BIOS E-127– 10.12.06 Evolution of pathogens (Grenfell et al., 2004)
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Transcript of BIOS E-127– 10.12.06 Evolution of pathogens (Grenfell et al., 2004)
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BIOS E-127– 10.12.06
Evolution of pathogens
(Grenfell et al., 2004)
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(Kerr et al., 2006. Nature)
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(Grenfell et al., 2004)
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(Smith et al., 2004)
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Monday (12/13):
***Avida presentations***Revised projects due 12/15
Graduate reviews due 12/17
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Mutation Rate vs. Mutation #
• Can a large number of slow mutators adapt faster than a few fast mutators?
• Evolve Mut+ and Mut- in an environment that awards some tasks.
• Compete Mut+ and Mut- in a new environment awarding different tasks.
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Conlusions
• Mutators have an advantage• Mutators’ advantage counteracted by
population size.• Can’t determine the balance point where
neither have an advantage- need more granularity and larger N.
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Patrick SchlossUniversity of Michigan, Department of Microbiology and Immunology
“The only constant is change: temporal dynamics of host-associated microbiota”
Thursday, December 9th @ 6PM***Note Alternate Location: Haller Hall, Geological Museum 1st Floor (Rm 102)***24 Oxford St, Harvard University, Cambridge
Please join us for a wine and cheese reception at 5:30 pmHost: Curtis Huttenhower- MSI Seminar Schedule: http://www.msi.harvard.edu/thursdays.html- Directions to 24 Oxford St: http://www.msi.harvard.edu/ov_dir.html