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Benign Prostatic HyperplasiaBenign prostatic hyperplasia (BPH) is an age-related, nonmalignant enlargement of the prostate glandIt is characterized by the formation of large, discrete lesions in the periurethral region of the prostate the peripheral zones, which commonly are affected by prostate cancer

Pathophysiology of BPHBoth androgens (testosterone and dihydrotestosterone (DTH) and estrogens appear to contribute to the development of BPH.The prostate consists of a network of glandular elements embedded in smooth muscle and supporting tissue, with testosterone being the most important factor for prostatic growthContFree plasma testosterone enters prostatic cells, where at least 90% is converted into DHT by the action of 5-reductaseBPH is related to prostatic smooth muscle tone. The 1-adrenergic receptors are the main receptors for the smooth muscle component of the prostateDTH) In normal men, the male hormone testosterone affects a number of things in the body including muscle function and sexual function. An enzyme in the body called 5-alpha reductase converts testosterone into another form called dihydrotestosterone (DHT) which has slightly different effects..

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