Biosynthesis of peptide hormones DNA (gene) Hormone.
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Transcript of Biosynthesis of peptide hormones DNA (gene) Hormone.
Biosynthesis of peptide hormones
DNA (gene)
Hormone
Protein secretory pathway
rough endoplasmic reticulum
Protein secretory pathway
Secretory pathway
rough ER
Signal sequences & SRP
Signal sequences & SRP
SRP (signal recognition
particle)
Multiple hormone cleavage products
pro-opiomelanocortin polypeptide (POMC)
ACTH-lipotropin
-MSH -lipotropin-MSH
CLIP -endorphin
-MSH
MET-enk
Steroid hormone synthesis
• tissues involved in steroid hormone synthesis:
testosterone
estradiol
Steroid hormone synthesis
• synthesis occurs in
cholesterol
Biosynthesis of steroids
cholesterol (C27)
Gluco- and mineralo-corticoid synthesis
glucocorticoidglucocorticoid
mineralorticoidmineralorticoid
Androgen & estrogen synthesis
androgenandrogen
estrogensestrogens
Vitamin D synthesis
UV light
liver, kidney
Thyroid hormone synthesis
• thyroid hormone synthesis
• forms of active thyroid hormone:
Thyroid hormone biosynthesis
Biosynthesis of eicosanoids
arachidonic acid
Biosynthesis of eicosanoids
Anti-inflammatory drugs & eisosanoids
thromboxane leukotriene
inflammation response
phospholipase A
arachidonic acid
fatty acids
Hormone delivery
• endocrine:
• paracrine:
• autocrine:
• neuroendocrine:
Plasma transport of hormones
Hormone turnover
• typical half-life
• peptide hormones
• steroid & thyroid hormones