Bishler-Napieralski Reaction
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Stepholidine is a promising anti-psychotic. This molecule was isolated from a Chinese herb. It is a D1 dopamine receptor agonist, but a D2 dopamine receptor antagonist. - PowerPoint PPT Presentation
Transcript of Bishler-Napieralski Reaction
Slide 1
Cheng, Jian-Jun; Yang, Yu-She. Enantioselective Total Synthesis
of (-)-(S)-Stepholidine. Journal of Organic Chemistry (2009),
74(23), 9225-9228.
Stepholidine is a promising anti-psychotic. This molecule was
isolated from a Chinese herb. It is a D1 dopamine receptor agonist,
but a D2 dopamine receptor antagonist.
Bishler-Napieralski Reaction
The Bishler-Napieralski Reaction is an electrophilic aromatic
substitution whereby a suitably placed amide is transformed into an
electrophile through the action of phosphorus
oxychloride.
Asymmetric Transfer Hydrogenation