronger spontaneous synchronization is related to better perceptual abilities
Study
Methods I
Spectral power represents efficiency of
neural synchronization.
Changes in spectral power are related to
grate number of brain pathologies.
Methods II
Neural synchronization exhibits complex
temporal patterns.
Temporal coordination and stability-
flexibility balance are crucial for cognition.
Loss of complexity is related to a number
of pathological conditions.
Linkenkaer-Hansen et al., 2001; Montez et al., 2009
• In patients resting-state high alpha activity exhibits:
- lower amplitudes
- less complex, more noise-like temporal patterns
• Although cortex is intact it‘s functional activity is permanently impaired
• Spontaneous cortical synchronization is related to perceptual abilities
Conclusions
Visual system lesion
Vision lossImpaired
synchronization
Thank you forattention!
Collaborators:Dr. Carolin Gall
Christian Moewes
Anton Fedorov
Prof. Hermann Hinrichs
Prof. Bernhard Sabel