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Blood Types and Sex-linkage. Human Blood Types Human Blood Types have a gene that displays multiple...
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Transcript of Blood Types and Sex-linkage. Human Blood Types Human Blood Types have a gene that displays multiple...
Human Blood TypesHuman Blood Types
Human Blood Types have a gene that Human Blood Types have a gene that displays displays multiple alleles multiple alleles and and codominancecodominance
The gene has three alleles:The gene has three alleles:– A codes for an A codes for an A antigen A antigen (protein) on red (protein) on red
blood cellsblood cells– B codes for a B codes for a B antigen B antigen (protein) on red blood (protein) on red blood
cellscells– O codes for O codes for no antigen no antigen on red blood cellson red blood cells
The A and B alleles are The A and B alleles are codominantcodominant
O allele is O allele is recessiverecessive
Blood Type Phenotypes and Blood Type Phenotypes and GenotypesGenotypes
PhenotypesPhenotypes GenotypesGenotypes
Type A blood Type A blood AA or AOAA or AO
Type B blood Type B blood BB or BOBB or BO
Type AB blood Type AB blood ABAB
Type O blood Type O blood OOOO
Sex-linked GenesSex-linked Genes
Sex-linkageSex-linkage– Gene for trait is found on a sex chromosomeGene for trait is found on a sex chromosome– Most (almost all) are found on the Most (almost all) are found on the X X
chromosomechromosome; there are very few Y-linked ; there are very few Y-linked disordersdisorders
– Can be sex-linked Can be sex-linked dominantdominant or sex-linked or sex-linked recessive recessive
X-linked Genotypes and X-linked Genotypes and PhenotypesPhenotypes
Genotypes of each parent are written as Genotypes of each parent are written as superscripts on their sex chromosomessuperscripts on their sex chromosomes– Ex: H=“healthy” allele; h= hemophilia alleleEx: H=“healthy” allele; h= hemophilia allele
XXHHXXh h female carrier of hemophilia
XHHXXHH female w/o hemophiliafemale w/o hemophilia
XhXh female with hemophilia
XHY male w/o hemophilia
XhY male with hemophilia
Sex-linked Punnett SquaresSex-linked Punnett Squares
DO NOT CROSS TWODO NOT CROSS TWO FEMALES FEMALES
Females are XX, males XYFemales are XX, males XY
Hemophilia Punnett SquareHemophilia Punnett SquareHemophilia is x-linked recessiveHemophilia is x-linked recessive
X-linked Recessive DisordersX-linked Recessive Disorders
Show up more in malesShow up more in males– Females have two X chromosomesFemales have two X chromosomes
rare to inherit two “bad” X’s to show disorderrare to inherit two “bad” X’s to show disorder
One “good” X masks the “bad” X; One “good” X masks the “bad” X; healthy dominant healthy dominant allele masks the recessive alleleallele masks the recessive allele
– Male have only one X chromosomeMale have only one X chromosomeMales only need Males only need one recessive alleleone recessive allele to show the to show the trait b/c they don’t have another X which could trait b/c they don’t have another X which could carry a healthy dominant allele to carry a healthy dominant allele to maskmask the the recessive allele.recessive allele.