BioProduct Design Study Guide 2009/2010

PDEng Programme

BioProduct Design

Study Guide 2009/2010

Faculty of Applied SciencesLorentzweg 12628 CJ DelftThe Netherlands

T +31 (0)15 27 89806E [email protected]

www.pdeng.tudelft.nl/bpd

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69374560Order number: 06942480013

BioProduct Design2 |

Disclaimer

Every effort has been made by the faculty in putting together this guide. However, further details about a number of subjects will only be available after the guide has been printed. For that reason, the information published by the faculty in this handbook is subject to change. Amendments, further details, and a more extensive description of the subjects can be found on Blackboard: http://blackboard.tudelft.nl and in the digital study guide http://studyguide.tudelft.nl.

combined_1.fm Monday, July 13, 2009 5:13 PM

Study Guide 2009/20103 |

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Preface

Dear Designer,

Welcome to the Faculty of Applied Sciences at Delft University of Tech-nology, and a special welcome to the PDEng-programme in BioProduct Design. The programme recently started, in September 2007, and it is the first to combine Life Sciences and Technology with Design Methodology. Through this innovative combination of different fields you learn to design new products for the Food, Pharma and Fine Chemicals industry. Your course programme is to a certain extent tailor-made, which means that when choosing your profile you have the freedom to select courses depending on your interest and objectives. Please use this Handbook and the different websites to deliberately draw up your programme. Further-more, you will find details about the programme, research groups, faculty members, practicalities and other useful information.During the year, two other important source of information are the univer-sity Blackboard site (blackboard.tudelft.nl) and the Electronic Studyguide (studyguide.tudelft.nl), which provide you with the most up-to-date infor-mation on courses offered by Delft University of Technology. The latest news about the university can be found on www.tudelft.nlIf anything is unclear or if you have other questions, do not hesitate to ask the Course Coordination Team, another faculty member or an advanced Designer.I’m looking forward to your contribution in BioProduct Design and I wish you an interesting, fruitful and enjoyable time in Delft.

Prof. Dr. Han de Winde Programme Director



Contents

Personal Data 3Preface 4

1 University Profile 71.1 Education & Student Affairs 91.2 Service Desk 91.3 BLACKBOARD - Virtual learning environment 101.4 The TU Delft Library 101.5 Self-study spaces 121.6 Student & Career Support 121.7 Facilities for handicapped students 131.8 Sports & Cultural Centre 131.9 Student ombudsman 141.10 Health & Safety, University Emergency Services 141.11 Accommodation 161.12 Medical Care 161.13 MoTiv 171.14 Public Lecture Series 181.15 Delta 19

2 Information about the PDEng-praogramme in BioProduct Design 212.1 People responsible for the programme/important addresses 222.2 Research Groups in the Department of Biotechnology 232.3 Faculty Building Addresses (see map) 252.4 Courses: Registration and Grading 272.5 The building 302.6 Other Important Information 322.7 Useful (web) Addresses 33



3 Designer Programme 353.1 Programme structure of BioProduct Design 363.2 First year 363.3 Second year 393.4 Timetables 40

4 Course descriptons 41

5 Map of TU Delft Campus 115

6 Year planner 1196.1 Lecture hours 122

7 Diary 123


1.University Profile


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TU Delft aims to be a preferred partner in education for students worldwide by offering intrinsically challenging and didactically inspiring courses. Intrinsically challenging because of the direct connection with urgent soci-etal themes, particularly in the area of sustainability.Didactically inspiring through the use of active educational methods to give our students’ own creativity as much freedom as possible. TU Delft sees its students as its future alumni, alumni who can be flexibly deployed and can take up a prominent position on the international labour market. The programme leading to the qualification of Delft engineer is an A-brand worldwide. To maintain this quality guarantee, TU Delft is constantly devel-oping its curriculum, both intrinsically and didactically.The university also collaborates closely with national and international universities, research institutes and partners in industry. These ties are a means for our students to gain valuable and relevant knowledge and expe-rience, providing them with the building blocks for a successful future career.

TU Delft (Delft University of Technology)

Visitor address Mekelweg 52628 CC Delft

Postal addressPostbus 52600 AA DelftTel.: +31 (0)15 27 89111 (switchboard)Fax: +31 (0)15 27 86522E-mail: [email protected] (enquiries)Web site: www.tudelft.nl


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1.1

Education & Student AffairsThe Education & Student Affairs department provides educational activity support: administration, student guidance, support for foreign students, sports, culture and international projects.

Jaffalaan 9A (visitor entrance on Mekelweg)2628 BX DelftTel.: +31 (0)15 27 84670Fax: +31 (0)15 27 87233E-mail: [email protected] site: www.student.tudelft.nl

1.2

Service DeskEvery faculty has a service desk. This is the contact point for students (and staff) for all questions concerning educational and student affairs, ICT and facility services, such as:

ProspectusesTranscriptsTurning in mark sheetsCertificates for students (such as for completion of programme compo-nents, marks or study credits for purposes of switching to another programme or credit-related/achievement-related grant)Degree audit applicationQuestions on the TAS examination registration system.

More information, including opening times, can be found on www.servicedesk.tudelft.nlThe Servicedesk of the faculty of Applied Sciences is located in the TN-Building, Lorentzweg 1.


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1.3

BLACKBOARD - Virtual learning environmentBlackboard is TU Delft’s virtual learning environment. All TU Delft students registered in the student enrolment system ISIS, all teaching staff and other personnel registered in Peoplesoft, as well as alumni, have access to Blackboard and can make use of the virtual learning environment. Almost all communication between students, instructors and staff goes through Blackboard. After logging in, you will find the relevant information on stud-ying and working at TU Delft.

Tel.:+31 (0)15 27 89194Web site: http://blackboard.tudelft.nlSupport: http://els.tudelft.nl

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The TU Delft LibraryYour virtual reference desk!

All relevant technical and scientific informationThe TU Delft Library is the largest technical and scientific library in the Netherlands. The library selects, administers, processes and supplies infor-mation relevant to your study collected from the Netherlands and abroad. Much of this information is in electronic form.

All the relevant science and technology information you needThe TU Delft Library is the largest technical and scientific library in the Netherlands. The library selects, administers, processes and supplies infor-mation relevant to your studies from in and outside the Netherlands. Much of the information is digital.

Stop searching, start finding!During your course, you will find that the Virtual Knowledge Centre (VKC) of your programme will come in very useful.The VKC is the ideal place to start when looking for information in your field, as it provides ‘virtually all knowledge in your field’. Learn about your VKC at http://vkc.library.tudelft.nl .


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The digital windowAt www.library.tudelft.nl you will find not just information on specific subjects, but also practical information about the Library, the online cata-logue, databases, works of reference, internet sources, instructions and maps. There are also articles, PhD theses, reports, graduation disserta-tions, lecture notes, patents and other TU Delft publications at http://repository.tudelft.nl.If you are looking for specific information, or if you have a question, request, complaint or comment about the services provided by the Library, go to http://AskYourLibrary.tudelft.nl, the digital window of the Library.For maps, go to http://kaartenkamer.library.tudelft.nl .

Get your questions answered immediatelyYou can communicate with the Library Customer Services via Ask Your Library at a time, place and manner of your own choosing. Many of your questions will be answered immediately. During office hours you can chat to a Library employee, who can also browse along with you. The employee is then able to help you find specific sources by pointing out information with the cursor. The answers to some questions can be found in the Frequently Asked Questions, but you can also telephone us (+31 (0)15 – 27 85678), mail us ([email protected]), or visit one of our branches. You can find them on www.library.tudelft.nl

EasyIf you use a computer that is connected to the TU Delft campus network, you can use, digitally, virtually every service provided by the Library. The Central Branch on Prometheusplein 1, behind the Aula Congress Centre, is open during the daytime, evening, and at weekends, for browsing through the books, studying with or without a computer, meeting, and making copies. The opening times of the Library are extended yet further during examination periods. The Central Branch is also where you will find the Trésor, the treasure house with unique, fragile and valuable items. The Trésor can be visited by appointment (http://tresor.library.tudelft.nl).

Central LibraryPrometheusplein 12628 ZC DelftTel.: +31 (0)15 27 85678E-mail: [email protected]


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1.5

Self-study spacesSpecially set up self-study spaces are available to you in the faculties and library for independent study. You will find these self-study spaces in sepa-rate spaces and in the foyers of the buildings. Many self-study spaces are equipped with laptop connections.

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Student & Career SupportStudent & Career Support is there to help you when you encounter issues that impede good studying. Both individuals and groups can consult Student & Career Support for support and advice. Consult the student counsellors, student psychologists and/or the information centre for assist-ance with: legal issues, scholarships/grants and financial support, psycho-social support, help with studies and career orientation on the labour market.

At the desk in the Education & Student Affairs building at Jaffalaan 9a (Mekelweg entrance), you can make an appointment with a student coun-sellor or student psychologist, or obtain more information about the infor-mation centre.

The student psychologists also have an open consultation hour on Tuesday and Thursday mornings from 11.30-12.30, during which you can see a student psychologist without an appointment. Please report to the desk when you come to attend the open consultation. Additionally, Student & Career Support will also appreciate a phone call or e-mail to let the office know that you are coming.

At Student & Career Support you can also attend workshops and trainings such as Constructive Thinking, Relaxing, Mind Mapping, Applications, Stud-ying with Dyslexia, and Personal Effectiveness. For more information, see www.smartstudie.tudelft.nl.On the ground floor at the Education & Student Affairs desk, you will also find the Information Centre (open from 9.00 to 17.00), where you can go for information about your academic or future professional career. The Information Centre can provide information on subjects such as university and higher professional education programmes, study and career choices, studies abroad, exchange programmes, summer courses, financial aid/


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grants and language courses. Most of the day, the desk will be staffed with someone to help you.Opening hours: Monday through Friday from 9.00 to 17.00.Jaffalaan 9A (visitors entrance on Mekelweg).2628 BX DelftTel.: +31 (0)15 27 88004E-mail: [email protected] site: www.studentandcareersupport.tudelft.nl

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Facilities for handicapped studentsThe university will ensure that the education is also accessible to students with a disability. This means that there must be appropriate facilities for disa-bled students or students with a chronic illness, whether financially or by providing special educational facilities. If you have special needs, contact your academic counsellor. Please give notice of any needs you may have as early as possible, as some facilities may take some time to organise.

1.8

Sports & Cultural CentreThe Sports & Cultural Centre offers nearly every kind of indoor and outdoor sport. Most fields and pitches are lit for evening play.You can also take part in a variety of cultural activities:

Courses, including videography, photography, painting, drawing, sculpting, ceramics, instrument building, classical music, light & popular music, computer-assisted sound processing, modern and oriental dance, capoeira, philosophy and writing.Vocal and instrumental musical groups.Use of musical instruments, including pianos, drum sets, saxophones and guitars.

TU Delft Sports CentreMekelweg 82628 CD DelftTel.: +31 (0) 15 27 82443E-mail: [email protected] Web site: www.snc.tudelft.nl


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TU Delft Cultural CentreMekelweg 102628 CD DelftTel: +31 (0) 15 27 83988E-mail: [email protected] Web site: www.snc.tudelft.nl

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Student ombudsmanIf you, as a student, have a complaint about TU Delft, the faculty or staff, you should first try to resolve the situation with your faculty’s academic counsellor. If that doesn’t work, visit the student ombudsman. The student ombudsman can help you to solve problems and make proposals aimed at preventing others from encountering similar circumstances.The ombudsman for TU Delft is W.J.M. Knippenberg.

Aula TU DelftMekelweg 52628 CC DelftTel.: +31 (0)15 27 84403E-mail: [email protected] the ombudsman by e-mail first.

1.10

Health & Safety, University Emergency ServicesLike the staff of TU Delft, students are entitled to a safe and healthy work-place/study space. This also entails the obligation to act in the interests of your own safety and that of others. The Netherlands has working condi-tions legislation (‘ARBO legislation’) in place governing safety standards and rules of conduct.TU Delft also has specific environmental, health & safety rules.

Basic rulesStudents may not enter technical areas. Performance of actions and exper-iments involving an element of risk are only permitted on the instruction of and with permission of the supervisor. Anyone who suspects that he or she may be exposed to risk in the performance of an assignment may refuse


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that assignment and contact the Health & Safety Adviser concerning the matter.

Undesirable behaviour Aggression, sexual intimidation, threats, pestering and discrimination are considered undesirable behaviour and are not tolerated. Undesirable behaviour can be reported to the Executive Board. You can also contact your faculty’s confidential advisor, www.confidentialadvisor.tudelft.nl, who can handle complaints discretely.

Smoking prohibitedTU Delft is a non-smoking institution. Smoking is not permitted anywhere except in the smoking areas and locations where smoking is temporarily permitted. Violation of the non-smoking rule is considered undesirable behaviour. Anyone who is being disturbed by smoking can report it to the Health & Safety Adviser or the confidential adviser.

Computer workIntensive computer work can lead to neck and upper body problems. These conditions are commonly referred to as ‘RSI.’ The chance of RSI is increased when working under pressure, in situations such as completing a thesis. Advanced RSI is very difficult to cure and should be avoided at all costs. Make sure your working posture is always correct and take short work breaks at regular intervals. One useful tool to help you do this is the ‘Workpace’ programme.The Health & Safety Adviser can help you and evaluate your workspace.

Emergencies and University Emergency ServicesTU Delft has a University Emergency Services organisation. The members of the University Emergency Services organisation are known to the staff. They perform first aid and act in the event of an emergency Any time you are injured, always seek treatment. Always report any accidents or near-accidents to University Emergency Services.In the event of fire, a work-related accident or a dangerous situation, follow these rules:

A ‘slow whoop’ siren over the public address system indicates that an alarm has been sounded.

Follow the instructions immediately.Get yourself to safety and warn others.In the event of fire, activate a fire alarm.In the event of an emergency, dial the emergency number (112) on a land line and answer the questions.


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Follow the instructions of University Emergency Services personnel.For more information, see www.tudelft.nl and follow the links to ‘Staff,’ ‘A-Z index.’

1.11

AccommodationIn principle, you have to arrange your own accommodation. The ‘consent’ system is fairly widely in effect in Delft student residences. This means that you will have to ‘interview’ with the residents of the house. Finding housing in Delft is difficult, and finding cheap housing is even harder, so start looking as early as possible!

DUWOTU Delft has a contract with accommodation organisation DUWO for the housing of foreign students and guests. The contracts with the students/guests or foreign students are fixed-term contracts with the option of extension. Applications for housing will be granted on a ‘first come first served’ basis.

Visitors addressStichting DUWOKanaalweg 42628 EB Delft

Postal addressPostbus 542600 AB DelftTel.: +31 (0)15 21 92200E-mail: [email protected] site: www.duwo.nl

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Medical CareThe student healthcare organisation Stichting Studentengezondheidszorg (SGZ) provides both medical and psychotherapeutic healthcare for students.Because the SGZ principally provides preventative help, we recommend you have your own GP who can visit you if you are ill. This can be one of the SGZ’s own GPs.


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SGZBeukenlaan 4G2612 VC DelftWeb site:www.sgz.nl

General Practitioners:To make an appointment, call : +31(0)15 212 1507,Monday to Friday 8:30-12:30 hrs and 13:30-16:30 hrs. (Closed Friday after-noon)E-mail: [email protected]

Vaccinations: Tel.: +31 (0)15 21 21507E-mail: [email protected]

Psychologists: Tel.: +31 (0)15 21 33426E-mail: [email protected].

1.13

MoTivMoTiv is a church organisation at TU Delft. Its aim is to engender motiva-tion, inspiration and passion in those who choose a profession in tech-nology. Participants in the MoTiv programmes explore their inner strength and commitment. MoTiv’s activities are designed to augment personal skills and social support and to make a contribution to the technical/cultural debate in society.MoTiv has pastors with whom you can make an appointment for individual pastoral coaching. For those seeking reflection, there is an Ecumenical church service every Sunday at 11.15 at Noordeinde 4.

Voorstraat 602611 JS DelftTel.: +31 (0)15 21 23421E-mail: [email protected] site: www.motiv.tudelft.nl


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1.14

Public Lecture SeriesStudium Generale, the TU Delft Public Lecture Series, helps you stay on top of the oldest and newest developments in science, art, culture and society. Studium Generale offers you the opportunity to expand your horizons and learn about disciplines other than your own area of study.Twice per year, Studium Generale issues its programme listings announcing all activities. The programme listings are distributed in all TU buildings and can also be obtained individually.To be sure you are always informed of the programme’s offerings, you might want to sign up for the weekly electronic newsletter. You’ll never miss a thing!To register, send an e-mail to [email protected]. The latest programme can also be found on www.sg.tudelft.nl. Studium GeneraleFaculteit TBMRoom a.0.260Jaffalaan 52628 BX DelftTel.: +31(0)15 27 85235E-mail: [email protected] site: www.sg.tudelft.nlSecretariat opening hours:Monday through Thursday, 9.00 uur to 17.00


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DeltaDelta is TU Delft’s information and opinion journal, published by a journalis-tically independent editorial board.

Delta Editorial BoardUniversity Library, room 0.18 – 0. 28Prometheusplein 12628 ZC DelftPostal address:Postbus 1392600 AC DelftTel.: +31 (0)15 27 84848E-mail: [email protected] site: www.delta.tudelft.nl

The electronic version of this study guide can also be found on the faculty’s campus web site.


2.Information about the PDEng-programme in BioProduct Design


Information about the PDEng-programme in BioProduct Design


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2.1

People responsible for the programme/important addresses

Department of BiotechnologyDelft University of TechnologyJulianalaan 672628 BC DelftTel: +31 (0)15 27 89615Fax: +31 (0)15 27 82355E-mail: [email protected]

Programme DirectorProf.dr. Han de WindeE-mail: [email protected]: Ms. Jennifer AchterhofTel: +31 (0)15 86990E-mail: [email protected]

The Programme Director is chairman to the Selection, Programme and Exam Committee, responsible for the content of the programme and the selection of candidates.

Course Coordination TeamDrs. Florien de BrouwerE-mail: [email protected]: +31 (0)15 27 81171Drs. Janine Kiers, M. BiotechE-mail: [email protected]: +31 (0)15 27 86645

The Course Coordination Team is responsible for the organisation of the programme, dealing with public relations, selection, appointment and moni-toring of PDEng trainees, quality assurance of the programme.




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Research on BioProduct Design and supervision of projectsProf. dr. ir. Klaas van ‘t RietEmail:[email protected]. Janine KiersE-mail: [email protected] research group assures the scientific quality of design projects and provides education in BioProduct Design. The research group analyses the bioproduct design process. It supervises design projects and assures their quality. The group provides education in BioProduct Design.

Institute BSDLDepartment of BiotechnologyCoordinator: dr.ir. Lies van der Meer-LerkOffice Manager: ms. Ger AggenbachTel: +31 (0)15 27 81922Secretary: ms. Ginie KlumpersTel: +31 (0)15 27 84621

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Research Groups in the Department of Biotechnology

Analytical Biotechnology (ABT)prof.dr. Peter D.E.M. Verhaertprof.dr.ir. Gijs W.K. van Dedem (emeritus)Web site: www.bt.tudelft.nl/abt

Biocatalysis and Organic Chemistry (BOC)prof.dr. Isabel W.C.E. Arendsprof.dr. Roger A. Sheldon (emeritus)Web site: www.bt.tudelft.nl/boc

Bioprocess Technology (BPT)prof.dr.ir. Sef HeijnenWeb site: www.bt.tudelft.nl/bpt

Bioseparation Technology (BST)Prof. dr.ir. Luuk A.M. van der WielenWeb site: www.bt.tudelft.nl/bst




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Environmental Biotechnology (EBT)prof.dr.ir. Mark C.M. van Loosdrechtprof.dr.ir. Mike S.M. Jetten (part-time)prof.dr. J. Gijs Kuenen (emeritus)Web site: www.bt.tudelft.nl/ebt

Enzymology (ENZ)prof.dr. Wilfred R. Hagenprof.dr. Simon de VriesWeb site: www.bt.tudelft.nl/enz

Industrial Microbiology (IMB)prof.dr. Jack T. Pronkprof.dr. Han de Windeprof.dr. Hans van Dijken (part-time)prof.dr. Paul Hooykaas (part-time)Web site: www.bt.tudelft.nl/imb

Complex Fluids TheoryProf.dr. T. OdijkWeb site: www.bt.tudelft.nl/tcv

Biotechnology and Society (BTS)prof.dr. Julian KinderlererWeb site: www.bt.tudelft.nl/bts




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2.3

Faculty Building Addresses (see map)

Faculty of Applied SciencesVisiting address: Lorentzweg 12628 CJ DelftThe Netherlands(building 22 on map)Postal address: PO Box 50462600 GA DelftThe NetherlandsTel: +31 (0)15 27 87774Fax: +31 (0)15 27 82655E-mail: [email protected] site: www.tnw.tudelft.nl

Department of Biotechnology / Biochemical EngineeringDirector Prof. J.H. (Han) de WindeVisiting address: Julianalaan 672628 BC DelftThe Netherlands(building 5 on map)Postal address: Julianalaan 672628 BC DelftThe NetherlandsTel: +31 (0)15 27 86990Fax: +31 (0)15 27 82355E-mail: [email protected] Web site: www.bt.tudelft.nl




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Department of Chemical Technology / DelftChemTechDirector Prof. E.J.R. (Ernst) SudholterVisiting address: Julianalaan 1362628 BL DelftThe Netherlands(building 12 on map)Postal address: PO Box 50452600 GA DelftThe NetherlandsTel: +31 (0)15 27 85029Fax: +31 (0)15 27 88668E-mail: [email protected] Web site: www.dct.tudelft.nl

Imaging Science and TechnologyLaboratory of Applied PhysicsAddress: See Faculty of Applied SciencesTel: +31 (0)15 27 87164Fax: +31 (0)15 27 87075E-mail: [email protected] Web site: www.ist.tudelft.nl

Kavli Institute of NanoscienceLorentzweg 12628 CJ [email protected]

Department of Multi-Scale PhysicsDirector: Prof. H.E.A. (Harry) van den AkkerLaboratory of Applied PhysicsAddress: See Faculty of Applied SciencesandKramers Laboratorium voor Fysische TechnologiePrins Bernhardlaan 62628 BW Delft (building 15 on map)Tel: +31 (0)15 27 81400Fax: +31 (0)15 27 82838E-mail: [email protected] Web site: www.msp.tudelft.nl




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NanoScienceLaboratory of Applied PhysicsAddress: See Faculty of Applied SciencesTel: +31 (0)15 27 85936Fax: +31 (0)15 26 17868E-mail: [email protected] Web site: www.ns.tudelft.nl

Radiation, Radionuclides & ReactorsReactor Institute DelftMekelweg 152629 JB DelftThe NetherlandsTel: +31 (0)15 27 85052Fax: +31 (0)15 27 86422E-mail: [email protected] site: www.rrr.tudelft.nl/

The various Applied Sciences buildings have their own ‘cafes’, where people gather regularly for a chat and a drink. These are:• The ‘TPKV’, in the D-wing basement of the Applied Physics building at Lorentzweg 1, open on Fridays from 16.00.• ‘Ecast’, in the basement of the ChemTech building at Julianalaan 136, open Thursdays from 16.00.• ‘t Keldertje’, room 2.290 in the attic of the Department of Biotechnology, Julianalaan 67, open Fridays from 16.30.

2.4

Courses: Registration and Grading

Course registration You are responsible for registering for all courses in your programme. Youcan register as soon as your programme is approved or when a course isapproved individually. For Advanced Courses you are advised to sign in as soon as possible and well in advance as places usually fill up quickly. As "PDEng trainee" always try to sign in for the reduced PhD-student fee.

Examinations and examsPlease note: Examinations are usually called ‘tentamens’ in Dutch. Formally an ‘examen’ in Dutch is the degree audit taking place at the end of a programme phase such as a Propaedeuse (end of first year), a Bachelor or




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a Master phase. These ‘examens’ are formalities in the Dutch university system. There are no end-of-year examinations!

Study progress administrationYou are responsible to keep track of your study results in your Excel Study File. You will discuss your study progress in regular meetings with the Course Coordinators. You need to check regularly that your file is up-to-date and, when approaching the finalisation of your programme, that it is complete.Course results administration may differ: 1 For regular Master courses at TU Delft, just provide the lecturer with

your name and study number and it should work out fine. If an assign-ment is part of the course, you have to work together with another PDEng-trainee, as your work is usually evaluated differently from the work of Master students. Sometimes also the coursecode is therefore different, you and the lecturer are responsible for the correct adminis-tration of this.

2 For special PDEng assignments etcetera: The teacher should complete a TU Delft grade sheet and send it to the coordinator.

3 For Advanced Courses the coordinator need a copy of the course certifi-cate. For AC’s with assignment we also need a grade sheet.

4 For all courses you take outside TU Delft: the coordinator needs an offi-cial letter of the lecturer stating the name of the course, your name, grade, study number and the amount of ECTS points.

NB: Please note that you are responsible for providing the coordinators with all your grades in time for the diploma.

Examination registrationIn order to take an exam, you need to register in advance. Since the regis-tration may differ from one course to another, you need to check with the lecturer on how to register.

TASIn TAS (Tentamen aanmeld system) you can find where and when an exam will take place. PDEng. trainees need to log in as ‘demo’, password ‘demo’, go to ‘overview’, mark the box ‘limit selection to…’ and enter course code.

Credits, marking scheme and gradesThe weight of all modules at TU Delft is expressed in European Credit Transfer System (ECTS) points. One year of study comprises 60 credit points or 1680 hours of study in an academic year. This includes lecture hours, homework, projects, practical work etc.




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This means that there is no strict relation between lecture hours and credit points, but a general rule is that each module, which takes one lecture hour per week for the duration of one semester, earns you about 1 credit point. The scale used for grading is 1-10, i.e. each examination awards a maximum grade of 10. The passing mark is a 6 and a 5 or lower is consid-ered a ‘fail’. In some instances you are not awarded a numerical grade, but you either pass (‘voldoende’) or fail (‘onvoldoende’).This system is quite common for practical work. A table converting the Dutch grading system into the European one has been proposed, but this has not yet been adopted at TU Delft. The table below shows an unofficial translation from Dutch grades into ECTS grades.

Graduation CeremonyThe great day has arrived! You have fulfilled all obligations of your Designer Programme and you can participate in the graduation ceremony. You should make sure that your grades are available at least two weeks in advance. This means that you should plan your Final Presentation of your Design Project at least two weeks in advance of the ceremony. A check will be performed to ensure that you are entitled to graduate. The Graduation Ceremony is, in intself, merely a formality, but it marks an important mile-stone in your career and provides the opportunity for you to publicly congratulated by family, friends and academic staff - much deserved acco-lades after an intensive period of study!

Dutch Distribution ECTS

Grading system percentage grade

8 <grade < 10 best 10 % A

7.5<grade < 8 next 25 % B

7 <grade <7.5 next 30 % C

6 <grade <7 next 25% D

5.5<grade <6 next 10% E

grade < 5.5 Fail F or FX




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2.5

The building

Designer OfficeThe office for the Designers in the Department of Biotechnology is equipped with computing and internet facilities. The key to the PDEng-room requires a deposit of EUR25 and can be collected from Ms Ginie Klumpers. The deposit will be refunded to you upon return of the key.

The location is:Department of BiotechnologyJulianalaan 67

2628 BC DelftThe NetherlandsRoom 2.800 Tel: +31 (0)15 27 82349

Regulations Department of BiotechnologyThe Course coordinator of BioProduct Design will provide you with the form to register for the Department of Biotechnology. You will also receive the Safety Guide. Everyone is obliged:

to read the Safety Guide, to participate in the Fire drill, to register for the department of Biotechnology,to have their picture taken for the employees’ boards.

Please observe the rules and regulations for working at the Department outside of office hours!!

Access to the buildingDelft University of Technology has a university card system called Campus Card. The Campus Card has several functions:

an ID function that, together with the Campus Card, allows you to participate in exams and working groups. an identification function that allows you to make use of the services of the TU Delft Library. a right of entry to some TU buildings, among them all buildings of the Faculty of Applied Sciences.

This Campus Card is a valuable document and must be handled as such. You will receive a letter stating to collect your card. The Campus Card is




|2

comprised of a (digital) photo. New employees can have their picture taken at the OSA building (Jaffalaan 9a). You can have a passport photo taken every weekday from 09:30 to 16:30. If the Campus Card has been lost or damaged, you can request a duplicate Campus Card (price: EUR 3.00). When using the academic or exam facilities, the Campus Card must be shown. If you are unable to show your Campus Card, you will not be permitted to use the facilities.

Hours registrationYour name will be in the list down at the clock on the ground floor. You need to enter your arrival time and departure time in the list. If you take more than half an hour lunch break, you need to enter lunch leaving and return as well. In this list you register your WORKING HOURS - your non-working presence in the building (e.g. 't Keldertje) should not be registered here

LunchOfficially you have half an hour lunch time. If you take a longer lunch break, you have to register leaving time and return in the list down at the clock.

TIM leave registration systemIf you want to take holidays, you need to enter them in TIM (hours.tudelft.nl). Please ask your PDEng colleagues how to handle it. Your request will be approved by L van der Meer.

Call in sickWhat to do when you are ill and can not come to work? Call the secretary of Bioprocesstechnology (Jennifer or Maltie or Miranda) at 82342 before 9:00 am. Once you are fine again, let them know as well before 9:00 am on the day you return to work. If you have a serious illness (with absence longer than one week) please inform the coordinator as well.

Beamer reservationA beamer can be booked and collected at the workshop at the ground floor.

Room reservationA lecture or discussion room can be booked at secretary Ginie.




2 |

MailFor internal mail you put mail in yellow envelopes (A3 format). For business mail sent outside the university you can use the white university envelopes. You do not have to put a stamp on it and leave it in the huismeester room.

2.6

Other Important Information

Refund of books and travelThe programme can refund your study books for 50% and traintickets for traveling.Drop off your completed C1 form (including remarks section: what is the purpose of your expense) in the mailbox of the coordinator. The DIM 1 and 2 codes of the BioProduct Design programme are TAT and T11705.

Dutch Language course for foreignersTU Delft offers a Dutch course, which is partly on your own expense.

Healthcare system The Dutch healthcare system differs from most other countries. The General Practitioner plays an important role and is the first one with whom you should get into contact when you experience medical problems. For this reason it is advisable to register with a General Practitioner in your environment. How to find a general practitioner? Also for finding a dentist.Look at: http://www.sgz.nl/huisartsen.htmlWhen having complaint or problems which are related to your working environment then you can make an appointment with the company doctor, phone number: 83685.

Health insuranceMost of the staff of the TU Delft has their insurance at Ohra (www.ohra.nl). Ask one of the PDEng trainees about the insurance.

Personnel DepartmentThe personnel department is situated in the building of the Department of Civil Engineering and Geosciences at the Stevinweg 1, 5th floor, in the centre of the university campus.

Residence permit (if applicable)Normally you will receive a letter from IND 3 months prior to your ending data of residence permit reminding you to extend your residence permit.




|2

You are responsible for the extension and payment of your residence permit.

2.7

Useful (web) Addresseswww.tudelft.nl(general Information about Delft University, history, programmes, research, etc.)

www.studyat.tudelft.nl(information about all MSc and MSc programmes offered by Delft University of Technology, information about the requirements, how to apply, costs, funding, insurance, housing, medical and pastoral care, facilities for special needs students etc.)

www.snc.tudelft.nl(TU Delft Sports & Cultural Centre)

www.dsdelft.nl/centrum

www.delft.nl(information about the city of Delft)

www.denhaag.org(for activities in the nearby city of Den Haag)

www.uitaandemaas.nl(activities in Rotterdam)

www.amsterdam.nl(activities, news, public transport in and around Amsterdam)




2 |

Student Restaurants in Delft- University main cafeteria, Aula, Mekelweg 5- SnC Café, Mekelweg 8- Sint Jansbrug, Oude Delft 50-52- Koornbeurs, Voldersgracht 1- DSB, Oude Delft 123- CSR, Oude Delft 9- De Bolk, Buitenwatersloot 1-3- Novum, Verwersdijk 102-104


3.Designer Programme


Designer Programme


3 |

3.1

Programme structure of BioProduct Design

Credits and Duration of the programmeThe complete programme consists of 120 European Credits, EC, as defined in the European Credit Transfer System. The trainees take 60 EC per year which is a full time study load. The duration of the programme is 2 years.

Preparing your individual programmeDepending on your educational background and your envisaged develop-ment, you draw up your own programme together with the Course Director and one of the Course Coordinators. The programme is defined in discus-sion with the PDEng trainee, tailoring it to the trainee’s background and interest, while controlling the balance between deepening and broadening coursework. The PDEng trainee makes a proposal after identifying interesting courses at www.studyguide.tudelft.nl and other websites (see paragraph 4.2). He or she needs to take into acount the scheduling of the courses (Black-board.tudelft.nl) and the work balance (e.g. 30 ects per semester).

SchedulingThe academic year at Delft University of Technology is divided in 2 semes-ters, from September till January and from February till June. Each semester consists of 2 periods, in September starts period 1 and in February starts period 3. During these semesters courses are given. July and August are regarded as period 5, the period for re-sits, holidays and the Group Design Project. Please note that courses exclusively for PDEng-trainees or Advanced Courses may be scheduled in lecture-free weeks.

3.2

First year The first year consists of coursework and the Group Design Project.

Advanced Coursework 43 ECThe coursework is divided in three phases that are not necessarily sepa-rated in time. Due to its nature, phase 1 is in the first months of the programme:


Designer Programme


|3

Phase 1 EqualizationThis phase is to eliminate deficiencies. Depending on the PDEng trainee’s background and intended Study Programme, 0 to 9 EC may be included to obtain a uniform trainee population. Phase 2 DeepeningThe PDEng trainee develops him/herself in the area of his/her background, but on a new level (post-MSc) or with a different approach of the material. The courses are organized for PhD and PDEng students or professionals, or contain new, e.g. integrating, approaches.Phase 3 BroadeningThe PDEng trainee broadens his/her scope and learns more in disciplines that are new to him/her. These courses may be on MSc or BSc level, or are specifically organized for PDEng-trainees. The PDEng trainee defines his/her individual Study Programme in discus-sion with the Programme Coordinator. The trainee has a certain freedom to choose from the Deepening and Broadening courses. Care is taken that the courses form a balanced total, which means that a certain specialization is necessary, while at the same time the different disciplines are represented. Special attention is given to the integration of different disciplines.

Level of the coursesIn the definition of a PDEng trainee’s programme, care is taken to balance deepening and broadening courses. Deepening courses are of an advanced, post-MSc level and are organized for PDEng and/or PhD students and professionals. Broadening courses may be of a post-graduate, but also of an MSc, or occasionally even of a BSc level. For MSc-courses, you attend the lectures with MSc students and in the content of the examination or the evaluation of the performance it may be taken into account that you are at a post-MSc level. For group assigments, you work in principle together with your fellow PDEngtrainees.

Core Courses & ProjectsThe obligatory part concerns the Group Design Project and its theoretical preparation, several broadening disciplines, plus the course “Industrial BioProduct Design”.


Designer Programme


3 |

Elective coursesThe trainee’s specialization is determined by the choice of coursework in combination with the Individual Design Project. The following specializations are identified:

Drug Design & DiagnosticsCell FactoryFunctional Genomics & Bio-informaticsMolecular Design

The 23 (maximum) EC can be chosen in different areas.At www.stuyguide.tudelft.nl and in this studyguide (chapter 4) you find a non-exhaustive list of courses and their course codes for the PDEng programme in BioProduct Design. Please note that the list is not complete. You are encouraged to suggest suitable courses yourselves.

Websites providing information on additional courses you can include in your programme:BODL Biotechnologie Opleidingen Delft Leiden / Biotechnology Studies Delft Leiden: www.bsdl-edu.bt.tudelft.nl/

LACDR Leiden Amsterdam Centre for Drug Research: www.lacdr.nl

LIC Leiden Institute of Chemistry: www.chem.leidenuniv.nl/licmain/Engels/Home/ScheikundeLeiden.htm

VLAG Graduate School Voeding, Levensmiddelentechnologie, Agrobiotech-nologie en Gezondheid: www.vlaggraduateschool.nl/eduvlco.html

Title Credits

Design Theory and Methodology 3

Group Design Project 17

Project Management 2

Economic Evaluation 6

Turning Technology into Business 6

Industrial BioProduct Design 3

Total 37 EC


Designer Programme


|3

Leiden Lecture Series in the Master programme Bio-Pharmaceutical Sciences: www.studiegids.leidenuniv.nl/index.php3?m=921&c=2341#next%20year

LST Master programme Life Science & Technology: www.lst.delftleiden.nl/msc/index.php

OSPT Dutch Graduate School on Process Technology: http://ospt.tnw.utwente.nl/ospt4/index.php?static=education

Group Design Project 17 ECIn the Group Design Project, the trainees work in groups of 4 (range 3-6) students on a design project in collaboration with industry. The supervision is in the hands of a steering group consisting of an industrial principal, and academic representatives, with ample (industrial or academic) design expe-rience. The team experiences working in an industrial context, dividing tasks within the team, interacting with different stakeholders and planning and control issues. At the same time, a detailed design has to be delivered, in which systematic and quantitative argumentation is provided for the choices made. The design team communicates regularly with the industrial principal and supervisors by intermediate reporting, which includes presen-tations and meetings.

3.3

Second year The second year of the programme is devoted to the Individual Design Project (60 EC) in (or in collaboration with) industry. This project is performed in, or in collaboration with, the R&D department of an industry or as a developer in a smaller industry. It may be providing a solution for a specific problem, but it may also regard the whole design process, from idea to feasibility. As in the Group Design Project, a focus is on the delivery of the systematic and quantitative argumentation for the final design solu-tion. The supervision of this project is handled by at least one academic super-visor and one industrial supervisor.

Code Course Title Credits

ST6813 Group Design Project 17


Designer Programme


3 |

3.4

TimetablesYou can find the timetables of your programme on the Blackboard website.

Code Title

ST6902pr PDEng Individual Design Project - practice

ST6902th PDEng Individual Design Project - theory

ST6902vc PDEng Individual Design Project - communication


4.Course Descriptons


Course Descriptons


4 |

BE3131TU | Fermentation Technology | ECTS: 3

Responsible Instructor Dr.ir. R.G.J.M. van der Lans ([email protected]), Prof.dr.ir. J.J. Heijnen ([email protected])

Contact Hours / Weekx/x/x/x

2/2/0/0

Education Period 1, 2

Start Education 1

Exam Period 2

Course Language English

Expected prior know-ledge

Basic biosciences (biochemistry and microbiology) and Engineeringprinciples.

Course Contents Stoichiometry, thermodynamics, kinetics of growth andproduct formation, Metabolic networks, Modeling of batch,chemostat, fed batch fermentation, Role of mass transfer,mixing and heat transfer.

Study Goals Designing/evaluating industrial fermentation processes fromtechnological and microbial fundamentals.

Education Method Lectures, exercises.

Literature and StudyMaterials

Lecture notes on BlackboardRecommended: Basic Bioreactor design, van 't Riet en Tramper,Dekker, New York 1991

Assessment Assignments and examination. PdEng trainees are subject to special requirements (code ST6532).

Permitted Materialsduring Tests

Open book

Enrolment /Application

Via blackboard

Location Delft

BE3141TU | Environmental Biotechnology | ECTS: 3

Responsible Instructor Prof.dr.ir. M.C.M. van Loosdrecht ([email protected])


0/0/4/0


Start Education 2

Exam Period 3


Course Descriptons


|4


Course Contents - Stoichiometry and kinetics in environmental biotechnology processes;- reaction/diffusion in biofilm systems;- dynamic modelling of activated sludge processes;- anaerobic processes;- nutrient removal;- design of integrated purification processes.

Study Goals - To get a general view on environmental biotechnological processes- To be able to design environmental biotechnological processes.

Education Method Lectures and assignments


Lecture notes and handouts.

Prerequisites General reactor engineering courses

Assessment The final grade is determined from the results of the lecture assignments (60%) and an oral examination

Remarks The course is oriented towards the design of environmental biotechnolo-gical processes. The specific aspects of using open mixed microbial cultures and undefined substrates will get particular attention. Topics: Stoichiometry and kinetics, mass transfer processes, biomass retention systems, dynamic modelling of mixed microbial cultures, process design.The case study is focussing on a global design of an industrial trea-tment. (ABET)Planning: 14 hours class, 46 hours assignments, 20 hours preparation of exam

BE3161 | Microbial Physiology | ECTS: 4

Responsible Instructor Dr.ir. A.J.A. van Maris ([email protected])


periode 3: 2 uur in de eerste week, 2 uur in week 3 en 2 uur in week 7

Education Period 3

Start Education 3

Exam Period 3


Course Contents Microbial metabolism under nutrient excess and nutrient limited condi-tions. Mixed substrate utilization, fermentation, aerobic- and anaerobic respiration and methanogenesis. Quantitative physiology. Selection and evolution. Microbial interactions with industry and our environment. The role of microorganisms in the geochemical elemental cycles.

Study Goals Basic knowledge on microbial physiology.

Education Method Selfstudy combined with 3 Q&A sessions.


Course Descriptons


4 |

Books Brock Biology of Microorganisms, Martinko, Madigan (12th ed).

Assessment Oral/Written exam

BE3201 | Analytical Biotechnology | ECTS: 3

Responsible Instructor Prof.dr. P.D.E.M. Verhaert ([email protected])


0/0/0/4

Education Period 4

Start Education 4

Exam Period 4


Course Contents This course treats various aspects of Analytical Biotechnology, in particular those which comprise the current research topics of the Section at the TUDelft Biotechnology Department bearing that name.The goal is to make (bio)chemical engineers in spe familiar with modern Analytical Biotechnology.The following items are discussed:- Analytical miniaturization (towards single cell analysis on chip).- Peptidomics and its link to modern Biology research (from comparative neurobiology, over the discovery of novel drug candidates in amphibian skin, to microbiology).- Proteomics and its applications with particular focus on the pharmaceu-tical and biotechnology industry.- Mass spectrometry imaging.In this framework, special attention will go to the technology of protein/peptide mass spectrometry and its many applications for qualitative as well as quantitative analyses.

Papers related to other aspects of interest in the field of Analytical Biote-chnology will be selected, presented and discussed by the course partici-pants.

Study Goals Understanding of a selection of modern analytical techniques, applied in the field of biotechnology (and beyond).

Education Method Primarily lectures, but also presentations by the course attendees them-selves of selected papers on the topic.


All course material, including lecture presentations as well as selected lite-rature, is made available on blackboard.

Prerequisites Basic biochemistry

Assessment Written exam or term paper.


Course Descriptons


|4

BE3311 | Green Chemistry and Sustainable Technology

| ECTS: 3

Responsible Instructor Prof.dr. I.W.C.E. Arends ([email protected])

Exam Coordinator Dr. F. Hollmann ([email protected])


Different

Education Period Different, to be announced

Start Education 1, 2, 3, 4, 5

Exam Period Different, to be announced


Course Contents Green chemistry is aimed at the development of processes and products that reduce or prevent the use of toxic and environmentally polluting substances. In the lectures the 12 principles of green chemistry will be introduced and applied to the fine chemical industry. Topics discussed: Homogeneous and heterogeneous chemocatalytic methodologies, fermentation, enzymes as catalysts, production of chiral pure compounds, use of green solvents. Ample industrial examples are given.

Study Goals To present examples of incorporation of green technology in the fine chemical industry: To understand chemocatalytic and biocatalytic transfor-mations and to recognize the importance of renewables. The student will make a proposal for a literature study on a topic within the area of green technology and will have to indicate to what extent the twelve principles of green chemistry apply therein.

Education Method Lecture Sheets, specialized books, articles and patents


lectures and hand-outs

Assessment essay

Remarks This course is equal to the CH3311 course

CH3052 | Applied Transport Phenomena | ECTS: 3

Responsible Instructor Prof.dr.ir. H.E.A. van den Akker ([email protected]), Prof.dr.ir. M.T. Kreutzer ([email protected])


2/2/0/0

Education Period 1

Start Education 1

Exam Period 2


Course Descriptons


4 |


Expected priorknowledge

Transport Phenomena (on BSc level)

Course Contents In many industrial processes, fluid flow including turbulence, heat transfer and mass transfer play an important role. The emphasis is on application in process equipment. Generic rules as to estimating characteristic times, scales and regimes are dealt with. Concepts such as axial/radial dispersion and reaction-diffusion systems are presented.

Study Goals The students are able:- to solve practical and more advanced chemical engineering problems- to set up a simplified mathematical model for complex transport pheno-mena in equipment

Education Method Lectures, supported by exercises

Assessment Will be announced later

CH3131 | Applied Numerical Mathematics | ECTS: 6

Responsible Instructor Dr. J.M. Schins ([email protected]), Prof.dr.ir. C.R. Kleijn ([email protected])


4/4/0/0

Education Period 1

Start Education 1

Exam Period 1, 2


Course Contents Linear algebra - Gaussian elimination, determinants, inversion, norm, rank, sparse/banded matrices;Nonlinear algebra - bracketing, iterative methods, Newton, secant, systems of nonlinear equations, Levenberg-Marquart, steepest descent;Eigenvalues;Initial value problems - ODE's, euler, implicit/explicit, stability/accuracy, stiff problems, DAE systems;Optimization - parameter estimation, least squaresBoundary value problems - finite differences, upwinding, preconditioning;Fourier analysis - convolution, correlation;Probability - distributions, Monte-Carlo;


Course Descriptons


|4

Study Goals A short introduction to Matlab will be provided at the beginning of the course.The mandatory exercises require a minimum of Matlab skills.

After succesfully completing this course students will be:- Acquainted with those numerical methods that are required to solve problems in later MSc courses;- able to use software libraries of solvers;- understand what goes on inside such solvers.

Education Method Theory is explained in the Lectures; it is the proper material for the exami-nation.The final grade is a weighed average over the examination mark (50%) and that for the Matlab assignments (50%).


Numerical Methods for Chemical Engineering - Applications in Matlab, Kenneth J. Beers, Cambridge University Press, 2007Selected extra material available via Blackboard (Course Documents)

Assessment The examination concludes the second period.Reexamination takes place in March.Only the theoretical part can be reexamined.

CH3151 | Molecular Transport Phenomena | ECTS: 3

Responsible Instructor Prof.dr. R.F. Mudde ([email protected]), Prof.dr.ir. M.T. Kreutzer ([email protected])


4/0/0/0

Education Period 1

Start Education 1

Exam Period 1


Course Contents The classical analysis of transport phenomena finds its origin in the mass, energy and momentum balance equations. Supplementing these balance equations with the Gibbs equation - a formulation of the Second Law of Thermodynamics - provides a multi-scale approach to engineering concepts as controllability, stability and efficiency and leads to a quantita-tive route to address sustainability.


Course Descriptons


4 |

Course Contents(continued)

1. Microscopic scale Force-flux framework: molecular kinetic origin; Maxwell-Stefan model; entropy production rate: minimization schemes.2. Mesoscopic scaleHeat- and mass transfer, charge transport: conduction and diffusion: free and defect-controlled; fluid mechanics: Stokes flow, transport in flow systems; reaction-diffusion systems. 3. Macroscopic scaleExergy: concept, minimization schemes and economy.Controllability based on the principle of dissipation rate manipulation.Process control based on the principle of time constant manipulation by means of dissipation rates.

Mathematical analysis methods: scaling and approximation techniques, analytical and numerical approaches.

Study Goals After this course, the student can1. assess and apply advanced descriptions of chemical processes at

various length and time scales;2. assess and apply optimization schemes for controllability, stability and

efficiency; 3. analyze complex sets of (transport) equations using approximative

scaling, analytical and numerical methods.

Education Method Lectures and (computer) working classes


Lecture notes.

Prerequisites BSc: Transport Phenomena, Physical Chemistry, Thermodynamics

Assessment Written exam

CH3181 | Scale Up / Scale Down | ECTS: 3



2/2/0/0

Education Period 1

Start Education 1




All (obligatory) courses on (bio)chemical engineering should have been finished.


Course Descriptons


|4

Course Contents General aspects of scale up: why and how. Scaling factors. Similarity. Characteristic dimensionless groups, dimensional analysis. Regime analysis of processes. Scale up criteria. Scale down methodology. Pilot plant studies. Examples Physical, Chemical and Biotechnological examples. Cases from industry.

Study Goals To understand advantages and restrictions of scale up.To have knowledge of scale-up/down bottlenecksTo be able to differentiate between scaling processes and scaling equip-mentTo have knowledge of and experience with some formal methods and corresponding concepts such as dimension, dimensional analysis, charac-teristic groups, regime analysis, pure regime, regime transition, and scaling criterionTo be able to use methods such as similarity, dimensional analysis and regime analysis for scaling technological processesTo have knowledge of scaling methodologies, both theoretical and in prac-tice.To understand the relation between knowledge level and scaling methodTo have knowledge of the scale down method to solve problems in exis-ting equipment.

Education Method Lectures, assignments, case study.


Blackboard, lecture notes, handouts; own notes

Prerequisites This course is primarily intended for (bio)chemical engineering students in their last year or postgraduate students with a (bio)chemical engineering grade.

Assessment Based on assignments(in couples)(50%)and the final group case study with individual test (50%).PDEng trainees have to meet additional requirements (code ST6171).

CH3191TU | Bioseparations | ECTS: 3

Responsible Instructor Dr.ir. M. Ottens ([email protected]), Prof.dr.ir. L.A.M. van der Wielen ([email protected])


2/0/0/0


Start Education 1




Course Descriptons


4 |

Course Contents Concerns itself with the systematic design of integratedseparations processes specially geared to biotechnology. Muchattention is focussed on the consequences resulting fromthe choice made, the order of the process and the interfacebetween the various steps in the process, in particular, in cases of multi-component separations.

Study Goals - Knowledge of basic terms and theory.- Be able to make estimates on equipment size and operation conditions using simple models.- Be able to set up more advanced, mathematical models for specific problems and to use these models.- Be able to make grounded choices for unit operations and separation chains with estimates of efficiency and possible bottle-necks

Education Method Lectures

Assessment Optional examination

Schedule see blackboard time schedules

Location Delft

CH3804 | Product & Process Design | ECTS: 5

Responsible Instructor Dr.ir. M. Makkee ([email protected]), Dr.ir. N.A.M. Besseling ([email protected]), Drs. H.W. Nugteren ([email protected])


0/0/6/0

Education Period 2

Start Education 3

Exam Period 3


Course Contents - Product Design & Material Supply Chains- Relation between Product Performance and Composition- Process Design Methodology- Process Integration- Process Flow Sheet Modelling- Process Control Design- Process and Product Evaluation and Optimisation- Ethics of Design- Health, Safety and Environmental aspects of design


Course Descriptons


|4

Study Goals The student should be able to:- understand the generic design cycle- decompose a process design in hierarchical levels- process sysnthesis, analysis and evaluation methods- identify opportunities for new products- select performance specifications- identify relevant aspect of safety,ethics and sustainability- perform an economical evaluation of the process

Education Method Lectures and team assignments

Prerequisites Relevant BSc (Chemical Engineering)

Assessment By means of assignments

ID4010 | Design Theory and Methodology | ECTS: 3

Responsible Instructor Dr. K. Lauche ([email protected])


3/0/0/0

Education Period 1

Start Education 1

Exam Period 1, 2


Course Contents The goal of this course is to help students to gain a deeper understanding of designing as a problem solving activity in a specific context. The course offers Design Theory and Methodology as a framework that integrates theoretical concepts from different fields, which all contribute to the process and thus to the product. Lectures, discussions and assignments help the students to develop the ability to think critically about the design process and thus to improve their own design processes.

Students should already be acquainted with a few models of the design process and some popular design methods and theories. During this course we explore the theoretical and methodological foundation of desig-ning in more depth, and look at current debates and practices. The course attempts to stimulate students into actively engaging with the subject through a number of assignments. Blackboard will be used to manage reading and discussion.


Course Descriptons


4 |


The course is divided into four sections:1. 'Design Theory' provides an overview of different approach to what

design is all about: as science, as design thinking, as a social process and as art. The topic is introduced through a guest lecture by a practi-tioner and a panel discussion with the lecturers.

2. 'Structuring the Design Process' looks at the historical development of design methodology. We also address fundamental questions about design methodology: What is the use of methods? What is the value of methods? What are the differences between 'traditional' approaches and 'modern' methods?

3. 'Designing as Problem Solving' refers to different implications of desig-ning as complex problem solving; requirements of coping with complex problems and limitations of human information processing will be discussed.

3. 'The Designer' focuses on how specific characteristics of the designer such as experience influence how designers think and act. Case-study material of design processes will be analysed in order to gain an understanding of different strategies in thinking and acting.

4. 'Design teams' addresses the specific challenges of teams in New Product Development and the conditions that help design team to be effective .

Study Goals After this course, students should be able to- outline the history and development of the subject of Design Theory

and Methodology. - discuss Design Theory and Methodology as a framework for analysing,

understanding and explaining designing as human activity. - explain the difference between models, theories, and practice of

designing and to think critically about the value of all three. - reflect consciously and critically on their own personal methods of

designing.

Education Method There are three main elements to the course. Firstly, a series of lectures provides an overview of the topic and the literature. Secondly, students work on assignments, which reflect the topics of the five sections of the course. Thirdly, tutorials provide an oppoprtunity enagage about the course content in a more practical and interactive manner. Students can ask questions about assignments and obtain feedback on marks. The lecture material is structured to provide an overview of the material that students are required to study or collect for each assignment. There will be reading associated with each assignment.


The majority of the course material can be found in the current version of the reader, which should be obtained from print on demand before the start of the course. During the course all material: references, documents, lectures, and exercises will be available for download from blackboard. See course code ID4010.


Course Descriptons


|4

Reader Design Theory and Methodology, version 2009 (a complete revision)

Assessment All three assignments are carried out in groups of two.1. Comparison of own design process against guest lecture and struc-

tured approaches, due 22.09.09, hand in at the lecture2. Analysis of a design process compared to systematic models and lite-

rature on problem solving, due 06.10.09, hand in at the lecture3. Interviews about Designing, due 05.11.07 at 14:00, hand in at the

PIM Secretariat Final grade: Assignment 1 pass / fail (1 bonus point); Assignment 2 (40%); Assignment 3 (60%)

Special Information Dr. Kristina Lauche (course coordinator)[email protected] Room 4A-19, phone: +31(0)15 27 89054

Prof.dr. Petra [email protected] 4A-06, phone 015 27 81403

Dr. Carlos [email protected] : 4A-08, phone: +31 (0)15 27 83451

ir. Jaap [email protected] : 4A-10, phone: +31 (0)15 27 83816

Ir. Norbert [email protected] 4A-09, phone 015 27 83472

ID4215 | Context and Conceptualisation | ECTS: 6

Responsible Instructor Prof.dr. P.J. Stappers ([email protected])


4/4/0/0


Start Education 1

Exam Period 1, 2, Different, to be announced



Course Descriptons


4 |

Course Contents The Master's course 'Context and Conceptualisation'deals with the various contexts surrounding the productand the users' interaction with the product. Examplesof such contexts are the situation in which the productis used, the people that are involved and the role of theproduct in the user's life, even when the user is not physicallyusing it. Contexts can be examined from, amongothers, local, societal, cultural, technological and futureperspectives.As products grow in complexity, these contexts are becomingincreasingly important for understanding, defining,designing and developing new products and services.

Study Goals On completion of this course, the student will be ableto:- Understand the different contexts of user-productinteraction and their role in design.- Select relevant contexts for a design problem.- Use contextmapping techniques to involve users inexploring a current or future context.- Analyse and communicate insights about user contexts with different partiesin the design process by visual and verbal means.- Understand the use of scenario-building techniques- Understand the basic ideas of the Vision in Product Design (ViP) metho-dology- Translate contextual information into new conceptsfor user-product interactions and products.

Education Method The course consists of a series of lectures dealing with the aboveelements, and practical sessions, some in the form ofworkshops. In the first term, lectures and practicalsalternate, with each lecture providing background forthe following practical.Topics of the lectures include the notion of context, contextmapping techniques, cultural probes and generative tools, analysis techniques for experience design research, visualisation techniques (mindmaps, infogra-phics, storyboards) for communicating user experiences, fundamentals of the VIP (Vision In Product design) approach, and basic scenario-building techniques. The practicals and assignments are meant to provide a first experience of the methods and techniques. Further training in these skills should be undertaken by students in appropriate projects, such as Explo-ring Interactions (DfI), and the Design Strategy Project (SPD).At the end of the course, students demonstrate their understanding of the theory by writing a short essay/report.


The course is accompanied by a reader and by materials on the blackboard site.


Course Descriptons


|4

Assessment Portfolio assessment including: written examination atthe end of first Quarter, active participation in practicalsessions, and an essay at the end of the course. The finalcourse mark is a weighted average of these elements.

Special Information prof. dr. P.J. StappersRoom 3B-13, phone +31 (0)15 27 85202.E-mail: [email protected]

IE3600 | General Introduction to Industrial Ecology

| ECTS: 4

Responsible Instructor Dr.ir. G. Korevaar ([email protected])


16/0/0/0

Education Period 1

Start Education 1

Exam Period 1


Course Contents The General Introduction gives an overview of the status quo inthe fi eld of Industrial Ecology. It also gives an overview of thesustainability contents of this Master Program and it introducesthe students to the interdisciplinary character of the program.

Study Goals - overview of the fi eld of Industrial Ecology including its history- knowledge of the most important Industrial Ecology concepts/theories- insight in the signifi cance of Industrial Ecology in the societalsustainability debate- introduction to various defi nitions and meanings of theconcepts 'sustainability' and 'sustainable development'- overview of the main drivers for unsustainability

Education Method Lectures, excursions, group projects


Handout of the draft version of the Industrial Ecology Textbook by H. Brattebo et al. (eds.), Industrial Ecology Textbook (preliminary title), to be published 2007. Available via the Programme Coordinator.

Assessment Group presentations

Schedule Master Programme Industrial Ecology

Location Leiden, Delft


Course Descriptons


4 |

IN4085 | Pattern Recognition | ECTS: 6

Responsible Instructor Dr.ir. R.P.W. Duin ([email protected])

Instructor Dr. D.M.J. Tax ([email protected]), M. Loog ([email protected])


2/2/0/0Pract.


Start Education 1

Exam Period 2, 3



Linear algebra, multivariate statistics.

Course Contents Recapitulation of multi-dimensional statistics, data visualisation, density esimation, cluster analysis. Representation of real world objects by features, prototypes and dissimilarities. Training pattern classifiers by examples. Feature extraction. Bayes' rule. Classification by statistical discriminants, neural networks, decision trees or support vector machines. Statistical learning theory. One-class classifiers. Combined appraoches. EM algorithm. Partially supervised learning.Evaluation procedures, cross validation. Overtraining, regularisation.

Study Goals After succesfully completing this course, the student is able to: recognise pattern recognition problems and select algorithms to solve them; read and comprehend recent articles in engineering-oriented pattern recogni-tion journals, such as IEEE Tr. on PAMI; construct a learning system to solve a given simple pattern recognition problem, using existing software.

Education Method Lectures, lab work


A. Webb, Statistical Pattern Recognition (2nd ed.), Wiley, New York, 2002, ISBN-13: 978-0470-84514-1; Sheets; PRTools user manual; Pattern Recognition exercises with PRTools.

Assessment Homework, Computer laboratory assignment and written examination.

Remarks see also http://www.delftleiden.nl/BIO/index.php?id=curriculum


Course Descriptons


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IN4176 | Functional Genomics and Systems Biology

| ECTS: 6

Responsible Instructor Dr.ir. D. de Ridder ([email protected]), Prof.dr.ir. M.J.T. Reinders ([email protected])


0/0/2/2


Start Education 3

Exam Period Exam by appointment



The student is expected to have a basic knowledge of molecular biology, statistics and linear algebra. It is advisable to have followed IN4085 (Pattern Recognition) and LM3482 (Advanced Bioinformatics).

Course Contents This course gives an overview of systems biology, a relatively new field of research encompassing biology and computational sciences. Systems biology takes a holistic approach to understanding life, by modelling cells using high-throughput molecular measurements at various levels of orga-nisation in the cell (-omics): genome, transcriptome, proteome, metabo-lome, fluxome, interactome, regulome, etc.

The goals and methodology of systems biology will be discussed first, followed by a brief overview of the most important types of biological measurements used. Networks (the main data type used) and their properties (small-worldness, motifs) will then be discussed, as well as a number of network models often used: linear, Boolean and Bayesian. The last half of the course will show how various -omics levels can be described using these models. Finally, a few examples of fully integrated models will be given.

Study Goals After succesfully completing this course, a student is able to: list the basic elements of a living cell and their interactions, and describe how these can be measured; explain what type of mathematical model is applicable to what measurement(s), at what level(s), in a given systems biology problem; read and comment upon recent systems biology literature; discuss the state-of-the-art in systems biology and integrative bioinforma-tics, and future challenges.


Course Descriptons


4 |

Education Method The course will consist of a mixture of lectures by the teachers and paper presentations by one or more of the students. All other students will hand in a review-type discussion on one aspect of the paper. A discussion is required for each scheduled presentation (i.e. there are meetings for which 2 such discussions are required). There will also be a practical session allowing students to get hands-on experience with network models , integration and analysis, mainly through Cytoscape.


Slides, collection of papers and lab course manual (Blackboard).

Assessment The weekly discussion papers will be graded. A final grade for the course will be based on these grades as well as on a final written assignment or a written examination (still under deliberation).

Remarks As students depend on each other (to present the material to the class), a commitment to follow the course through to the end is required.

LB2771 | Metabolic Engineering | ECTS: 4

VerantwoordelijkDocent

Prof.dr.ir. J.J. Heijnen ([email protected])

Contacturen / weekx/x/x/x

0/0/0/28

Onderwijsperiode 4

Start onderwijs 4

Tentamenperiode 4

Cursustaal Nederlands

Voorkennis 1st and 2nd year Basic biosciences, Microbial Physiology

Vakinhoud The course on Metabolic Engineering aims at the various ways toengineer the metabolism of living cells ('Cell Factories') to improveproduct formation. One distinguishes between optimization ofprocess conditions ("physiological engineering"), classical strainimprovement (mutagenesis and selection), and the application ofrecombinant-DNA technology ("metabolic engineering sensustrictu").

Leerdoelen Basic knowledge of metabolic engineering

Onderwijsvorm Lectures

Literatuur enstudiemateriaal

Lectures notes, Case studies using scientific literature for moreinsight, followed by plenary discussion. Computer practicals tofamiliarise the students with metabolic network models.

Wijze van toetsen Written exam with open questions

Studielast/week The lecturer will inform you


Course Descriptons


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Vervolgcursussen Metabolic Engineering I and II, Biosystems Engineering, Genomics/Proteomics and Bio-informatics.

Locatie Kluyverlab, Delft

LM3061 | Gene-Expression | ECTS: 5

Responsible Instructor J. Brouwer ([email protected])


0/0/0/13 dagdelen

Education Period 4

Start Education 4

Exam Period 4


Course Contents Regulation of Transcription in eukaryotes. Structure of Polymerase-complex, general transcriptionfactors. Chromatin structure and epigene-tics. RNA processing. Integrated view on eukaryotic transcription.

Study Goals <>

Education Method <>


t.b.a.


Enrolment / Applica-tion

not later than March 24 via Black Board Leiden(courses > Fac. Wisk. and Natuurwet. > LS&T > Master)

Schedule Tuesdays, Wednesday afternoons and Fridays in week 15, 16 , 17

Location Leiden

LM3131 | Transcriptome & Proteome Analysis

| ECTS: 5

Responsible Instructor J. Brouwer ([email protected]), M.H.M. Noteborn ([email protected])


see schedule

Education Period 4

Start Education 4

Exam Period 4



Course Descriptons


4 |

Expected prior knowledge

Good knowledge on molecular cell biology and on genomicstechnology

Course Contents Enormous progress has been made in the field of genetics.However, to understand how a cell functions, we have to knowthe regulation of the expression of its genes (transcriptome)and its protein-protein interactions (proteome). Lectures andtechnical sessions will illustrate the current state of severalmodern transcriptome & proteome techniques.

Study Goals To get familiar with the latest developments in transcriptomeand proteome analysis

Education Method Lectures, workshops and practicals


Course lecture notes

Assessment Oral presentations, reporting and interview


Not later than May 1 via Black Board Leiden(courses > Fac. Wisk& Nat.Wet. > LST > Master)

Schedule may 29, june 2, 5,9,10,11,12

Location Leiden

LM3411TU | Industrial Genomics | ECTS: 3

Responsible Instructor Prof.dr. J.H. de Winde ([email protected])


0/0/0/30

Education Period 4

Start Education 4

Exam Period 4



Good knowledge on molecular cell biology and microbial physiology. Some basic knowledge on genomics technologies is an advantage.

Course Contents Introduction into genomics technologies. Application ofgenomics technologies and functional genomics approachesin the set up and maintainance of modern biotechnologicalprocesses. Importance for the investigation and improvementof industrial cell factories. Target identification for metabolicengineering via classical and modern genomics approaches.Application of genomics in industrial strain and process improvementprograms.

Study Goals Obtain insight into the utility and application of genomicstechnologies in modern biotechnology.


Course Descriptons


|4

Education Method Interactive workshop format; introduction and short presentations,followed by and intermingled with round table discussions. Several assignments for self-study or study in small groups; presentation and discussion of results. Final assignment with report.


Hand outs of presentations and explanations. Scientific literatureto be distributed during the course.

Assessment Interactive and cooperative attitude, original contribution tointermediate assignments, handling of final assignment andquality of report.


not later than March 24 via Black Board Delft(courses > Master . LS&T)

Remarks Clear motivation and interactive participation are expected.

Schedule 4th period: Wednesday and Thursday 1/2 (not 10, 11 June)

Location Delft

LM3432 | Analysis of Metabolic Networks | ECTS: 6

Responsible Instructor Prof.dr.ir. J.J. Heijnen ([email protected])


42/0/0/0

Education Period 1

Start Education 1

Exam Period 1


Course Contents - Refreshment of pre-knowledge (organization of the cell, mass balances, q-rates, black box kinetics/ stoichiometry, energy-, product-, growth pathways, modular reaction models of metabolism

- Quantification/ checking of q-rates- Microbial diversity/ thermodynamics of growth and product formation- Metabolic Flux analysis of large networks- 13C based flux analysis- Transport over cellular membranes- Kinetics of metabolic pathways, metabolic control analysis- Mathematical modeling of central metabolism- Regulation of enzym expression, principles/ modeling- Sources of bio-information/ databases


Course Descriptons


4 |

Study Goals - To relate metabolic network structure to maximal biomass and product yields/ product rates

- To understand the thermodynamic and redox constraints in metabolic networks

- To be able to formulate gene targets based on understanding the metabolic bottlenecks

- To formulate experiments to calculate fluxesTo set-up mathematical models which relate network/ enzyme properties to fluxes

Education Method Lecture, with assignments


Handouts on Blackboard

Assessment Assigments


not later than one week before the first lecture via Black Board Delft(courses > Master > LS&T)

LM3442 | Metabolic Reprogramming | ECTS: 6

Responsible Instructor Dr. P.A.S. Daran-Lapujade ([email protected]), Prof.dr. J.T. Pronk ([email protected])


16/24/0/0


Start Education 1

Exam Period 2


Required for MSc track Cell Factory, Life Science & Technology


This course requires BSc-level knowledge in Microbial Physiology, Mole-cular Genetics and insight into the quantitative aspects (yields, rates) of Biotechnological processes (LST BSc courses LB2762TU, LB2161 and LB1511TU or equivalents thereof).


Course Descriptons


|4

Parts Detailed lecture schedule:1. General introduction to metabolic reprogramming and the course.

Distribution of scientific publications to the students2. Increasing fluxes and yields in existing pathways3. Broadening substrate range. Evolutionary and reverse engineering

strategies.4. Classical versus rational approaches.5. Deletion of competing pathways.6. New products and synthetic biology.7. Selection of host8. Heterologous protein production. Glycosylation and secretion.

Course Contents Application of targeted genetic modification and rational application of evolutionary strategies for the optimization of existing product formation pathways in micro-organisms, introduction of new product formation pathways, physiological constraints on process optimization

Study Goals After this course, the students should:- understand fundamental aspects, possibilities, limitations and chal-

lenges in the rational optimization of microbial cells for industrial product formation

- be able to critically read scientific papers and discuss their contents with colleagues in a structured manner

Education Method This course is a combination of a lecture series and presentations/discus-sions of scientific publications. The lecture series will consist of 8 two-hour sessions and will introduce key principles of metabolic reprogramming and introduce the format of the second part of the course. For this second part, a collection of relevant scientific publications will be handed out. Each student participating in the course prepares a critical (oral) presenta-tion on one of these papers. Furthermore, all students read the complete set of publications, which allows them to participate in plenary discussions (led by the teachers) on the papers. Before each analysis session, a A4 with critical comments and questions about the paper that will be presented have to be handed in by all participants. In addition to the scientific content, attention will be given to key quality aspects of the scientific publications (style, statistics, internal consistency, impact). Sessions of 2 hours will be used for the presentation and discussion of two scientific papers.


A set of scientific publications will be provided by the teachers at the outset of the course (via Blackboard)


Course Descriptons


4 |

Assessment Students will be assessed based on:1. An (written) exam that will cover the subject matter taught in the

lecture series as well as key elements discussed during the evaluation of the scientific paper.

2. Their presentation and critical analysis of a chosen scientific publica-tion and, importantly, on their contribution to the discussion following presentations by their fellow participants. The quality/relevance of the short written critical evaluation will also be taken into account.


Pen, paper


not later than one week before the first lecture via Blackboard Delft(courses > Master > LS&T)

Location Department of Biotechnology, Delft University of Technology

LM3452 | Bioprocess Integration | ECTS: 6

Responsible Instructor Dr.ir. A.J.J. Straathof ([email protected])


42/0/0/0

Education Period 1

Start Education 1

Exam Period 1


Required for This is an introductory course for the MSc LST and prepares especially for the Design project, for Fermentation Technology & Environmental Biotech-nology, and for Transport & Separation


Basic biosciences and process technology as required for admittance to the MSc programme Life Science & Technology

Course Contents - Introduction in industrial and environmental biotechnology - Mass and energy balances of integrated bioprocesses - Raw materials, products, wastes, utilities, process economy- Short-cut design of fermenters and enzymatic reactors- Separation process principles and short-cut design of unit operations (centrifugation, filtration, extraction, adsorption, membrane processes, chromatography, distillation, crystallization) - Bioprocess structure; integration of product formation and separation; other integration options - Process design basics: design cycle, performance specification, process synthesis, analysis and evaluation; Basics of process control and batch scheduling- Computer tools for flow sheeting (SuperProDesigner); Flow sheeting case study


Course Descriptons


|4

Study Goals - To obtain an overview of industrial biotechnology processes, their process structures, raw materials, energy and waste streams- To be able to perform short-cut designs of reactors and unit operations that are important in biotechnology- To be able to work out a simple bioprocess flowsheet including mass and energy balances- To be able to perform a basic economic evaluation of a process- To be able to identify semi-quantitatively the potential impact of protein or metabolic engineering on overall improvements of a production process

Education Method Lecture series with assignments

Computer Use MathCad, SuperProDesigner


Handouts on Blackboard

Assessment Assignments during the course


Not later than one day before the first lecture via Black Board

Remarks This course is not meant for PD Eng trainees. The previous version of this course (until 2008/2009) was only 5 ECTS and the contents have been modified.

Schedule A detailed lecture schedule will be published on Blackboard shortly before the course

LM3471 | Modern Drug Development Techno-logy

| ECTS: 3

Responsible Instructor Prof.dr. P.D.E.M. Verhaert ([email protected])


0/0/0/5 dagen

Education Period 4

Start Education 4

Exam Period 4



Bachelors degree in LST or equivalent

Course Contents The development of a new medicine from the early research phase to a registered product on the market is globally described. When possible, an excursion to a pharmaceutical company will be included.

Study Goals The course aims at providing the students with insight in the manner in which a modern and innovative pharmaceutical company operates.

Education Method Lectures, demonstrations and a workshop.


Course Descriptons


4 |


All lecture handouts and other relevant course materials are made avai-lable on Blackboard.

Assessment Group assignment: the preparation of a synopsis of selected lectures (to be judged by the lecturers and by the course organizers).Individual assignment: personal essay on various issues brought forward during the lectures.


no later than March 1 via Black Board Delft(courses > Master > LS&T)

Location Delft

LM3482 | Advanced Bioinformatics (D) | ECTS: 4

Responsible Instructor Dr.ir. D. de Ridder ([email protected])

Instructor L.F.A. Wessels ([email protected])


0/0/21/0

Education Period 3

Start Education 3

Exam Period 3, 4



Linear algebra, basic mathematics and (multivariate) statistics.

Course Contents Nowadays, many high-throughput, genome-wide measurement techni-ques are available, allowing us to measure everything from entire genome sequences to presence/concentration of all types of molecules (mRNA, protein, metabolites) and their interactions. Being able to process this data to test simple hypotheses or make simple predictions is a requi-rement for any life scientist. However, there is often much more to be gained from this data. For example, (crude) models of biological processes can be constructed in silico, exploiting the wide range of avai-lable prior knowledge. Specific high-throughput measurements can then be interpreted in the context of these models, allowing us to infer novel interactions or functionality, which can in turn lead to novel experiments. Such a "systems" approach to molecular biology demands that scientists know when and how to develop and apply both wet lab and computer experiments to solve a problem.


Course Descriptons


|4


This course continues where the BSc course "Genome-Scale Data Analysis" stopped. We will briefly review the various high-throughput measurement techniques available, the required methods of pre-proces-sing (e.g. normalisation), and some elementary statistical approaches to interpret this data (hypothesis testing, multiple testing, classification, feature selection). The main focus of the course will then be on how this data can be integrated using these elementary statistical methods, in the light of knowledge available in databases and literature. Among others, we will discuss examples of the derivation of regulatory modules from gene expression compendia, of the integration of various measurement types to derive genetic interactions and of aligning pathways between different organisms.

Study Goals After successfully completing this course, the student is able to discuss the basic systems biology approach, and the role of high-throughput measurements, prior knowledge and elementary statistical approaches such as gene selection, regression and classification therein.


Computer Use Computer lab work is to be performed (approx. 1 day) to improve under-standing of the algorithms discussed.

Course Relations This course continues on "Genome-Scale Data Analysis", but this course is not required prior knowledge.


1) Collection of papers [Blackboard]; 2) Sheets [Blackboard]; 3) Exercises [Blackboard]; 4) Optional self-study computer lab

Assessment Students write essays and five questions about the papers that will be discussed during the lectures. These essays are graded. There will also be a written (open-book) exam.


The exam is open book: all written material can be brought along. Calcu-lators are useful, laptops etc. are not allowed.


Via Blackboard Delft

Remarks In each meeting, papers are discussed and the teachers explain parts that are not understood. One group of students is assigned to present and explain the details of one of the papers. The presenting students need to highlight the bioinformatics methodology of the paper. All students need to prepare for the discussions by writing a small essay on each paper and preparing five questions about the paper. As students depend on each other (to present the material to the class), a commitment to follow the course through to the end is necessary.

Schedule 3rd period: Thursday afternoons

Location Delft


Course Descriptons


4 |

LM3511TU | Systems Biology | ECTS: 6

Responsible Instructor Prof.dr.ir. J.J. Heijnen ([email protected])


0/0/28/24


Start Education 3

Exam Period 4


Course Contents For most of the biological processes is no fundamental, theoreticaldescription available. To obtain a meaningful descriptionof nature, it is therefore important to discover the adherenceto the laws of nature. This is the subject of this course, in whichbiological processes are being described in models withoutknowing the theory behind these processes.

Study Goals <>

Education Method <>


Handouts.

Assessment <>


nor later than January 20 via Black Board Delft(community > Master > LST)

Schedule 3rd period: Wednesdays 1/2/3/4, 4th period: Monday 5/6/7/8

Location Delft

LM3561 | Ethical, Legal and Social Issues in Biotechnology

| ECTS: 3

Responsible Instructor Prof.dr. P. Osseweijer ([email protected])


0/0/0/2 weken

Education Period 4

Start Education 4

Exam Period 4



This course is open to MSc students with a relevant background (LST, Biochemical Engineering, SMST) that completed the Design project LM3821.


Course Descriptons


|4

Course Contents In this course you will explore the ethical, legal and societal issues of biotechnology and of your future work as a professional in biotechnology.This course is a combination of lecture series and workshops, coupled with a reflection upon your design project. The course starts with a series of lectures, in which the subjects are introduced. Each lecture is followed by a workshop where the theoretical aspects are explored in more detail and are connected to professional practice in biotechnology.In a finalising assignment you will reflect upon your design, which you made in the Design project LM3821, by writing an essay about its ethical, legal and societal issues encountered.

Study Goals After having completed the course you:- can recognise and analyse ethical, legal and societal issues of your professional work in biotechnology.- will be able to explore and assess possibilities of dealing with existing and emerging ethical, legal and societal problems related to the work of professionals in biotechnology.

Education Method A lecture series with connected work sessions.Writing an essay on ethical, legal and societal issues of your design project.


Book "BioTechnology-Ethics: An introduction" available as PDF files on Blackboard; Powerpoint lecture notes as PDF files on Blackboard.

Assessment Written essay


Enrolment via Black Board Delft (courses > Master > LS&T) is required one week before the first lecture.

Schedule Detailed lecture schedule:1. Introduction of ELSI in biotechnological practice2. Logical argumentation and collective reasoning3. Scientific integrity and "soft law"4. Liability, law and patents in biotechnology5. Risk, uncertainty and precaution6. Public acceptance and risk perceptions7. Democracy and participation8. How to write an essay

Location Delft


Course Descriptons


4 |

LM3601 | Molecular Biotechnology & Geno-mics

| ECTS: 6

Responsible Instructor Dr. J.G. Daran ([email protected]), Prof.dr. J.H. de Winde ([email protected])


16/24/0/0


Start Education 1

Exam Period 2


Course Contents The Molecular Biotechnology and genomics course offers an in-depth overview of contemporary biotechnology. The program aims at providing the student with a profound fundamental basis, as well as offering him an integrated study package, compiled from a wide scope of scientific disci-plines, which together underscore the practical realizations of application-oriented molecular biotechnology.

1 Genomes (strains, genome sequences, sequencing technologies).Origin of industrial strains/applicationsSequencing industrial organism, why?Methods from Sanger to next generation sequencing techniquesAnalysis of genome sequences

2 Strain improvement strategies.Classical strain improvement

High throughput screening genome shuffling

Molecular Genetics/Metabolic engineering Examples

3 Molecular genetics (strain design)Genetic engineering solutions

Deletion, silencing, overexpressionVector design

Restriction versus recombination)Host design

integration HR vs NHEJ4 Cloning strategies Identification of industrial enzymes by expression cloning


Course Descriptons


|4


5 Transcriptomics. Measuring transcriptArray design and manufacturingDNA array and applicationTranscriptomicsArray basedQ-PCRRNA seqAnalysis and interpretationDatabasing

6 Genomics (proteomics, metabolomics).Genome-wide location analysisProteomicsMetabolomicsFluxomics

7 Genome-wide mutant collectionsKnock-out librarySynthetic lethalityGenome-wide localization collection

8 Protein engineering 9 Genomics driven Metabolic Engineering 10 Future directions.

Study Goals After this course the students should:- Obtain a deeper understanding of the possibilities and limitations of

molecular cell biology/molecular genetics and genomics applications in modern biotechnology.

- Integrate knowledge on (i) molecular cell biology/molecular genetics, (ii) genomics and (iii) cell factory research.

Education Method E.G.: Lecture series, with assignments

Assessment E.g.: Two assignments during the course, a written exam and a final lite-rature essayequivalent to 32 h.


not later than one week before the first lecture via Black Board Delft (courses > Master > LS&T)


Course Descriptons


4 |

Schedule In period 1: Thursday 03-Sept from 13:45 to 15:30Thursday 10-Sept from 13:45 to 15:30Thursday 17-Sept from 13:45 to 15:30Thursday 24-Sept from 13:45 to 15:30Thursday 01-Oct from 13:45 to 15:30Thursday 08-Oct from 13:45 to 15:30Thursday 15-Oct from 13:45 to 15:30

In period 2:Wenesday 11-Nov from 13:45 to 15:30 and from 15:45 to 17:30Wenesday 18-Nov from 13:45 to 15:30 and from 15:45 to 17:30Wenesday 25-Nov from 13:45 to 15:30 and from 15:45 to 17:30Wenesday 02-Dec from 13:45 to 15:30 and from 15:45 to 17:30Wenesday 09-Dec from 13:45 to 15:30 and from 15:45 to 17:30Wenesday 16-Dec from 13:45 to 15:30 and from 15:45 to 17:30

Exam: Tuesday 19-Jan

Location To be mentioned on due course

LM3611 | Microbial Community Engineering | ECTS: 6

Responsible Instructor Dr. G. Muijzer ([email protected]), Dr.ir. R. Kleerebezem ([email protected])


0/0/42/0

Education Period 3

Start Education 3

Exam Period 3



BSc-level knowledge in Microbial Physiology (LST BSc-course LB2762TU or equivalent thereof)

Course Contents The course will discuss the metabolic potential of microbes and their role in the cycling of chemical elements. It will indicate the fundamental aspects of microbial community-based bioprocesses, such as wastewater treatment, biocorrosion, and the production of chemicals and bioenergy.


Course Descriptons


|4

Study Goals After this course, the students should:- Understand the concept and methodology of natural selection-based microbial community engineering as a means for the development of bioprocesses.- Be aware of the enormous microbial diversity in nature and its potential application in biotechnology.- Understand and be able to explain the different diagnostic tools that are currently available to study the diversity and activity of microorganisms in natural and man-made environments.- Have a general knowledge of the global element cycles and the orga-nisms that catalyze the reaction in these cycles.

Education Method The course starts with a lecture series, which is finished with a written exam. The second half of the course is a literature study on a topic related to theme of the course. The literature study will be summarized in an essay and presented as a VODcast, a short video that can be published on YouTube.


- Handouts on Blackboard- Optional books: Brock - Biology of Microorganisms, Madigan, M.T. and Martino, J.M.

Assessment (1) Examination, (2) Essay, (3) Presentation in the form of a VODcast


Not later than one week before the first lecture via Black Board Delft(courses > Master > LS&T)

Remarks

Schedule Detailed lecture schedule:1. Kleerebezem - Introduction into Microbial Community Engineering I2. Kleerebezem - Introduction into Microbial Community Engineering II3. Muyzer - Introduction into Microbial Diversity I4. Muyzer - Introduction into Microbial Diversity II5. Kleerebezem - Anaerobic digestion6. Kleerebezem - Nitrogen cycle7. Muyzer - Sulfur cycle8. Muyzer - Metal cycles9. Muyzer - Extreme environments10. Kleerebezem - Storage products11. Picioreanu - Biofilms I12. Picioreanu - Biofilms II

Location Delft


Course Descriptons


4 |

LM3701 | Advanced Enzymology | ECTS: 6

Responsible Instructor Dr.ir. P.L. Hagedoorn ([email protected]), Prof.dr. S. de Vries ([email protected])


16/24/0/0


Start Education 1

Exam Period 2



Bsc LST, Bsc Mst or equivalent in terms of Biochemistry/Chemistry

Course Contents In Part A (3 ECTS) of the course Advanced Enzymology basic bio-inorganic principles are applied to understanding catalysis by metallo-enzymes, their biological function and their dysfunction in disease. In addition, examples of medical applications of (non-biological) metals are treated. Part B (3 ECTS) focuses on theoretical and practical backgrounds of various spectroscopic, electrochemical and pre-steady state kinetic methods, as well as on the use of computer visualization programs. Students will learn how to employ these methodologies to the determina-tion of the structure of metallo-centers and function in terms of the mole-cular mechanism of catalysis. To successfully apply metallo-enzymes in research or industrial applications, specific problems related to the (over)expression of metallo-proteins -such as cofactor biosynthesis - are addressed.

Study Goals After the course the students should -be able to apply basic bio-inorganic principles to metallo-enzyme cata-lysis, understand the biological role of metallo-enzymes and the conse-quences of their dysfunction is disease- have obtained a basic theoretical level in various spectroscopic and kinetic methods, in electron transfer theory and be able to apply theory to the determination of metallo-enzyme structure and molecular mechanism- be able to judge the scope and limitations of metallo-enzymes in indus-trial applications



t.b.a.





Course Descriptons


|4

Schedule Detailed lecture schedule:Introduction to/refreshment of (Bio)inorganic chemical principles

Periodic systems of Elements, Ionic radius, Lewis acid catalysis, HSAB, Ligand substitution kinetics, Coordination chemistry of amino acids, Crystal Field theory

Bio-electrochemistry-INernst equation, Pourbaix diagrams, Marcus Theory of Electron transfer, Proton coupled electron transfer, Cyclic voltammetry, Biosen-sors

Metals in BiologyBioavailability of metals, structure and function of cofactors/metal sites/metallo-enzymes (oxidoreductases), biosynthesis of metallo-cofactors , cellular uptake, storage and distribution of metals metal-loproteomics

Metals in relation to MedicineDiseases related to dysfunction of metallo-enzymes, NMR-imaging, metals as therapeutics in disease (e.g. cancer)

EnzymologyWhich sources (criteria= why and how), enzyme purification, enzyme immobilization

Visualization techniques for enzymesPymol, Rasmol to study docking

Bio-electrochemistry-II Proton coupled electron transfer, Cyclic voltammetry, , Cofactor rege-neration, Applications as Biosensors and in enantioselective conver-sions

Kinetics and molecular mechanismsSteady-state and pre-steady state kinetic reaction equations, analysis equipment, reaction mechanisms of metallo-enzymes and radical enzymes, single enzymes


Course Descriptons


4 |

LM3711 | Proteomics 1 | ECTS: 3

Responsible Instructor Dr. M.W.H. Pinkse ([email protected]), Prof.dr. P.D.E.M. Verhaert ([email protected])


0/0/28/0

Education Period 3

Start Education 3

Exam Period 3



Bachelor's courses "Biochemistry 1 & 2"

Course Contents The course "Proteomics 1" focuses on qualitative protein analysis, and basic proteomics technologies; this in contrast to the course "Proteomics 2" which deals with quantitative protein analysis, and some specific novel proteomics technologies.After a (advanced) recapitulation of protein structure ("Biochemistry 1") and protein function/activities ("Biochemistry 2"), various "conventional" analytical techniques to probe protein structure and activity will be discussed. This is followed by an introduction to modern protein analytics, based on mass spectrometry (MS) and protein sequence database bioin-formatics. Focus will be on qualitative, so-called protein profiling techni-ques, explaining protein identification technologies based on peptide mass fingerprinting, as well as tandem MS sequencing.

Study Goals After this course the students should:- Understand the principles of modern protein identification and characte-rization techniques based on various mass spectrometry systems, as applied to current proteomics projects (with an emphasis on Delft ones).- Be able to interpret MALDI and ESI protein and peptide MS and tandem MS spectra for protein identification purposes.- Have gained an insight in the use of various web-based database search engines available, as well as in the relationship between the quality of MS data and database search parameters and results (identification success).

Education Method Lecture series, literature assignments and demo/bioinformatics workshop

Assessment Literature assignment during the course, and evaluation of practical and workshop


Not later than two weeks before the first lecture via Blackboard Delft (courses > Master > LS&T)


Course Descriptons


|4

Schedule Detailed lecture schedule:1. Protein structure2. Protein function/activity and relation with protein structure3. Classical protein analytics (Edman degradation, molecular cloning) pro and contra4. Mass spectrometry based protein analysis (various ionizations and mass analyzers)5. Protein sequence/structure databases and basic protein bioinformatics6. Basic proteomics techniques 1 (Gel based) pro and contra7. Basic proteomics techniques 2 (Gel-free) pro and contra

Location Delft

LM3721 | Proteomics 2 | ECTS: 3

Responsible Instructor Dr. M.W.H. Pinkse ([email protected]), Prof.dr. P.D.E.M. Verhaert ([email protected])


0/0/28/0

Education Period 3

Start Education 3

Exam Period 3



"Proteomics 1"

Course Contents The course "Proteomics 2" focuses on quantitative protein analysis, as well as protein imaging techniques, including some specific novel and advanced proteomics technologies; this in contrast to the course "Proteo-mics 1" which deals with qualitative protein analysis, and basic proteomics technologies.After a (advanced) recapitulation of conventional protein quantification strategies (colorimetric as well as antibody based), various typical 'proteo-mics' quantification strategies will be discussed. These include 2D gel based techniques including DIGE, as well as various MS based techniques including isotopic and isobaric labelings. Examples of various actual projects (including Delft ones) will be discussed. The course continues with an overview of in situ protein visualization methods (both in vitro and in vivo ones) and a description of the technique of MS imaging. AT the end of the course there will be room to discuss selected promising recent developments in proteomics.


Course Descriptons


4 |

Study Goals After this course the students should:- Understand the principles of modern protein MS based quantification techniques, as applied to current proteomics projects (with an emphasis on Delft ones).- Be able to explain the difference between, as well as the pros and cons of protein quantification methods at the MS and at the tandem MS level.- Have gained an insight in the use of various isotopic labeling strategies.- Be able to explain the technique of MS Imaging

Education Method Lecture series, literature assignments and demo (workshop)


Handouts on BlackboardSelected scientific papers and reviews

Assessment Literature assignments during the course (and evaluation of workshop participation)


Not later than two weeks before the first lecture via Blackboard Delft (courses > Master > LS&T)

Schedule Detailed lecture schedule:1. Conventional protein quantification strategies (colorimetric, antibody-based (RIA, ELSIA),2. Gel-based quantification strategies, applications, pros and cons.3. Isotopic labeling strategies, applications, pros and cons.4. Isobaric labeling strategies, applications, pros and cons.5. Classical protein imaging technologies (basic histochemistry, immuno-histochemistry, fluorescence)

Location Delft

LM3731 | Biocatalysis | ECTS: 6

Responsible Instructor Dr. U. Hanefeld ([email protected]), Prof.dr. I.W.C.E. Arends ([email protected])


16/28/0/0


Start Education 1

Exam Period 2



BSc degree LST or MST


Course Descriptons


|4

Course Contents This course gives an introduction to the use of enzymes for the synthesis of chemicals and medicins. Starting from a basic knowledge in bioche-mistry, enzymology and organic chemistry, we will study proteins for their capacity to act as catalysts for different classes of reactions (such as reductions, oxidations and C-C bond formations). The importance of enzymes for the synthesis of chiral compounds will be an important theme. In addition the advantage and technique of immobilization of enzymes will be treated. Finally the possibility of using enzymes in combi-nation with chemical catalysts will be dealt with.

Study Goals During this course the student will acquire in depth knowledge about enzymes as biocatalysts and their application in Organic Chemistry. Based on this knowledge the student should be able to choose a suitable bioca-talyst for an industrially important reaction and he/she should be able to explain why which type of approach is more suitable for the production of a given bulk or fine chemical.

Education Method Lectures, Selfstudy


Handouts/Blackboard/Book: K. Faber, Biotransformations in Organic Chemistry, 5th ed., Springer-Verlag, Berlin, 2004.

Assessment Written examination, critical review and presentation of a self-chosen scientific paper



Schedule 1. Introduction2. Why are enzymes such good catalysts/kinetics3. Classes of enzymes4. Hydrolysis/enantioselectivity5. Reaction media: water or no water6. Reductions7. Oxidations8. C-C bond formation9. Immobilisation10. Enzymes in combination with other catalysts11. Which (chemo)enzymatic route is the best towards a product

Location Delft


Course Descriptons


4 |

LM3741 | Fermentation Technology & Environmental Biotechnology

| ECTS: 6

Responsible Instructor Prof.dr.ir. J.J. Heijnen ([email protected]), Prof.dr.ir. M.C.M. van Loosdrecht ([email protected])

Instructor Dr.ir. R.G.J.M. van der Lans ([email protected])


16/24/0/0


Start Education 1

Exam Period 2



Microbial diversity, Black box kinetics of growth/ product formation, mass balances, transport phenomena.

Course Contents Fermentation Technology- Refreshment of prior knowledge (Black box kinetics/ stoichiometry,

chemostat, mass balances). Stoichiometry of non-defined substances (COD/BOD)

- The bioreactor and economy of bioprocesses- Check your rates/ reconciliation- Rate based design of bioprocesses- Modelling / design of fed batch process- O2/CO2 transfer- Modelling of and bottlenecks in transport chains O2/CO2/heat- Mixing in fermentors- Degeneration/ diauxic growth/ substrate gradients/ gene responses- Scale-up/ down- Transport correlationsEnvironmental Biotechnology- Refreshment of prior knowledge (Microbial diversity/ global cycles,

thermodynamics of growth)- Kinetics of growth on mixed substrates, SRT-concept, composition

mixed culture- Microbial selection strategies nutrients and wash-out principle/

Example: design of NH4+-removal process (SHARON)- Biomass retention (flocculation, biofilms, membranes)- Modelling biofilms (reaction/ diffusion)/ design of biofilm reactors- The activated sludge process for integrated nutrient removal (cycles/

bypasses modelling platforms)- From waste to products CH4, poly-Pi, PHA, S0- Extremophiles (alkalophiles/ bioleaching)


Course Descriptons


|4

Study Goals How to model and design bioprocesses for fermentation and environ-mental biotechnology

Education Method Lectures, with assignments

Assessment Assignments and examination


Not later than one week before the first lecture on Blackboard

Schedule On Blackboard

Location Delft

LM3751 | Transport & Separation | ECTS: 6

Responsible Instructor M.C. Cuellar Soares ([email protected]), Prof.dr.ir. L.A.M. van der Wielen ([email protected])


0/0/42/0

Education Period 3

Start Education 3

Exam Period 3


Course Contents - Introduction to the course: refreshing prior knowledge on transport phenomena and thermodynamics (mass/energy/momentum balances, fluid flow, heat and mass transfer, phase equilibria) and basic concepts of separation processes (separation factor, modes of contacting, basic sizing aspects).- Process equipment sizing: hydraulic load, thermodynamic cycles, ener-getic yield. Sizing of heat exchange equipment, pumps and compressors. Integrated use of this equipment within whole processes.- Multi-component separations: equilibria, heat and mass transfer in multi-component systems. Further equipment sizing and link to thermodynamic cycles and energetic yield.

Study Goals After this course the students should:- Understand the basic principles underlying separation processes.- Be able to use these principles for the design of separation equipment.- Be able to integrate processing steps and calculate their efficiency. - Be able to perform basic (complete) bioprocess simulations including mass and energy balances.

Education Method Lectures, computer exercises, assignments.

Assessment Assignments during the course and a final case study.


Course Descriptons


4 |

LM3761 | Numerical Methods, Modeling & Simulation Technics

| ECTS: 6

Responsible Instructor Ir. C. Picioreanu ([email protected])


16/24/0/0


Start Education 1

Exam Period 2



BSc degree (Mathematics 1st and 2nd year; Transport phenomena; Biotechnology)

Course Contents The course deals with formulation and solution of mathematical (nume-rical) models and with different simulation (computational) techniques in bioengineering.

Study Goals After this course the students should:- be able to formulate coherent mathematical models for certain bioengi-neering problems- be able to recognize the type of numerical problem they have - learn how to put the model equations in a format that is solvable with numerical (computer-based) techniques.- be aware of the numerical tools existing for the solution of a certain type of problem- understand the principle of the main numerical techniques and to be able to choose an adequate method for their specific problem- be able to use general simulation-oriented software such as Matlab

Education Method Lecture series and computer-based practicals with assignments


Handouts on BlackboardOptional books: Press et al, Numerical Receipes, Cambridge University Press, 2007Wayne Bequette, Process dynamics - Modelling, analysis and simulation, Prentice Hall, 1998Matlab and Comsol tutorials

Assessment Two assignments during the course and final written examination




Course Descriptons


|4

Schedule 1. A few introduction hours in general model formulation. Introduction to different types of models (deterministic/stochastic, steady-state/time-dependent, linear/non-linear, algebraic/differential, etc.). Getting basic knowledge in balance equations.

2. In parallel, with (1) there will be practical classes on the use of general simulation software, Matlab especially but probably also Comsol.

3. The basic numerical methods used for the solution of mathematical models. Solution of linear algebraic systems (e.g., data reconciliation, stoichiometry). Solution of non-linear algebraic equations and systems of equations (e.g., chemical equilibria, speciation, steady-state mass balances). Solution of ordinary differential equations (e.g., CSTR stabi-lity, enzymatic and microbial kinetics in batch systems). Optimization (e.g., fed-batch bioreactors). Parameter estimation and data fitting. Solution of partial differential equations (e.g., diffusion-reaction mass balances).

4. Process control, different types of control systems.

Location Delft

ME1590CH | Separation Processes, Design & Operation

| ECTS: 6

Responsible Instructor Dr.ir. J.H. ter Horst ([email protected])

Instructor Dr.ing. A. Bardow ([email protected])


0/4/0/0

Education Period 2

Start Education 2

Exam Period 2


Course Contents Separation processes are very important in all sectors of modern process industry. A reaction section in a chemical plant is typically surrounded by 3-6 separation units, which perform a variety of functions (e.g. feed concentration, product purification, solvent-recycling, off-gas treatment and water-recovery). Separation processes consume approximately 40% of the energy consumption and 75% of the investment cost in the process industry. Consequently as an engineer you are likely to become involved sooner or later in your career in the design and/or operation of separation units.

Focus is given on the conceptual design of the main separation processes in the chemical industry: distillation, extraction, crystallization and membranes or adsorption. The main features of these processes are highlighted and illustrated with examples from industrial practice.


Course Descriptons


4 |

Study Goals Students are taught to select industrial separation units, to master various design methodologies and to recognize their potentials and limitations. Hands-on experience with computer-aided design is developed through instructions and homework assignments.

Education Method Lectures, class assignments

Books "Separation Process Principles", J.D.Seader & E.J.Henley, John Wiley & Sons, 2nd Ed., 2006

Assessment The developed knowledge and acquired skills are tested by means of homework assignments, which can be worked out in groups of two students. These design groups defend their results in an oral examination session.

NS3161 | Advanced Biophysics | ECTS: 6

Responsible Instructor M. Dogterom ([email protected])


Start Education 3



Biophysics; Statistical Physics and Thermodynamics.

Course Contents This course is intended for advanced master's students and Ph.D. students and builds on the material covered in the course Biophysics (NS3511). Topics covered include photophysics, protein folding, selforga-nized systems and pattern formation, cell networks, molecular motors, gene regulation, and bioinformatics.

Study Goals An understanding of the physical principles underlying the many facets of modern biological physics, as well as an appreciation of their biological context.


To be announced.

Location Leiden


Course Descriptons


|4

NS3501 | Nanotechnology | ECTS: 6

Responsible Instructor Prof.dr. H.W.M. Salemink ([email protected])

Instructor T. schmidt ([email protected])


x/x/0/0


Start Education 1

Exam Period 1, 2


Course Contents Material deposition methods, pattern definition, pattern transfer, atomicand molecular manipulation, scanning probe techniques, singlemolecule techniques, methods of inspection, analysis and characteriza-tion, applications. The course aims to impart the nanoscientist withthe awareness required to make him/her an effective technologist forhis/her own nanostructures.

Study Goals Knowledge of, and insight in fabrication and analysis methods ofnano-objects of electronic materials.

Education Method Lectures, student presentation & discussion sessions


"Nanoelectronics and Information technology", edited by R. Waser;BlackBoard: articles to be prepared for working groups, powerpointpresentation of the lectures, student presentations and other supplemen-tary information is posted on BlackBoard (blackboard.tudelft.nl)


Location Leiden & Delft

NS3511TU | Biophysics | ECTS: 6

Responsible Instructor Dr. J.E. Keymer Vergara ([email protected])

Instructor Dr. S.G. Lemay ([email protected]), Prof.dr. C. Dekker ([email protected])


14/14/0/0


Start Education 1

Exam Period 2



Course Descriptons


4 |


Knowledge of mechanics, thermodynamics and electromagnetismat the 2nd year undergraduate physics level.

Course Contents This course explores the fundamental physical principles(heat, hydrodynamics, electrostatics) that underlie the cell'sfunctioning. The primary focus is on phenomena at the scale ofindividual molecules, currently a very active area of research.Both theoretical concepts and modern single-molecule experimentaltechniques are discussed.

Study Goals To provide the participants with a firm foundation in the fundamentalsof molecular biophysics and an overview of the areasof current active research.

Education Method LectureReading of pre-selected scientific articlesHomework


The textbook "Biological physics: Energy, Information, Life" byPhilip Nelson (W.H. Freeman, New York, 2004).

Assessment Written examination (60%), problem sets (40%). Examination date: January 30th (14:00-17:00)


not later than September 15 via Black Board Delft(courses > Master > LS&T)

Schedule 1st and 2nd period Thursday5/6

Location Delft

OSPT 10 | Sustainable Process, Product and Systems Design + Assignment

| ECTS: 4

Responsible Instructor Drs.ir. G. Bierman ([email protected])


one week, full time, once a year, see http://ospt.tnw.utwente.nl/ospt4





Course Descriptons


|4

Course Contents Engineers have the ability and opportunity to make a difference in sustai-nability issues. Societies worldwide increasingly require proper living stan-dards embedded in ecologically and resource balanced surroundings. In this respect, the process industry can be viewed upon as an intermediate between resources and products. Consequently, the process industry nowadays faces huge challenges to fulfill these demands and require-ments, such as to reduce and abandon resource depletion, improve health conditions, and supply soundly produced goods. Being the technological expert in the process industry, engineers are key in the efforts to sustai-nable development, for they can make the connection between societal demands and novel process systems and new products.

The purpose of this course is to learn to design processes, products and systems with sustainable development goals and constraints.The term Sustainable Development contains social, cultural, environ-mental and economic aspects and it takes worldwide and long-term perspectives into account. It focuses on two types of developments; one that is about improving the welfare of a society, as used in the term 'deve-loping countries' and one that leads to technological innovation, as used in the term "Research and Development" in the industrialised countries.The learning objectives of the course are connected to the four stages of designing:- settlement of problem definition for sustainable design- analysis of system elements and emission streams- synthesis: apply innovative sustainable technologies and solutions in context- evaluation: define your role and impact as an chemical engineerEach specific topic will be taught by an OSPT teacher. As design is mainly learned by doing, the course will provide for each topic some theory followed by case design improvements.

Study Goals The learning objectives of the course are connected to the four stages of designing:

- settlement of problem definition for sustainable design- analysis of system elements and emission streams- synthesis: apply innovative sustainable technologies and solutions in context- evaluation: define your role and impact as an chemical engineer

Each specific topic will be taught by a different OSPT teacher.

Education Method As design is mainly learned by doing, the course will provide for each topic some theory followed by case design improvements.

Assessment PDEng-trainees need to do an assignment


Course Descriptons


4 |

OSPT 1-3 | Unified Approach to Mass Transfer + assignment

| ECTS: 3

Responsible Instructor Ing. Y.M. van Gameren ([email protected]), Prof.dr.ir. L.A.M. van der Wielen ([email protected])


one week, full time once a year, see http://ospt.tnw.utwente.nl/ospt4




Course Contents http://ospt.tnw.utwente.nl/ospt4

Study Goals http://ospt.tnw.utwente.nl/ospt4

Education Method http://ospt.tnw.utwente.nl/ospt4

Assessment PDEng-trainees need to do an assignment

OSPT 5-2 | Distillation, Absorption & Extrac-tion + assignment

| ECTS: 4



-




Course Contents The course deals with design and operation of the important industrial multi-component separations: distillation, absorption and extraction. It will provide you with state-of-the-art procedures on multi-component phase equilibria, ideal and non-ideal hydrodynamics and mixing in trays and packings, non-equilibrium multi-component stage calculation (based on thermodynamics of irreversible processes) and dynamic behaviour. The emphasis will be on fundamentals, although empirical correlations will be used where necessary.Many of the exercises will make use of 'ChemSep', a multi-component non‚â†equilibrium distillation design program written by R.Taylor and H.Kooijman of Clarkson University. The course represents a new develop-ment in Separation Engineering. Our documentation is good and is still being improved.


Course Descriptons


|4


Course Outline: Monday: introduction and course strategy‚ equilibrium stage calculations‚ design and hydrodynamics of trays‚ determining the operation limits of an existing column;

Tuesday: introduction to multi-component mass transfer‚ the non-equili-brium model - non-ideal equilibria using UNIQUAC and UNIFAC - non-equilibrium effects in multi-component distillation;

Wednesday: separation column sequencing‚ extractive and azeotropic distillation‚ absorption; simultaneous heat and mass transfer; Thursday: hydrodynamics and mass transfer in packed columns‚ vacuum distillation‚ dynamic simulation of a distillation column‚ liquid-liquid extraction;

Friday: mass transfer and hydrodynamics in liquid-liquid extraction‚ choice of equipment‚ summary and prospects‚ course evaluation.

Study Goals -

Education Method -

Assessment Two-week assignment

OSPT 6-4 | Advanced Process Integration and Plantwide Control

| ECTS: 4



-




Course Contents This course deals with advanced features in Process Integration, in the field of Process Analysis and Synthesis, Process Dynamics and Plant Wide Control. Systematic methods are presented to design flowsheets, not only economically efficient, but also with superior controllability. Special atten-tion is paid to Flowsheeting, both in steady-state and dynamic mode. Conceptual Design, Retrofitting and Dynamics & Control are treated in an unified frame. The theoretical concepts are consolidated by means of an optional project.


Course Descriptons


4 |


This OSPT course, is scheduled on a full week, with half day lectures and half day computer exercises. The optional two weeks project gives the right for three credit points in the case of TWAIO students. The lectures are provided by Dr. Ir. A. C. Dimian and Prof. Dr. S.Bildea. The working classes involve ASPEN Dynamics and MATLAB. The course is meant for Ph.D. and PDEng students, but it is of highest interest for engineers from Process Industries involved in Design and Operation of complex plants. Basic knowledge in Process Control and Energy Integration is welcome, as well as some practice with simulation software. Course Outline:

Module 1: Flowsheeting Architecture of flowsheeting software Degree of Freedom Analysis Methodology in Simulation Fundamentals of Steady-state Flowsheeting

Module 2:Process Synthesis and Integration Revised Hierarchical Approach of Conceptual Design Mathematical Programming Synthesis of Separation Systems by Residual Curve Maps

Module 3: Integration of Design and Control 2Fundamentals of Process Dynamics Transition from steady-state to dynamic flowsheeting Linear Analysis of Complex Systems Multivariable Controllability Analysis Dynamics of Recycles in a Complex Plant Integration of Conceptual Design and Plantwide Control

A comprehensive case study illustrates the approach, from flowsheet architecture through closed loop dynamic simulation. The "dynamic design" of the reaction and separation systems is interrelated with energy integration. The case study outlines the development of a plantwide control strategy.

Study Goals -

Education Method -

Assessment Two-week Assignment


Course Descriptons


|4

OSPT 7 | Advanced Molecular Separations | ECTS: 2



one week, once a year, see http://ospt.tnw.utwente.nl/ospt4




Course Contents In the field of separation technology many new technologies, offering tremendous potential for process improvement and new process concepts, have been developed during the past twenty years. However, at present many chemical engineers are not fully aware what these new technologies can offer in process development studies. Therefore utiliza-tion of advanced molecular separations is usually hardly considered.

Creating awareness was the main incentive to develop this course for the OSPT. We aim to present an overview of recent developments and indus-trial applications of advanced molecular separation technologies. For each topic the operating principles, basic modeling approach, industrial applica-tions and potential applications will be discussed. Several exercises and case studies are included in the program to become familiar with the basic design procedures.

Study Goals -

Education Method -

Assessment PDEng trainees need to do a two-week assignment

SC4190CH | Process Dynamics and Control | ECTS: 6

Responsible Instructor Ir. A.E.M. Huesman ([email protected])


0/4/4/0

Education Period 2, 3, None (Self Study)

Start Education 2

Exam Period 3, 4



Course Descriptons


4 |

Course Contents IntroductionOverview of the process industry.Design versus operation.Batch and continuous operation.Objectives of process control.

Dynamic modelingMotivation.General procedure.Conservation laws and constitutive equations.Degrees of freedom.Examples of lumped and distributed process systems.Identification.

AnalysisLinearization, non-linearity in process systems.State space format.Laplace transformation and analysis.The concept of transfer function and block diagram.Common transfer functions; 1st order, integrator, 2nd order etc.Model approximation (first/second order plus dead time).Frequency domain transformation and analysis. Interaction.

ControlFeedback and feedforward.Actuation and sensing; instrumentation.Control in the Laplace domain.Control in the frequency domain.PID control (choice and tuning).Direct synthesis and Internal Model Control (IMC).Extensions; ratio, feedforward, cascade, override etc.Dealing with interaction.

Advanced topicsBatch control (by sequential function charts).Plantwide control; some aspects.Optimization; role during operation.

Study Goals 1. Have a general understanding of process operation.2. Be able to analyze process dynamics (model based).3. Be able to design a control system for a unit operation.4. Understand the control system of a complete plant.

Education Method Lectures and Matlab instruction.


Handouts and Matlab tutorial.


Course Descriptons


|4

Books Process Dynamics and Control, D.E. Seborg, T.F. Edgar and D.A. Mellichamp, 2nd edition, Wiley, 2004.

Assessment 1 assignment and 2 written tests.

ST6063A | Process Simulation Laboratory | ECTS: 2

Responsible Instructor Ing. M. de Niet ([email protected])


0/0/8/0

Education Period 2

Start Education 3

Exam Period none


Course Contents Applied thermodynamic methods; systems for separation processes; mass and energy balances; sequential modular flowsheeting; selection of convergence methods; heat integration; project-based simulation of a complete chemical process.

Study Goals Be able to: make flowsheet of experimental set-up & understand existing one; simulate a process with Aspen; solve problems related to modeling of processes. Possess: practical skills in modeling & analysis of complex systems; insight into simulation of several processes; insight into chemical processes as a whole.

Education Method Student centered, problem directed practical: this form of education focuses on the student and therefore doesn't specify any procedures to be followed, but merely specifies a target to be accomplished.


Practical manual, software manual, literature for individual projects (all available at practical).

Practical Guide Will be handed out at start of the course.

Assessment Assessment based on practical execution of the assignment and practical report.Evaluation within two weeks after finishing the report.

Location Large or small DCT computer room (depends on amount of participants).


Course Descriptons


4 |

ST6072 | Thermodynamics for Process Engineers

| ECTS: 3

Responsible Instructor Drs.ir. G. Bierman ([email protected]), Ir. P.L.J. Swinkels ([email protected])


-




Course Contents For the design of industrial processes reliable values of the properties of the pure components and mixtures which are involved in the process are very important. Often experimental data are not or only partly available. This course handels state of the art methods for description of thermody-namic properties; chemical equilibria and phase equilibria. Advanced equations of state, models for the calculation of interaction coefficients. Thermodynamic analyses of processes; exergy analyses.

Course outlineMonday : Intermolecular forces, equations of stateTuesday : Thermodynamic properties of process streamsWednesday : G-excess models for non-electrolytes; Polymer- and electro-lyte solutions; G-excess mixing rules for equations of stateThursday : Statistical-mechanical equations of state; Algorithms for phase and chemical equilibrium; The use of thermodynamics in flowsheetersFriday : Exergy analysis

Study Goals -

Education Method -

Books The textbook "The Properties of Gases and Liquids" by B.E. Poling ., J.M. Prausnitz and J.P. O'connell will be used for the main body of the course.

Assessment Individual Assignment

ST6111 | Project Management | ECTS: 2

Module Manager Drs. F.G. de Brouwer ([email protected])


This course is for PDEng-trainees only: two days and two half day sessions + individual coaching sessions. The workshop sessions will take place on the 7th and 8th of September 2009.

Education Period 1

Start Education 1


Course Descriptons


|4

Exam Period none


Course Contents The set up of the Project Management Training is combining theory with daily (project) work and applying the method into practice. Session 1A two-day training in which you get an overview of the theory of project management. Main questions to be answered are 'What do I have to do to structure and plan my project successfully?' (hard-skills) and 'How can I do that?'(soft-skills)Session 2 (one month later)An afternoon session that focusses on the systematic risk analysis and translating this to your own projects. Sharing experiences and learning from each otherSession 3 (another month later)An afternoon session that will focus on the 'soft-skills' like influencing styles, managing the project environment to improve your personal skills of managing a successful project- In between the different sessions participants do some experiments

based on a personal improvement plan. Approach of the experiments and the outcome will be discussed with a personal coach.

- Personal coaching will be used as an instrument to help you to apply the theory into practice, to reflect on your approach and to support you in your own personal development (on the 'hard- and soft skills').

Study Goals - Understanding the theory of setting up and controlling a project. Trai-ning your 'hard-skills' of starting-up, structuring and controlling successful projects.

- Being able to apply theory of project management into practice in your own projects and daily work (bringing the theory to 'life')

- Being able to identify and develop specific learning points in 'hard skills' and 'soft-skills' of project management with the help of personal coaching

- Improving on specific 'soft-skills' like e.g. leadership, providing and receiving feedback, team cooperation, influencing the project environ-ment and self reflection.

- Being able to learn from other participants by sharing experiences from own experiments. Goal is to develop a shortlist of best practices.

Education Method Workshop and sessions + individual coaching sessions

Assessment No exam, active participation in the workshop and sessions is required


This course is exclusively held for PDEng-trainees in one of the Designer programmes BioProduct Design, Bioprocess Engineering or Process & Equipment Design.


Course Descriptons


4 |

Special Information This course is given by Mr. Chris Wigboldus and Drs. Anne Spruyt (AMI)AMI (Advanced Management Implementation) is a professional organisa-tion with ample experience in implementing the method of project mana-gement in relation to the (hard and soft) skills necessary to set-up, run and manage a project successfully.

ST6161 | Fermentation Technology | ECTS: 3



X/X/0/0

Education Period 1

Start Education 1

Exam Period 1



Basic biosciences (biochemistry and microbiology) and Engineeringprinciples.

Course Contents Stoichiometry, thermodynamics, kinetics of growth andproduct formation, Metabolic networks, Modeling of batch,chemostat, fed batch fermentation, Role of mass transfer,mixing and heat transfer.

Study Goals Designing/evaluating industrial fermentation processes fromtechnological and microbial fundamentals.

Education Method Lectures, exercises.


Lecture notes on BlackboardRecommended: Basic Bioreactor design, van 't Riet en Tramper,Dekker, New York 1991

Assessment Assignments and examination.

Enrolment / Applica-tion

Via blackboard

Special Information This course is organizational part of LM3741

Location Delft


Course Descriptons


|4

ST6221 | SuperPro Designer | ECTS: 1

Responsible Instructor Ing. Y.M. van Gameren ([email protected])


one day full time, to be announced


Start Education 1, 2, 3, 4



Course Contents -

Study Goals -

Education Method computer practicals

Assessment -

ST6471 | In-vivo Biomolecular Interactions | ECTS: 4



Please see www.leidenuniv.nl


Start Education 3



Course Contents Please see www.leidenuniv.nl

Study Goals Please see www.leidenuniv.nl

Education Method Lectures, presentation and exam.

Prerequisites Basic biochemistry knowledge

Assessment Presentation and exam

Location Leiden University


Course Descriptons


4 |

ST6481 | Modern Drug Discovery | ECTS: 4



Please see www.leidenuniv.nl

Education Period 1, 2, Different, to be announced

Start Education 1



Course Contents Please see www.leidenuniv.nl

Study Goals Please see www.leidenuniv.nl



Location Leiden University

ST6491 | Biopharmaceuticals as Innovative Drugs

| ECTS: 1



Please see www.lacdr.nl.


Start Education 3

Exam Period none


Course Contents Please see www.lacdr.nl

Study Goals Please see www.lacdr.nl

Education Method Please see www.lacdr.nl

Assessment Please see www.lacdr.nl


Course Descriptons


|4

ST6503 | AC Downstream Processing + assignment

| ECTS: 3

Course Coordinator G.W.J.O. Aggenbach ([email protected])


one week full time, see www.bsdl-edu.bt.tudelft.nl


Start Education 4



Course Contents Course is given once a year and includes an assignment. For course content, period, and other details see website www.bsdl-edu.bt.tudelft.nl

Study Goals www.bsdl-edu.bt.tudelft.nl

Education Method www.bsldl-edu.bt.tudelft.nl

Assessment An assignment will be given

Location Department of Biotechnology, Delft.

ST6523 | AC Environmental Biotechnology + exam or assignment

| ECTS: 6



10 days full time, once a year, see www.bsdl-edu.tudelft.nl

Education Period 4, Different, to be announced

Start Education 4



Course Contents www.bsdl-edu.tudelft.nl

Study Goals www.bsdl-edu.tudelft.nl

Education Method www.bsdl-edu.tudelft.nl

Assessment an oral exam or assignment is part of this course


Course Descriptons


4 |

ST6532 | AC Microbial Physiology & Fermentation Technology

| ECTS: 7



2 weeks full time, once a year, see www.bsdl-edu.bt.tudelft.nl


Start Education 2



Course Contents For a better understanding of the lectures and to enhance active participa-tion by those attending, this intensive two-weeks course consists of lectures, practical demo's, computer simulations, exercises and case studies. Morning and eveningThe lectures are mainly scheduled in the mornings and the early evenings. In the lectures, attention will be paid to the following themes:- Energy transduction and growth thermodynamics- Kinetics of growth and product formation- Regulation of metabolism by environmental parameters- High-cell density fermentation- Metabolic energy and stoichiometry- Quantification and modification of metabolic fluxes- Scale-up / scale-down- Engineering of pathway kinetics- Production of (heterologous) proteins- Capita selecta

AfternoonDemo's in fed-batch fermentation. Discussions and interpretation of results. On- and off-line measurements in the gas and liquid phase of reaction parameters and determination of the kinetics of biological conver-sions. Statistical data processing using mass balances. Tutorials in setting-up and simulating computer models of metabolic networks. Introduction to methods for down- and up-scaling (critical-time constants and regime analysis). Possibilities to visit the research projects of the Graduate School Biotechnological Sciences Delft Leiden, BSDL.

The course will be given in English.

A pocket calculator is required.


Course Descriptons

Study Guide 2009/2010101 |

|4

Study Goals The Advanced Course 'Microbial Physiology and Fermentation Technology' aims to familiarize participants with the integrated, interdisciplinary approach required in modern biotechnology. Microbial physiologists, enzy-mologists and (bio)chemical engineers from the faculty staff, together with invited (inter)national experts from other universities and industry, will offer a combination of theoretical (lectures, tutorials, mathematical modelling) and practical work (demonstrations, data collection and inter-pretation of results). In this way, the course will present an intensive and in-depth treatment of the state of the art. At the same time, the course provides the necessary link between, on one hand, fundamental subjects (e.g. biochemistry / enzymology) and, on the other hand, practical appli-cations in large-scale biotechnological processes.

Education Method <>

Assessment For PDEng-trainees obligatory. The total ECTS for course and exam is 7. If you have followed both Microbial Physiology and Fermentation Technology MSc courses separately, the total ECTS is 3.

Remarks A pocket calculator is needed

Studyload/Week 2 weeks full time

Schedule www.bsdl-edu.bt.tudelft.nl

Location Department of Biotechnology, Delft, room 5A

ST6533 | AC Microbial Physiology & Fermentation Technology

| ECTS: 3

Responsible Instructor Ing. Y.M. van Gameren ([email protected])


two weeks full time, once a year, see www.bsdl-edu.bt.tudelft.nl


Start Education 2



Course Contents www.bsdl-edu.bt.tudelft.nl


Education Method www.bsdl-edu.bt.tudelft.nl

Assessment PDEng-trainees need to do ST6532 or take the courses Microbial Physio-logy and Fermentation Technology separately including exam and assign-ments


Course Descriptons


4 |

ST6584 | AC Biocatalysis + assignment | ECTS: 3



one week, full time, once a year, see www.bsdl-edu.bt.tudelft.nl


Start Education 3






Assessment PDEng trainees will receive assignments. Request for the assignment two months on beforehand.

ST6612 | Techno-economic Evaluation in the Process Industry

| ECTS: 6

Module Manager Ing. Y.M. van Gameren ([email protected])


10 days full time for PDEng-trainees only


Start Education 2



Course Contents The Course is comprised of three modules. The first module examines the state of the economy and the characteristics and working of the chemical process industry business in general and the 'project development, design and construction pipeline' in particular, both from a product and a process technology point of view. The second part covers best practices in capital & operating cost estimating and assessing project profitability and invest-ment return in life-cycle terms (Discounted Cash Flow-Analysis). The last module offers an introduction to 'Finance for non-accountants' in which a company's financial performance is discussed in the light of its financial statements.


Course Descriptons

Study Guide 2009/2010103 |

|4

Study Goals The present Course offers a tailor-made package of knowledge and prac-tical skills in the fields of strategy & marketing as well as economics & finance. Particular attention is paid to industry analysis, formulation & analysis of options, capital & operating cost estimating, investment appraisal and evaluation of corporate financial performance. The course teaches product & process developers and engineers to put a price tag on their ideas and so offer the best solutions from an integral technical and economic point of view. Finally, the course offers students/trainees in science & technology a broad orientation on the non-technical (business administration) aspects of their discipline and, hence, the opportunity to put their affinity with such issues into a better perspective.

Education Method 8 days full time classes and assignments in groups: An intensive, full-day method is adopted, comprising lectures, case studies (Harvard Case Method), group work, individual assignments and role play. Outside speakers (like from Fluor) also take part.

Assessment group assignments

ST6651 | Quality Management: THe role of the QP

| ECTS: 1



3 days full time, once a year, see www.bsdl-edu.bt.tudelft.nl







Assessment -

ST6661 | Quality Management: Drug Development and GxP's

| ECTS: 1








Course Descriptons

Study Guide 2009/2010105 |

|4

ST6813 | Group Design Project (BioProduct) | ECTS: 17

Responsible Instructor Drs. J.A. Kiers ([email protected])


Project


Start Education 1, 3

Exam Period none


Course Contents In the Group Design Project, you work in groups on a real-life design project in collaboration with industry. The guidance is in the hands of a steering group consisting of an industrial principal, and academic repre-sentatives, with ample (industrial or academic) design experience. The team experiences working in an industrial context, dividing tasks within the team, interacting with different stakeholders and planning and control issues. At the same time, a detailed design has to be delivered, in which systematic and quantitative argumentation is provided

Study Goals Design in an industrial context, Project Management, Teamwork

Education Method Project

Assessment Assessment is in three parts: content, project management and presenta-tion/reporting

ST6821 | Adv. Course Applied Genomics of Industrial Fermentation

| ECTS: 3

Module Manager G.W.J.O. Aggenbach ([email protected])


one week full time in fall 2010


Start Education 1

Exam Period none



Course Descriptons


4 |

Course Contents This intensive, high-diversity, one-week course is aiming at active partici-pation of those attending. To this end, the course is built with an alterna-ting program of expert lectures, case studies, workshops and round table discussions.

Morning programmeExpert lectures (except the closing lecture) are scheduled in the mornings. Attention will be on a variety of themes:- Genome sequencing and annotation- Molecular cell biology- Transcriptomics technology- Proteomics technology- Metabolomics technology- Bioinformatics- Metabolic engineering & network analysis- Biodiversity & classical genetics- Evolutionary engineering- Regulation, legislation and society- Examples from biotechnology industry

Afternoon programmeIn the afternoons (except on the final day) several case studies and work-shops illustrate the utility and utilization of Genomics in modern biotech-nology. The expert lecturers will be available for round-table discussions with small groups on selected themes. Hand outs and supplementary material will be made available to the parti-cipants. The official course language is English.

Who should attend?This Advanced Course is aimed both at participants from industry, who want to up-date and extend their theoretical knowledge and practical insight in this field and at participants from universities and research insti-tutions with a wish to evaluate practical implications of their research. The course is intended for postgraduates (MSc, PhD), with a sound back-ground in microbiology, microbial physiology, molecular cell biology, biochemistry or biochemical engineering, with a basic working knowledge in some of the other disciplines. Having some basic insight into one or more of the Genomics technologies or in bioinformatics is not compulsory, but certainly is an advantage.


Course Descriptons

Study Guide 2009/2010107 |

|4

Study Goals The Advanced Course on "Applied Genomics of Industrial Fermentation" aims to familiarize industrial and academic research professionals (i.e. MSc, PhD) with the modern concepts of Genomics, their use in microbial research and development, and their utility in contemporary biotechnolo-gical industry. The Course is organized under the Kluyver Centre for Geno-mics of Industrial Fermentation (described on the back of this brochure), and is instrumental in the dissemination of the results of this Centre of Excellence. Applied Genomics is defined as the singular and combined utilization of the modern molecular research tools transcriptomics, proteomics, and metabolomics to elucidate cellular regulatory mechanisms of sensing and signalling, metabolic flux and physiology. Mathematical tools are indispen-sable to analyze, interpret and model the experimental data. In combined approaches, these tools offer unprecedented possibilities for industrial fermentation research.Experts will present lectures on genome analysis and -interpretation, genome-wide gene expression analysis (DNA micro arrays, transcripto-mics), whole-organism protein expression and activity analysis (proteo-mics), and metabolic pathway analysis (metabolomics). Data handling and bioinformatics are key to the successful application of Applied Genomics and hence, will be an integral part of the course. Application of these technologies in industrial R&D (modelling, network analysis and metabolic engineering) will be illustrated with real-life examples. The necessary links between theory and practice will be provided in interactive case studies and demo-workshops. In addition, there will be ample opportunity to interact and discuss with the expert lecturers in several small-group, round-table discussions.

Education Method Workshops

Assessment None

ST6831 | AC Thermodynamics in Biochemical Engineering

| ECTS: 2

Responsible Instructor Prof.dr.ir. L.A.M. van der Wielen ([email protected])


One week full time, once every two years (see http://kwi.dechema.de/en/education.html for the 2009 course information)




Course Contents http://kwi.dechema.de/en/education.html

Study Goals http://kwi.dechema.de/en/education.html

Education Method http://kwi.dechema.de/en/education.html


Course Descriptons


4 |

Assessment PDEng trainees need to do an asignment

ST6861 | AC Bioreactor Design & Operation | ECTS: 3

Responsible Instructor Prof.dr.ir. K. van 't Riet ([email protected])


one week full time, once a year in Wageningen, see http://www.vlaggra-duateschool.nl/courses/reactor-design.htm




Course Contents http://www.vlaggraduateschool.nl/courses/reactor-design.htm

Study Goals http://www.vlaggraduateschool.nl/courses/reactor-design.htm

Education Method http://www.vlaggraduateschool.nl/courses/reactor-design.htm

Assessment PDEng trainees need to do an assignment

ST6871 | Industrial BioProduct Design | ECTS: 3



-

Education Period 4

Start Education 4



Course Contents The currently active Industrial BioProduct Designers have been trained by their many years experience in designing and developing products in the bio-(tech)-industry.

Several industrial speakers share and analyse their experience in BioPro-duct Design, and deal with topics including the Development Process, Market introduction, Technology Transfer, Success factors, etc.Different product categories in pharma, fine chemicals and food will be discussed.

Study Goals The Study Goal of this course is to obtain an insight in the design and development process of Industrial BioProduct Design.

Education Method Lectures, combined with case studiesThe schedule of the lectures will have an irregular character, since they will have to fit the agendas of the speakers.


Course Descriptons

Study Guide 2009/2010109 |

|4


Material will be provided by the speakers

Prerequisites An MSc-degree in Life Science & Technology or comparable. This course is part of the core programme of the PDEng-programme in BioProduct Design.

Assessment Case studies, participation in the discussion

ST6881 | Molecular Genetics, Self Study | ECTS: 3

Responsible Instructor Dr. L.G. Otten ([email protected])


2 afternoon sessions with lectures and two Q&A sessions.


Start Education 3




None

Course Contents Molecular Genetics, basics and applications

Study Goals The student will know and understand terms used in molecular genetics. Furthermore (s)he will understand how this can be used in daily enginee-ring life.

Education Method Self study, Blackboard assignments, 4 lectures (2x2)

Books From Genes to Genomes: Concepts and Applications of DNA Technology, 2nd Edition

Prof Jeremy Dale, Malcolm von Schantz

ISBN: 978-0-470-01734-0

Assessment Written exam, 2 Blackboard assignments

Exam Hours May 29, 10.45-12.45

Location BT building, room 5B


Course Descriptons


4 |

ST6902PR PD | Individual Design Project, Practice | ECTS: 20



Full-time



Exam Period none


Course Contents The Individual Design Project is performed in, or in collaboration with, the R&D department of an industry or as a developer in a smaller industry. It may be providing a solution for a specific problem, but it may also regard the whole design process, from idea to feasibility. The focus is on the deli-very of the systematic and quantitative argumentation for the final design solution. The PDEng-trainee combines the functions of project manager, technological expert and designer. The Industrial Design Project has an industrial principal and a coach from the university. Several different experts may be involved.


Assessment Report and presentation

ST6902TH PD | Individual Design Project, Theory | ECTS: 20



Full-time



Exam Period none





Course Descriptons

Study Guide 2009/2010111 |

|4


ST6902VC PD | Individual Design Project, Communication

| ECTS: 20



Full-time.



Exam Period none





WM0516TU | Turning Technology into Business | ECTS: 6

Module Manager Dr. L. Hartmann ([email protected])


0/X/0/0

Education Period 2

Start Education 2

Exam Period none



Course Descriptons


4 |

Course Contents 'Turning Technology into Business' (TTiB) aims to equip participants with a strong conceptual foundation to actively understand the dynamic process of technology-based entrepreneurship. Participants learn how business strategies are best formulated and how (through entrepreneurship) tech-nology can create value. TTiB consists of seven lectures, introducing the theoretical backgrounds of technological, market and business analyses. A unique aspect of TTiB is that existing technologies (developed and patented by the TU Delft) are used as case subjects. The patent project is the focal point of the curriculum. Each group of 4-5 students will be assigned an original patent, and is expected to evaluate the commercial potential of this technology. This includes choosing promising applications (products) for the technology, and making recommendations for the most suitable business model to commercialize the technology. The patent project should provide a coherent and structured answer to the central question: which strategy is most likely to generate business from this patent? In addition to equipping participants with a thorough knowledge of the course subject, the section Technology, Strategy & Entrepre-neurship (TSE) hopes that this course will be the starting point for a variety of university spin-offs in which the students will participate. To accommodate this, TSE offers the course WM0506TU - Writing a Business Plan.

Study Goals The course "Turning Technology into Business" aims to equip students with a strong conceptual foundation to an active understanding of two domains:

The dynamic process of technological innovation through concepts such as technology life-cycles, dominant design, disruptive technologies, Schumpeterian competition and the diffusion of innovations How business strategies are formulated and, through entrepreneurship, technology can create value. This multi-faceted process of technology commercialization process is addressed in terms of assessing technology position, discovering market opportunities, competitive analysis, approp-riability and the various modes of entrepreneurship.

Education Method Lectures, assignments, individual group coaching


<>

Assessment Each group writes a report on their analysis, findings and recommenda-tions for the technology (patent) they used as a case, and give a 20 minute oral presentation. The reports will be discussed and graded indivi-dually.


Course Descriptons

Study Guide 2009/2010113 |

|4

ZB4FCOL2 | Pharmacology: Blood Brain Barrier: Drug Transport to the Brain

| ECTS: 4



see www.lacdr.nl


Start Education 3



Course Contents This course is offered by LACDR (Leiden Amsterdam Centre for Drug Research).

Study Goals More information can be found at www.lacdr.nl.

Education Method Lectures and self-study

Assessment PDEng-trainees need to make an extra assignment in order to obtain the ECTS credits.

Remarks For Education period, start education and exam period see www.lacdr.nl


5.Map of TU Delft Campus


Map of TU Delft Campus


116 |

A13



Study Guide 2009/2010117 |

117 |




5 |

Latest update: May 2008

No. Address NameA Ezelsveldlaan 61 Delft Technology Museum 3 Mijnbouwstraat 120 Centre for Technical Geoscience 5 Julianalaan 67 Biotechnology (Kluyver laboratory) 6 Poortlandplein 6 Botanic Gardens 8 Julianalaan 132-134 Former main building / Temporary location Faculty of

Architecture 12 Julianalaan 136 Delft ChemTech 15 Prins Bernhardlaan 6 Kramerslab. Physical Technology 17 iWeb Virtual reality pavillion 20 Mekelweg 5 Aula Congress Centre 21 Prometheusplein 1 TU Delft Library / Marketing & Communication 22 Lorentzweg 1 Faculty of Applied Sciences 23 Stevinweg 1 Faculty of Civil Engineering and Geosciences / University

Corporate Office 28 Van Mourik Broekmanweg 6 TNO Built Environment and Geosciences 30 Jaffalaan 9 OTB Research Institute

Jaffalaan 9a Education & Student Affairs (CSA, International Office) 31 Jaffalaan 5 Faculty of Technology, Policy and Management 32 Landbergstraat 15 Faculty of Industrial Design Engineering / SSC ICT 33 Landbergstraat 19 Composites laboratory / INHOLLAND 34 Mekelweg 2 Faculty of Mechanical, Maritime and Materials Engineering

(3mE) / CICAT / NIMR 34a Cornelis Drebbelweg 9 Executive Board / Supervisory Board 35 Cornelis Drebbelweg 5 EEMCS Examination and Laboratory Class Building 35 36 Mekelweg 4 + 6 Faculty of Electrical Engineering, Mathematics and

Computer Science (EEMCS) / DIMES / IRCTR / MultiMedia Services (MMS)

37 Mekelweg 8 Sports Centre 38 Mekelweg 10 Cultural Centre 43 Leeghwaterstraat 36 Cogeneration plant 44 Rotterdamseweg 145 Technostarter share building, YES!Delft 45 Leeghwaterstraat 42 Low Speed Wind Laboratory & VSSD 46 Leeghwaterstraat 44 Process and Energy Laboratory (API) 50 Mekelweg 15 Reactor Instituut Delft (RID, former IRI) /

Radiation Radionuclides & Reactors (RRR) 57 Watermanweg Datacenter 60 Anthony Fokkerweg 5 Logistics & environment 61 Kluyverweg 3 Delft Aerospace Structures & Materials Laboratory 62 Kluyverweg 1 Faculty of Aerospace Engineering / Adhesion Institute 63 Anthony Fokkerweg 1 SIMONA Research Flight Simulator 64 Kluyverweg 2 High Speed Wind Laboratory 65 Kluyverweg 4 + 6 SUPAIR / TRAIL / Facility Management & Real Estate 180 Rotterdamseweg 380 Annex Faculty AE & EEMCS / ASTI / ANWB driving

simulator

Legend of map TU Delft


6.Year planner


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|6

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6 |

6.1

Lecture hours1 8.45 - 9.302 9.45 - 10.303 10.45 - 11.304 11.45 - 12.30

5 13.45 - 14.306 14.45 - 15.307 15.45 - 16.308 16.45 - 17.30

A1 18.45 - 19.30A2 19.45 - 20.30A3 20.45 - 21.30


7.Diary


Juli - July


2009|

Maandag - Monday

Dinsdag - Tuesday

Woensdag - Wednesday

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10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

Juli - July


week 31

Study Guide 2009/2010125 |

|

Donderdag - Thursday

Vrijdag - Friday

Zaterdag - Saturday Zondag - Sunday

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

week 31

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |


Augustus - August


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

Augustus - August


week 32

Study Guide 2009/2010127 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

week 32

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |


Augustus - August


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |


week 33

Study Guide 2009/2010129 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

week 33

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |


Augustus - August


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |


week 34

Study Guide 2009/2010131 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

week 34

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |


Augustus - August


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |


week 35

Study Guide 2009/2010133 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

week 35

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |


September - September


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |



week 36

Study Guide 2009/2010135 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

week 36

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |




2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |


week 37

Study Guide 2009/2010137 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

week 37

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |




2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |


week 38

Study Guide 2009/2010139 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

week 38

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |




2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |


week 39

Study Guide 2009/2010141 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

week 39

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |




2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |


week 40

Study Guide 2009/2010143 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

week 40

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |


Oktober - October


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

Oktober - October

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |


week 41

Study Guide 2009/2010145 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

week 41

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |


Oktober - October


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |


week 42

Study Guide 2009/2010147 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

week 42

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |


Oktober - October


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |


week 43

Study Guide 2009/2010149 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

week 43

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |


Oktober - October


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |


week 44

Study Guide 2009/2010151 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

week 44

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |


November - November


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

November - November

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |


week 45

Study Guide 2009/2010153 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

week 45

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |


November - November


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |


week 46

Study Guide 2009/2010155 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

week 46

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |


November - November


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |


week 47

Study Guide 2009/2010157 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

week 47

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |


November - November


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |


week 48

Study Guide 2009/2010159 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

week 48

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |


December - December


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

December - December


week 49

Study Guide 2009/2010161 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

week 49

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |


December - December


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |


week 50

Study Guide 2009/2010163 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

week 50

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |


December - December


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |


week 51

Study Guide 2009/2010165 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

week 51

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |


December - December


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |


week 52

Study Guide 2009/2010167 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

week 52

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |


December - December


2009|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |


week 53

Study Guide 2009/2010169 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

week 53

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |


Januari - January


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

Januari - January


week 1

Study Guide 2009/2010171 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

week 1

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |


Januari - January


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |


week 2

Study Guide 2009/2010173 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

week 2

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |


Januari - January


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |


week 3

Study Guide 2009/2010175 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

week 3

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |


Januari - January


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |


week 4

Study Guide 2009/2010177 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

week 4

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |


Februari - February


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

Februari - February


week 5

Study Guide 2009/2010179 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

week 5

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |


Februari - February


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |


week 6

Study Guide 2009/2010181 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

week 6

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |


Februari - February


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |


week 7

Study Guide 2009/2010183 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

week 7

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |


Februari - February


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |


week 8

Study Guide 2009/2010185 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

week 8

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |


Maart - March


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

Maart - March


week 9

Study Guide 2009/2010187 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

week 9

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |


Maart - March


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |


week 10

Study Guide 2009/2010189 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

week 10

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |


Maart - March


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |


week 11

Study Guide 2009/2010191 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

week 11

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |


Maart - March


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |


week 12

Study Guide 2009/2010193 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

week 12

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |


Maart - March


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |


week 13

Study Guide 2009/2010195 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

week 13

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |


April - April


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

April - April


week 14

Study Guide 2009/2010197 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

week 14

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |


April - April


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |


week 15

Study Guide 2009/2010199 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

week 15

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |


April - April


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |


week 16

Study Guide 2009/2010201 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

week 16

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |


April - April


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |


week 17

Study Guide 2009/2010203 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

week 17

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |


Mei - May


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

Mei - May


week 18

Study Guide 2009/2010205 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

week 18

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |


Mei - May


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |


week 19

Study Guide 2009/2010207 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

week 19

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |


Mei - May


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |


week 20

Study Guide 2009/2010209 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

week 20

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |


Mei - May


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |


week 21

Study Guide 2009/2010211 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

week 21

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |


Juni - June


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

Juni - June


week 22

Study Guide 2009/2010213 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

week 22

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |


Juni - June


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |


week 23

Study Guide 2009/2010215 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |

week 23

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |


Juni - June


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |


week 24

Study Guide 2009/2010217 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |

week 24

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |


Juni - June


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |


week 25

Study Guide 2009/2010219 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |

week 25

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |


Juni - June


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |


week 26

Study Guide 2009/2010221 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

week 26

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |


Juli - July


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

Juli - July


week 27

Study Guide 2009/2010223 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |

week 27

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

9 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

10 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

11 |


Juli - July


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

12 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

13 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

14 |


week 28

Study Guide 2009/2010225 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

15 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

16 |

week 28

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

17 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

18 |


Juli - July


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

19 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

20 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

21 |


week 29

Study Guide 2009/2010227 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

22 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

23 |

week 29

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

24 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

25 |


Juli - July


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

26 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

27 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

28 |


week 30

Study Guide 2009/2010229 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

29 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

30 |

week 30

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

31 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

1 |


Augustus - August


2010|

Maandag - Monday

Dinsdag - Tuesday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

2 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

3 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

4 |

Augustus - August


week 31

Study Guide 2009/2010231 |

|


Vrijdag - Friday


1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

5 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

6 |

week 31

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

7 |

1 |2 |3 |4 |5 |6 |7 |8 |9 |

10 |

8 |


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BioProduct Design Study Guide 2009/2010

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Transcript of BioProduct Design Study Guide 2009/2010