BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics...

13
Biotech Financin All data supplied a BIOTECH F INANCING September saw financing activit picking up the pace after the ind raised was USD 583m - the third the financing value raised by Eu 242m was the largest over the 1 high average deal value of USD 2 bigger than the second, achieve performance came right after a venture rounds were recorded i companies. On the other side of the Atlantic 341m. This figure was by 22% r smaller than the U.S. average o would suspect, September’s num compared to 19). Indeed, the av different path than that of their previous month and was by 34% In September, two European com Adaptimmune completed a USD financing. In what follows, we al Pharma and summarize the fina The graph contains only financing rounds of private rounds from previous months may alter as new info added. ng Summary and available from Biotechgate www.biotec G SUMMARY ty for Biotech companies (Therapeutics a dustry’s summer slothfulness. The total fi d largest within the last 12 months, and w uropean companies. Specifically, Europe’s 12 months trailing and was achieved with 26.9m; the highest within the sample peri ed in October 2013 (USD17.9m). It is wort a diametrically opposite one seen in Augus in the region for Biotech (Therapeutics an c, the total financing value in September a reduced compared to that of August (USD over the period studied (USD 389m). Contr mber of U.S. rounds was well above the p verage financing value raised by U.S. com r European counterparts. It shrank by 46% % smaller than the period’s average for th mpanies raised the largest financing roun 104m Series A and Swiss Cardiorentis re lso highlight the raising of USD 40m by Bo ancing events within the industry for Septe e & independent biotech therapeutic and diagnostic companies. Fina ormation on financing rounds is received and/or new tranches to ex chgate.com 1 October 2014 and Diagnostics) inancing value was mainly driven by s total value of USD h an exceptionally iod and by 50% th noting that this st, in which no nd Diagnostics) amounted to USD D 438m) and 12% rary to what one period’s average (26 mpanies followed a % compared to the he region. nds. U.K. - based eceived a EUR 45m oston-based Flex ember 2014. ancing amounts and number of xisting financing rounds are Source: Biotechgate.com

Transcript of BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics...

Page 1: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

BIOTECH FINANCING

September saw financing activity for Biotech companies (Therapeutics and Diagnostics)

picking up the pace after the industry’s summer slothfulness.

raised was USD 583m - the third largest within the

the financing value raised by European companies. Specifically, Europe’s total value of USD

242m was the largest over the 12 months

high average deal value of USD 26.9m; the highest with

bigger than the second, achieved in October 2013

performance came right after a diametrically

venture rounds were recorded in the region for Biotech (Therapeutics

companies.

On the other side of the Atlantic, the total financing value in September

341m. This figure was by 22% reduced compared to that of August (USD 438m) and 12%

smaller than the U.S. average over the period studied

would suspect, September’s number of U

compared to 19). Indeed, the average

different path than that of their European co

previous month and was by 34% smaller than the period’s average for the region.

In September, two European companies

Adaptimmune completed a USD 104m Series A and Swiss Cardiorentis received a EUR 45m

financing. In what follows, we also highlight the raising of USD 40m by

Pharma and summarize the financing events within

The graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amou

rounds from previous months may alter as new information

added.

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

INANCING SUMMARY

saw financing activity for Biotech companies (Therapeutics and Diagnostics)

picking up the pace after the industry’s summer slothfulness. The total financing value

the third largest within the last 12 months, and was mainly driven

raised by European companies. Specifically, Europe’s total value of USD

242m was the largest over the 12 months trailing and was achieved with an exceptionally

high average deal value of USD 26.9m; the highest within the sample period

bigger than the second, achieved in October 2013 (USD17.9m). It is worth noting that this

performance came right after a diametrically opposite one seen in August

venture rounds were recorded in the region for Biotech (Therapeutics and Diagnostics)

the other side of the Atlantic, the total financing value in September amounted to USD

341m. This figure was by 22% reduced compared to that of August (USD 438m) and 12%

smaller than the U.S. average over the period studied (USD 389m). Contrary to what one

, September’s number of U.S. rounds was well above the period’s average (26

compared to 19). Indeed, the average financing value raised by U.S. companies

than that of their European counterparts. It shrank by 46% compared to the

34% smaller than the period’s average for the region.

, two European companies raised the largest financing rounds. U.K.

Adaptimmune completed a USD 104m Series A and Swiss Cardiorentis received a EUR 45m

also highlight the raising of USD 40m by Boston

Pharma and summarize the financing events within the industry for September

he graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amou

hs may alter as new information on financing rounds is received and/or new tranches to existing financing rounds are

www.biotechgate.com

1

October 2014

saw financing activity for Biotech companies (Therapeutics and Diagnostics)

The total financing value

was mainly driven by

raised by European companies. Specifically, Europe’s total value of USD

and was achieved with an exceptionally

period and by 50%

. It is worth noting that this

opposite one seen in August, in which no

and Diagnostics)

amounted to USD

341m. This figure was by 22% reduced compared to that of August (USD 438m) and 12%

Contrary to what one

rounds was well above the period’s average (26

raised by U.S. companies followed a

unterparts. It shrank by 46% compared to the

34% smaller than the period’s average for the region.

est financing rounds. U.K. - based

Adaptimmune completed a USD 104m Series A and Swiss Cardiorentis received a EUR 45m

Boston-based Flex

the industry for September 2014.

he graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amounts and number of

existing financing rounds are

Source: Biotechgate.com

Page 2: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Selected Financing Highlights

Adaptimmune secures USD 104

Oxford, U.K.-based Adaptimmune Limited, a biotechnology company focused on the use of T

cell therapy to treat cancer and infectious disease

completion of a USD 104m Series A financing round.

The oversubscribed round was led by New Enterprise Associates (NEA), and additional new

investors participating included OrbiMed Advisors LLC, Wellington Management Company,

LLP, Fidelity Biosciences, Foresite Capital Management,

Novo A/S, QVT, Rock Springs Capital, venBio Select and Merlin Nexus. Existing investors

participating included the University of Oxford and others.

Adaptimmune plans to use the proceeds from the Series A financing to advance

company’s internal programmes into the clinic in multiple cancer indications.

(Source: press release)

Cardiorentis Announces EUR 45m

Partners to Fund Ularitide Registration Program in Acute Heart Failure

Zug, Switzerland-based Cardiorentis AG, a privately

announced on the 17th of September 2014

agreement with HealthCare Royalty Partners (“HC Royalty”), a U.S. based healthcare

investment firm. The proceeds will be used to finance the Company’s registration program

for the natriuretic peptide Ularitide in acute heart failure.

The TRUE-AHF Phase III trial was initiated in August 2012. It is led by the international

principal investigator Milton Packer, M.D., University Texas, Southwestern Medical Center in

Dallas, Texas and includes over 200 centers across the U.S., Europe, Canada and Latin

America. TRUE-AHF is an event driven trial, which may enroll up to 4,000 patients with acute

heart failure. There are two co-

acute heart failure which assesses a patient’s symptoms and persistent or worsening heart

failure within the first 48 hours after treatment initiation. The second co

is cardiovascular mortality. (Source: press release

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

ighlights

104m in Series A Financing

Adaptimmune Limited, a biotechnology company focused on the use of T

cell therapy to treat cancer and infectious disease, announced on the 5th

Series A financing round.

The oversubscribed round was led by New Enterprise Associates (NEA), and additional new

participating included OrbiMed Advisors LLC, Wellington Management Company,

Biosciences, Foresite Capital Management, Ridgeback Capital Management,

Novo A/S, QVT, Rock Springs Capital, venBio Select and Merlin Nexus. Existing investors

participating included the University of Oxford and others.

Adaptimmune plans to use the proceeds from the Series A financing to advance

company’s internal programmes into the clinic in multiple cancer indications.

Cardiorentis Announces EUR 45m (USD 58.1m) Financing with HealthCare Royalty

Partners to Fund Ularitide Registration Program in Acute Heart Failure

Cardiorentis AG, a privately held biopharmaceutical company,

on the 17th of September 2014 that it has entered into a EUR 45m

agreement with HealthCare Royalty Partners (“HC Royalty”), a U.S. based healthcare

stment firm. The proceeds will be used to finance the Company’s registration program

for the natriuretic peptide Ularitide in acute heart failure.

AHF Phase III trial was initiated in August 2012. It is led by the international

tor Milton Packer, M.D., University Texas, Southwestern Medical Center in

Dallas, Texas and includes over 200 centers across the U.S., Europe, Canada and Latin

AHF is an event driven trial, which may enroll up to 4,000 patients with acute

-primary endpoints. The first is a composite endpoint for

acute heart failure which assesses a patient’s symptoms and persistent or worsening heart

failure within the first 48 hours after treatment initiation. The second co

Source: press release)

www.biotechgate.com

2

Adaptimmune Limited, a biotechnology company focused on the use of T-th of September the

The oversubscribed round was led by New Enterprise Associates (NEA), and additional new

participating included OrbiMed Advisors LLC, Wellington Management Company,

Ridgeback Capital Management,

Novo A/S, QVT, Rock Springs Capital, venBio Select and Merlin Nexus. Existing investors

Adaptimmune plans to use the proceeds from the Series A financing to advance the

company’s internal programmes into the clinic in multiple cancer indications.

Financing with HealthCare Royalty

Partners to Fund Ularitide Registration Program in Acute Heart Failure

held biopharmaceutical company,

that it has entered into a EUR 45m financing

agreement with HealthCare Royalty Partners (“HC Royalty”), a U.S. based healthcare

stment firm. The proceeds will be used to finance the Company’s registration program

AHF Phase III trial was initiated in August 2012. It is led by the international

tor Milton Packer, M.D., University Texas, Southwestern Medical Center in

Dallas, Texas and includes over 200 centers across the U.S., Europe, Canada and Latin

AHF is an event driven trial, which may enroll up to 4,000 patients with acute

primary endpoints. The first is a composite endpoint for

acute heart failure which assesses a patient’s symptoms and persistent or worsening heart

failure within the first 48 hours after treatment initiation. The second co-primary endpoint

Page 3: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Flex Pharma Raises USD 40m

Boston-based Flex Pharma, Inc., a biopharmaceutical company dedicated to creating

innovative, novel treatments for neuromuscular disorders, announced on the 8

September 2014 that it has raised USD 40m in private funding from a number of blue chip

public and private investors.

With this financing, Flex Pharma plans to further advance the science and its clinical

candidates addressing neuromuscular disorders

Flex Pharma Co-Founder and Co

MacKinnon M.D., who won the 2003 Nobel Prize in Chemistry commented: “Our early stage

clinical studies have shown initial human efficacy. We are hopeful that we may be able

help individuals suffering from muscle cramps and other neuromuscular disorders related

to muscle cramping in healthy volunteers

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

Flex Pharma, Inc., a biopharmaceutical company dedicated to creating

innovative, novel treatments for neuromuscular disorders, announced on the 8

September 2014 that it has raised USD 40m in private funding from a number of blue chip

With this financing, Flex Pharma plans to further advance the science and its clinical

candidates addressing neuromuscular disorders

Founder and Co-Chair of the Company’s Scientific Advisory Board, Rod

MacKinnon M.D., who won the 2003 Nobel Prize in Chemistry commented: “Our early stage

clinical studies have shown initial human efficacy. We are hopeful that we may be able

help individuals suffering from muscle cramps and other neuromuscular disorders related

to muscle cramping in healthy volunteers.” (Source: press release)

www.biotechgate.com

3

Flex Pharma, Inc., a biopharmaceutical company dedicated to creating

innovative, novel treatments for neuromuscular disorders, announced on the 8th of

September 2014 that it has raised USD 40m in private funding from a number of blue chip

With this financing, Flex Pharma plans to further advance the science and its clinical

Chair of the Company’s Scientific Advisory Board, Rod

MacKinnon M.D., who won the 2003 Nobel Prize in Chemistry commented: “Our early stage

clinical studies have shown initial human efficacy. We are hopeful that we may be able to

help individuals suffering from muscle cramps and other neuromuscular disorders related

Page 4: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Equity Financing Breakdown by

Diagnostics) – End of Most

In Q3 2014 the overall percentage of private biotech companies (Therapeutics and

Diagnostics) receiving mid-sized

highest of the last 5 quarters (55%).

15m represented 32% of the whole

while investments between USD 1

in size only when compared to their corresponding Q2 2014 figure (24%).

On the other hand, investments

system represented only 46% of all and were thus significantly shrunk compared with the

corresponding numbers seen within the last

however, the values of 32% and 14% for investments smaller than USD 5m and larger than

USD 30m respectively, are the second lowest ones

represented a smaller amount of investments in Q2 2014, while the second saw its

percentage in Q3 2013.

The graph above shows the proportion of financing for private biotech companies (therapeutics and diagnostics) by investment

The data-set includes only private Biotech (Therapeutics and Diagnostics)

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

reakdown by Investment size (Therapeutics &

ost Recent Quarter

2014 the overall percentage of private biotech companies (Therapeutics and

sized financings (between USD 5m and USD 30

(55%). Specifically, investments between USD

represented 32% of the whole - a higher percentage than in all 5 preceding quarters,

investments between USD 15m and USD 30m represented 23% of all and

in size only when compared to their corresponding Q2 2014 figure (24%).

n the other hand, investments occupying the extreme ranks within our classification

system represented only 46% of all and were thus significantly shrunk compared with the

corresponding numbers seen within the last 5 quarters. When looked at individually

, the values of 32% and 14% for investments smaller than USD 5m and larger than

are the second lowest ones within the sample. The first category

represented a smaller amount of investments in Q2 2014, while the second saw its

The graph above shows the proportion of financing for private biotech companies (therapeutics and diagnostics) by investment

Biotech (Therapeutics and Diagnostics) companies from the U.S. and Europe.

Source: Biotechgate.com

www.biotechgate.com

4

herapeutics &

2014 the overall percentage of private biotech companies (Therapeutics and

and USD 30m) was the

USD 5m and USD

a higher percentage than in all 5 preceding quarters,

represented 23% of all and were second

in size only when compared to their corresponding Q2 2014 figure (24%).

occupying the extreme ranks within our classification

system represented only 46% of all and were thus significantly shrunk compared with the

. When looked at individually

, the values of 32% and 14% for investments smaller than USD 5m and larger than

within the sample. The first category

represented a smaller amount of investments in Q2 2014, while the second saw its smallest

The graph above shows the proportion of financing for private biotech companies (therapeutics and diagnostics) by investment size

companies from the U.S. and Europe.

Source: Biotechgate.com

Page 5: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Total Value of Quarterly

Diagnostics) – 3-Year Historical

In Q3 2014 the total value of financing deals by private Biotech companies (Ther

Diagnostics) was USD 1,116m, the

2011 after those of Q2 2014 and Q3 2012. Compared to the previous quarter, the total

financing value was reduced by 45%, while the average deal size

European financing in Q3 2014 totaled USD 2

three years and by 15% larger than

financing value of the most recent

rounds. Indeed, the average deal size in Europe for

region over the past 12 quarters (USD 23.5m) and by 45% larger than the second biggest,

seen in Q4 2013 (USD 16.2m)

Being the main driver behind total financing values, the U.S. total financing value compares

with past quarters just as the value across both geographies.

U.S. in Q3 2014 was the third highest within our sample and

quarterly average (USD 712m).

The graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amo

and number of rounds from previous quarters may

existing financing rounds are added.

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

uarterly Financings Biotech (Therapeutics &

istorical Data

2014 the total value of financing deals by private Biotech companies (Ther

the third highest within the three-year period starting in Q

2011 after those of Q2 2014 and Q3 2012. Compared to the previous quarter, the total

financing value was reduced by 45%, while the average deal size was reduced

2014 totaled USD 258m, and was thus the third biggest of the past

than the corresponding Q2 2014 figure (USD 2

the most recent quarter was amassed in only 11 European venture

rounds. Indeed, the average deal size in Europe for Q3 2014 was the highest seen in the

region over the past 12 quarters (USD 23.5m) and by 45% larger than the second biggest,

ing the main driver behind total financing values, the U.S. total financing value compares

with past quarters just as the value across both geographies. The USD 858m raised in the

U.S. in Q3 2014 was the third highest within our sample and by 20% larger th

The graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amo

and number of rounds from previous quarters may alter as new information on financing rounds is received and/or new tranches to

www.biotechgate.com

5

herapeutics &

2014 the total value of financing deals by private Biotech companies (Therapeutics and

year period starting in Q3

2011 after those of Q2 2014 and Q3 2012. Compared to the previous quarter, the total

reduced by 28%.

the third biggest of the past

(USD 224m). The

quarter was amassed in only 11 European venture

was the highest seen in the

region over the past 12 quarters (USD 23.5m) and by 45% larger than the second biggest,

ing the main driver behind total financing values, the U.S. total financing value compares

The USD 858m raised in the

20% larger than the period’s

The graph contains only financing rounds of private & independent biotech therapeutic and diagnostic companies. Financing amounts

alter as new information on financing rounds is received and/or new tranches to

Source: Biotechgate.com

Page 6: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Worldwide financing

Biotechnology - Therapeutics/Diagnostics

Private/independent Companies

Year 2013 2013 2013 2013

Month Sep Oct Nov Dec

Total 347 613 583 227

US 274 366 418 133

Europe 72 224 161 86

RoW1 1 22 4 8

1 Rest of the world.

The table above shows the total global financing in biotechnology in the therapeutics and diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

Therapeutics/Diagnostics

2014 2014 2014 2014 2014 2014 2014

Jan Feb Mar Apr May Jun Jul

313 428 500 1192 518 543 355

211 304 401 989 437 480 259

89 113 86 159 81 63 67

14 11 13 45 0 0 29

the total global financing in biotechnology in the therapeutics and diagnostics subclass.

www.biotechgate.com

6

All units in USD M

2014 2014 2014 Grand

l Aug Sep Total

355 486 612 6717

259 438 341 5051

67 0 242 1443

29 48 29 223

subclass.

Page 7: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

September 2014 financing rSource: Biotechgate – www.biotechgate.com

Company Name Sector

TransEnterix, Inc. Medical Technology

ChromaDex Inc. Biotechnology - other

Twist Bioscience Corp. R&D Services

Argos Therapeutics, Inc. Therapeutics / Diagnostics

Tetra Discovery

Partners

Therapeutics / Diagnostics

Allakos Inc. Therapeutics / Diagnostics

Cerebral Diagnostics

Canada Inc.

Medical Technology

Acutus Medical, Inc. Medical Technology

Lpath Incorporated Therapeutics / Diagnostics

Vitae Pharmaceuticals Therapeutics / Diagnostics

Suzou Xinrong Best

Medical Instrument Co.,

Ltd.

Medical Technology

BioMotiv, LLC Therapeutics / Diagnostics

Eutropics

Pharmaceuticals

Therapeutics / Diagnostics

Adaptimmune Limited Therapeutics / Diagnostics

Zyga Technology, Inc. Medical Technology

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

financing rounds summary www.biotechgate.com

Amount

m USD

Type of

Round

Financing

Stage

Medical Technology 25.0 Other Debt

financing

other 5.0 Other Post-IPO

10.0 Other Debt

financing

Therapeutics / Diagnostics 25.0 Other Debt

financing

Therapeutics / Diagnostics 1.0 UD Equity -

Seed

Diagnostics 10.0 Series A / 1.

Round

Equity -

Start-up

Medical Technology 0.9 Series A / 1.

Round

Equity -

First stage

Medical Technology 26.2 Series B / 2.

Round

Equity -

Start-up

Therapeutics / Diagnostics 12.5 Other Post-IPO

Therapeutics / Diagnostics 48.4 Other IPO

Medical Technology 100.0 UD Equity -

Later stage

Therapeutics / Diagnostics 25.0 UD Other

Therapeutics / Diagnostics 1.5 Other Research

grants

Therapeutics / Diagnostics 104.0 Series A / 1.

Round

Equity -

First stage

Medical Technology 10.0 Other Other

www.biotechgate.com

7

Ownership Country

Public USA

Public USA

Private /

independent

USA

Public USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

Canada

Private /

independent

USA

Public USA

Public USA

Private /

independent

China

Private /

independent

USA

Private /

independent

USA

Private /

independent

United

Kingdom

Private /

independent

USA

Page 8: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Agrisoma Biosciences

Inc.

Biotechnology - other

Avanir Pharmaceuticals,

Inc.

Therapeutics / Diagnostics

Allele Biotechnology and

Pharmaceuticals, Inc.

R&D Services

VentiRx

Pharmaceuticals, Inc.

Therapeutics / Diagnostics

Inivata R&D Services

Ivantis, Inc. Medical Technology

Navidea

Biopharmaceuticals, Inc.

Therapeutics / Diagnostics

Oncoceutics, Inc. Therapeutics / Diagnostics

Minerva Surgical Inc. Medical Technology

Eureka Therapeutics,

Inc.

Therapeutics / Diagnostics

PlantForm Corporation Therapeutics / Diagnostics

Syndax

Pharmaceuticals, Inc.

Therapeutics / Diagnostics

CVRx, Inc. Medical Technology

TRACON

Pharmaceuticals, Inc.

Therapeutics / Diagnostics

Aeras Therapeutics / Diagnostics

iHealth Lab, Inc. Medical Technology

Soligenix, Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

other 7.3 Series A / 1.

Round

Equity -

First stage

Therapeutics / Diagnostics 200.2 Other Post-IPO

7.0 Series A / 1.

Round

Equity -

First stage

Therapeutics / Diagnostics 19.3 UD Equity -

Second

stage

6.5 UD Other

Medical Technology 25.0 Series B / 2.

Round

Equity -

Start-up

Therapeutics / Diagnostics 1.7 Other Research

grants

Diagnostics UD UD Equity -

Start-up

Medical Technology 25.0 Other Equity -

Seed

Therapeutics / Diagnostics 21.0 Series C / 3.

Round

Equity -

Second

stage

Therapeutics / Diagnostics 20.0 Other Private

placement

Therapeutics / Diagnostics 5.0 Other Debt

financing

Medical Technology 15.0 Other Debt

financing

Therapeutics / Diagnostics 27.0 Series B / 2.

Round

Equity -

Second

stage

Therapeutics / Diagnostics 2.0 Other Research

grants

Medical Technology 25.0 Series A / 1.

Round

Equity -

Start-up

Therapeutics / Diagnostics 24.7 Other Research

grants

www.biotechgate.com

8

Private /

independent

Canada

Public USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

United

Kingdom

Private /

independent

USA

Public USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

Canada

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Subsidiary USA

Public USA

Page 9: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Eisai Co., Ltd. Pharma

Syntrix Biosystems, Inc. Therapeutics / Diagnostics

Kaketsuken Pharma

Eisai Co., Ltd. Pharma

Eisai Co., Ltd. Pharma

Oncothyreon Inc. Therapeutics / Diagnostics

KIYATEC Inc. R&D Services

BioCryst

Pharmaceuticals, Inc.

Therapeutics / Diagnostics

ProQR Therapeutics BV Therapeutics / Diagnostics

Foamix Pharmaceuticals

Ltd.

Pharma

Tokai Pharmaceuticals,

Inc.

Therapeutics / Diagnostics

Cardiorentis AG Therapeutics / Diagnostics

MGB Biopharma Limited Therapeutics / Diagnostics

Qu Biologics Inc. Therapeutics / Diagnostics

Avraham

Pharmaceuticals

Therapeutics / Diagnostics

Parion Sciences, Inc. Therapeutics / Diagnostics

Avinger Medical Technology

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

3.0 Other Research

grants

Therapeutics / Diagnostics 1.7 Other Research

grants

3.0 Other Research

grants

3.8 Other Research

grants

2.0 Other Research

grants

Therapeutics / Diagnostics 20.0 Other Post-IPO

2.0 Other Research

grants

Therapeutics / Diagnostics 2.0 Other Research

grants

Therapeutics / Diagnostics 98.0 Other IPO

40.0 Other IPO

Diagnostics 97.2 Other IPO

Therapeutics / Diagnostics 58.1 UD Equity -

Later stage

Therapeutics / Diagnostics 6.5 UD Equity -

Start-up

Therapeutics / Diagnostics 4.6 UD Equity -

Second

stage

Therapeutics / Diagnostics 4.5 UD Equity -

Later stage

/ Diagnostics 3.0 Other Research

grants

Medical Technology 35.0 UD Equity -

Later stage

www.biotechgate.com

9

Public Japan

Private /

independent

USA

Private /

independent

Japan

Public Japan

Public Japan

Public USA

Private /

independent

USA

Public USA

Public Netherlands

Public Israel

Public USA

Private /

independent

Switzerland

Private /

independent

United

Kingdom

Private /

independent

Canada

Private /

independent

Israel

Private /

independent

USA

Private /

independent

USA

Page 10: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

NewLeaf Symbiotics Biotechnology - other

Molecular Templates Therapeutics / Diagnostics

nLife Therapeutics SL Therapeutics / Diagnostics

Genisphere, LLC R&D Services

Scholar Rock Therapeutics / Diagnostics

Affimed Therapeutics AG Therapeutics / Diagnostics

Corindus Vascular

Robotics

Medical Technology

ReWalk Robotics Ltd. Medical Technology

AM-Pharma Therapeutics / Diagnostics

ViaCyte, Inc. Therapeutics / Diagnostics

Cellerant Therapeutics,

Inc.

Therapeutics / Diagnostics

Lq3 Pharmaceutical Therapeutics / Diagnostics

Airway Therapeutics,

LLC

Therapeutics / Diagnostics

Harpoon Medical, Inc. Medical Technology

Alizé Pharma Therapeutics / Diagnostics

Tryton Medical, Inc. Medical Technology

Euclises

Pharmaceuticals, Inc.

Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

other 17.0 Series B / 2.

Round

Equity -

Second

stage

Therapeutics / Diagnostics 3.5 Series C / 3.

Round

Equity -

Start-up

Therapeutics / Diagnostics 9.7 UD Equity -

First stage

2.0 Other Other

Therapeutics / Diagnostics 20.0 Series A / 1.

Round

Equity -

Start-up

Therapeutics / Diagnostics 56.0 Other IPO

Medical Technology 26.6 Other Post-IPO

Medical Technology 36.0 Other IPO

Therapeutics / Diagnostics 15.7 UD Equity -

Second

stage

Therapeutics / Diagnostics 16.6 Other Research

grants

Therapeutics / Diagnostics 47.5 Other Government

subvention

Therapeutics / Diagnostics 10.0 Series A / 1.

Round

Equity -

Seed

Therapeutics / Diagnostics 4.6 Series A / 1.

Round

Equity -

Start-up

Medical Technology 3.2 Series A / 1.

Round

Equity -

Seed

Therapeutics / Diagnostics 6.5 Series A / 1.

Round

Equity -

First stage

Medical Technology 20.0 UD Equity -

Later stage

Therapeutics / Diagnostics 1.3 Series A / 1.

Round

Equity -

Start-up

www.biotechgate.com

10

Private /

independent

USA

Private /

independent

USA

Private /

independent

Spain

Private /

independent

USA

Private /

independent

USA

Public Germany

Public USA

Public Israel

Private /

independent

Netherlands

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

France

Private /

independent

USA

Private /

independent

USA

Page 11: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Poxel SA Therapeutics / Diagnostics

SGB, Inc Biotechnology - other

Avelas Biosciences, Inc. Medical Technology

NanoViricides, Inc. Therapeutics / Diagnostics

Edge Therapeutics, Inc. Therapeutics / Diagnostics

Sonendo, Inc. Medical Technology

Flex Pharma Inc. Therapeutics / Diagnostics

Diffusion

Pharmaceuticals, LLC

Therapeutics / Diagnostics

Stealth Therapeutics,

Inc

Medical Technology

Biocartis SA R&D Services

Fractyl Laboratories,

Inc.

Medical Technology

Clovis Oncology Therapeutics / Diagnostics

Depomed, Inc. Pharma

Immunophotonics Inc Therapeutics / Diagnostics

AcuFocus, Inc. Medical Technology

WHILL, Inc. Medical Technology

Clearside Biomedical,

Inc.

Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

Therapeutics / Diagnostics 12.9 Series B / 2.

Round

Equity -

Second

stage

other 11.0 Series C / 3.

Round

Equity -

First stage

Medical Technology 7.4 Series B / 2.

Round

Equity -

Start-up

Therapeutics / Diagnostics 7.5 Other Post-IPO

Therapeutics / Diagnostics 10.0 Other Debt

financing

Medical Technology 35.0 UD Equity -

Start-up

Therapeutics / Diagnostics 40.0 Other n/a

Therapeutics / Diagnostics 3.5 UD Equity -

Second

stage

Medical Technology 0.4 UD Equity -

Seed

83.3 UD Equity -

Second

stage

Medical Technology 40.0 Series C / 3.

Round

Equity -

Later stage

Therapeutics / Diagnostics 250.0 Other Convertible

loan

300.0 Other Convertible

loan

Therapeutics / Diagnostics 1.8 Series A / 1.

Round

Equity -

Start-up

Medical Technology 21.0 UD Equity -

Start-up

Medical Technology 11.0 Series A / 1.

Round

Equity -

Start-up

Therapeutics / Diagnostics 16.0 Series B / 2.

Round

Equity -

First stage

www.biotechgate.com

11

Private /

independent

France

Private /

independent

USA

Private /

independent

USA

Public USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

Switzerland

Private /

independent

USA

Public USA

Public USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Private /

independent

USA

Page 12: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

Mapp

Biopharmaceutical, Inc.

Therapeutics / Diagnostics

Affimed Therapeutics AG Therapeutics / Diagnostics

Zai Laboratory, Inc. R&D Services

Affimed Therapeutics AG Therapeutics / Diagnostics

UD: Undisclosed

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

Therapeutics / Diagnostics 24.9 Other Research

grants

Therapeutics / Diagnostics 13.6 Other Debt

financing

30.0 Series A / 1.

Round

n/a

Therapeutics / Diagnostics 15.1 Series E / 5.

Round

Equity -

Later stage

www.biotechgate.com

12

Private /

independent

USA

Public Germany

Private /

independent

China

Public Germany

Page 13: BIOTECH FINANCING SUMMARY October 201 4 · Argos Therapeutics, Inc. Therapeutics / Diagnostics Tetra Discovery Partners Therapeutics / Diagnostics Allakos Inc. Therapeutics / Diagnostics

Biotech Financing Summary

All data supplied and available from Biotechgate

About this summary

The Biotech Financing Summary is published on a monthly basis by Venture Valuation and

can be downloaded for free either from our newsletter or from the website

http://www.biotechgate.com/services/v3/statisticsvcdeal

The data used for this summary is taken from Venture Valuation’s global Biotech and life

science database Biotechgate. Biotechgate is a popular source for life sciences company

and licensing deals information. If you are in

hesitate to contact us and to apply for a trial.

Click here to learn more about

Venture Valuation

Kasernenstrasse 11

8004 Zurich

Switzerland

Phone: +41 (43) 321 86 60

Web: www.venturevaluation.com

Email: [email protected]

Copyright © 2014 Venture Valuation VV Ltd. All rights reserved. This report is provided

for information purposes only. All information regarding financing rounds, deal

summaries and merger and acquisition transactions was obtained from company

websites, press-releases, conference profiles and different

above information can also be accessed on the Biotechgate website. All graphical

information was provided via Biotechgate. While the information contained herein has

been obtained from sources deeme

guarantees that it is accurate, complete, timely, or sequential. For more information

about Biotech companies, including deal, licensing and financing round details, please

visit the Biotechgate website at

Biotech Financing Summary

All data supplied and available from Biotechgate – www.biotechgate.com

The Biotech Financing Summary is published on a monthly basis by Venture Valuation and

can be downloaded for free either from our newsletter or from the website

om/services/v3/statisticsvcdeal

The data used for this summary is taken from Venture Valuation’s global Biotech and life

science database Biotechgate. Biotechgate is a popular source for life sciences company

and licensing deals information. If you are interested in learning more, please do not

hesitate to contact us and to apply for a trial.

about Biotechgate »

www.venturevaluation.com

Email: [email protected]

Venture Valuation VV Ltd. All rights reserved. This report is provided

for information purposes only. All information regarding financing rounds, deal

summaries and merger and acquisition transactions was obtained from company

nference profiles and different industry newsletters. The

above information can also be accessed on the Biotechgate website. All graphical

information was provided via Biotechgate. While the information contained herein has

been obtained from sources deemed reliable, Venture Valuation VV Ltd makes no

guarantees that it is accurate, complete, timely, or sequential. For more information

about Biotech companies, including deal, licensing and financing round details, please

visit the Biotechgate website at www.biotechgate.com

www.biotechgate.com

13

The Biotech Financing Summary is published on a monthly basis by Venture Valuation and

can be downloaded for free either from our newsletter or from the website

The data used for this summary is taken from Venture Valuation’s global Biotech and life

science database Biotechgate. Biotechgate is a popular source for life sciences company

terested in learning more, please do not

Venture Valuation VV Ltd. All rights reserved. This report is provided

for information purposes only. All information regarding financing rounds, deal

summaries and merger and acquisition transactions was obtained from company

industry newsletters. The

above information can also be accessed on the Biotechgate website. All graphical

information was provided via Biotechgate. While the information contained herein has

d reliable, Venture Valuation VV Ltd makes no

guarantees that it is accurate, complete, timely, or sequential. For more information

about Biotech companies, including deal, licensing and financing round details, please