Bioinformatics Database and Applications

7/30/2019 Bioinformatics Database and Applications

1/82

@ebedibplgvenfgvg `g~h~ gdf

vmhep

g{{ ng bd~


2/82

NBDVHDV^7% Chuwbpf~

0% Edvpbfxnvebd

>% Fhiedevebd6% Fgvg`g~h~

`% ^hgpnm vbbj~

n% ^bivwgph~

8% G{{jengvebd~

9% Nmgjjhdoh~

?% Nbdnjx~ebd

=% Phihphdnh~$


3/82

7$CHU_BPF^ DN@E

Ohd@gdc

HL@J

@JG^V IG^VG

Fgvg nxpgvebd

Phfxdfgdnu


4/82

0$EDVPBFXNVEBD

Byhp vmh {g~v ihw fhngfh~* lgabp gfygdnh~ed vmh iehjf bi lbjhnxjgp èbjbou* nbx{jhf

wevm gfygdnh~ ed ohdblen vhnmdbjboeh~*mgyh jhf vb gd h}{jb~eyh opbwvm ed vmh

èbjboengj edibplgvebd ohdhpgvhf ù vmh

$

@xejfedo bd vmh phnbodevebd bi vmhel{bpvgdnh bi edibplgvebd vpgd~le~~ebd*

gnnxlxjgvebd gdf {pbnh~~edo ed èbjboengj

~u~vhl~* [gxjehd Mbohwho ed 75?= nbedhfvmh vhpl "@ebedibplgven~" vb ~vxfu vmh

edibplgvebd {pbnh~~h~ ed èbven ~u~vhl~$


5/82

Vhpledbjboeh~ Fgvg lededo , vmh h}vpgnvebd bi {phyebx~ju xdcdbwd gdf {bvhdvegjju

x~hixj edibplgvebd $

Gnnh~~ebd dxl`hp , g xdexh efhdveiehp oeyhd vb g èbjboengj {bjulhp

~hxhdnh -FDG* {pbvhed% wmhd ev e~ ~x`levvhf vb g ~hxhdnh

fgvg`g~h$

Gddbvgvebd , {pbnh~~ bi lgpcedo vmh ohdh~ ed g FDG ~hxhdnh$

Fgvg nxpgvebd , g vhpl x~hf vb edfengvh lgdgohlhdv gnveyeveh~*phxephf vb lgedvged ph~hgpnm fgvg ibp jbdo,vhpl ~xnm vmgv* ev e~

gygejg`jh ibp phx~h gdf {ph~hpygvebd$

Fgvg edvhopevu , gnnxpgnu* ygjefevu gdf nbd~e~vhdnu bi fgvg$

Gjobpevml , ~vh{,ù,~vh{ {pbnhfxph ibp ngjnxjgvebd~$

Phfxdfgdnu vmh {ph~hdnh bi lbph vmgd bdh lhnmgde~l ed gèbjboengj ~u~vhl* vmgv ngd vgch byhp g ixdnvebd ei bdh lhnmgde~l

igej~$


6/82

>$FHIEDEVEBD

@ebedibplgven~ e~ vmh ~nehdnh nbdnhpdhf wevm vmh

fhyhjb{lhdv gdf g{{jengvebd bi nbl{xvhpmgpfwgph gdf ~bivwgph vb vmh gnxe~evebd*

~vbpgoh* gdgju~e~ gdf ye~xgjeqgvebd bi `ebjboengj

edibplgvebd$

^udbdul~1

Nbl{xvgvebdgj @ebjbou* Nbl{xvgvebdgj

Lbjhnxjgp @ebjbou* @eb nbl{xvedo$


7/82

Gel~ bi `ebedibplgven~ Ph~hgpnmhp~ gnnh~~edo h}e~vedo edibplgvebd

gdf vb ~x`lev dhw hdvpeh~$

Fhyhjb{lhdv bi vbbj~ gdf ph~bxpnh~ vmgv gef

ed v h gdg u~e~ b gvg$ X~h bi vmh~h vbbj~ vb gdgjuqh vmh fgvg gdf

edvhp{phv vmh ph~xjv~ ed g `ebjboengjju

lhgdedoixj lgddhp$


8/82


9/82

6$FGVG@G^H^

Vpgfevebdgjju* `ebjboe~v~ phjehf bd vh}v`bbc~

gdf ph~hgpnm gpvenjh~ {x`je~mhf ed ~nehdveien

abxpdgj~ g~ vmh lged ~bxpnh bi edibplgvebd$

b bo ng gvg g~h~ , pgp h~ b h~nehdnh~$

Nbdvged~ edibplgvebd* nbjjhnvhf ipbl ~nehdveien

h}{hpelhdv~* {x`je~mhf jevhpgvxph* meom,vmpbxom{xv h}{hpelhdv vhnmdbjbou gdf

nbl{xvgvebdgj gdgju~h~$


10/82

@ebjboengj fgvg`g~h~

Ev e~ g jgpoh* bpogdeqhf `bfu bi{hp~e~vhdv fgvg* x~xgjjug~~bnegvhf evm nbl{xvhpeqhf~bivgph fh~eodhf vb x{fgvh*wxhpu* gdf phvpehyhnbl{bdhdv~ bi vmh fgvg ~vbphf

$

Vb lgch `ebjboengj fgvggygejg`jh vb ~nehdve~v~

Vb lgch `ebjboengj fgvggygejg`jh ed nbl{xvhp,phgfg`jh ibpl$

@ebjboengj ~hwxhdnh fgvg`g~h~$


11/82

DN@E

Ohd@gdc , FDG ~hxhdnh fgvg`g~h ipbl DgvebdgjNhdvhp @ebvhnmdbjbou Edibplgvebd -DN@E%* X^G$ Ev

~{jev~ edvb ~lgjjhp fe~nphvh feye~ebd~* ignejevgvedo ed

gd hiienehdv ~hgpnm ibp lbph edibplgvebd$

HL@J -Hxpb{hgd Lbjhnxjgp @ebjbou Jg`bpgvbpu* XC%

, FDG ~hxhdnh fgvg`g~h ipbl Hxpb{hgd

@ebedibplgven~ Ed~vevxvh -H@E%$ Ev ednjxfh~ ~hxhdnh~

ipbl fephnv ~x`le~~ebd~* ohdblh ~hxhdnedo{pbahnv~* ~nehdveien jevhpgvxph gdf {gvhdv

g{{jengvebd~$

FF@A -FDG Fgvg @gdc bi Ag{gd% e~ vmh ~bjh

dxnjhbvefh ~hxhdnh fgvg `gdc ed G~eg* bpogdeqhf`u DEO3 Dgvebdgj Ed~vevxvh bi Ohdhven~$ Ev nbjjhnv~

~hxhdnh fgvg lgedju ipbl Ag{gdh~h ph~hgpnmhp~*

gnnh{v~ fgvg gdf e~~xh vmh gnnh~~ebd dxl`hp vb

ph~hgpnmhp~ ed gdu bvmhp nbxdvpeh~$


12/82


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17/82

6g$VU[H^ BI FGVG@G^H^ [pelgpu Fgvg`g~h~1

Fgvg`g~h~ nbd~e~vedo bi fgvg fhpeyhfh}{hpelhdvgjju ~xnm g~ dxnjhbvefh ~hxhdnh~ gdf

{pelgpu fgvg`g~h~$

^hnbdfgpu Fgvg`g~h~1

Fgvg vmgv gph fhpeyhf ipbl vmh gdgju~e~ bpvphgvlhdv bi {pelgpu fgvg -~hnbdfgpu

~vpxnvxph~%gph cdbwd g~ ~hnbdfgpu fgvg`g~h~$


18/82

Ijgviejh~

Ed `ebjboengj fgvg`g~h~* g ijgv iejh e~ g vh}v iejh* vmgv x~xgjju

nbdvged~ bdh -~hwxhdnh% phnbpf$

$

Fgvg , fe~{jguhf ed g ygpehvu bi ibplgv~$

Bdh bi vmh lb~v nbllbd ibplgv ibp ~hwxhdnh phnbpf e~

IG^VG$


19/82


20/82

G njb~hp jbbc gv Ijgviejh~

Dglh efhdveiehp1 g

xdexh efhdveiehp

ibp hgnm ~h xhdnh$

Jhdovm bi lPDG e$h$ dbv g nepnxjgp

lbjhnxjh

Vmh iep~v jedh e~ ngjjhf vmh mhgfhp

Vme~ e~ gj~b cdbwdg~ vmh{pelgpu

gnnh~~ebd dxl`hp

Ed vme~ ng~h* vmh ~hxhdnh wg~ ~x`levvhf

g~ gd lPDG ~hxhdnh$ Vmh D lhgd~

dxnjhbvefh gdf vmh L lhgd~ lPDG$

Je h g { g~lef

Vg}bdblen

nbfh

Fgvh wmhd

jg~v

x{fgvhf$


21/82

Ijgviejh~ nbdvedxhfVmh ~hnbdf jedh e~ ngjjhf vmh Fhiedevebd Jedh* vmh obgj bi wmenm e~ vb

~xllgpeqh vmh h~~hdvegj `ebjboengj edibplgvebd hdnbfhf `u vmh hdvpu$

Ohdx~ ~{hneh~ Ohdh dglh

Dbvh1 Ohdh bdvbjbou ngd `h nbdix~edo$ Edvme~ ng~h* vmh ohdh e~ dglhf givhp g ipxeviju

lxvgdv$

@g~en fh~npe{vebd bi~vpxnvxph gdf ixdnvebd


22/82

Vmh lb~v el{bpvgdv hdvpu$

Ei x~edo vme~ ~hxhdnh ed g

{x`jengvebd* vme~ e~ nevhf vb

phihp phgfhp~ vb vmh fgvg`g~h

hdvpu x~hf bp nphgvhf$

Vmh yhp~ebd e~ yhpu ~elejgp vb vmh

gnnh~~ebd dxl`hp* `xv ei vmh

~hxhdnh e~ x{fgvhf hevmhp

`hngx~h ev wg~ wpbdo bp

ednbl{jhvh* vmh dxl`hp givhp vmh

fhnelgj edfengvh~ vmh yhp~ebd

Ohd@gdc ~{hneienohdhedib

efhdveiehp


23/82

^bxpnh bpogde~l


24/82

Gjj Ohd@gdc hdvpeh~ lx~v `h

g~~bnegvhf wevm g nevgvebd

Vme~ hd~xph~ vmgv vmh lhgd~ `u wmenm vmh ~hxhdnh~ whph gnxephf mgyh`hhd phyehwhf$ Vme~ hdg`jh~ vmh ~nehdveien nphfe`ejevu vb vmh xgjevu bi

fgvg`g~h~$

Vme~ e~ gd HL@J gnnh~~ebd

dxl`hp* wmenm lhgd~ vmgv ev

wg~ dbv bpeoedgjju ~x`levvhfvmpbxom vmh Ohd@gdc {bpvgj


25/82

^bxpnh ihgvxph

Gjj ~hxhdnh~ lx~v nblh ipbl ~blhwmhph*

~b vmh ledelxl fgvg -bpogde~l~ gdf vu{h bi

lbjhnxjh% e~ hdvhphf mhph* wevm g jedc vb vmh

Vg}bdblu @pbw~hp$

Vmh je~v bi gnnh{vg`jh

fgvg`g~h npb~~ phihphdnh~ -e$h$

f`R}phi%


26/82

Gjj gddbvgvhf dxnjhbvefh hdvpeh~ nbdvged g

yepvxgj vpgd~jgvebd edvb gledb gnef ~hxhdnh

Ed vme~ ng~h* vmh vpgd~jgvebd e~ fhpeyhf fephnvju ipbl g lPDG~hwxhdnh* ~b vmhph e~ g obbf nmgdnh ev e~ nbpphnv* `xv ei vmhvpgd~jgvebd e~ fxh vb nbl{xvgvebdgjju fhpeyhf ohdblen ~hwxhdnh* ev~mbxjf ygjefgvhf goged~v g nxpgvhf fgvg`g~h$


27/82

^hxhdnh fgvg

Vmh ~hxhdnh fgvg edvmh ijgviejh ngd `h

fe~{jguhf bp

fbwdjbgfhf ed gygpehvu bi feiihphdv

wgu~$

G IG^VG iejh e~ g yhpu

nbllbd ibplgv$


28/82

6`$ ^hgpnm vbbj~ 1 IG^VG ^vgdf~ ibp IG^V,Gjj* phijhnvedo vmh ignv vmgv ev ngd `h x~hf

ibp g ig~v {pbvhed nbl{gpe~bd bp g ig~v dxnjhbvefh

nbl{gpe~bd$

G fgvg`g~h ~hgpnm vbbj x~hf vb nbl{gph g dxnjhbvefh bp

$

Fh~npe`hf ù Fgyef A$ Je{lgd gdf _ejjegl P$ [hgp~bd ed75=8$

Iep~v wefhju x~hf gjobpevml ibp fgvg`g~h ~elejgpevu

~hgpnmedo$mvv{1ig~vg$èbnm$yepoedeg$hfx

mvv{1www$hè$gn$xcig~vg>>

mvv{1www$hè$gn$xcig~vg>>ohdblh~$mvlj


29/82

IG^VG iejh4~hxhdnh

GOVNNOGVNOGVNOVGONVGNOVGNOVGNOVGONVGONVGNOVGNOVGNOGVNOGVOGVNOGVNOGVNOG

VNOGVNOGVNOGVNOGVNOGVNOGVNOGVNOGVNO

Vme~ IG^VG ~hxhdnh iejh mg~ gjj bi vmh dhnh~~gpu hjhlhdv~

ibp g fgvg`g~h hdvpu* `xv ev e~ dbv yhpu edibplgveyh$

Ibp h}gl{jh* wh fbdv cdbw wmgv fgvg`g~h ev e~ ipbl*wmgv bpogde~l ev mg~ nblh ipbl* wmgv lbjhnxjh ev

hdnbfh~* ei gdu hvn$


30/82

IG^VG ibplgvG vh}v,`g~hf ibplgv ibp ph{ph~hdvedo hevmhp

dxnjhbvefh ~hxhdnh~ bp {h{vefh ~hxhdnh~$

4 , fhdbvh~ vmh `hoeddedo bi g dhw ~hxhdnh$

4G ~hxhdnh

NGONVOGNGOGVNOVGNOGVNOGVONONGNOGGONGNVGNVGONVGOOV

4Gdbvmhp ~hxhdnhNONVGONVNONOGVNOVGVNGGNONONONONONONONGVGNVNGNONON


31/82


32/82

@JG^V @g~en Jbngj Gjeodlhdv ^hgpnm Vbbj

Fhyhjb{hf ed 755; gdf 755? -^$ Gjv~nmxj%

G lhvmbf ibp {hpibpledo jbngj gjeodlhdv~

v pbxo ~hgpn h~ b Meo ,~nbpedo holhdv[gep~ -M^[~%$


33/82

Feiihphdv Cedf~ bi @JG^V @JG^V[ , {pbvhed xhpu goged~v {pbvhed F@

@JG^VD , FDGPDG xhpu goged~v Ohd@gdc -FDG%

@JG^V] , 9 ipglh vpgd~$ FDG xhpu goged~v{pbvhedF@

, $

V@JG^V] , 9 ipglh FDG xhpu vb 9 ipglh O@ vpgd~j$

[^E,@JG^V ,{pbvhed {pbiejh xhpu goged~v {pbvhedF@

[ME,@JG^V , {pbvhed {gvvhpd goged~v {pbvhed F@

LHOG@JG^V , ibp nbl{gpe~bd bi jgpoh ~hv~ bi jbdo FDG

~hxhdnh~$


34/82

DN@E @JG^V

mvv{1www$dnè$djl$dem$oby@JG^V

Ngdgfegd @ebedibplgven~ Ph~bxpnh @JG^V

mvv{1n`p,p`n$dpn,ndpn$on$ng`jg~v

Hxpb{hgd @ebedibplgven~ Ed~vevxvh @JG^V

mvv{1www$hè$gn$xc`jg~vgjj

mvv{1www$hè$gn$xc`jg~v0


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38/82

Dxnjhbvefh ^hwxhdnh Fgvg`g~h~

> lged fgvg`g~h~

HL@JOhd@gdc

FF@A

Vmh > fgvg`g~h~ gph ~udnmpbdeqhf bd g fgeju `g~e~ gdfvmh gnnh~~ebd dxl`hp~ gph oeyhd$

Vmhph gph db jhogj ph~vpenvebd ed vmh x~goh bi vmh~hfgvg`g~h~$ Mbhyhp* vmhph gph ~blh {gvhdvhf~hwxhdnh~ ed vmh fgvg`g~h$


39/82

XdeOhdh

-mvv{1""www$dn`e$djl$dem$oby"~evh~"hdvphq2f`


40/82

H@E Ohdblh~ -www$h`e$gn$xc"ohdblh~" % ,{pbyefh~ gnnh~~ gdf ~vgve~ven~ ibp vmh nbl{jhvhf

ohdblh~* gdf edibplgvebd g`bxv bd obedo {pbahnv~$

Ohdblh @ebjbou-www$dn`e$djl$dem$oby"Ohdblh~" % , nbdvged~

edibplgvebd g`bxv vmh gygejg`jh nbl{jhvh ohdblh~$

Hd~hl`j -www$hd~hl`j$bpo % , abedv {pbahnv`hvwhhd HL@J,H@E gdf vmh ^gdohp Nhdvph vb

fhyhjb{ g ~bivwgph ~u~vhl wmenm {pbfxnh~ gdf

lgedvged~ gxvblgven gddbvgvebd bd hxcgpubvenohdblh~$


41/82

Lb~v {b{xjgp gdf wefhju x~hf ~bxpnh$

Ednjxfh~ vmphh lhl`hp fgvg`g~h~

HL@J 3 Ohd@gdc 3 FF@A

Hgnm bi vmh vmphh opbx{~ nbjjhnv~ g {bpvebd bi vmhvbvgj ~hxhdnh fgvg ph{bpvhf wbpjfwefh$

Gjj dhw gdf x{fgvhf fgvg`g~h hdvpeh~ gph h}nmgdohf

`hvwhhd vmh opbx{~ bd g fgeju `g~e~$ Vmh~h fgvg`g~h~ gph fh~eodhf vb {pbyefh gdf

hdnbxpgoh vmh ~nehdveien nbllxdevu$

[ v e ^ F v `


42/82

[pbvhed ^hwxhdnh Fgvg`g~h~

^_E^^,[PBV -www$h}{g~u$nm"~{pbv" % , e~ g {pbvhed~hxhdnh fgvg`g~h wmenm ~vpeyh~ vb {pbyefh g meom jhyhj bi

gddbvgvebd~ -~xnm g~ vmh fh~npe{vebd bi vmh ixdnvebd bi g{pbvhed* ev~ fblged~ ~vpxnvxph* {b~v,vpgd~jgvebdgj

lbfeiengvebd~* ygpegdv~* hvn$%* g ledelgj jhyhj bi phfxdfgdnu

$

[EP -{ep$ohbpohvbwd$hfx % , [pbvhed Edibplgvebd Ph~bxpnh e~g feye~ebd bi vmh Dgvebdgj @eblhfengj Ph~hgpnm Ibxdfgvebd

-D@PI%* X^$Ev mg~ g fgvg`g~h bi ~hxhdnh~ h}vpgnvhf ipbl vmh vmphh,

felhd~ebdgj ~vpxnvxph~ ed vmh [pbvhed Fgvg`gdc -[F@%$


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46/82

Ohdblh ~hxhdnh fgvg`g~h Fgvg`g~h bi {x`jenju gygejg`jh dxnjhbvefh

~hxhdnh ) vmhep g~~bnegvhf `ebjboengj )`e`jebopg{men edibplgvebd$

Ph~bxpnh~ - DNOP%$

Nbdvged~ `bvm ohdblen h}{ph~~hf )

dxnjhbvefh ~hxhdnh~ ipbl vmh bpogde~l~$


47/82


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49/82

Lenpbègj Fgvg`g~h

Bpogde~l1

Dglh

Ohdh -{pbvhed nbfedo phoebd~%1

Dglh

Fgvg g`bxv vmh {pbvhed nbfedo phoebd~ ed vmh lenpbègj

ohdblh ~hwxhdnh~$

Gnnh~~ebd dxl`hp

Ohdblh ~eqh

Phjhg~h fgvh

Ohdblh nhdvhp

^hxhdnh

nnh~~ bd dxl hp

Bpogde~l

Jbngvebd bd vmh nmpblb~blh-~vgpv*hdf%

^vpgdf êqh

[pbfxnv

^hxhdnh


50/82

Phjgvebdgj Fgvg`g~h Fgvg e~ bpogdeqhf edvb vg`jh~1 pbw~ ) nbjxld~

Hgnm pbw ph{ph~hdv~ gd ed~vgdnh bi gd hdvevu Hgnm nbjxld ph{ph~hdv~ gd gvvpe`xvh bi gd hdvevu

ygjxh~ ~vbphf ed vmh nbjxld~ bi vmh nbpph~{bdfedovg`jh~ -chu~%

Gnnh~~e`jh vmpbxom ^vgdfgpf Wxhpu Jgdoxgoh -^WJ ,

~vgvhlhdv~ x~hf vb phvpehyh gdf x{fgvh fgvg ed gfgvg`g~h%$


51/82

Lhvgfgvg

Fgvg vmgv fh~npe`h~ vmh {pb{hpveh~ bp

nmgpgnvhpe~ven~ bi bvmhp fgvg$

Fbh~ dbv ednjxfh ~gl{jh fgvg$

Gjjbw~ fgvg`g~h fh~eodhp~ gdf x~hp~ vbxdfhp~vgdf vmh lhgdedo bi vmh fgvg$


52/82

_h` Fgvg`g~h~ Fgvg e~ gnnh~~e`jh vmpbxom Edvhpdhv

Mgyh feiihphdv xdfhpjuedo fgvg`g~h lbfhj~

H}gl{jh1 `ebjboengj fgvg`g~h~

Lbjhnxjgp fgvg1 DN@E * ^we~~{pbv * [F@ $Bpogde~l ~{hneien1 Lbx~h * _bpl* Uhg~v$

Jevhpgvxph1 [x`lhf

Fe~hg~h$


53/82

Fgvg Lgde{xjgvebd JgdoxgohIbp h}hnxvedo xhpeh~* x{fgvedo* ed~hpvedo* gdf

fhjhvedo phnbpf~$

,

ED^HPV EDVB , ed~hpv~ dhw fgvg edvb g vg`jh

X[FGVH , x{fgvh~ fgvg ed g vg`jh

FHJHVH IPBL , fhjhvh~ fgvg ipbl g vg`jh$


54/82

Hdvphq Lgdu bi vmh fgvg`g~h~ gph jedchf vmpbxom g xdexh

~hgpnm gdf phvpehygj ~u~vhl* ngjjhf Hdvphq$

Ev mhj{~ vb gnnh~~ edvhopgvhf edibplgvebd ipbl lgduDN@E fgvg`g~h~$

H}gl{jh , Vmh Hdvphq [pbvhed fgvg`g~h e~ npb~~,jedchf vbvmh Hdvphq Vg}bdblu fgvg`g~h$ Vme~ gjjbw~ g

ph~hgpnmhp vb iedf vg}bdblen edibplgvebd* ibp vmh

~{hneh~ ipbl wmenm g {pbvhed ~hxhdnh wg~ fhpeyhf$


55/82

6n$Je~v bi ^bivwgph~


56/82

^E$DB$ ^bivwgph Fh~npe{vebd

7 @mgohhpgvm

[phfenv~ dgveyh,jech ~vpxnvxph~ ibp ~lgjj ojb`xjgp {pbvhed~

6n$Je~v bi ^bivwgph~

0 [pbvhed vpxnvxph Ohdhpgvebd

^vpxnvxph Ohdhpgvebd ipbl oeyhd femhfpgj~

> [hp~e~vhdnh Jhdovm

Iejvhp~ ibp Ojb`xjgp [pbvhed Hygjxgvebd

6 Pgfex~ bi Oupgvebd


57/82


8 Mufpb{mb`enevu


9 [pbPhoEd

[pbvhed Phoxjgpevu Edfh}

? [pbvhed ~vpxnvxph b{veleqhp Hdhpou ledeleqhp ibp {pbvhed~

= [pb^HH , ^nbpedo Ixdnvebd ibp [pbvhed ^vpxnvxph Hygjxgvebd

Ngjnxjgvh~ edvpglbjhnxjgp hdhpou bi g {pbvhed ed nbl{bdhdv,we~h `phgc

x{$

Ohdblen~

7 O H j v -Nm O 7 7%


58/82

7 Ohdh Hygjxgvbp-NmhlOhdblh7$7%

Nmgpgnvhpeqh~ g FDG ~hxhdnh g~ ohdh bp dbdohdh

0 Ohdh [phfenvbp-NmhlOhdblh0$;%

_mbjh ohdblh gdgju~e~

Fpxo Fh~eod

7 @edfedo Giiedevu [phfenvebd bi [pbvhed,Jeogdf -@G[[J% ~hpyhp

Nbl{xvh~ vmh `edfedo iphh hdhpou bi g {pbvhed,jeogdf nbl{jh}$

0 @edfedo Giiedevu [phfenvebd bi [pbvhed,Jeogdf nbl{jh} nbdvgededo

Qedn -@G[[J,Q% ~hpyhp

Nbl{xvh~ vmh `edfedo iphh hdhpou bi g lhvgjjb{pbvhed,jeogdf nbl{jh}

nbdvgededo qedn$

> Fpxo,FDG Edvhpgnvebd Hdhpou -[phFFENVG%

Ngjnxjgvh~ vmh Fpxo,FDG edvhpgnvebd hdhpou $

F@L^


59/82

F@L^

^bivwgph {gncgoh ibp fhiededo gdf lgdgoedo g fgvg`g~h$

H}gl{jh~1[pb{pehvgpu1 L^ Gnnh~~* L^ ^WJ ^hpyhp* F@0* Bpgnjh*

^u`g~h

B{hd ~bxpnh1 Lu^j* [b~voph^WJ

, El{pbyhf fgvg nbd~e~vhdnu ) wxgjevuGnnh~~ nbdvpbj

Vpgd~gnvebd nbdvpbj, El{pbyhf gnnh~~e`ejevu ) fgvg ~mgpedo, Ednphg~hf {pbfxnveyevu bi g{{jengvebd fhyhjb{lhdv$

EDFEGD FGVG@G^H^


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EDFEGD FGVG@G^H^ OL Npb{~ fgvg`g~h Fhyhjb{hf

ù DPN bd [jgdv @ebvhnmdbjbou*

Dhw Fhjme$

, Edvhpgnveyh wh` ph~bxpnh ~vbpedo

edibplgvebd bd èb~gihvu bi

, 7>5 vpgd~ohden jedh~ x~edo 6ohdh~ -npu7G`* npu0G` ) ye{>G%

gph ~xàhnvhf$

Ygd~mgdxfmgd gd bxvnblh biEdfegd penh ohdblh edevegveyh*

nbdvged~ edibplgvebd bd 89*05=

penh ohdh~$


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@ebedibplgven~ G}e~ FDG Ph~hgpnm Nhdvph Edfeg*Gdfmpg [pgfh~m$

@ebedibplgven~ Nhdvph* [bdfenmhppu$

@ebedibplgven~ Nhdvph* Chpgjg$

@ebedibplgven~ Nhdvph Fh{gpvlhdv bi@ebvhnmdbjbou* @mb{gj* Lgfmug [pgfh~m$

Ed~vevxvh bi @ebedibplgven~* @gdogjbph$

8 G[[JENGVEBD^ BI @EBEDIBPLGVEN^


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8$G[[JENGVEBD^ BI @EBEDIBPLGVEN^

Dxnjhen gnef ~hxhdnh fgvg`g~h

^hpyh~ g~ vmh `g~e~ ibp ~vgve~vengj gdgju~e~ ) ibp vmh nbl{gpe~bd

bi jgpoh dxl`hp~ bi ~hxhdnh~$^hxhdnh Phvpehygj vb iedf vmh dxnjhbvefh ~hxhdnh ibp g

hdh bi edvhph~v$

^hxhdnh Efhdveiengvebd vb iedf ixdnvebd gdf {b~~e`jh bpeoedbi ohdh ipbl g ~hxhdnh$

^hxhdnh gdgju~e~ , _evm vmh~h g{{jengvebd~ wh ngd gjeod vwb~hxhdnh~* gjeod lxjve{jh ~hxhdnh~* gdf {hpibpl

{mujbohdhven gdgju~h~$


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Ohd @gdc {pbyefh~ g nbl{xvhp fgvg`g~h bi gjj{x`je~mhf FDG ) PDG ~hxhdnh~ ) `ebjboengj

edibplgvebd$

HL@J fgvg je`pgp vb nbjjhnv bp gdeqh )

fe~vpe`xvh g fgvg`g~h bi dxnjhbvefh ~hxhdnh~) phjgvhf fh~npe{veyh edibplgvebd h}vpgnvhf

ipbl {x`jengvebd ed ~nehdveien abxpdgj~$

[pbvhed ~hxhdnh fgvg`g~h


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Edibplgvebd nbdnhpdedo vmh ~hxhdnh gdf {pb{hpveh~ bi g {pbvhed$

Fhvhplededo [pbvhed ^hxhdnh [pb{hpveh~ lbjhnxjgp wheomv

-L_%* e~bhjhnvpen {bedv -{E%* hvn$* ibp {gpvenxjgp {pbvhed$

fgvg`g~h$

[gepwe~h ^hxhdnh Gjeodlhdv gjeod vwb {pbvhed ~hxhdnh~ vb

hgnm bvmhp$

Lxjve{jh ^hxhdnh Gjeodlhdv gjeod lgdu ~hxhdnh~ goged~v g

~edojh ~hxhdnh$

^ G j e


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^vpxnvxph Gdgju~e~

, vmphh felhd~ebdgj ~mg{h bi {pbvhed~ gdf

dxnjhbvefh~$

, h}glededo g {pbvhed ed >F gjjbw~ ophgvhpxdfhp~vgdfedo bi {pbvhed ixdnvebd~$

Vg}bdblu Fgvg`g~h , nbdvged~ vmh dglh~ gdfjedhgoh~ bi hyhpu bpogde~l ph{ph~hdvhf ù gv

jhg~v bdh dxnjhbvefh bp {pbvhed ~hxhdnh edvmh DN@E ohdhven fgvg`g~h~$

Mu`pef vhnmdbjboeh~ nblèdedo èbjboengj {pbnh~~h~


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Mu`pef vhnmdbjboeh~ nblèdedo èbjboengj {pbnh~~h~

wevm ~nehdveien gfygdnh~ ) vhnmdbjboengj eddbygvebd~oeyh~ pe~h vb ~udhpoe~ven ~hv bi dhw vhnmdbjboeh~$

@eb~hd~bp vhnmdbjbou lhg~xph~ dxvpevebdgj ygjxh*iph~mdh~~ ) jbngvh~ yevgj `jbbf nbl{bdhdv~*

* $

Lhg~xpedo èbfeyhp~evu x~hf vb nbjjhnv vmh ~{hneh~dglh~* fh~npe{vebd~* fe~vpe`xvebd~* ohdhven edibplgvebd*

~vgvx~ ) ~eqh bi {b{xjgvebd~* mgèvgv dhhf~ ) mbw hgnmbpogde~l edvhpgnv~ wevm bvmhp ~{hneh~$


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Bvmhp g{{jengvebd~


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Lbjhnxjgp lhfenedh ohdh~ g~~bnegvhf wevm fe~hg~h~ ) vmh

lbjhnxjgp `g~e~ bi g {gpvenxjgp fe~hg~h ngd `h xdfhp~vbbf

lbph njhgpju$ Vme~ hdg`jh~ `hvvhp vphgvlhdv ) hyhd

{phyhdveyh vh~v~ gph fhyhjb{hf$ [hp~bdgjeqhf lhfenedh g`jh vb gdgjuqh g {gvehdv~ ohdhven

ipbl vmh `hoeddedo$ [phyhdvgveyh lhfenedh wevm vmh ~{hneien fhvgej~ bi vmh

ohdhven lhnmgde~l~ bi fe~hg~h~* fegodb~ven vh~v~ gph

fhyhjb{hf vb lhg~xph g {hp~bd~ ~x~nh{ve`ejevu vb feiihphdv

fe~hg~h~$

Ohdh vmhpg{u e~ vmh g{{pbgnm x~hf vb vphgv* nxph bp hyhd

{phyhdv fe~hg~h `u nmgdoedo vmh h}{ph~~ebd bi ohdh~ -ngdnhp

njedengj vpegj~%$

Fpxo fhyhjb{lhdv gv {ph~hdv bdju g`bxv 8;; {pbvhed~ gph


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o { { u {

vgpohvhf g~ fpxo~* wevm gd el{pbyhf xdfhp~vgdfedo bi fe~hg~hlhnmgde~l~ ) x~edo nbl{xvgvebdgj vbbj~ ~{hneien fpxo~ wevm ihw

~efh hiihnv~ ngd `h fhyhjb{hf$

_g~vh njhgdx{ Fehdbnbnnx~ pgfebfxpgd~ ibp vb}en nmhlengj~

-wbpjf/~ vbxomh~v `gnvhpexl%$

Gjvhpdgveyh hdhpou ~bxpnh~

Nmjbpb`exl vh{efxl


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{

ohdhpgvedo hdhpou ipbljeomv$

Gdve`ebven ph~e~vgdnhHdvhpbnbnnx~ ighngje~ ngx~h~

`gnvhpegj edihnvebd* g

yepxjhdnh phoebd lgfh x{ bi

g dxl`hp bi gdve`ebven,ph~e~vgdv ohdh~ cdbwd g~ g

{gvmbohdenevu e~jgdf gph

fe~nbyhphf$ Vme~ {pbyefh~

x~hixj lgpchp~ ibp fhvhnvedo

{gvmbohden ~vpged~ wmenm

{phyhdv~ vmh ~{phgf bi

edihnvebd$

Ibphd~en gdgju~e~ bi lenpb`h~ x~edo ohdblen vbbj~* njb~hju


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phjgvhf ~vpged bi@gnejjx~ gdvmpgne~ )Gdvmpg}~vpged~ gphfe~vedoxe~mhf$

Hybjxvebdgpu ~vxfeh~ vmh ~hxhdnedo bi ohdblh~ ipbl gjj

vmh > fblged~ bi jeih* gpnmghg* `gnvhpeg ) hxcgpug* vb

fhvhpledh vmh vphh bi jeih ) vmh jg~v xdeyhp~gj nbllbd

gdnh~vbp$

@ebvhnmdbjbou

Nbpudh`gnvhpexl ojxvglenxl ju~edh -bi {pbvhed ed gdelgj


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Nbpudh`gnvhpexl ojxvglenxl ju~edh -bi {pbvhed ed gdelgj

dxvpevebd%$]gdvmblbdg~ ngl{h~vpe~ }gdvmgd oxl -ye~nb~eiuedo )

~vg`eje~edo gohdv ed edfx~vpeh~%$

Jgnvbnbnnx~ jgnve~ ibp fgepu {pbfxnv~ ) vb {ph{gph `hhp* wedh*bvmhp ihplhdvhf ibbf~$

Npb{ el{pbyhlhdv


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Npb{ el{pbyhlhdv

Ed~hnv ph~e~vgdnh @gnejjx~

vmxpedoehd~e~ $

El{pbyh dxvpevebdgj xgjevu

yev G ed penh$

G ohdh ipbl uhg~v ed~hpvhf edvb

vblgvb vb h}vhdf ~mhji jeih$

Fhyhjb{lhdv bi fpbxomv

ph~e~vgdnh ygpehveh~ nhphgj

ygpehveh~ ibp ~bej gjcgjedevu* iphhgjxledexl ) epbd vb}eneveh~$


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Yhvedgpu ~nehdnh {pbfxnvebd bi vmhpg{hxven {pbvhed~ x~edo

igpl gdelgj~$

Nbl{gpgveyh ~vxfeh~ dxl`hp~* jbngvebd~ ) `ebnmhlengj

ixdnvebdgj ohdh~ ed feiihphdv bpogde~l~ gph nbl{gphf x~edo

b d bplgv n~ vbb ~$

Bpogde~l~ vmgv gph ~xevg`jh ibp x~h ed h}{hpelhdvgj ph~hgpnm

gph vhplhf g~ lbfhj bpogde~l~$


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Vmh ixvxph pbjh ibp `ebedibplgven~ ed {jgdv gdfnpb{ ph~hgpnm

Fhvhnvebd bi gjjhpohdenevu bi ohdhvengjju$

[jgdv ~nehdnh nbllxdevu vb h}vhdf ohdblen~ipbl lbfhj~ vb npb{~$


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[pb`jhl~ ed @ebedibplgven~

_evm vmh h}{bdhdvegj opbwvm bi cdbwjhfoh ed `ebjbou*vmhph gph pg{efju opbwedo {pb`jhl~ ~xnm g~

~vbpg h phvpehygj ) gdgj ~e~ bi vmh fgvg$

9$NMGJJHDOH^


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Vmh bpeoed* ~vpxnvxph* gdf igvh bi vmh xdeyhp~h

Vmh ixdfglhdvgj ~vpxnvxph bi lgvvhp

Hgpvm/~ {mu~engj ~u~vhl~

Vmh feyhp~evu bi jeih bd Hgpvm

Vmh vphh bi jeih

Vmh `pged gdf gpveienegj vmedcedo lgnmedh~

[pbvhed ~vpxnvxph {phfenvebd

Lxjve{jh gjeodlhdv gdf {mujbohdu nbd~vpxnvebd

Ohdblen ~hxhdnh gdgju~e~ gdf ohdh,iedfedo$

?$NBDNJX^EBD


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@ebedibplgven~ e~ gd edibplgvebd

vhnmdbjbou g{{jehf vb lgdgoh ) gdgjuqhèbjboengj fgvg$

èbjboengj edibplgvebd DN@E ed nbjjg`bpgvebdwevm bvmhp bpogdeqgvebd~ lgfh èbjboengj

fgvg`g~h wmenm ~hpyh~ g~ vmh je`pgpeh~ bi jeih

~nehdnh~ wevm lgdu g{{jengvebd~ ù fhyhjb{edo

vbbj~ ) ~bivwgph~$

=$PHIHPHDNH^


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Qyhjh`ej* L$ gdf @gxl* A$B$ 0;;=$ @ebedibplgven~$ Ogpjgdf^nehdnh* Dhw Ubpc$ [{ 1 69,98$

[bjgd~ce* G$ gdf Cellhj* L$ 0;;?$ @ebedibplgven~$ ^{pedohp@hpjed Mhefhj`hpo* Dhw Ubpc$ [{ 1 >65,>80$

* $ $ $ $ * $ ,

75;$ Fhgp* [$M$ 0;;?$ @ebedibplgven~$ ^nebd {x`je~mhp~*

Ngl`pefoh* XC$ [{ 1 7,7>$

@pbwd* ^$L$ 0;;;$ @ebedibplgven~$ Hgvbd {x`je~mhp~* DhwUbpc$ [{ 1 6?,=0$

mvv{1www$dn`e$djl$dem$obyG`bxvojgdnh{pbopgl~$mvlj


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mvv{1www$~nièbeevf$ph~$edèbedibplgven~èbedibplgven~~biv

wgph$mvl

mvv{1www$hè$gn$xc0ngdfgvg`g~h~fdg$mvlj

mvv{1www$dnè$djl$dem$oby`jg~v`jg~vnoemhj{$~mvlj

mvv{1www$dnè$djl$dem$oby`bbc~D@C08697

mvv{1www$obbojh$nb$edeloph~2xl


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Bioinformatics Database and Applications

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