Biomedical Research to Translational Medicine Saigal A. MS *, Tuteja D. PhD and Chaturvedi D. PhD...
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Biomedical Research to Translational Medicine Saigal A. MS * , Tuteja D. PhD and Chaturvedi D. PhD Bio Business Inc., 400 Continental Blvd, 6th Floor, El Segundo, CA 90245 * [email protected] INTRODUCTION Drug Discovery, the first step towards creation of blockbuster and orphan drugs, occurs at a variety of academic institutions and pharmaceutical, biotechnology and / or life science industries, that predominantly work independently. With increasing new drug disapprovals, regulatory constraints and the inevitable “patent cliff”, escalating drug prices and funding impediments (also referred as “Valley of Death”), an amiable and a collaborative nexus between academia and industry offers a promising solution. This can be achieved by adopting a Translational Medicine (TM) approach. TM ensures that bounty of biomedical research is “translated” into benefits in oncology, inflammation, metabolomics and unmet needs in other challenging fields. It thus, helps in, not only improving the quality of human healthcare effectively but also streamlines resources requisite for supporting meaningful research endeavors. TM is slowly gaining momentum in leading nations of the world such as USA, UK, Netherlands, Austria, Singapore, China, Australia, Japan, Japan, India, Malaysia and South Korea. At BioBusiness Inc., we facilitated vital affiliations, innovative thinking and offered tools for speedy and effective translation of biomedical research into clinical applications thereby bridging the translational gap while providing an appropriate platform for professionals to learn, network and make crucial strategic decisions. This section underscores the relevance of TM, identifies major logjams hindering its implementation, discusses propitious strategies to mitigate such hurdles, acknowledges global efforts advocating TM and how TM has facilitated overall progress in R&D. TRANSLATIONAL GAP TRANSLATIONAL MEDICINE Stratify Disease + Population BIOMARKER DEVELOPMENT Predictibility Personalized v/s “One- model-fits-all” Cordial Nexus RADICAL RE-STRUCTURING Autocracy + Tech Transfer Fragmentation of R&D + Manufac. / Mktg. Biotech Incubators and hubs EDUCATION / TRAINING Curriculum revision Obdurate diseases - multiple causes Economic growth Reduction of Translational Gap Innovative solutions Incentivize progress Cost effectiveness Lack of TRANSLATIONAL EDUCATIONAL METRICS Lack of ROBUST MANAGEMENT WITH A TM VISION Lack of FUNDING SOURCES Lack of GOVERNMENT SUPPORT C H A L L E E N G S (i) THE BELIEF (ii) CURRENT STATE OF AFFAIRS (iii) THE TRANSLATIONAL APPROACH (iv) GLOBAL PROGRESS IN TRANSLATIONAL MEDICINE (v) SCOPE OF IMPROVEMENT TM helps in improving the quality of human healthcare by providing innovative solutions for hard-to-cure diseases and streamlines resources necessary to support meaningful research endeavors, hence encouraging economic growth. Heeding emerging biomarkers from regulatory and human prognosis perspective, cordial nexus amidst academia and industry and tenacious approaches to promote TM globally can render optimism regarding winning the translational race. www.biobusinessinc.com METHODS RESULTS CONCLUSION REFERENCE i. Woolf, S.H. (2008) The meaning of translational research and why it matters JAMA 299(2) : 211-213. ii.Zhang, F., P. Cooke, and F. Wu, State-sponsored Research and Development: A Case Study of China’s Biotechnology. Regional Studies, 2011. 45(5): p. 575-595. Caleb Perry (1755- 1822) “It is much more important to know what kind of patient has a disease, than to know what kind of disease a patient ZIAGEN GEFITINIB TRASTUZUMAB IVACAFTOR
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Transcript of Biomedical Research to Translational Medicine Saigal A. MS *, Tuteja D. PhD and Chaturvedi D. PhD...
Biomedical Research to Translational MedicineSaigal A. MS*, Tuteja D. PhD and Chaturvedi D. PhD
Bio Business Inc., 400 Continental Blvd, 6th Floor, El Segundo, CA 90245 *[email protected]
Biomedical Research to Translational MedicineSaigal A. MS*, Tuteja D. PhD and Chaturvedi D. PhD
Bio Business Inc., 400 Continental Blvd, 6th Floor, El Segundo, CA 90245 *[email protected]
INTRODUCTIONINTRODUCTION
Drug Discovery, the first step towards creation of blockbuster and orphan drugs, occurs at a variety of academic institutions and pharmaceutical, biotechnology and / or life science industries, that predominantly work independently. With increasing new drug disapprovals, regulatory constraints and the inevitable “patent cliff”, escalating drug prices and funding impediments (also referred as “Valley of Death”), an amiable and a collaborative nexus between academia and industry offers a promising solution.
This can be achieved by adopting a Translational Medicine (TM) approach. TM ensures that bounty of biomedical research is “translated” into benefits in oncology, inflammation, metabolomics and unmet needs in other challenging fields. It thus, helps in, not only improving the quality of human healthcare effectively but also streamlines resources requisite for supporting meaningful research endeavors. TM is slowly gaining momentum in leading nations of the world such as USA, UK, Netherlands, Austria, Singapore, China, Australia, Japan, Japan, India, Malaysia and South Korea.
At BioBusiness Inc., we facilitated vital affiliations, innovative thinking and offered tools for speedy and effective translation of biomedical research into clinical applications thereby bridging the translational gap while providing an appropriate platform for professionals to learn, network and make crucial strategic decisions.
This section underscores the relevance of TM, identifies major logjams hindering its implementation, discusses propitious strategies to mitigate such hurdles, acknowledges global efforts advocating TM and how TM has facilitated overall progress in R&D.
TRANSLATIONAL GAP
TRANSLATIONAL MEDICINE
Stratify Disease + Population
BIOMARKER DEVELOPMENT
Predictibility
Personalized v/s “One-model-fits-all”
Cordial Nexus
RADICAL RE-STRUCTURING
Autocracy + Tech Transfer
Fragmentation of R&D + Manufac. / Mktg.
Biotech Incubators and hubs
EDUCATION / TRAINING
Curriculum revision
Obdurate diseases - multiple causes
Economic growth Reduction of Translational
Gap Innovative solutions Incentivize progress Cost effectiveness
Lack of TRANSLATIONAL EDUCATIONAL METRICS
Lack of ROBUST MANAGEMENT WITH A TM VISION
Lack of FUNDING SOURCES
Lack of GOVERNMENT SUPPORT
CHALLE
E
NG
S
(i) THE BELIEF
(ii) CURRENT STATE OF AFFAIRS
(iii) THE TRANSLATIONAL APPROACH
(iv) GLOBAL PROGRESS IN TRANSLATIONAL MEDICINE
(v) SCOPE OF IMPROVEMENT
TM helps in improving the quality of human healthcare by providing innovative solutions for hard-to-cure diseases and streamlines resources necessary to support meaningful research endeavors, hence encouraging economic growth. Heeding emerging biomarkers from regulatory and human prognosis perspective, cordial nexus amidst academia and industry and tenacious approaches to promote TM globally can render optimism regarding winning the translational race.
www.biobusinessinc.com
METHODSMETHODS
RESULTSRESULTS
CONCLUSIONCONCLUSION
REFERENCEREFERENCE
i. Woolf, S.H. (2008) The meaning of translational research and why it matters JAMA 299(2) : 211-213.
ii. Zhang, F., P. Cooke, and F. Wu, State-sponsored Research and Development: A Case Study of China’s Biotechnology. Regional Studies, 2011. 45(5): p. 575-595.
Caleb Perry (1755-1822)
“It is much more important to know what kind of patient has a disease, than to know what kind of disease a patient has”
ZIAGEN GEFITINIB TRASTUZUMAB IVACAFTOR
