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Transcript of Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical © 2006 by Pearson Education,...
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Chapter 9Hematology
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Topics
Anatomy, Physiology, and Pathophysiology
General Assessment and Management
Managing Specific Patient Problems
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Hematology
The Study of Blood and Blood-Forming Organs– Includes study of blood disorders:
Red blood cell disorders
White blood cell disorders
Platelet disorders
Coagulation problems
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Anatomy, Physiology, and Pathophysiology
Components– Blood, bone marrow, liver, spleen,
kidneys
Hematopoiesis– Pluripotent stem cell– Erythropoietin
Blood Volume
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (1 of 6)
Plasma– Water
90–92% by volume
– Proteins6–7% by volume
– Other2–3% by volume
Fats, carbohydrates, electrolytes, gases, and chemical messengers
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (2 of 6)
Red Blood Cells– Hemoglobin– Oxygen transport– Bohr effect– 2,3 DPG– Oxygen–hemoglobin
dissociation curve
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (3 of 6)
Red Blood Cells– Production
Erythropoiesis
Hemolysis
Sequestration
– Laboratory analysis of red blood cells
Red blood cell count
Hematocrit
Hemoglobin
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (4 of 6)
White Blood Cells– Margination– Phagocytosis– White blood cell count
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (5 of 6)
White Blood Cells– Leukopoiesis
GranulocytesNeutrophilBasophilEosinophil
LymphocytesMonocytes
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood (6 of 6)
White Blood Cells– Immunity
Subpopulation of lymphocytes known as T cells and B cells
T cells develop cellular immunity.
B cells produce humoral immunity.
– Autoimmune disease– Alterations in the immune process– Inflammatory process
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Immune Response
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Components of Blood
Platelets– Megakaryocytes– Thrombocytopenia– Thrombocytosis
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Hemostasis (1 of 3)
Controlling Blood Loss– Vascular spasms– Platelet plugs– Stable fibrin blood clots
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Hemostasis (2 of 3)
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Hemostasis (3 of 3)
FibrinolysisThrombosis– Fibrinolytics– Medications
affecting clot formation
Alter the enzyme on the plateletAffect the coagulation cascadeEnhance clotting
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Blood Products and Blood Typing (1 of 2)
Blood Types– Antigens
A, B, AB, O
– Universal donors– Rh factor
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Blood Products and Blood Typing (2 of 2)
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Transfusion Reactions (1 of 2)
Hemolytic Reactions– Signs and Symptoms
Facial flushing, hyperventilation, tachycardia, hives, chest pain, wheezing, fever, chills, and cyanosis.
– TreatmentStop transfusion, change all IV tubing, and initiate IV therapy with normal saline or lactated Ringer’s.Consider furosemide, dopamine, and diphenhydramine.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Transfusion Reactions (2 of 2)
Febrile Nonhemolytic Reactions– Signs and Symptoms
Headache, fever, and chills.
– TreatmentStop transfusion, change all IV tubing, and initiate IV therapy with normal saline or lactated Ringer’s.Consider diphenhydramine and an antipyretic.Observe closely to ensure reaction is nonhemolytic.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
General Assessment and Management (1 of 3)
Scene Size-up
Initial Assessment
Focused History and Physical Exam– SAMPLE history
Hematological disorders are rarely the chief complaint.
– Physical examEvaluate nervous system function.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Physical exam– Skin signs– Lymphatic signs– Gastrointestinal
signs– Musculoskeletal
signs– Cardiorespiratory
signs– Genitourinary signs
General Assessment and Management (2 of 3)
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
General Assessment and Management (3 of 3)
General Treatment Guidelines– Maintain ABCs.
Provide high-flow, high-concentration oxygen or assist ventilations as indicated.
Consider volume replacement.
– Monitor cardiac rhythm and vital signs.Treat rhythm disturbances.
– Provide reassurance, comfort care, and transport.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Managing Specific Patient Problems
Diseases of the Red Blood Cells
Diseases of the White Blood Cells
Diseases of the Platelets/Blood Clotting Abnormalities
Other Hematopoietic Disorders
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the Red Blood Cells (1 of 4)
Anemias– Anemia is a sign, not a separate disease
process.Signs and symptoms may not be present until the body is stressed.
Differentiate chronic anemia from acute episode.
– Treat signs and symptoms.Maximize oxygenation and limit blood loss.
Establish IV therapy if indicated.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the Red Blood Cells (2 of 4)
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the Red Blood Cells (3 of 4)
Sickle Cell Disease– Sickle cell crises
Vaso-occlusive
Hematological
Infectious
– ManagementFollow general treatment guidelines.
Consider analgesics.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the Red Blood Cells (4 of 4)
Polycythemia– Overproduction of erythrocytes– Occurs in patients >50 years old or with
secondary dehydration.– Results in bleeding abnormalities
Epistaxis, spontaneous bruising, GI bleeding
– ManagementFollow general treatment guidelines.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the White Blood Cells (1 of 3)
Leukopenia/Neutropenia– Too few white blood cells or neutrophils.– Follow general treatment guidelines and
provide supportive care.
Leukocytosis– An increase in the number of circulating
white blood cells, often due to infection.Leukemoid reaction
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the White Blood Cells (2 of 3)
Leukemia– Cancer of hematopoietic cells– Initial presentation
Acutely ill, fatigued, febrile and weak, anemic
Often have a secondary infection
– ManagementFollow general treatment guidelines.
Utilize isolation techniques to limit risk of infection.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the White Blood Cells (3 of 3)
Lymphomas– Cancers of the lymphatic system– Presentation
Swelling of the lymph nodesFever, night sweats, anorexia, weight loss, fatigue, and pruritis
– ManagementFollow general treatment guidelines.Utilize isolation techniques to limit risk of infection.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Diseases of the Platelets
Thrombocytosis and Thrombocytopenia– Thrombocytosis
An abnormal increase in the number of platelets
– ThrombocytopeniaAn abnormal decrease in the number of platelets
– ManagementProvide supportive care and follow general treatment guidelines.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Blood Clotting Abnormalities (1 of 2)
Hemophilia– Deficiency or absence of a blood clotting
factorDeficiency of factor VIII causes hemophilia A.
Deficiency of factor IX causes hemophilia B.
Deficiency is a sex-linked, inherited disorder.Defective gene is carried on the X chromosome.
– Signs and SymptomsNumerous bruises, deep muscle bleeding, and joint bleeding.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Blood Clotting Abnormalities (2 of 2)
Hemophilia– Management
Treat the patient similarly to others.Administer supplemental oxygen.Establish IV access.
Be alert for recurrent or prolonged bleeding, and prevent additional trauma.
Von Willebrand’s Disease– Deficient component of factor VIII
Generally results in excessive bleeding.Generally is not serious; provide supportive care.
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Other Hematopoietic Disorders
Disseminated Intravascular Coagulation– System activation of coagulation cascade– Results from sepsis, hypotension, OB
complications, severe tissue or brain injury, cancer, and major hemolytic reactions
Multiple Myeloma– Cancerous disorder of plasma cells– Pathologic fractures common
Bledsoe et al., Paramedic Care Principles & Practice Volume 3: Medical© 2006 by Pearson Education, Inc. Upper Saddle River, NJ
Summary
Anatomy, Physiology, and Pathophysiology
General Assessment and Management
Managing Specific Patient Problems