Biologically-derived Materials for Powering Next Generation Biomedical … · 2018-07-13 ·...
Transcript of Biologically-derived Materials for Powering Next Generation Biomedical … · 2018-07-13 ·...
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Biologically-derived Materials for Powering
Next Generation Biomedical Electronics
Young Jo Kim, Ph.D. Assistant Professor
Department of Chemical Engineering
University of New Hampshire
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Implantable biomedical devices
Stimulate deep brain for treating obesity
Tissue
stimulation Biosensor
Monitor pH, T, and glucose
Controlled
release
Deliver drugs
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Challenges with implantable devices
Infection
Chronic inflammation
Costly surgeries
Replace batteries
Reduce infection risk
Temporary
Cost-effective deployment
What if we could build the devices…
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Most people feel comfortable with taking pills.
Why Edible Electronics?
Balance of functional device lifetime with rapid deployment
Non-invasive, high patient compliance
Reduced sterilization burden
Obviate issues associated with chronic implants
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Helius (Proteus Biomedical)
PillCam (Given Imaging)
Indication Monitor compliance Non-invasive imaging
Function Trigger, communication Image acquisition, transfer
Device lifetime ~10 min ~8 hr
Power source Mg-Cu galvanic cell 2 x 1.5V Ag2O batteries
Logic elements Silicon Silicon
Packaging None Polycarbonate
Size (D x L) 2 mm x 2 mm 11 mm x 26 mm
Mass 0.003 g 3.45 g
Retention risk 0.001% 1.47%
www.proteus.com
www.givenimaging.com
Device comparison
5
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Edible Battery
Anode Activated carbon Cathode
MnO2
Electrically- conductive elastomer
• Made of edible materials • Temporary • Non-invasive
operated by Na+ in gastric fluid
1 cm
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Reliability
+ Long operational lifetimes
+ Robust performance
+ Manufacturing
Safety
+ Possible bioabsorption
+ Reduced risk of event
+ Materials of known risk
Ideal electrodes for edible electronics
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Inspired by Cuttlefish Ink…
Inspired by cuttlefish ink
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10 mm 0.5 mm
Eumelanins from cuttlefish (sepia officinalis)
• Homogeneous nanostructure (diameter= ~100nm)
• Stable (non-soluble) in aqueous solution
• Hydration dependent electronic-ionic hybrid conductivity
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Eumelanins in multi-scale
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Activated carbon anode MnO2 cathode
Melanin anode MnO2 cathode
Is eumelanin a viable solution?
~10
~20
Specific Capacity (mAh/g)
10 20
Activated carbon anode MnO2 cathode
Melanin anode MnO2 cathode
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~?
~10
~20
Specific Capacity (mAh/g) 10 20
Activated carbon anode MnO2 cathode
Melanin anode MnO2 cathode
Can we tune the capacity?
Synthetic Melanin Electrode
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[P1801-02]
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Thank you