Biotechnology
description
Transcript of Biotechnology
Biotechnology
Thermal “Needs”
Paul Nesvadba
EVITHERM meeting at PTB Berlin,
17th May 2004
Biotechnology
• Technology of 21st century
• Practical applications of biological organisms or their components
• Genetic engineering, genomics, proteomics, transgenic crops and animals
• Brewing beer, treatment of sewage, wastewater, drug development, agriculture
Fields of Biotechnology• Molecular / Cell Biology• Biochemistry• Genetics / Genomics / Proteomics• Immunology• Microbiology / Virology• Biological/ Biochemicals/ Chemicals Manufacturing• Pharmaceutical Science & Research• Plant Sciences / Agribiotech• Bioprocessing / Bioengineering• Ecology / Environment• Diagnostics• Food & Drink• Bioinformatics• Vaccines
Molecular Biology & Bioinformatics• Genetic and Molecular basis of disease
• Gene editing (e.g. GM crops)
• Discovery systems (e.g. drug discovery)
• Protein separation and fusion systems
• Antibody engineering
• High throughput
Heat and Temperature
• “Bioinformatics”– Low energy, high precision of control (e.g.
PCR - polymerase chain reaction)
• Large scale Industrial processes– High energy consumption– Optimisation– Knowledge for reducing environmental impact
“Hardware” in Biotechnology
Laboratory
• PCR Thermocyclers
• Tissue Culture - Incubators
Industrial
• Vaccines / Pharmaceuticals – TTIs - TIs
• Fermenters – heat removal!
• Waste treatment plants
Industrial Fermentation
• The optimum fermentation temperature is about 32 °C
• The heat of formation of ethanol is 1.2 MJ / kg of ethanol
• Cooling is necessary in order for the yeast to survive and work efficiently
Brewing
• The oldest biotechnology process
• 8000 years ago in Babylon
• Today’s large scale brewing is highly sophisticated
• Involves many heating and cooling steps
Heat Exchangers
• Energy efficiency (higher heat transfer coefficient, recycling)
• Small size, low mass, easy capacity modification• Ease of cleaning• Shell-and-tube exchangers (traditional) • Plate
Tubular Heat Exchanger (Alfa Laval Viscoline TM)
• Heating, cooling, heat regeneration
• Pasteurisation
• UHT treatment of viscous fluids
Plate Heat Exchanger (Alfa Laval)
Waste Water Treatment
• The need for efficient handling of wastewater and sludge is increasing worldwide.
Processes and equipment
• Decanter centrifuges for dewatering • Spiral heat exchangers
• Heating, cooling, heat recovery and pasteurisation
• Drum thickeners/dryers for sludge volume reduction • Decanter autopilot optimising plant operation
Objective:
To reduce the volume of wastewater
Compilation of contacts
• Alfa Laval (UK, Sweden)• Biometra Gmbh (Göttingen, Germany)• BioProcess Engineering Services Ltd (UK)• GE Healthcare and GE Bio-Sciences (UK)• Grant Instruments (Cambridge, UK)• New Brunswick Scientific (UK) Ltd• Thermo Electron Corporation (USA)• Technical University Berlin, Inst. Food Technology
Conclusions• Biotechnology
– Large area– Diverse processes– Scale from laboratory to industrial
• Identification of users in need of EVITHERM
• Started compiling a list of users
• Contacting users