D. Braun / SS 2013 BPZ§4.1 1

Biophysics of excitable cells

H.Gaub / SS 2007 BPZ§4.1 2

Multiple exitatory and inhibitory synaptic contacts allow complex neuronal interconnects

BPZ§4.1 3

Cell-Semiconductor-Hybrids: Neuron on the Chip

More: Fromherz MPI Martinsried

D. Braun / SS 2013

BPZ§4.1 4

The electrical activity of neurons results from the opening and closing of specific ion-channels proteins in the neuron plasma membrane

D. Braun / SS 2013

BPZ§4.1 5

Voltage-gated cation channels generate action potentials

D. Braun / SS 2013

BPZ§4.1 6

Membrane depolarizations spread passively only short distances

D. Braun / SS 2013

BPZ§4.1 7

Action potentials are propagated unidirectionally without diminution

Movements of onlya few Na+ and K+

ions generate theaction potential

D. Braun / SS 2013

BPZ§4.1 8

Patch clamps permit measurement of ion movements through single channels

D. Braun / SS 2013

BPZ§4.1 9

Different patch clamping configurations

D. Braun / SS 2013

BPZ§4.1 10

Current flux through individual voltage-gated channels determined by patch clamping of muscle cells

D. Braun / SS 2013

BPZ§4.1 11

All five subunits in the nicotinic acetylcholine receptor contribute to the ion channel

D. Braun / SS 2013

BPZ§4.1 12

P segments form the ion-selectivity filter

D. Braun / SS 2013