Body Fluids Introduction.docx
Transcript of Body Fluids Introduction.docx
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Minindu Ekanayake[Email address]
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#E$$%$A&
E'(I&)'ME'*IDI)*s +roup
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,,- /-
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Introduction
,,- of her body weight 0/ kg 1standard
male1
23 liters of water
/- of his body
weight
This lower percent being due to a higher fat
'eonates contain more water
than adults4 0,56/- water
With proportionately more
extracellular uid (ECF)
then adults.
At birth! the amount ofinterstitial 7uid isproportionally three times
larger than in an adult.
8y the age of 12 months!
this has decreased to /-
which is the adult 9alue.
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0,- 56/-
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*otal body water as a percentage
of total body weight;*8Wlasma4 93% water;? 0- 1plasma
solids1leural
>eritoneal
Byno9ial
>ericardial
#erebrospinal
Intraocular
%rinary
$umen
+.I. $umen
Body l!id "ompartments #$0 g male&
Body l!id "ompartments #$0 g male&
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% ofBody
(eight
% of )otalBody
(ater
*ol!me#+itres&
," 2$ '5 19
lasma '.5 $.5 3.2
/ 12.0 20.0 .'
ense ")water
! $.5 3.2
Bone water ! #! 3.2
)ranscell!lar 1.5 2.5 1.0
/" 33 55 23
)B( 0% 100%'2
liters
*i+erence in ICF and ECF by ma,or Cations
and -nions
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Intracellular Fluid
*he Intracellular :luid is composed of at least C/C2 separate tiny
cellular packages. *he concept of a single united compartment called intracellular
7uid is clearly articial.
*he I#: compartment is really a 9irtual compartment considered
as the sum of this huge number of discontinuous small collections.
Fow can the term Gintracellular 7uid be used as though it was a
single body of 7uidH
*he reason is that though not united physically! the collections
ha9e e=tremely important unifying similarities which make the I#:
concept of practical usefulness in physiology. In particular!
similarities of location! composition and beha9iour4
o +ocation4 )he distinction between /" and ," is clear
and is easy to !nderstand4 they are separated by thecell membranes
o "omposition4 /ntracell!lar !ids are high in potassi!m
and magnesi!m and low in sodi!m and chloride ionso Beha6io!r4 /ntracell!lar !ids beha6e similarly to
tonicity changes in the ,"
8ecause of this physiological usefulness! it is con9enient to talk of
an idealised I#: as though it were a single real entity. *he use of this
con9ention allows predictions to be made about what will happen
with 9arious inter9entions and within limits these are physiologically
meaningful.
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Extracellular Fluid
A similar argument applies to the E=tracellular :luid.
*he E#: is di9ided into se9eral smaller compartments ;e.g.45 plasma!Interstitial 7uid! 7uid of bone and dense connecti9e tissue and
transcellular 7uid
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*he IB: bathes all the cells in the body and is the link between the
I#: and the intra9ascular compartment.
)=ygen! nutrients! wastes and chemical messengers all pass
through the IB:. IB: has the compositional characteristics of E#: ;as
mentioned abo9e< but in addition it is distinguished by its usually
low protein concentration ;in comparison to plasmalasma is the only ma"or 7uid compartment that e=ists as a real 7uid
collection all in one location.
It diers from IB: in its much higher
protein content and its high bulk 7ow
;transport function
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