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Transcript of Brain Injury during Fetal-Neonatal Transition - pedrad > · PDF file• Injury resulting...
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Brain Injury during Fetal-Neonatal Transition
Adre du Plessis, MBChB Fetal and Transitional Medicine
Children’s National Medical Center Washington, DC
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• Injury resulting during abnormal transition from fetal to stable neonatal physiology
• Pathophysiologies include
• Compromised compensatory mechanisms
• Immature anatomy / physiology
• Abnormal systemic / cerebral circulation
• Focus will be on cerebral hypoxia-ischemia /reperfusion injury
Brain injury during fetal-neonatal transition
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Hypoxia-ischemia/reperfusion brain injury in the full-term infant
Systemic hypoxia-ischemia/reperfusion
• Transient severe asphyxia
• Prolonged partial asphyxia
Regional cerebral hypoxia-ischemia/reperfusion
Focal cerebral hypoxia-ischemia/reperfusion
• Arterio-occlusive insults (‘stroke’)
• Veno-occlusive insults
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Definition of Perinatal Asphyxia
• Perinatal asphyxia is an acquired metabolic condition that results when gas exchange is impaired between the maternal and fetal circulations, or in the early newborn period
• The initial effects are a decrease in circulating arterial oxygen (hypoxemia) and an accumulation of circulating carbon dioxide (hypercarbia) causing fetal respiratory acidosis
• If fetal hypoxemia is sustained, tissue oxygen levels begin to fall (hypoxia), and the anaerobic metabolism that ensues leads to lactate accumulation, metabolic acidosis, and eventual energy failure
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1. Prolonged partial asphyxia
• Placental failure with prolonged labor
• Tetanic uterine contractions
• Nuchal cord
Systemic fetal hypoxia-ischemia/reperfusion
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1. Partial Prolonged Fetal Hypoxia
Liver
Kidneys
Heart
Cortex
Basal GangliaCentralizationof perfusion
Brainstem
Systemic fetal hypoxia-ischemia/reperfusion
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Major Cerebral Arterial Supply Territories
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Prolonged Partial Insult Parasagittal Injury
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“Circulatory centralization” eventually collapses when• tissue lactate accumulation causes vasodilation,
overriding adrenergic vasoconstriction • myocardial lactate accumulation and glycogen
depletion causes hypotension
Cerebral pressure autoregulation fails with progressive hypoxemia and hypercarbia
Hypotension and pressure-passive cerebral circulation cause serious cerebral circulatory insufficiency
Systemic end organ injury prominent; often severe acidosis
Prolonged Partial Asphyxia
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CB
F (%
of n
orm
al)
MABP (mmHg)
Very PrematurePremature NBTerm NBChild
180
160
140
120
100
80
60
40
20
00 10 20 30 40 50 60 70 80 90 100
Infant Adult
Fetal asphyxia causes sustained disruption of cerebral pressure autoregulation
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CB
F (%
of n
orm
al)
MABP (mmHg)
Very PrematurePremature NBTerm NBChild
180
160
140
120
100
80
60
40
20
00 10 20 30 40 50 60 70 80 90 100
Infant Adult
Fetal asphyxia causes sustained disruption of cerebral pressure autoregulation
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2. Transient severe asphyxia
• Uterine rupture
• Placental abruption
• Cord prolapse
Systemic fetal hypoxia-ischemia/reperfusion
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2. Transient Severe Fetal Hypoxia
Liver
Kidneys
Heart
Cortex
BasalGangliaBrainstem
Centralizationof perfusion fails
Systemic fetal hypoxia-ischemia/reperfusion
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Transient severe fetal hypoxia
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Transient severe asphyxia Basal ganglia-thalamic injury
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Transient Severe Perinatal Asphyxia
• Topography of brain injury • Basal ganglia : putaminal• Thalamus : dorsolateral • Brainstem : dorsal • Cerebral : sensorimotor gray / white
• Systemic end organ injury may be mild-absent
• Cord blood gases may not show severe acidosis
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Regional cerebral intrapartum hypoperfusion
• Prolonged obstructed labor with cranial compression
• Shoulder dystocia
• Pattern of injury resembles prolonged partial HI/R but has addition features of venous ischemia and hemorrhage
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Neonatal arterial stroke
• Etiology often unclear
• ? Role of transitional circulation
Focal cerebral hypoxia-ischemia/reperfusion
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Fetal-transitionalcirculation
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• Increasingly important for management (therapeutic windows)
• Medicolegal issues
Importance of timing of injury
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Primary energy failure
Secondary energy failure
8 - 24 hours
Phases of cerebral energy failure
Hypoxia Reperfusion
Lactate NLactate Lactate
pHi pHi pHi N
ATP ATPATP N
N
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Ongoing challenges for the management of perinatal brain injury
Establishing the
• Severity of the initial insult
• The nature of the insult
• The timing of the insult
• The acute response to treatment
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Summary and conclusions