CURRICULUM VITAE

PERSONAL BACKGROUND:Name: Charles R. Rosenfeld, MD

Birth date and place of birth: August 25, 1941Atlanta, GA

Present address and telephone number: 4123 Shady HillDallas, Texas 75229(214) 357-5801

Marital Status: Married - Ann Marie 3 sons (Evan, Scott, Jason)

EDUCATION BACKGROUND:Emory University, Atlanta, Georgia - No degree 1959-1962

Emory University School of Medicine 1962-1966Atlanta, GA - M.D.

POSTGRADUATE TRAINING:Intern, Pediatrics 1966-1967Yale-New Haven Medical CenterNew Haven, CT

Resident, Pediatrics 1967-1969Bronx Municipal Hospital Center and Albert EinsteinCollege of MedicineBronx, NY

Chief Resident, Pediatrics 1969-1970Bronx Municipal Hospital & Albert Einstein Collegeof MedicineBronx, NY

Postdoctoral Fellow - Pediatric Pulmonary 1970-1971Albert Einstein College of MedicineBronx, NY

Postdoctoral Fellow - Perinatal Medicine 1971-1973University of Colorado Medical CenterDenver, CO

UNIVERSITY APPOINTMENTS:Assistant Clinical Instructor in Pediatrics 1969-1970Albert Einstein College of MedicineBronx, NY

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Clinical Instructor in Pediatrics 1970-1971Director of Pediatric Extended Home Care UnitAlbert Einstein College of MedicineBronx, NY

Assistant Professor of Pediatrics and OB/GYN 1973-1977UT Southwestern Medical SchoolDallas, Texas

Associate Professor of Pediatrics and OB/GYN 1977-1981UT Southwestern Medical SchoolDallas, Texas

Director, Training Program, Neonatal-Perinatal Medicine 1978-2007Department of PediatricsUT Southwestern Medical CenterDallas, Texas

Director, Division of Neonatal-Perinatal Medicine 1980-2008Department of PediatricsUT Southwestern Medical CenterDallas, Texas

Professor of Pediatrics and OB/GYN 1981-presentUT Southwestern Medical CenterDallas, Texas

Assistant Professor of Anesthesiology 1995-presentand Pain Management

Faculty, Graduate Program in Integrative Biology 1996-present

Coordinator for Subspecialty Training 2007-presentDepartment of Pediatrics

HOSPITAL APPOINTMENTS:Medical Director of Nurseries 1973-2006Parkland Memorial Hospital, Dallas, Texas

Active Attending 1973-presentParkland Memorial Hospital, Dallas, Texas

Active Attending 1973-presentChildren's Medical Center, Dallas, Texas

Director of Neonatology 1990-2006Children’s Medical Center, Dallas, Texas

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Consulting Staff – Pediatrics 1973-presentSt. Paul Hospital, Dallas, Texas

Interim Medical Director, NNICU 2000-2009Parkland Memorial Hospital, Dallas, TX

HONORSStipes Scholar, Emory University 1961

Alpha Kappa Alpha National Honorary in Sociology 1962Emory University

Human Embryology and Development Study Section 1978-1982of the National Institutes of Health

Perinatal Research Society 1981-present

Sigma Xi 1983-present

Ad Hoc Member, Various Study Sections of the NIH 1984-present

Ad Hoc Reviewer - Pediatric Research, Am J Physiol., 1984-presentNeuroendocrinology, Endocrinology, J Clin EndocrinolMetab., Am J Obstet Gynecol, J Clin Invest, Science, Circ. Res.,Cardiovas. Res., Biol Neonate, Arch Dis Childhood, Pediatrics,J. Perinatology, J. Pediatrics, J. Appl. Physiol, Pediat Nephrology.

Associate Editor Early Human Development 1986-present

Magness R.R., Brown C.E.L., Gant N.F., and Rosenfeld C.R. (Mentor). In vitro prostacyclin (PGI2) production by uterine arteries from normotensive (NORM) and hypertensive pregnant women: Effects of angiotensin II (AII) and saralasin (SAR). Society for Gynecologic Investigation, March 16-19, 1988 (Presented). President's Poster Award.

International Scientific and Program Committee, 8th & 9th November 8-12, 1992World Congress on Hypertension in Pregnancy, March 13-15, 1994 Buenos Aires, Argentina and Sydney, Australia

Program Committee, Annual Meeting of the Society 1990-1992for Gynecologic Investigation

NIH Reviewers Reserve 1992-present

Cox B.E., Ipson M.A., Kamm K.E., Shaul P.W., Horning K.M., and Rosenfeld CR (Mentor): Angiotensin II (AII) myometrial smooth muscle receptors (MSMR) change subtype during ovine pregnancy. FASEB, Anaheim, CA, April 1992. Dupont Merck Pharmaceutical Research Travel Award.

Ad Hoc Reviewer - Medical Research Council of Canada, CIHR 1992-2006

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George L. MacGregor Professorship of Pediatrics 1993-present

Associate Editor, (Journal of the Society for 1993-2005Gynecologic Investigation) J Reproductive 2005- presentSciences

Chern J, Rosenfeld C.R. (Mentor), and Kamm K.E. Smooth muscle (SM) myosin heavy chain isoforms (MHCI) and protein in male fetal-neonatal sheep are developmentally regulated. The Southern Society for Pediatric Research, New Orleans, LA, February 3-5, 1994. (Presented) Finalist for Young Investigator Award.

Sixteenth Edition of Men of Achievement 1994

Ad Hoc Reviewer - March of Dimes Birth Defects Foundation 1995

Cox B.E., Word R.A., Williams C.E., and Rosenfeld C.R. (Mentor). Alterations of myometrial and uterine artery angiotensin II receptor subtype expression and function during human pregnancy. Southern Society for Pediatric Research, New Orleans, LA, February 2-4, 1995. (Presented) Basic Scientist Young Investigator Award.

Editorial Board, American Journal of Physiology: 1996-1999Regulatory, Integrative and Comparative Physiology

Texas Hall of Fame 1996

The Best Doctors in America: Central Region 1996-1997, 2001-2004, 2007-2008

Who's Who in Medicine and Health Care (1st Edition) 1996-present (reselected 2006 – 2007)

Kaiser JR, Cox B.E., and Rosenfeld C.R. (Mentor). In fetal sheep angiotensin II (ANG II)-induced increases in mean arterial pressure (MAP) are mediated through umbilical artery (UA) AT1 receptors. Southern Society for Pediatric Research, New Orleans, LA, January 31 - February 2, 1996. (Presented) Finalist Basic Scientist Young Investigator Award.

Arens YHJM, Rosenfeld C.R. (Mentor), Jabbar W, and Kamm K.E. Comparison of expression of contractile proteins and myosin heavy chain isoforms (MHCI) in ovine aorta (Ao) and bladder from early fetal through late neonatal periods. Southern Society for Pediatric Research, New Orleans, LA, January 31 - February 2, 1997. (Presented) Basic Scientist Young Investigator Award.

Salhab W, Shaul P.W., Cox B.E., and Rosenfeld C.R. (Mentor). Nitric oxide synthase activity in ovine uterine arteries is increased following acute estradiol-17 exposure. The Society for Gynecologic Investigation, San Diego, CA, March 19-22, 1997 (Presented). Recipient of the President’s Presenter’s Award.

Ad Hoc Reviewer for The Wellcome Trust 1997-present

Higher Manpower Development Program Consultant, Ministry of Health, Singapore, October 20-November 1, 1998. Visited and lectured at all major government supported hospitals, and consulted on program development.

Best Doctors in Dallas, Dallas Magazine 1998, 2002 - 2005

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Salhab WA, Shaul P.W., Cox B.E., Rosenfeld C.R. (Mentor). Acute and chronic estrogen treatment modulate uterine artery type I and III nitric oxide synthases. Section on Perinatal Pediatrics, Annual Meeting of the Academy of Pediatrics, October 8-13, 1999. (Presented) Mead Johnson Young Investigator Award for Basic Science.

Reviewer for Medical Research Council of Canada, “Initial Interdisciplinary Health Research Teams” Grants Committee. January 1, 2000-December 31, 2000.

Nagar D, Rosenfeld C.R. (Mentor). Estrogen increases expression of the β1-subunits of the large conductance calcium activated potassium channel in ovine uterine vascular and visceral smooth muscle. Southern Society for Pediatric Research, February 13-15, 2004, New Orleans, LA. (Young Investigator Award for Basic Research)

Koch J., Hensley G., Ramaciotti C., and Rosenfeld C.R. (Mentor). A Prospective study characterizing ductus arteriosus closure in inborn neonates <1000 G birth weight. Southern Society for Pediatric Research, February 25, 2005, New Orleans, LA. (Young Investigator Award for Clinical Research)

Founder’s Award for Research Improving the Health of Children, Southern Society for Pediatric Research, February 25, 2005, New Orleans, LA.

Who’s Who in America 2005-present

Who’s Who in the World 2005-present

Fellow, Cardiovascular Section of American Physiological Society March 2005

Best Doctors in America 2005-present

Canadian Institute of Health Research, December 12 – 13, 2005Clinical Investigation A Committee

Who’s Who in Science and Engineering 2006-present

Parkland Memorial Hospital, Legends Award for Outstanding Service 2007

Ennis BJ, Roy L, Rosenfeld CR (Mentor). Basal total and free cortisol measurements are unrelated to blood pressure in the first postnatal week in neonates 28-32 weeks gestation. American Academy of Pediatrics 2007 National Conference and Exhibition, October, 2007. (Klaus Award presentation)

Who’s Who Among Executives and Professionals 2008-

Guide to America’s Top Pediatricians 2008-

Who's Who Among Executives and Professionals, "Honors Edition" 2008-2009

Student Teaching Award, Senior Acute Care Medicine, Class of 2008 2008

Duncan AF, Heyne RJ, Morgan JS, Ahmad N, Rosenfeld CR (Mentor). Systolic Blood Pressure (SBP) in Very-Low-Birth-Weight Infants (VLBW) Exceeds A Reference Population in the First 3 Yr of Life. American Academy of Pediatrics 2009 National Conference and Exhibition, October 17, 2009. Klaus Award presentation

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Referee for abstracts, Southern Society for Pediatric Research 2009

NIH Special Emphasis Panel, Pregnancy, Reproductive Biology and 2009Development SRG 2010/01 ZRG1 EMNR-B

Punjwani P, Rosenfeld CR, Ramaciotti C. Echocardiographic Prediction of Spontaneous Closure of the Ductus Arteriosus in Neonates Less Than 30 Weeks of Gestation. Outstanding Poster Award, 1st Annual Senior Fellows’ Research Day, May 25, 2010, UT Southwestern Medical School, Dept. of Pediatrics and AAP Travel Award, Section on Perinatal Pediatrics, October 1, 2010.

Canadian Institute of Health Research, Review Committee December 7 – 9, 2010Clinical Investigation A Committee

Co-moderator, Session on Maternal Physiology and Biology March 18, 2011Abstract Review CommitteeJudge, New Investigator Poster PresentationsAnnual Meeting, Society for Gynecologic Investigation, Miami Beach, FL

Judge, New Investigator Poster Presentations March 22, 2012Abstract Review CommitteeAnnual Meeting, Society for Gynecologic Investigation, San Diego, CA

Symposium Review Committee, Pediatric Academic Societies April 28, 2012Annual Meeting

Frankfurt J, Duncan A, Heyne R, Rosenfeld CR. Growth Patterns in Preterm Very-Low-Birth-Weight (PT-VLBW) Infants at 1-3yrs Correlate with Elevated Serum Leptin. Pediatric Academic Societies’ 2012 Annual Meeting, Boston, MA. April 27-May 1, 2012. (Oral presentation, chosen CTSA Child Health Research Fellow, Travel Award)

“Top Doctors", as recognized by US News & World Report May 2012

PROFESSIONAL ORGANIZATIONS:Southwestern Gynecologic Assembly 1974-1980

American Academy of Pediatrics 1976-presentSection on Perinatal Pediatrics

Texas Perinatal Association (Founding member) 1976-2008

Society for Pediatric Research 1977-present

Society for Gynecologic Investigation 1978-present

The Endocrine Society 1979-present

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American Thoracic Society 1980-1988

Perinatal Research Society 1981-present

The American Pediatric Society 1983-present

American Association for the Advancement of Science 1983-present

American Physiological Society 1985-present

International Society for the Study 1985-2004of Hypertension in Pregnancy

American Pediatric Program Directors 2008-present

American Heart Association 1999-present

LICENSURE:Georgia 1966, New York 1970, California 1970, Texas 1973

CERTIFICATION:Diplomate, American Board of Pediatrics July 1, 1971Diplomate, Sub-Board of Neonatal-Perinatal Medicine November 15, 1975

MILITARY:Lt. Commander, U.S. Navy, Discharged, February, 1974

COMMITTEES:Regional Medical Program of Texas, Inc. 1974-1976Ad Hoc Advisory Committee for Perinatal Medicine

Task Force on Perinatal Health Care 1974-1975Regional Health Planning Council of the NorthCentral Texas Council of Government

Board of Directors, Dallas Chapter of the American 1975-1982Lung Association

Infection Control Committee 1975-1983Parkland Memorial Hospital

Texas Perinatal Association, Steering Committee 1976-1978

State Advisory Board and Regional Representative 1976-1977

Texas Perinatal Association (Regional V) 1981-1983

Nutrition Advisory Committee 1976-1982Dallas Public Health Department

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Texas Area 5 Health Systems Agency, Inc. 1979-1980Study Committee for the Perinatal Healthand Facilities Report of 1979

Committee of Delegates 1979-1980University of Texas Health Science Center at Dallas

Chairman, Committee on Pediatric Lung Diseases 1979-1982Dallas Chapter of the American Lung Association

Space Allocation Committee - Medical Services 1979-1986Parkland Memorial Hospital

Grants Management Advisory Committee 1980-1981UT Southwestern Medical School

Continuing Education Committee 1980-1984UT Southwestern Medical School

Capital Budget Committee - Parkland Memorial Hospital 1980-1991

Upper Trinity Perinatal Association - Regional V 1981-1982Vice President

Chairman, Health Professional Advisory Committee 1981-1984National Foundation - March of Dimes, North Texas Chapter

Animal Resources Center Advisory Committee 1981-1991UT Southwestern Medical School, Chairman (1987-1991)Ad hoc member 1991-2004

Standardization Subcommittee 1982-1983Medical Advisory Council, Parkland Memorial Hospital

Risk Management Committee 1982-1983University of Texas Health Science Center at Dallas

Long Range Planning Committee 1982-1984National Foundation - March of Dimes, North Texas Chapter

Treasurer, Board of Directors 1982-1985A.W. Harris Faculty-Alumni Center

Promotions and Tenure Committee 1983-2004UT Southwestern Medical School

Chairman, Institutional Review Board 1985-1987for Animal Research

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Academic Support Services Committee 1988-1991UT Southwestern Medical Center

Board of Directors, Dallas Aquatic Club 1988-1996Secretary (1988-1991), Vice President (1991-1996)

Institutional Six Year Plan-Academic Support 1991-presentServices and Administration & Business Affairs Committee

Program Committee, Annual Meeting, 1989-2008 the Society for Gynecologic Investigation

Search Committee, Director of Animal Resources, 1995-1996UT Southwestern Medical School

Performance Improvement Committee, Dallas County 1995-2000Hospital District, Parkland Memorial Hospital

Chairman, Performance Improvement Committee 1998-presentNursery Services, Parkland Memorial Hospital

Executive Committee, Section of Perinatal Pediatrics 2002-2008American Academy of Pediatrics, District VII

Medical Advisory Council, Pediatric Representative 2002-2009Parkland Memorial Hospital

Promotions Committee, Department of Pediatrics 2005-present

Imaging Strategy Committee 2008-2009Parkland Memorial Hospital

Critical Care Committee 2009-2010Parkland Memorial Hospital

Leadership Committee, WISH, Nursery Services 2007- presentParkland Memorial Hospital

Training Program Directors’ Committee 2010- presentChildren’s Medical Center

CONTRACTS AND GRANTS:Principal Investigator, National Institutes of Health Grant No. HD08783 "Studies of Uteroplacental Circulation", $158,708, 1974-1977.

Principal Investigator, National Institutes of Health Grant No. HD08783 "Studies of Uteroplacental Circulation", $329,480, 1977-1981

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Co-investigator, National Institutes of Health Grant No. NIH-1-PO1-HD13912, "Fetal Lung Maturation: Prevention of RDS", J.M. Johnston, P.I., $225,000, 1980-1985 (5% effort).

Principal Investigator, National Institutes of Health Grant No. HD08783 "Studies of Uteroplacental Circulation", $613,567, 1981-1986.

Co-Investigator, "In   Vitro Vascular Reactivity During Pregnancy and Preeclampsia". American Heart Association - Texas Affiliate. $25,000/year, 1985-1986.

Co-Investigator, "In   Vitro Vascular Reactivity During Pregnancy and Preeclampsia." American Heart Association - Texas Affiliate. Competitive Renewal $27,500/year, 1986-1987.

Associate Director, Co-Principal Investigator (with Joseph B. Warshaw), NIH Training Grant No. 1-T32 HD07308-01, "Research in Developmental Medicine" $84,901, 1986-1991.

Principal Investigator, National Institutes of Health Grant No. HD20720-01, "Fetal Hormonal Adaptation to Intrauterine Stress", $383,096, 1986-1989.

Co-Investigator, "In Vitro Vascular Reactivity During Pregnancy and Preeclampsia." American Heart Association - Texas Affiliate. Competitive Renewal. $55,000 total award, 1987-1989.

Principal Investigator, Director, NIH Training Grant No. 1-T32-HD07308-02, "Research in Developmental Medicine", 1987-1991.

Principal Investigator, National Institutes of Health Grant No. HD08783, "Studies of Uteroplacental Circulation", $952,982, 1986-1992, $52,800, 12/91-11/92.

Principal Invest, Project 5, "Lung Development in Stressed Fetuses"; Project Director, Jack Johnston, PhD., NIH Grant No. PO1-HD13912-09, "Fetal Lung Maturation: Prevention of RDS", $905,116, 1987-1993.

Co-investigator, National Institutes of Health Grant No. NIH-5-P50-HD11149, "Initiation of Human Labor: Prevention of Prematurity", P.C. MacDonald, P.I.; Project VI "Regulation of Steroidogenesis and fetal adrenals placenta during pregnancy and parturition, J.I. Mason, P.I., $ 816,907, 1988-1993.

Principal Investigator, National Institutes of Health Grant No. 5 RO1 HD08783-19, "Studies of Uteroplacental Circulation", $1,050,215, 1992-1997.

Co-investigator, National Institutes of Health Grant No. NIH-5-P50-HD11149, "Initiation of Human Labor: Prevention of Prematurity", P.C. MacDonald, P.I.; Project V "Regulation of Steroidogenesis and fetal adrenals placenta during pregnancy and parturition, J.I. Mason, P.I., $ 634,096, 1993-1998.

Co-Investigator, NIH-R01-HL-49210-01, "Endothelium-Derived Vasodilators During Pregnancy", R.R. Magness, PI; Total Annual Direct Costs $109,185; 1993-1997.

Principal Investigator, Neurex Pharmaceutical, “Studies of Fenoldopam, a DA2 Agonist, in Pregnancy; Total award $69,379; 1998-2000. Principal Investigator, National Institutes of Health Grant No. 5 RO1 HD08783-24, "Studies of Uteroplacental Circulation", $1,143,483, 1998-2004

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Principal Investigator, Forest Pharmaceuticals, “Characterization of Ductus Arteriosus in Neonates <1000grams”, Fellows Award Program to Shannon Brown, MD, $7,000, 2000-2002.

Principal Investigator, National Institutes of Health Grant No. 5 RO1 HD08783-28A1, "Studies of Uteroplacental Circulation", $1,405,108, 2004-2009.

*Co-Investigator, Farmacon-IL, LLC - FCR-00-01/Ross CB88, AA Randomized, Double-Blind Study of Ibuprofen L-Lysine Intravenous Solution in Premature Infants for the Early Treatment of PDA@, 2003-2004.

Principal Investigator, National Institutes of Health Grant No. 5 U10 HD040689-04, “Cooperative Multicenter Neonatal Research Network”, $341,786; 2004-2006.

External Advisor. National Institutes of Health Grant No. 1 T32 HD046420-01, "Training in Developmental Biology", Principal Investigator De-Ann M. Pillers, M.D., Ph.D., Department of Pediatrics, Oregon Health and Science University, 2005 – 2009.

Mentor for Becky Ennis, M.D. (Postdoctoral Trainee). M. Klaus Award, Section on Perinatal Pediatrics, American Academy of Pediatrics, Hormonal Regulation of Blood Pressure in Neonates <32 Weeks Gestational Age. $5,000, 2004-2005.

Mentor for Andi Duncan, M.D. (Postdoctoral Trainee). M. Klaus Award, Section on Perinatal Pediatrics, American Academy of Pediatrics, Effects of Very Low Birth Weight, Prematurity and Postnatal Growth on Blood Pressure During the First 3 Years of Life. $5,000, 2007-2008.

Principal Investigator, National Institutes of Health Grant No. 5 RO1 HD008783-33A1, "Studies of Uteroplacental Circulation", $1,962,500, 2009-2014.

Co-investigator, Mentor for Lena Chalak, MD and Debra Weinberger, MD, National Institutes of Health Grant 1- KL2-RR024983, Clinical and Translational Science Award, 2007-2012

Mentor for Michel Mikhael, MD (Postdoctoral Trainee). Children’s Medical Center Foundation Award for “Peri-operative assessment of the hypothalamic-pituitary-adrenal axis predicts postoperative morbidity in neonates undergoing cardiac surgery,” $30,000, 2011-2012.

POSTGRADUATE EDUCATIONDirector, "Postgraduate Course in High-Risk Pregnancy and Perinatal Medicine," Texas Medical Association, May 7, 1976.

Co-Director, "Southwestern Perinatal Nursing Seminar," The University of Texas Health Science Center at Dallas, June 1-5, 1976.

Director, "Annual Southwestern Nursing Seminar," The University of Texas Health Science Center at Dallas, 1977-present.

Director, "Seminar on Critical Evaluation of Fetal-Neonatal Care," Symposia Medicus, Park City, Utah, February 13-20, 1982.

Co-Director, "Clinical Issues in Perinatal Care," Contemporary Forums, Park City, Utah, February 5-12, 1983.

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Co-Director, "Perinatal Dilemmas," Contemporary Forums, Park City, Utah, February 25 - March 3, 1984.

Co-Director, "Clinical Dilemmas in Perinatal Medicine," Contemporary Forums, New York City, New York, October 11 - October 14, 1984.

Co-Director, "Perinatal Dilemmas," Contemporary Forums, Park City, Utah, February 9-16, 1985.

Co-Director, South Central Conference for Perinatal Research, Austin, TX. Mead Johnson Nutritionals, Oct 1995-2007.

Co-Chairman, Symposium on “The Renin-Angiotensin System and Development”, Experimental Biology 2003, The American Physiological Society: Endocrinology and Metabolism Section, San Diego, CA, April 13, 2003.

Co-Director, AAP District VII Leadership Development Seminar, Dallas TX, October 19-20, 2007

Coordinator for Subspecialty Training, Department of Pediatrics, 2007-present

CONSULTATIONS:Review of Neonatal Facilities, Department of Health, Singapore, October 30-November 1, 1998.

Review, Division of Neonatal Medicine, Department of Pediatrics, University of Oklahoma School of Medicine; September, 2000.

5 year review, CMRI Reba McIntire Chair in Neonatal Medicine. University of Oklahoma School of Medicine, Department of Pediatrics, December 14-16, 2006.

Review, Division of Neonatal Medicine, Department of Pediatrics, University of Arkansas School of Medicine; April, 2006.

INVITED TALKS:"Renin Angiotensin System," International Symposium on Uterine and Placental Blood Flow, Chicago, IL, March 24, 1980.

"Uterine Blood Flow and Placental Transport," Clinical Nutrition and Early Development branch of the Center for Research for Mothers and Children, National Institute of Child Health and Human Development, "Workshop on Intrauterine Growth Retardation," Bethesda, MD, July 17-20, 1983.

"The Ewe: A model for cardiovascular changes in pregnancy," American Association for Laboratory Animal Science, San Antonio, TX, November 10, 1983.

"Arginine Vasopressin in Fetal Adaptation," Symposium on Perinatal Endocrinology, University of Maryland Medical School, Baltimore, MD, June 17, 1985.

"Development of Vascular Refractoriness in Pregnancy," Visiting Professor, Department of Reproductive Medicine, University of California at San Diego, February 20, 1986.

"Alterations in the Uterine Vascular Bed During Ovine Pregnancy," 17th Annual Meeting of the Perinatal Research Society, Carefree, AZ, September 29, 1986.

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Visiting Professor, Department of Obstetrics/Gynecology and Pediatrics, Southern Illinois University School of Medicine, November 5-6, 1986.

"Maternal Cardiovascular Adaptation to Pregnancy," Division of Vascular Medicine and Atherosclerosis, Dept. of Medicine, Brigham and Women's Hospital, Harvard Medical School, December 11-12, 1986.

Visiting Professor, Department of Pediatrics, Washington University School of Medicine, January 22-23, 1987.Gordon Conference on Angiotensin II, "Developmental Aspects of the Renin-Angiotensin System"Santa Barbara, CA, February, 1987.

Visiting Professor, Department of Pediatrics, Loyola University Stritch School of Medicine, November 3-4, 1987."Arginine Vasopressin in Various Aspects of Fetal Adaptation," 11th Japanese Perinatal ME Conference, Matsuyama, Japan, July 23, 1988.

Rosenfeld, CR: "Fetal Lung Development." Videotape for American Association for Respiratory Care, 1988.

Visiting Professor, Department of Physiology, Dartmouth School of Medicine, Hanover, VT, October 4-5, 1988.

"Amniotic Fluid and the Fetus," Symposium on the Newborn Kidney, Royal Postgraduate Medical School, Institute of Obstetrics and Gynecology, London, England, December 9, 1988.

Visiting Professor, Departments of Pediatrics and Physiology, "Neuroendocrine Aspects of Fetal Adaptation" and "AVP and CRF, Which is the CRF?" Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, January 24-26, 1989.

Visiting Professor, South Australian and Australian Perinatal Society, Adelaide, Australia, September 22-October 9, 1989.

Guest Lecturer, New Zealand and Perinatal Society, Auckland, Australia, October 11-12, 1989.

"Vasopressin in the fetus and neonate," Symposium on Neonatal Hypertension, American Heart Association and National Institutes of Health, Bethesda, MD, October 17-18, 1989.

Visiting Professor, McGill University, Departments of Pediatrics and Obstetrics/Gynecology; "Endocrine Control of Uteroplacental Blood Flow." September 26-27, 1991. Montreal, Quebec.

Visiting Professor, University of Montreal, Department of Pediatrics and Obstetrics/ Gynecology; "The Role of Angiotensin II in Fetoplacental and Uteroplacental Blood Flow." October 2, 1991, Montreal, Quebec.

Chairman, Postgraduate Seminar on Cardiovascular Changes in Pregnancy, 64th Scientific Sessions, American Heart Association, November 11-14, 1991, Anaheim, California

Nelson Foundation Professorship, Departments of Physiology and Reproductive Animal Sciences, University of Missouri School of Medicine, "Mechanisms for refractoriness to ANG II during ovine pregnancy. April 20-21, 1992, Columbia, Missouri.

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Visiting Professor, Department of Pediatrics, University of Missouri School of Medicine, "The use of the white blood cell count in the diagnosis of neonatal infection and alterations associated with maternal hypertension", April 21, 1992, Columbia, MO.

Serono Foundation Symposia, "Vascular aspects of the renin-angiotensin system in the fetus", July 6-7, 1992, Paris, France.

Parke-Davis Symposium, Biochemical properties and physiological roles of the AT2 receptor, "Modification of angiotensin II receptor subtypes during ovine pregnancy and the puerperium." July 10-11, 1992, Ypsilanti, MI. Gordon Research Conference on Angiotensin II, "Vascular and uterine angiotensin II receptor subtypes in pregnancy" February 8-12, 1993, Oxnard, CA.

Special Lecturer, 14th Japan Society for the Study of Toxemia in Pregnancy, "Vascular angiotensin II receptors during pregnancy and their role in cell function," September 3, 1993, Matsuyama, Japan.Visiting Professor, Dept. of Obstetrics and Gynecology, School of Medicine, Ehime University, "The mechanisms controlling uteroplacental blood flow in pregnancy," September 4, 1993, Kumamoto, Japan.

Chairman and Speaker, Symposium on Control of the Uteroplacental Circulation, Presentation: "Growth and Development of the Uteroplacental Vascular Bed During Pregnancy," The 9th Congress of the International Society for the Study of Hypertension in Pregnancy, March 16-19, 1994, Sydney, Australia.

Symposium on Angiotensin Receptor Subtypes and Their Pharmacology, "Developmental and Reproductive specs of the Angiotensin II Receptor," The International Congress of Pharmacology, July 24-29, 1994, Montreal, Canada.

Visiting Professor, Departments of Perinatal Biology and Pediatrics, Lomo Linda University School of Medicine, Lomo Linda, CA "Neonatal neutrophil values: Developmental and perinatal regulation" and "Mechanisms controlling uteroplacental blood flow during pregnancy," May 25-27, 1995.

Speaker, ASPET colloquium "Effects of Gonadal Steroids on Vascular Function" in Conjunction with Experimental Biology '96, "Estradiol modulates ovine uterine blood flow and systemic vascular resistance," April 17-18, 1996, Washington, DC.

Speaker, International Perinatal Collegium, “Differential Maturation of Umbilical and Peripheral Artery Smooth Muscle in Fetal Sheep,” July 18-22, 1997, Mont Tremblant Quebec, Canada.

Speaker, FASEB Summer Research Conference, “Perinatal Regulation of the Cardiovascular System,” August 17-22, 1997, Copper Mountain, CO.

Visiting Professor, Department of Physiology, University of Florida, “Mechanisms responsible for systemic and uterine responses to angiotensin II in pregnancy,” November 17, 1997, Gainesville, FL.

Speaker, Annual Symposium on Fetal Physiology “Mechanisms Regulating Angiotensin II Responsiveness by the Uteroplacental and Systemic Circulations.” Annual Meeting of the Society for Gynecologic Investigation, March 10, 1998, Atlanta, GA.

Visiting Professor, University of Utah School of Medicine, “Neutrophilic Parameters in the Diagnosis of Neonatal Infection”, “Pulmonary Artery Smooth Muscle: Ontogenic Changes and the Effects of Pulmonary Hypertension,” March 30-31, 1998, Salt Lake City, UT.

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Speaker, Symposium in Honor of Giacomo Meschia, MD, Depts of Physiology and Pediatrics, University of Colorado School of Medicine, “Mechanism of Estrogen-Induced Changes in Uterine Blood Flow,” June 11, 1998, Denver, CO.

Invited Speaker, 2nd Annual Scientific Meeting of Obstetrics and Gynecology, “Mechanisms Modifying Uteroplacental Blood Flow and Their Effects on the Fetus,” “Evidence-based Ethics and the Care of the Preterm Infant,” “Attenuated Uteroplacental Responses to Angiotensin II and Pregnancy-Induced Hypertension.” KK Women’s and Children’s Hospital, October 30-November 1, 1998, Singapore.

Speaker, Symposium on Nongenomic Effects of the Gonadal Steroids on Vascular Function: “Mechanisms Mediating Estrogen-Induced Increases in Ovine Uterine and Uteroplacental Blood Flow.” Experimental Biology 99, April 17-21, 1999, Washington, DC.

Speaker, Respiratory Care Lecture Series 2000: “Meconium Aspiration Syndrome.” Parkland Health and Hospital System, May 5, 2000, Dallas, TX.

Speaker, Neonatal Course for Senior Paediatricians, The Lesley Cooper Memorial Lecture: “Patent Ductus Arteriosus: An Old Problem with New Delimmas.” Imperial College School of Medicine, November 27 - December 1, 2000, London, England.

Speaker, “The development and maturation of pulmonary artery smooth muscle and its role in the development of pulmonary hypertension.” GROW Research Institute for Growth & Development, Maastricht University, January 25, 2001, Maastricht.

Speaker, Annual Neonatal Education Program, “Diagnosis of Neonatal Infection: Use of the Peripheral blood count.” University Hospital Maastricht, Division of Neonatology, January 26, 2001, Maastricht.

Speaker, “The Role of Animals in Biomedical Investigation: Understanding Pregnancy and Uteroplacental Blood Flow.” Southern Methodist University, Department of Biological Sciences and Maguire Center for Ethics and Public Responsibility, October 23, 2001, Dallas, TX.

Speaker, “Patent Ductus Arteriosus: Mechanisms of Closure and Non-closure in Term and Preterm Neonates.” Grand Rounds, University of Texas Southwestern Medical Center at Dallas, February 13, 2002, Dallas TX.

Speaker, “Angiotensin II and Fetal Vascular Function.” 6th Symposium International de Néphrologie Périnatale, June 21-22, 2002, Bandol, France.

Speaker, “Uterine Blood Flow Measurements and Control.” 9 th Annual South Central Conference on Perinatal Research, October 8-10, 2002, Austin, TX.

Speaker, “Ontogeny of Angiotensin Receptor Expression During Ovine Development,” Symposium on The Renin-Angiotensin System and Development, Co-Chairman, Experimental Biology 2003, April 13, 2003, San Diego, CA. Speaker, “The Renin-angiotensin System in The Newborn Sheep,” International Colloquium on Perinatal Medicine, June 28-July 2, 2003, Tours, France.

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Speaker, “Fetal Growth Restriction: Pathogenesis and Outcome,” The Fetus & Newborn: State-of-the-Art Care, September 22-24, 2003, New Orleans, LA.

Speaker, “Mechanisms for Failure of Ductal Closure in Very Preterm Neonates,” The Fetus & Newborn: State-of-the-Art Care, September 22-24, 2003, New Orleans, LA. Speaker, “Ontogeny of Angiotensin II Receptors in Vascular Smooth muscle: Relationship to Pressure Regulation in the Fetus and Neonate,” “Control of the Uteroplacental Circulation and Fetal Growth.” 63rd Perinatal & Developmental Medicine Symposium, “Fetal Origins of Adult Disease,” November 20-23, 2003, Marco Island, FL.

Visiting Professor, Department of Pediatrics, Division Neonatal Medicine, University of Illinois School of Medicine at Chicago; “Pathogenesis of PDA in VLBW neonates” and “The Role of the Renin-Angiotensin System in Vascular Smooth Muscle During Development”, September 9-10, 2004.

Founders Award, Southern Society for Pediatric Research. “Blood pressure regulation in the fetus and neonate: Development of the renin-angiotensin system.” New Orleans, LA, February 25, 2005.

Visiting Professor, Oregon Neonatal Seminar Series, Oregon Health Science Center; "Vascular smooth muscle development and the effects of fetal growth restriction;” Pediatric Grand Rounds, "Patent ductus arteriosus in extremely-low-birth-weight neonates: Natural history and development," June 8 – 10, 2005.

UIC Specialty Review in Neonatology/Perinatology. “Physiology and Management of Blood Pressure in the Newborn.” Chicago, IL August 22-26, 2005

Visiting Professor, Emory University School of Medicine; “Pediatric Grand Rounds: “Understanding Blood Pressure Regulation and Management in the Neonate;” Perinatal Research Conference: “Fetal Growth and Well-being: Mechanisms Modulating Uteroplacental Blood Flow in Pregnancy.” February 15-16, 2006.

Invited Speaker, Network of GA Neonatologists: “Patent Ductus Arteriosus in Extremely-Low-Birth-Weight Neonates: Physiology, Pathology and Treatment,” Atlanta, GA, February 15, 2006.

Billy F. Andrews Lectureship in Pediatrics: Department of Pediatrics, University of Louisville School of Medicine. “Patent Ductus Arteriosus in Neonates <1000 gm: Physiology, Pathology and Treatment.” Louisville, KY, October 20, 2006.

International Conference on Meconium Aspiration Syndrome and Meconium-induced Injury. “Molecular Basis of Meconium-induced Lung Injury.” Chicago, IL, March 23-24, 2007.

UT Southwestern Obesity Alliance, Weekly Seminar Series on Nutrition, Metabolism and Obesity. "Insulin Resistance in Hispanic Large For Gestational Age Neonates at Birth” Dallas, TX, December 13, 2007.

UT Southwestern, Department of Internal Medicine, Hypertension Grand Rounds. "Impact of fetal-neonatal programming on adult diseases-Effects of fetal growth and preterm birth.” Dallas, TX, May 30, 2008.

Visiting Professor, Departments of Obstetrics/Gynecology and Pediatrics, University of Western Ontario, London, Ontario, Canada. OB/GYN Grand Rounds: “Abnormal Fetal Growth and Preterm Birth May Predict Future Childhood and Adult Risk for Disease.” Canadian Health Research Institute Lecture: “Vascular Development in the Fetus and Neonate and the Effects of Fetal Growth Restriction.” October 28-30, 2008.

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Speaker, Clinical Advances in Pediatrics Symposium, Children’s Mercy Hospital in Kansas City, MO. “Diagnosis of Infection in the Newborn: Use of the Lab and Cultures,” “Implications of Fetal Growth and Preterm Delivery on Childhood and Adult Diseases,” and “Triage and Care of the Late-Preterm Neonate: Experience in a Large Hospital.” Nov 21, 2008.

Visiting Professor, Division of Neonatal Medicine, University of Missouri at Kansas City Medical School and Children’s Mercy Hospital. Division Conference: Understanding Mechanisms Regulating Uteroplacental Blood Flow in Pregnancy: How did I get here?” November 20, 2008.

Visiting Professor, Departments of Obstetrics/Gynecology and Neonatal Medicine, University of Tennessee School of Medicine. OB/GYN Grand Rounds: “Mechanisms Modulating Uterine Vascular Sensitivity to Norepinephrine and Angiotensin II in Human Uterine Arteries”; Neonatal Grand Rounds: “Diagnosis of Neonatal Infection: Revisiting the Manroe et al Neutrophil Values. November 8, 2011.

TRAINEES:Medical Students:Richard Rivera UT Southwestern Medical School Summer, 1977

G. Marc Jackson UT Southwestern Medical School Summer, 1983

Charles A. Iliya UT Southwestern Medical School Summer, 1984Studies of uteroplacental blood flow.

Starling Corbett UT Southwestern Medical School Summer, 1990Studies of neonatal intracranial hemorrhage.

Yvonne Arens Rijksuniversiteit Limburg, Fall, 1992Maastricht, The Netherlands

Studies of smooth muscle development.

Jennifer Chern UT Southwestern Medical School Summer, 1993Studies of vascular smooth muscle maturation.

René Chapados Sarnoff Fellow, Univ. of Chicago 1993 - 1994School of Medicine

Pulmonary vascular smooth muscle development.

Desiree van den Bongard Rijksuniversiteit Limburg, Fall, 1995Maastricht, The Netherlands

Studies of vascular smooth muscle maturation.

Liedeke van der Steeg Rijksuniversiteit Limburg, Fall, 1995Maastricht, The Netherlands

Studies of vascular smooth muscle maturation.

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Senthil Sankaralingam University of Hawaii School of Medicine Summer, 1999Society of Pediatric Res Summer Fellow

Effects of estrogen on smooth muscle proteins.

Shilpa Miniyar UT Southwestern Medical School Summer, 2002

Folashade Afolabi UT Southwestern Medical School 2003-2007Neutrophilic values in the diagnosis of nosocomial infection.

Renaud Viellevoye University of Liege May – June 2004Belgium

Laura R. Ley UT Southwestern Medical School Summer, 2005

Jules Bergmann UT Southwestern Medical School Summer, 2010Maternal weight gain, LGA and childhood obesity.49th Annual Medical Student Research Forum Poster Award

Helena Wojciechowski UT Southwestern Medical School Summer, 2011Early pregnancy nutrient restriction and uteroplacentalExpression of BKCa

Neonatal-Perinatal Fellows:Barbara L. Manroe, MD UT Southwestern Medical School 1975 – 1978

Assistant Professor, UT Southwestern 1978 - 1981Private practice 1981

Jaime A. Furzan, MD Univ. of Carabobo, Venezuela 1978 - 1980Univ. of Carabobo, Venezuela 1980

S. Wiriyathian, MD Maimonides Medical Center 1980 - 1983 Private Practice, Lubbock, TX (w/John Porter, PhD)

Daniel J. Faucher, MD University of Montreal 1983 - 1985 (w/John Porter, PhD)

Assistant Professor, UT Southwestern 1985-1987Associate Professor, McGill University 1987 - present

David J. Annibale, MD University of North Carolina 1987 - 1990 Presently at Medical Univ. of S. Carolina (w/Kris Kamm, PhD)Director, Division Neonatal Medicine

Larry A. Wallin, MD University of Utah 1987 - 1990Private Practice

Hasu R. Mackanjee, MD Hospital for Sick Children 1987 - 1989University of Toronto (w/Phil Shaul, MD)St. Joseph's Health Center 1989-1991London, Ontario, Canada

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Private Practice, South Africa

Blair E. Cox, MD Creighton Univ. Medical Center 1990 - 1993 Associate Professor, UT Southwestern (w/Phil Shaul, MD)

Med School 1994 - Died 2005 Merle A. Ipson, MD UT Southwestern Medical School 1991-1994

(w/Kris Kamm, PhD)Professor, Texas Tech Medical School, 1994-presentEl Paso, TX

Jeffrey Kaiser, MD Mt. Sinai Med Center, New York 1994 - 1997Associate Professor, University of Arkansas 1997 - 2011Medical Center, Little Rock, ARProfessor, Baylor College of Medicine 2012 – Texas Children’s Hospital, Director Clinical Research

Walid Salhab, MD Le Bonheur Children's Hospital 1995 - 1998Assistant Professor, UT Southwestern (w/Phil Shaul, MD)

Medical School 1998 – 2007 Private Practice 2007-

Sangkae Chamnanvanakij, Chulalongkorn University 1996-1999MD Bangkok, Thailand (w/Kris Kamm, PhD)

Director of NICU, Bangkok Thailand 1999 - present

Sithembiso Velaphi, MB University of the Witwatersrand 1998-2001Johannesburg, South AfricaAssociate Professor, University of Witwatersrand 2008 - presentDirector, Neonatal Medicine, Chris Hana HospitalHead, Department of Paediatrics, Chris Hani Baragwanath Academic Hospital

Shannon Brown, MD Children’s Medical Center of Dallas 1999-2002Private Practice, Orlando, FL

Deepa Nagar, MD Medical Branch University of Texas 2001-2004Private Practice

Mesfin Woldesenbet, MD Harlem Hospital Center, New York 2002 – 2005Addis Ababa University, Addis Ababa, (w/ Jeffery Perman, M.B.)EthiopiaAssistant Professor, University of 2005-2006Texas Health Science Center at Houston, Division of Neonatal-Perinatal MedicinePrivate Practice 2006

Becky Ennis, MD Children’s Medical Center of Dallas 2003 – 2006Michigan State University Medical School 2006 – 2008

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Assistant Professor, UT Southwestern Medical 2008 - present School, Dept of Pediatrics, Division of Neonatal-Perinatal Medicine

Hlwelekazi Bomela, MB University of Witwatersrand 2003 - 2006 Senior Consultant NICU, Steve Biko 2007- present

Academic HospitalPretoria, S. Africa

Andi Duncan, M.D. Children’s Medical Center of Dallas 2005 – 2008 (w/ Roy Heyne, M.D.) Univ. of New Mexico School of Medicine 2008- present Division of Neonatal Medicine, Director of Follow-up Program for LBW, Assistant Professor

Completed Masters of Science in Clinical Research Nov. 2011

Darryl Miao, M.D. Children’s Medical Center of Dallas 2005 – 2008 Private Practice, Ft Worth, TX 2008

Leo Kahn, M.D. Pennsylvania State Medical Center at Hershey 2006 - 2009Under Served Provider, Louisiana 2009

Joshua Frankfurt, M.D. Univ. of Miami School of Medicine 2009 – 2012Private practice, Dallas 2012

Michel Mikhael, MD Univ. of Cairo School of Medicine 2009 – 2012Orange County Children’s Hospital 2012Dept. of Pediatrics, Univ. California Irving SchoolOf Medicine

Ja’Near Anderson, MD Meharry Medical School 2010-

Anson Tang, MD UT Southwestern Medical School 2012-

Maternal-Fetal Medicine Fellows:Richard J. Worley, MD UT Southwestern Medical School 1976–1978

(w/ Norman Gant, MD)Assistant Professor, OB/GYN, UT Southwestern 1978 – 1980Professor OB/GYN, Univ of Utah Med Center 1980 - ?Private practice

Oscar Andujo, MD Mexico 1978Assistant Professor of Obstetrics and Gyn 1999-2011UT Southwestern Medical SchoolAssociate Prefessor 2011 – present

Chris Hernandez, MD UT Southwestern Medical School 1982 - 1984Private practice, Brownsville, TX

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Lowell E. Davis, MD UT Southwestern Medical School 1985 - 1986Professor of Obstetrics and Gynecology, 1986 - presentUniv. of Oregon Health Sciences Center

Susan M. Ramin, MD UT Southwestern Medical School 1989 – 1990Assistant Professor, OB/GYN, UT Southwestern 1990 - 1995Professor and Chairman, Obstetrics and 1995 - presentGynecology, Director of Maternal Fetal MedicineUT Houston Medical Center

Catalina Hutuna, MD University of Medicine and Pharmacy 2005 - 2006Iuliu Hatieganu, Romania

Presently, Private Practice Romania Working on PhD

Doctoral and Postdoctoral Students:

Ronald R. Magness, PhD Postdoctoral/Univ. of Iowa 1984 – 1986Assistant Professor, UT Southwestern 1986 - 1995Professor of Obstetrics and Gynecology 1995 - presentand Animal Sciences, Director of Perinatal Research, Univ. of Wisconsin - Madison

Yvonne Arens, MD, PhD. Doctoral Student, awarded January, 2001 1995 - 1998Rijksuniversiteit Limburg, Maastricht, The Netherlands; PhD awarded January, 2001Assistant Professor, Medical Genetics, 2003- presentMaastricht University

ZhenZhen Shan, MD, PhD Research Fellow 1997-1998Tongji Medical UniversityWuhan, China

Katelyn Finch, BS Doctoral student, UTSWMS 2011 –Deborah Clegg, PhD

Miscellaneous:Georgio Gabriele, MD Caracus, Venezuela 1975 - 1976

Raymond P. Naden, MD Auckland, New Zealand 1979 – 1982 Univ of Auckland Medical School, Dept of Medicine 1986 - 1992

Jennifer Dyer, MD Fellow, Endocrinology 2003 – 2006UT Southwestern Medical Center (w/Dana Hardin, MD)Assistant Professor, Ohio State

University Medical Center, Division of Endocrinology

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Poonan Panjwani, M.D. Fellow, Pediatric Cardiology 2007-2010UT Southwestern Medical Center (w/ C. Ramaciotti, MD)Assistant Professor, UTSWMS, Division of Cardiology

Debra Weinberger, M.D. Masters Program, Clinical and Translational 2008-2010Science Award (w/ Emily Tobey, PhD, Callier)UT Southwestern Medical Center Assistant Professor, Dept Otolaryngology andPediatrics

Lina Chalak, M.D. Masters Program, Clinical and Translational 2008 - 2011Science Award (w/ Pablo Sanchez, M.D.)UT Southwestern Medical Center, Assistant Professor, Dept of PediatricsK23 recipient, June 2012

Arlene Davis, M.D. Assistant Professor, Division Neonatal-Perinatal 2011-Faculty Mentor

Uzo Ukoha UT-SUMR Summer Program 2012Duke University

Pediatric Residents:Cindy Strand, MD Department of Pediatrics 1987

UT Southwestern Medical SchoolResident in Pediatrics

Adrian Gresores, MD Department of Pediatrics 1991UT Southwestern Medical SchoolResident in Pediatrics

Josh Koch, MD Department of Pediatrics 2002-2005UT Southwestern Medical School

Chief Resident in Pediatrics

Darryl Miao, MD Department of Pediatrics 2003-2005UT Southwestern Medical School Resident in Pediatrics

Graduate School, Integrative Biology; Qualifying Exams:Stephanie Pierce May, 2000

Gwyndolen Harburg July, 2001

Melissa McCoy September, 2004

Nathaniel Schaffer May, 2010

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Makito Sato May, 2011

Visiting Scientists:Shumpei Matsuura, MD Kyoto Univ. School of Medicine 1979 - 1980

Vice Chairman, Dept. of OB/GYN

Alfredo J. Perales, MD Department of OB/GYN 1981Valencia, Spain

Bernard Spitz, MD Department of OB/GYN 1986 - 1987Leuven, Belgium

John T. France, PhD Department of OB/GYN 1985 - 1986Auckland, New Zealand

Toshihiro Yoshimura, MD Department of OB/GYN 1987 – 1990Kumamoto, Japan

Ana Mouzinho, MD Lisbon, Portugal 1989 – 1992

Scholarship Oversight Committees   :

Liaqay Khan, MD, Division of Neonatal-Perinatal Medicine 2006 – 2009 Studies of BKCa channels in the regulation of uterine blood flow Mentor : CR Rosenfeld, MD

Laqietha Foster, MD, Division of Neonatal-Perinatal Medicine 2006 – 2009 Studies of SPA and P4 Receptors and the onset of Parturition Mentor : Carole Mendelson, PhD

Amanda Blair, MD, Chinni Pokala, MD and Puja Gupta, MD 2008 – 2010 Division of Hematology-Oncology Studies of iron overload in oncology patients, VEGFR and tumor angiogensis, and risk for fungal infection in oncology patients

Mari Afanador, MD, Division of Neonatal-Perinatal Medicine 2009 – 2011 EphrinB2 modulates distal pulmonary structure and function Mentor: Margart A. Schwarz, MD

CURRENT ACTIVITIES:1. Consultant to Director of the Postdoctoral Training Program in Neonatal-Perinatal Medicine.2. Laboratory Research

- role of estrogen in ovine pregnancy, maternal and fetal aspects.- factors influencing the magnitude and distribution of uterine blood flow in pregnancy.- factors influencing maternal cardiovascular adaptation during pregnancy.- fetal hormonal and cardiovascular responses to intrauterine stress.- ontogeny of angiotensin II receptors and receptor subtypes in the fetus and pregnancy.- ontogeny of smooth muscle proteins and myosin heavy chain isoforms in the fetus and pregnancy.

- regulation of blood pressure during development

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3. Clinical Research- evaluation and diagnosis of neonatal infection.- mechanisms modulating closure of the ductus arteriosus.- mechanisms regulating blood pressure after birth

- fetal growth and programming

4. Education- Lecturer, Sophomore course: “Clinical Medicine: Principles and Practice” 1995 – 2010 - Director, Fellows’ Physiology Course, Neonatal-Perinatal Medicine Training Program- Director, Pediatric Department, Core Curriculum for Fellows, 2000-2004, 2007-- Lecturer, HUMAN BIOLOGY AND DISEASE, graduate Program in Integrative Biology- Director, Division Research Conference and Journal Club

ABSTRACTS PRESENTED AND PUBLISHED: (Last 5 yrs)

255. Rosenfeld, CR, Liu X, Nagar D. Increased Expression of the Regulatory β1-Subunit of Large- Conductance K+ Channels (BKCa) in Uterine Artery Vascular Smooth Muscle (VSMUa) During Ovine Pregnancy. Society for Gynecological Investigation, March 21 – 25, 2006. (Poster Presentation)

259. Rosenfeld CR, Liu X. Large-Conductance K+ Channels (BKCa) are Up-Regulated in Myometrium (MYO) During Ovine Pregnancy and Decrease Soon After Delivery. Society for Gynecological Investigation. March 21 – 25, 2006. (Poster Presentation)

260. Hutanu C, Cox BE, DeSpain K, Liu X-t, Rosenfeld, CR. Developmental Changes in Ovine Carotid Artery (CA) Function, Morphology and Protein Contents. Pediatric Academic Societies’ 2006 Annual Meeting. April 29 – May 2, 2006. (Poster Presentation)

261. Dyer JS, Hardin, DS, Rosenfeld, CR. The Development of Metabolic Syndrome in Large for Gestational Age Infants. Pediatric Academic Societies’ 2006 Annual Meeting. April 29 – May 2, 2006. (Poster Presentation)

262. Bomela H, Rosenfeld CR, Bober M, Salhab W. The Prevalence and Impact of Congenital Anomalies (CA) on Neonatal Intensive Care (NICU). Pediatric Academic Societies’ 2006 Annual Meeting. April 29 – May 2, 2006. (Poster Presentation)

263. Hutanu C, Cox BE, DeSpain K, Liu X-t, Rosenfeld CR. Changes in Carotid Artery Smooth Muscle Phenotype, Function, Protein Contents and Morphology during Ovine Development. Fetal and Neonatal Physiological Society 2006 Annual Meeting. September 17 – 20, 2006. (Oral Presentation)

264. Rosenfeld CR, Roy TA. Large Conductance Ca2+-Dependent K+ Channels (BKCa) Contribute to Attenuated Uterine Vascular Responses to -Stimulation in Pregnant Sheep. 53rd Annual Meeting of Soc for Gynecologic Investigation, March 14-17, 2007. Reprod Sciences 14:110A, 2007. (Poster Presentation)

265. Rosenfeld C, DeSpain K, Liu XT. Human Uterine Arteries Express an Endothelium-Derived Contracting Factor and Large-Conductance K+ Channels that Modulate Constrictor Responses, Basal Tone and Nitroprusside-induced Relaxation. 53rd Annual Meeting of Soc for Gynecologic Investigation, March 14-17, 2007. Reprod Sciences 14:110A, 2007. (Poster Presentation)

266. Miao DC, Velaphi S, Roy T, Rosenfeld CR. The Mechanisms Regulating Blood Pressure in Conscious Newborn Sheep: Arginine Vasopressin and Metabolic Clearance Rate (MCRAVP). Pediatric Academic Societies’ 2007 Annual Meeting. May 5 -8, 2007. (Poster Presentation)

267. Ennis BJ, Rosenfeld CR. Total and Free Cortisol Values are Decreased in Preterm Neonates Exposed to Antenatal Steroids (AS). Pediatric Academic Societies’ 2007 Annual Meeting. May 5 -8, 2007. (Poster Presentation)

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268. Ennis BJ, Rosenfeld CR. Basal Total and Free Cortisol Measurements are Unrelated to Blood Pressure (BP) in the First Postnatal Week in Neonates 28-32 Weeks Gestation. Pediatric Academic Societies’ 2007 Annual Meeting. May 5 -8, 2007. (Oral Presentation)

269. Rosenfeld CR, Hutanu C, Cox BE, DeSpain K, Liu X-t. Changes in Carotid Artery Smooth Muscle Phenotype, Function, Protein Contents and Morphology during Ovine Development. International Perinatal Collegium, Stockholm, Sweden July 17-20, 2007. (Oral presentation)

270. Ennis BJ, Roy L, Rosenfeld CR. Basal total and free cortisol measurements are unrelated to blood pressure in the first postnatal week in neonates 28-32 weeks gestation. American Academy of Pediatrics 2007 National Conference and Exhibition, October , 2007. Klaus Award presentation.

271. Rosenfeld CR, Roy T. Inhibition of Uterine Vascular Nitric Oxide Synthase (NOS) Minimally Alters Basal Uteroplacental Blood Flow (UPBFb) in Ovine Pregnancy. 54th Annual Meeting of Soc for Gynecologic Investigation, San Diego, CA; March 27-29, 2008. Reprod Sciences 15:216A, 2008. (Poster Presentation)

272. Rosenfeld CR, Liu XT Uterine Artery Large Conductance Ca+2-dependent K+ Channels (BKCa) and Signaling Pathways are Up-Regulated During Ovine Pregnancy. 54th Annual Meeting of Soc for Gynecologic Investigation, San Diego, CA; March 27-29, 2008. Reprod Sciences 15:217A, 2008. (Poster Presentation)

273. Duncan AF, Rosenfeld CR, Morgan JS, Ahmad N, and Heyne RJ. Systolic blood pressure in very-low-birth-weight infants exceeds a reference population in the first 3 years of life. Pediatric Academic Societies’ 2008 Annual Meeting, Honolulu, Hawaii. May 1-6, 2008. (Poster Symposium Presentation)

274. Miao DC, Roy T, and Rosenfeld CR. Vascular sensitivity to angiotensin II and α-stimulation increases after the first month postnatal in conscious newborn sheep. Pediatric Academic Societies’ 2008 Annual Meeting, Honolulu, Hawaii. May 1-6, 2008. (Poster Presentation)

275. Miao DC, DeSpain K, and Rosenfeld CR. Vascular reactivity in newborn sheep is vessel and agonist dependent. Pediatric Academic Societies’ 2008 Annual Meeting, Honolulu, Hawaii. May 1-6, 2008. (Poster Presentation)

276. Ramos FG, Roy L, Koch J, Hensley G, Rosenfeld CR, Ramaciotti. Echocardiographic predictors of ductus arteriosus in extremely-low-birth-weight infants. Am Soc Echocardiography 2008 Annual Meeting, Toronto, Canada, JASE, May 2008; 21(5): 518. (Oral Presentation)

277. Khan LH, Liu X, Magness RR, Rosenfeld CR. The cGMP-PKG-dependent pathway and large conductance Ca2+-activated K+ channels (BKCa) are up-regulated in uterine artery smooth muscle during the ovine ovarian cycle. Society for Gynecologic Investigation, 2009 Annual Meeting. Glasgow, Scotland, March 16-25, 2009. (Oral presentation)

278. Rosenfeld CR, DeSpain K, Liu X. Uterine Artery Large Conductance Ca2+-Activated K+ channels (BKCa) Contribute to Attenuated Adrenergic Responses and Nitric Oxide-Mediated Relaxation in the Last Two-thirds of Ovine Pregnancy. Society for Gynecologic Investigation, 2009 Annual Meeting. Glasgow, Scotland, March 16-25, 2009. (Poster presentation)

279. Duncan AF, Heyne RJ, Morgan JS, Ahmad N, Rosenfeld CR. Systolic Blood Pressure in Very-Low-Birth-Weight Infants Exceeds A Reference Population in the First 3 Yr of Life. American Academy of Pediatrics, 2009 National Conference and Exhibition, October 17, 2009. (Klaus Award oral presentation)

280. Rosenfeld, CR, Liu X, DeSpain K. Mechanisms Modulating Angiotensin II Sensitivity in the Uteroplacental Vascular Bed Throughout Ovine Pregnancy. Society for Gynecologic Investigation, 2010 Annual Meeting. Orlando, FL, March 23-26, 2010. (Poster presentation)

281. Punjwani P, Rosenfeld CR, Ramaciotti C. Echocardiographic Prediction of Spontaneous Closure of the Ductus Arteriosus in Neonates Less Than 30 Weeks of Gestation. American Academy of Pediatrics, Section on Perinatal Pediatrics, 2010 National Conference and Exhibition, October 2, 2010, San Francisco, CA (Young Investigator Travel Award; Oral presentation)

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282. Alasmi M, Afolabi F, Rosenfeld CR. Reassessing the Neutrophil Count in the Diagnosis of Nosocomial Infection. 6th World Conf on Pediatric Critical Care, March 13-17, 2011, Sydney, Australia. (Oral presentation)

283. Rosenfeld CR, Xiao-tie L, DeSpain, K. Mechanisms modulating reduced sensitivity to angiotensin II in the uteroplacental vascular bed of pregnant women. Society for Gynecologic Investigation, 2011 Annual Meeting. Miami Beach, FL, March 16-19, 2011. (Oral presentation)

284. Rosenfeld CR, Xiao-tie L, DeSpain, K. Uterine artery function and remodeling during human pregnancy. Society for Gynecologic Investigation, 2011 Annual Meeting. Miami Beach, FL, March 16-19, 2011. (Poster presentation)

285. Frankfurt J, Duncan A, Heyne R, DeSpain K, Rosenfeld CR. Studies of Renal Function and Systolic Blood Pressure in Preterm Very-low-birth-weight Infants at 1-3yrs Chronologic Age. South Central Perinatal Research Meeting, Austin, TX, September 2010 (Oral Presentation). Pediatric Academic Societies’ 2011 Annual Meeting, Denver, CO. May 1-3, 2011. (Poster)

286. Bergmann J, Persaud D, Rosenfeld CR. Relationship Between Childhood Obesity, Maternal Weight Gain in Pregnancy and Fetal Growth. Pediatric Academic Societies’ 2011 Annual Meeting, Denver, CO. May 1-3, 2011. (Poster)

287. Alasmi M, Shade F, Rosenfeld CR. Serial Neonatal Neutrophil Counts and the Diagnosis of Late Onset Nosocomial Infection in the Neonatal ICU. Pediatric Academic Societies’ 2011 Annual Meeting, Denver, CO. May 1-3, 2011. (Poster)

288. Thankavel PP, Rosenfeld CR, Ramaciotti C. Echocardiographic prediction of spontaneous closure of the patent ductus arteriosus in neonates <30 wks gestational age. Pediatric Academic Societies’ 2011 Annual Meeting, Denver, CO. May 1-3, 2011. (Poster)

289. Rosenfeld CR, Roy T. Differential Uterine and Systemic Sensitivity to BKCa and KV Channel Inhibition After Estradiol-17β-Induced Uterine Vasodilation in Nonpregnant Ewes. Society for Gynecologic Investigation, 2012 Annual Meeting. San Diego, CA, March 21-23, 2012. (Poster presentation)

290. Wojciechowsk H, Liu X-t, Ford SP, Rosenfeld CR. Early Pregnancy Maternal Nutrient Restriction (NR) Does Not Alter Uterine Artery (UA) Expression of Large Conductance Ca+2-Dependent K+ Channels (BKCa). Society for Gynecologic Investigation, 2012 Annual Meeting. San Diego, CA, March 21-23, 2012. (Poster presentation)

291. Frankfurt J, Duncan A, Heyne R, Rosenfeld CR. Growth Patterns in Preterm Very-Low-Birth-Weight (PT-VLBW) Infants at 1-3yrs Correlate with Elevated Serum Leptin. Pediatric Academic Societies’ 2012 Annual Meeting, Boston, MA. April 27-May 1, 2012. (Oral presentation, CTSA Child Health Research Fellow, Travel Award)

292. Rosenfeld CR, DeSpain K, Baum M. Modified Carotid Artery Function at 1yr in Male Offspring of Protein Deprived Pregnant Rats. Pediatric Academic Societies’ 2012 Annual Meeting, Boston, MA. April 27-May 1, 2012. (Poster presentation)

293. Ennis B, DeSpain K, Rosenfeld CR. Arginine vasopressin levels are gestational age dependent in the first week of life and unrelated to the rise in blood pressure in neonates 24-32 weeks gestational age. Pediatric Academic Societies’ 2012 Annual Meeting, Boston, MA. April 27-May 1, 2012. (Poster presentation)

294. Mikhael, M, Brown LS, Rosenfeld CR. Do 1979 neutrophil reference ranges accurately diagnose the presence of early onset sepsis? American Academy of Pediatrics, Section on Perinatal Pediatrics, 2012 National Conference and Exhibition, October 20, 2012, New Orleans, LA (Poster presentation)

295.

PUBLICATIONS (Peer Reviewed):

1. Rosenfeld CR. Necrotizing enterocolitis. Bulletin of the New York Academy of Medicine 47:161-172, 1971.

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2. Killam AP, Rosenfeld CR, Battaglia FC, Makowski EL, Meschia G. Effect of estrogens on the uterine blood flow of oophorectomized ewes. Am J Obstet Gynecol 115:1045-1052, 1973.

3. Rosenfeld CR, Killam AP, Battaglia FC, Makowski EL, Meschia G. Effect of estradiol-17β on the magnitude and distribution of uterine blood flow in nonpregnant, oophorectomized ewes. Pediatr Res 7:139-148, 1973.

4. Rosenfeld CR, Eichenwald HF. The L-S ratio: Its use in the prediction of respiratory maturity in infants. JAMA 227:610-620, 1974.

5. Morris FH, Jr., Rosenfeld CR, Resnik R, Meschia G, Makowski EL, and Battaglia FC. Growth of uterine oxygen and glucose uptakes during pregnancy in sheep. Gynecol Invest 5:230-241, 1974.

6. Rosenfeld CR, Morris FH, Jr., Makowski EL, Meschia G, and Battaglia FC. Circulatory changes in the reproductive tissues of ewes during pregnancy. Gynecol Invest 5:252-268, 1974.

7. Rosenfeld CR, Barton MD, Meschia G. Effects of epinephrine on distribution of blood flow in the pregnant ewe. Am J Obstet Gynecol 124:156-163, 1976.

8. Rosenfeld CR, Morriss FH, Jr., Battaglia FC, Makowski EL, Meschia G. Effects of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes. Am J Obstet Gynecol 124:618-629, 1976.

9. Duenhoelter JH, Santos-Ramos R, Rosenfeld CR, Coln CD. Prenatal diagnosis of gastrointestinal tract obstruction. Obstet Gynecol 47:618-620, 1976.

10. Rosenfeld CR, West JA. Circulatory responses to systemic infusions of norepinephrine in the pregnant ewe. Am J Obstet Gynecol 127:376-383, 1977.

11. Rosenfeld CR. Distribution of cardiac output in ovine pregnancy. Am J Physiol 232:H231-H235, 1977.12. Rosenfeld CR. The estimation of gestational age: An important screening technique. Medical Record

News 48:54-60, 1977.13. Gabriele G, Rosenfeld CR, Fixler DE, Wheeler JM. Continuous airway pressure breathing with the head-

box in the newborn lamb: Effects on regional blood flows. Pediatrics 59:858-864, 1977.14. Manroe BL, Rosenfeld CR, Weinberg AG, Browne R. The differential leukocyte count in the assessment

and outcome of early-onset neonatal group B streptococcal disease. J Pediatr 91:632-637, 1977.15. Rosenfeld CR, Worley RJ, Gant NF, Jr. Uteroplacental blood flow and estrogen production following

dehydroisoandrosterone infusion. Obstet. Gynecol 50:304-307, 1977.16. Schreiner RL, Hurwitz RA, Rosenfeld CR, Miller W. Atrial tachyarrhythmias associated with massive

edema in the newborn. J Perinat Med 6:274-279, 1978.17. Rosenfeld CR, Worley RJ. The effect of systemic infusions of dehydroisoandrosterone on the distribution

of uterine blood flow in ovine pregnancy. Am J Obstet Gynecol 130:385-390, 1978.18. Rosenfeld CR, Rivera R. Circulatory responses to systemic infusions of estrone and estradiol-17β in

nonpregnant, oophorectomized ewes. Am J Obstet Gynecol 132:442-448, 1978.19. Sanchez AM, Mize SG, Jimenez JM, Manroe BL, Rosenfeld CR, Tyson JE. Systems approach to the

evaluation of maternal and neonatal care. Proceedings 12th Hawaii Int'l Conference on System Sciences, Selected Papers in Medical Information Processing, Vol. III, pp. 140-151, 1979.

20. Manroe BL, Weinberg AG, Rosenfeld CR, Browne R. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr 95:89-98, 1979.

21. Rosenfeld CR, Coln CD, Duenhoelter JH. Fetal cervical teratoma as a cause of polyhydramnios. Pediatrics 64:176-179, 1979.

22. Rosenfeld CR, Worley RJ, Milewich L, Gant NF, Jr., Parker CR, Jr. Ovine fetoplacental sulfoconjugation and aromatization of dehydorepiandrosterone. Endocrinology 106:1971-1979, 1980.

23. Rosenfeld CR, Andujo O, Johnston JM, Jimenez JM. Phosphatidic acid phosphohydrolase and phospholipids in tracheal and amniotic fluids during normal ovine pregnancy. Pediatr Res 14:891-893, 1980.

24. Rosenfeld CR. Response of reproductive and nonreproductive tissues to 17β-estradiol during ovine puerperium. Am J Physiol 239:E333-E339, 1980.

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25. Siegel JD, McCracken GH, Jr., Threlkeld N, Milvenan B, Rosenfeld CR. Single dose penicillin prophylaxis against neonatal Group B streptococcal infections: A controlled trial in 18,738 newborn infants. N Engl J Med 303:769-775, 1980.

26. Morris FH, Rosenfeld CR, Crandall SS, Adcock EW III. Effects of fasting on uterine blood flow and substrate uptake in sheep. J Nutr 110:2433-2443, 1980.

27. Rosenfeld CR, Gant NF, Jr. The chronically instrumented ewe, a model for studying vascular reactivity to angiotensin II in pregnancy. J Clin Invest 67:486-492, 1981.

28. Furzan JA, Gabriele G, Wheeler MJ, Fixler DE, Rosenfeld CR. Regional blood flows in newborn lambs during endotracheal continuous airways pressure and continuous negative pressure breathing. Pediatr Res 15:874-878, 1981.

29. Matsuura S, Naden RP, Gant NF, Jr., Parker CR, Jr., Rosenfeld CR. Effect of volume expansion on the pressor response to angiotensin II in pregnant ewes. Am J Physiol 240:H908-H913, 1981.

30. Naden RP, Rosenfeld CR. Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep. J Clin Invest 68:468-474, 1981.

31. Wiriyathian S, Kaojareren S, Rosenfeld CR. Dilantin toxicity in a preterm infant: persistent bradycardia and lethargy. J Pediatr 100:146-149, 1982.

32. Rosenfeld CR, Jackson GM. Induction and inhibition of uterine vasodilation by catechol estrogen in oophorectomized, nonpregnant ewes. Endocrinology 110:1333-1339, 1982.

33. DeVane GW, Naden RP, Porter JC, Rosenfeld CR. Mechanism of arginine vasopressin release in the sheep fetus. Pediatr Res 16:504-507, 1982.

34. Siegel JD, McCracken GH, Jr., Threlkeld N, DePasse BM, Rosenfeld CR. Single-dose penicillin prophylaxis of neonatal Group-B streptococcal disease. Conclusion of a 41 month controlled trial. Lancet 1:1426-1430, 1982.

35. Lasky RE, Tyson JE, Rosenfeld CR, Priest M, Kransinski D, Heartwell S, Gant NF. Principal component factor analyses of the Bayley Scans of Infant Development for a sample of high-risk infants and their controls. The Merrill-Palmer Quarterly 29:25-31, 1983.

36. Wiriyathian S, Porter JC, Naden RP, Rosenfeld CR. Cardiovascular effects and clearance of arginine vasopressin in the fetal lamb. Am J Physiol 245:E24-E31, 1983.

37. Cunningham FG, Leveno KJ, DePalma RT, Roard M, Rosenfeld CR. Perioperative antimicrobials for cesarean delivery: Before and after cord clamping? Obstet Gynecol 62:151-154, 1983.

38. Lasky RE, Tyson JE, Rosenfeld CR, Priest M, Krasinski D, Heartwell S, Gant N. Differences on Bayley's infant behavior record for a sample of high-risk infants and their controls. Child Develop 54:1211-1216, 1983.

39. Engle WD, Arant BS, Jr., Wiriyathian S, Rosenfeld CR. Diuresis and respiratory distress syndrome: Physiologic mechanisms and therapeutic implications. J Pediatr 102:912-917, 1983.

40. Nielsen HC, Wiriyathian S, Rosenfeld CR, Leveno K, Garriott JC. Chlorpromazine excretion by the neonate following chronic in utero exposure. Pediatric Pharmacology 3:1-5, 1983.

41. Matsuura S, Naden RP, Gant NF, Jr., Parker CR, Jr., Rosenfeld CR. Effect of hypertonic saline on vascular responses to angiotensin II in pregnancy. Am J Obstet Gynecol 147:231-240, 1983.

42. Rosenfeld CR, Jackson GM. Estrogen-induced refractoriness to the pressor effects of infused angiotensin II. Am J Obstet Gynecol 148:429-435, 1984.

43. Naden RP, Gant NF, Jr., Rosenfeld CR. The pressor response to angiotensin II: The role of peripheral and cardiac responses in pregnant and nonpregnant sheep Am J Obstet Gynecol 148:450-457, 1984.

44. Lasky RE, Tyson JE, Rosenfeld CR, Gant NF. Maternal-infant interactions at one-year of age in a sample of high-risk infants and their controls. Early Human Develop 9:145-152, 1984.

45. Laptook AR, Rosenfeld CR. Chloral hydrate toxicity in a preterm infant. Pediatric Pharmacology 4:161-165, 1984.

46. Engle WD, Rosenfeld CR. Neutropenia in high-risk neonates. J Pediatr 105:982-986, 1984.

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47. Weinberg AG, Rosenfeld CR, Manroe BL, Browne R. The neonatal blood count in health and disease. II. Values for lymphocytes, monocytes, and eosinophils. J Pediatr 106:462-466, 1985.

48. Naden RP, Rosenfeld CR. The role of α-receptors in estrogen-induced vasodilation in nonpregnant sheep. Am J Physiol 248:H339-H344, 1985.

49. Naden RP, Iliya CA, Arant BS, Jr., Gant NF, Jr., Rosenfeld CR. Hemodynamic effects of indomethacin in chronically-instrumented pregnant sheep. Am J Obstet Gynecol 151:484-494, 1985.

50. Laptook AR, Rosenfeld CR. Cerebral vascular responses to tolazoline infusions in the newborn piglet. Early Human Develop 11:81-90, 1985.

51. Naden RP, Coultrup S, Arant BS, Jr., Rosenfeld CR. Metabolic clearance of angiotensin II in pregnant and nonpregnant sheep. Am J Physiol 249:E49-E55, 1985.

52. Resta S, Luby JP, Rosenfeld CR, Siegel JD. Isolation and propagation of a human enteric coronavirus. Science 229:978-981, 1985.

53. Naden RP, Rosenfeld CR. Systemic and uterine responsiveness to angiotensin II and norepinephrine in estrogen-treated nonpregnant sheep. Am J Obstet Gynecol 153:417-425, 1985.

54. Furzan JA, Reisch J, Tyson JE, Laird P, Rosenfeld CR. Risk factors for development of hemodynamically significant patent ductus arteriosus among inborn low-birth-weight infants. Early Human Develop 12:39-48, 1985.

55. Magness RR, Osei-Boaten K, Mitchell MD, Rosenfeld CR. In vitro prostacyclin production by ovine uterine and systemic arteries: Effects of angiotensin II. J Clin Invest 76:2206-2212, 1985.

56. Wiriyathian S, Rosenfeld CR, Arant BS, Jr., Faucher DJ, Porter JC, Engle WD. Urinary arginine vasopressin: Pattern of excretion in the neonatal period. Pediatr Res 20:103-108, 1986.

57. Perales AJ, Naden RP, Laptook, AR, Rosenfeld CR. Fetal responses to maternal infusions of angiotensin II. Am J Obstet Gynecol 154:195-203, 1986.

58. Strickland DM, Guzick DS, Cox K, Gant NF, Rosenfeld CR. The relationship between abortion in the first pregnancy and development of pregnancy-induced hypertension in the subsequent pregnancy. Am J Obstet Gynecol 154:146-148, 1986.

59. Semmler CJ, Lasky RE, Maravilla A, Dowling S, Rosenfeld CR. Brainstem auditory evoked potentials in very-low-birth-weight neonates with intracranial hemorrhage. Early Human Develop 14:9-17, 1986.

60. Leveno KJ, Cunningham FG, Nelson N, Roark M, Williams ML, Guzick D, Dowling S, Rosenfeld CR, Buckley A. Selected versus universal electronic fetal monitoring: A randomized study of 34,995 women. N Engl J Med 315:615-619, 1986.

61. Magness RR, Rosenfeld CR. Systemic and uterine responses to α-adrenergic stimulation in pregnant and nonpregnant ewes. Am J Obstet Gynecol 155:897-904, 1986.

62. Lasky RE, Tyson JE, Rosenfeld CR, Priest M, Allen D, Krasinski D, Digiacomo M, Dowling S, Gant NF. Disappointing follow-up findings for indigent high-risk newborns. Am J Dis Child 141:100-105, 1987.

63. Faucher DJ, Lowe TW, Magness RR, Laptook AR, Porter JC, Rosenfeld CR. Vasopressin and catecholamine secretion during metabolic acidemia in the ovine fetus. Pediatr Res 21:38-43, 1987.

64. John ME, Simpson ER, Carr BR, Magness RR, Rosenfeld CR, Waterman MR, Mason JI. Ontogeny of adrenal hydroxylase: Evidence for cAMP-independent gene expression. Mol Cell Endocrinol 50:263-268, 1987.

65. Parker CR, Hankins GDV, Guzick DS, Rosenfeld CR, MacDonald PC. Ontogeny of unconjugated estriol in fetal blood and the relation of estriol levels at birth to the development of respiratory distress system. Pediatr Res 21:386-390, 1987.

66. Andujo O, Nielsen H, Rosenfeld CR, Snyder JM. Failure to detect a stimulatory effect of estradiol-17β on ovine fetal lung maturation. Pediatr Res 22:145-149, 1987.

67. Guzick DS, Klein VR, Tyson JE, Lasky RE, Gant NF, Rosenfeld CR. Risk factors for the occurrence of pregnancy-induced hypertension. Clin and Exper Hyperten in Preg B6 (2):281-297, 1987.

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68. France JT, Mason JI, Magness RR, Murray BA, Rosenfeld CR. Ovine placental aromatase: Studies of activity levels, kinetic characteristics and effects of aromatase inhibitors. J Steroid Biochemistry 28:155-160, 1987.

69. Faucher DJ, Laptook AR, Parker CR, Porter JC, Rosenfeld CR. Increased fetal secretion of cortisol by arginine vasopressin. Am J Physiol 254:R410-R416, 1988.

70. Tyson JE, Lasky RE, Rosenfeld CR, Dowling S, Gant N, Jr. An analysis of potential biases in the loss of indigent infants to follow-up. Early Human Develop 16:13-25, 1988.

71. France JT, Magness RR, Murray BA, Rosenfeld CR, Mason JI. The regulation of ovine placental steroid 17 α-hydroxylase and aromatase by glucocorticoids. Mol Endocrinol 2:193-199, 1988.

72. Magness RR, Rosenfeld CR. Mechanisms for the attenuated pressor responses to α-agonists in ovine pregnancy. Am J Obstet Gynecol 159:252-261, 1988.

73. Gilstrap LC, Leveno KJ, Cox CM, Burris JS, Mashburn M, Rosenfeld CR. Intrapartum treatment of acute chorioamnionitis: Impact on neonatal sepsis. Am J Obstet Gynecol 159:579-583, 1988.

74. Spitz B, Magness RR, Cox SM, Brown CEL, Rosenfeld CR: "Low-Dose Aspirin": I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in angiotensin II-sensitive pregnant women. Am J Obstet Gynecol 159:1035-1043, 1988.

75. Snyder JM, Kwun JE, O'Brien JA, Rosenfeld CR, Odom MJ. The concentration of the 35-kDa surfactant apoprotein amniotic fluid from normal and diabetic pregnancies. Pediatr Res 24:728-734, 1988.

76. Parker CR, Jr., Hauth JC, Hankins GDV, Leveno K, Rosenfeld CR, Porter JC, MacDonald PC: Endocrine maturation and lung function in premature newborns of diabetic women. Am J Obstet Gynecol 160:657-662, 1989.

77. Annibale DJ, Rosenfeld CR, Kamm KE. Alterations in vascular smooth muscle contractility during ovine pregnancy. Am J Physiol 256:H1282-H1288, 1989.

78. Magness RR, Rosenfeld CR. Local and systemic estradiol-17β: Effects on uterine and systemic vasodilation. Am J Physiol 256:E536-E542, 1989.

79. Mason JI, France JT, Magness RR, Murry BA, Rosenfeld CR. Ovine placental steroid 17α-hydroxylase/C-17, 20-lyase, aromatase and sulfatase in dexamethasone-induced and natural parturition. J Endocrinol 122:351-359, 1989.

80. Rosenfeld CR, Naden RP. Uterine and non-uterine vascular responses to angiotensin II in ovine pregnancy. Am J Physiol 257:H17-H24, 1989.

81. Little BB, Snell LM, Gilstrap LC, Gant NF, Rosenfeld CR. Alcohol abuse during pregnancy: Changes in frequency in a large urban hospital. Obstet Gynecol 74:547-550, 1989.

82. Parker CR, Jr., MacDonald PC, Guzick DS, Porter JC, Rosenfeld CR, Hauth JC. Prolactin levels in umbilical cord blood of human infants: Relation to gestational age, maternal complications and neonatal lung function. Am J Obstet Gynecol 161:795-802, 1989.

83. Wallin LA, Fawcett CP, Rosenfeld CR. Oxytocin stimulates glucagon and insulin secretion in fetal and neonatal sheep. Endocrinology 125:2289-2296, 1989.

84. Tyson JE, Guzick D, Rosenfeld CR, Lasky R, Gant, NF, Jimenez J, Heartwell S. Prenatal care evaluation and cohort analyses. Pediatrics 85:195-204, 1990.

85. Magness RR, Mitchell MD, Rosenfeld CR. Uteroplacental production of eicosanoids in ovine pregnancy. Prostaglandins 39:75-88, 1990.

86. Rosenfeld CR, Laptook AR, Jaishree N. Limited effectiveness of triple dye in preventing colonization with methicillin-resistant staphylococcus aureus in a special care nursery. Pediat Infect Dis 9:290-291, 1990.

87. Yoshimura T, Magness RR, Rosenfeld CR. Angiotensin II and α-agonist I. Responses of ovine fetoplacental vasculature. Am J Physiol 259:H464-H472, 1990.

88. Yoshimura T, Magness RR, Rosenfeld CR. Angiotensin II and α-agonist II. Effects on ovine fetoplacental prostaglandins. Am J Physiol 259:H473-H479, 1990.

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89. Strand C, Laptook AR, Dowling S, Campbell N, Lasky RE, Wallin LA, Maravilla AM, Rosenfeld CR. Changing pattern of periventricular intraventricular hemorrhage in inborn low-birth-weight infants. Early Human Develop 23:117-128, 1990.

90. Wallin LA, Rosenfeld CR, Laptook AR, Maravilla AM, Strand C, Campbell N, Dowling S, Lasky RE. Neonatal intracranial hemorrhage: Risk factor analysis in an inborn population. Early Human Develop 23:129-137, 1990.

91. Annibale DJ, Rosenfeld CR, Stull JT, Kamm KE. Protein content and myosin light chain phosphorylation in uterine arteries during pregnancy. Am J Physiol 259:C484-C489, 1990.

92. Little BB, Snell LM, Rosenfeld CR, Gilstrap LC, Gant NF. Failure to recognize fetal alcohol syndrome in newborn infants. Am J Dis Child 144:1142-1146, 1990.

93. Brown CEL, Gant NF, Cox K, Spitz B, Rosenfeld CR, Magness RR. Low-dose aspirin II. Relationship of angiotensin II pressor responses, circulating eicosanoids and pregnancy outcome. Am J Obstet Gynecol 163:1853-1861, 1990.

94. Yoshimura T, Rosenfeld CR, Magness RR. Angiotensin II and α-agonist: III. In vitro fetal-maternal placental prostaglandins. Am J Physiol 260:E8-E13, 1991.

95. Magness RR, Rosenfeld CR, Carr BR. Protein kinase C in uterine and systemic arteries during the ovarian cycle and pregnancy. Am J Physiol 260:E464-E470, 1991.

96. Ramin SM, Porter JC, Gilstrap LC, Rosenfeld CR. Stress hormones and acid-base status of human fetuses at delivery. J Clin Endocrinol Metab 73:182-186, 1991.

97. Faucher DJ, Laptook AR, Porter JC, Rosenfeld CR. Effects of acute hypercapnia on maternal and fetal release of vasopressin and catecholamines. Pediatr Res 30:368-374, 1991.

98. Mackanjee HR, Shaul PW, Magness RR, Rosenfeld CR. Angiotensin II vascular smooth muscle receptors are not downregulated during ovine pregnancy. Am J Obstet Gynecol 165:1641-1648, 1991.

99. Corbett SS, Rosenfeld CR, Laptook AR, Risser R, Maravilla AM, Dowling S, Lasky RE. Intraobserver and interobserver reliability in the assessment of the cranial ultrasound in very-low-birth-weight infants. Early Human Develop 27:9-17, 1991.

100.Mouzinho A, Rosenfeld CR, Risser R. Symptomatic patent ductus arteriosus in very-low-birth-weight babies. Early Human Develop 27:65-77, 1991.

101.Anyebuno MA, Rosenfeld CR. Chloral hydrate toxicity in a term infant. Develop Pharmacol and Therapeutics 17:116-120, 1991.

102.Snell LM, Little BB, Knoll LA, Johnston WL, Rosenfeld CR, Gant NF. Reliability of birth certificate reporting of congenital anomalies. Am J Perinatology 9:219-222, 1992.

103.Magness RR, Rosenfeld CR, Faucher DJ, Mitchell MD. Uterine prostaglandin production during ovine pregnancy: Effects of angiotensin II and indomethacin. Am J Physiol 263:H188-H197, 1992.

104.Mouzinho A, Rosenfeld CR, Sanchez P, Risser R. Effect of maternal hypertension on neonatal neutropenia and risk of nosocomial infection. Pediatrics 90:430-435, 1992.

105. Dollar ML, Mark MS, Yelderman ML, Quinn MD, McKown RC, Eberhart RC, Rosenfeld CR. Evaluation of a continuous thermodilution cardiac output catheter. ASAIO Journal 38:M351-M356, 1992.

106.Rosenfeld CR, Samson WK, Roy TA, Faucher DJ, Magness RR. Vasoconstrictor-induced secretion of atrial natriuretic peptide in fetal sheep. Am J Physiol 263:E526-E533, 1992.

107.Davis LE, Magness RR, Rosenfeld CR. Role of angiotensin II and α-adrenergic receptors during estrogen-induced vasodilation in ewes. Am J Physiol 263:E837-E843, 1992.

108.Rosenfeld CR, Cox BE, Magness RR, Shaul PW. Ontogeny of angiotensin II vascular smooth muscle receptors in ovine fetal aorta and placental and uterine arteries. Am J Obstet Gynecol 168:1562-92, 1993.

109.Magness RR, Rosenfeld CR. Calcium modulation of endothelium-derived prostacyclin production in ovine pregnancy. Endocrinology 132:2445-2452, 1993.

110.Hernandez C, Little BB, Dax JS, Gilstrap LC, Rosenfeld CR. Prediction of the severity of meconium aspiration syndrome. Am J Obstet Gynecol 169:61-70, 1993.

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111.Cox BE, Ipson MA, Shaul PW, Kamm KE, Rosenfeld CR. Myometrial angiotensin II receptor subtypes change during ovine pregnancy. J Clin Invest 92:2240-2248, 1993.

112.Hoffman DR, Favor S, Uauy R, Rosenfeld CR, Magness RR. Distribution of unsaturated fatty acids in phospholipids of arteries from nonpregnant, pregnant and fetal sheep. Prost Leuk & Essential Fatty Acids 49:907-914, 1993.

113.Magness RR, Parker CR, Rosenfeld CR. Systemic and uterine responses to chronic infusions of estradiol-17β. Am J Physiol 265:E690-E698, 1993.

114.Mouzinho A, Rosenfeld CR, Sanchez PJ, and Risser R. Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates. Pediatrics 94:76-82, 1994.

115.Magness RR, Cox K, Rosenfeld CR, Gant NF. Angiotensin II metabolic clearance rate and pressor responses in nonpregnant and pregnant women. Am J Obstet Gynecol 171:668-679, 1994.

116.Moya FR, Montes HF, Thomas VL, Mouzinho AM, Smith JF, Rosenfeld CR. Surfactant protein A and saturated phosphatidylcholine in respiratory distress syndrome. Am J Resp and Crit Care Med 150:1672-1677, 1994.

117.Rosenfeld CR, Gresores A, Magness RR, Roy TA. Comparison of angiotensin II in fetal and pregnant sheep. Metabolic clearance and vascular sensitivity. Am J Physiol 268:E237-E247, 1995.

118.Tyson JE, Kennedy KA, Broyles S, Rosenfeld CR. The small for gestational age infant: Accelerated or delayed pulmonary maturity? Increased or decreased survival? Pediatrics 95:534-538, 1995.

119.Chern J, Kamm KE, Rosenfeld CR. Smooth muscle myosin heavy chain isoforms are developmentally regulated in male fetal and neonatal sheep. Pediatr Res 38:697-703, 1995.

120.Cox BE, Word RA, Rosenfeld CR. Angiotensin II receptor characteristics and subtype expression in uterine arteries and myometrium during pregnancy. J Clin Endocrinol Metab 81:49-58, 1996.

121.Magness RR, Rosenfeld CR, Hassan A, Shaul PW. Endothelial vasodilator production by uterine and systemic arteries. I. Effects of ANG II on PGI2 and NO in pregnancy. Am J Physiol 270:H1914-H1923, 1996.

122.Cox BE, Rosenfeld CR, Kalinyak JE, Magness RR, Shaul PW. Tissue specific expression of vascular smooth muscle angiotensin II receptor subtypes during ovine pregnancy. Am J Physiol 271: H212-H221, 1996.

123. Ipson MA, Rosenfeld CR, Magness RR, Kamm KE. Alterations in myometrial stress during ovine pregnancy and the puerperium. Am J Physiol 271:R446-R454, 1996.

124.Turley SD, Burns DK, Rosenfeld CR, Dietschy JM. Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep. J Lipid Res 37: 1953-1961, 1996.

125.Rosenfeld CR, Cox BE, Roy T, Magness RR. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 98:2158-2166, 1996.

126.Engle WD, Rosenfeld CR, Mouzinho A, Risser A, Zeray F, Sanchez PJ. Circulating neutrophils in septic preterm neonates: Comparison of two reference ranges. Pediatrics 99:1-6, 1997.

127.Lantin-Hermoso RL, Rosenfeld CR, Yuhanna I, German Z, Chen Z, Shaul PW. Estrogen stimulates nitric oxide synthase activity in ovine fetal pulmonary artery endothelium. Am J Physiol 273:L119-L126, 1997.

128.Kaiser JR, Cox BE, Roy TA, Rosenfeld CR. Differential development of umbilical and systemic arteries: I. ANG II receptor subtype expression, Am J Physiol 274:R797-R807, 1998.

129.Arens Y, Chapados R, Cox BE, Kamm KE, Rosenfeld CR. Differential development of umbilical and systemic arteries: II. Contractile proteins. Am J Physiol 274:R1815-1823, 1998.

130.Cox BE, Rosenfeld CR. Ontogeny of vascular angiotensin II receptor subtype expression in ovine development. Pediatr Res 45:414-424, 1999.

131.Kaiser JR, Rosenfeld CR. A population-based study of congenital diaphragmatic hernia: Impact of associated anomalies and ventilatory parameters on survival. J Pediat Surg 34:1196-1202, 1999.

132.Cox BE, Williams CE, Rosenfeld CR. Angiotensin II indirectly vasoconstricts the ovine uterine circulation. Am J Physiol: Regulatory Integrative Comp Physiol 278:R337-R344, 2000.

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133.Arens HJM, Rosenfeld CR, Kamm KE. Maturational differences between vascular and bladder smooth muscles during ovine development. Am J Physiol: Regulatory Integrative Comp Physiol 278:R1305-R1313, 2000.

134.Salhab WA, Shaul PW, Cox BE, Rosenfeld CR. Regulation of type I and type III nitric oxide synthases by daily and acute estrogen exposure. Am J Physiol: Heart Circ Physiol 278:H2134-H2142, 2000.

135.Rosenfeld CR, White RE, Roy T, Cox BE. Calcium-activated potassium channels and nitric oxide co-regulate estrogen-induced vasodilation. Am J Physiol: Heart Circ Physiol 279:H319-H328, 2000.

136.LeFlore JL, Engle WD, Rosenfeld CR. Determinants of blood pressure regulation and need for blood pressure support in very low birth weight neonates. Early Human Develop 59:37-50, 2000.

137.Arens Y, Kamm KE, Rosenfeld CR. Maturation of ovine uterine smooth muscle during development and the effects of parity. J Soc Gynecol Invest 7:284-90, 2000.

138.Rosenfeld CR, Cornfield DN, Roy T. Ca2+ -activated K+channels modulate basal and E2 -induced rises in uterine blood flow in ovine pregnancy. Am J Physiol: Heart Circ Physiol 281:H22-H31, 2001.

139.Rosenfeld CR. Mechanisms regulating angiotensin II responsiveness by the uteroplacental circulation. Am J Physiol Regulatory Integrative Comp Physiol 281:R1025-R1040, 2001.

140.Velaphi SC, Roy T, DeSpain K, Rosenfeld CR. Differential responses to systemic and local angiotensin II infusions in postnatal sheep. Pediatr Res 52:33-341, 2002.

141.Rosenfeld CR, Roy T, Cox BE. Mechanisms modulating estrogen-induced uterine vasodilation. Vascular Pharmacol 38:115-125, 2002.

142.Rosenfeld CR, Chen C, Roy T, Liu X. Estrogen selectively up-regulates eNOS and nNOS in reproductive arteries by transcriptional mechanisms. J Soc Gynecol Invest 10:205-215, 2003

143.Cox BE, Roy TA, Rosenfeld CR. Angiotensin II mediates uterine vasoconstriction through α-stimulation. Am J Physiol: Heart Circ Physiol 287: H126-H134, 2004

144. Jackson GL, Engle WD, Sendelbach DM, Vedro DA, Josey S, Vinson J, Bryant C, Hahn G, Rosenfeld CR. Are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis? Pediatrics 113:1173-1180, 2004

145.Kaiser JR, Tilford JM, Simpson PM, Salhab WA, Rosenfeld CR. Hospital Survival of Very-Low Birth-Weight Neonates from 1977 to 2000. J Perinatol 24:343-350, 2004.

146.Cox BE, Liu X, Fluharty SJ, Rosenfeld CR. Vessel specific regulation of angiotensin II receptor subtypes during ovine development. Pediatr Res 57: 124-132, 2005.

147.Velaphi SC, Roy T, DeSpain K, Rosenfeld CR. Hemodynamic responses to systemic and hind limb infusions of a-agonist and arginine vasopressin in conscious postnatal sheep. Pediatr Res 58:58-65, 2005.

148.Nagar D, Liu X-t, Rosenfeld CR. Estrogen regulates the β1-subunit of the BKCa channel in uterine vascular smooth muscle. Am J Physiol: Heart Circ Physiol 289: H1417-H1427, 2005. PMID 15923308.

149.Rosenfeld CR, Roy T, DeSpain K, Cox, BE. Large-conductance Ca2+-dependent K+ channels regulate basal uteroplacental blood flow in ovine pregnancy. J Soc Gynecol Investig 12:402-408, 2005. PMID 15979352

150.Koch J, Hensley G, Roy L, Brown S. Ramaciotti C, Rosenfeld CR. Prevalence of Spontaneous Closure of the Ductus Arteriosus in Neonates ≤1000 gm Birth Weight. Pediatrics 117:1113-1121, 2006.

151.Velaphi SC, DeSpain K, Roy T, Rosenfeld CR. The renin-angiotensin system in conscious newborn sheep: metabolic clearance rate and activity. Pediatr Res, 61:681-686, 2007. P,ID 17426651

152.Hutanu C, Cox BE, Liu X-t, DeSpain K, Rosenfeld CR. Vascular development beginning in early ovine gestation: carotid smooth muscle function, phenotype and biochemical markers. Am J Physiol Regulatory Integrative Comp Physiol 293:323-333, 2007. PMID 17475675

153.Dyer JS, Rosenfeld CR, Rice J, Rice MS, Hardin DS. Insulin resistance in Hispanic large-for-gestational-age neonates at birth. J Clin Endocrinol Metab 92:3836-3843, 2007

154.Rosenfeld CR, Zagariya AM, Liu X-t, Willis B, Fluharty S, Vidyasagar D. Meconium increases type 1 angiotensin II receptor expression and alveolar cell death. Pediatr Res 63:251-256, 2008.

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155.Woldesenbet M, Rosenfeld CR, Ramilo O, Johnson-Welch S, Perlman JM. Severe neonatal hypoxic respiratory failure correlates with histologic chorioamnionitis and elevated concentrations of IL-6, IL-8 and CRP. Arch Dis Child Fetal Neonatal Ed. 93:F413-F417, 2008 (Published online Jan 11, 2008).

156.Rosenfeld CR, Word RA, DeSpain K, Liu X-t. Large conductance Ca+2-activated K+ channels contribute to vascular function in nonpregnant human uterine arteries. Reprod Sciences, 15:651-660, 2008. PMCID: PMC2727998. PMID 18836130

157.Duncan AF, Rosenfeld CR, Morgan JS, Ahmad N, Heyne RJ. Inter-rater variability and effect of state on blood pressure measurements in infants at 1-3 years of age. Pediatrics, 22(3):e590-594, 2008.

158.Miao DC, Velaphi SC, Roy T, DeSpain K, Rosenfeld CR. Metabolism and synthesis of arginine vasopressin in conscious newborn sheep. Am J Physiol:Endocrinol Metab, 295(3):E672-677, 2008. PMCID: PMC2536728. PMID 18612043.

159.Cole CR, Hansen NI, Higgins, Ziegler TR, Stoll BJ, for the Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: Incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics, 122(3):e573-82, 2008 (NICHD Network).

160.Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps et al. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med, 359:1885-1896, 2008 (NICHD Network).

161.Vohr BR, Tyson JE, Wright LL, Perritt RL, Poole WK. Maternal age, multiple births and extremely low birth weight infants. J Pediatr, 154:498-503, 2009 (NICHD Network).

162.Rosenfeld CR, Liu X-t, DeSpain K. Pregnancy modifies the large conductance Ca2+-activated K+ channel expression and cGMP-dependent signaling pathway in uterine vascular smooth muscle. Am J Physiol: Heart Circ Physiol. 296: H1878-H1887, 2009. PMCID: PMC2716109. PMID 19470517

163.Bhandari V, Finer NN, Ehrenkranz RA, Saha S, Das A, Walsh MC, Engle WA, VanMeurs KP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes. Pediatrics, 124(2):517-526, 2009 (NICHD Network).

164.Hintz SR, Bann CM, Ambalavanan N, Cotten CM, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predicting time to hospital discharge for extremely preterm infants. Pediatrics, 125(1):e146-54, 2010 (NICHD Network).

165.Oh W, Stevenson DK, Tyson JE, Morris BH, Ahlfors CE, Bender GJ, Wong RJ, Perritt R, Vohrs BR et al. Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants. Acta Paediatrica, 99: 673-678, 2010 (NICHD Network).

166.D’Angio CT, Heyne RJ, O’Shea TM, Schelonka RL, Shankaran S, Duara S, Goldberg RN, Stoll BJ, Van Meurs KP, et al. Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants. Pediatr Infect Dis J, 29:600-606, 2010 (NICHD Network).

167.SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Target ranges of oxygen saturation in extremely preterm infants. NEJM, 362:1959-1969, 2010 (NICHD Network).

168.SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Early CPAP versus surfactant in extremely preterm infants. NEJM, 362:1970-1979, 2010 (NICHD Network).

169.Rich WD, Auten KJ, Gantz MG, Hale EC, Hensman AM, Newman NS, Finer NN and for the NICHD Neonatal Research Network. Antenatal consent in the SUPPORT Trial: Challenges, costs and representative enrollment. Pediatrics, 126: e215-e221, 2010 (NICHD Network).

170.Ramos FG, Rosenfeld CR, Roy L, Koch J, Ramaciotti C. Echocardiographic predictors of a symptomatic patent ductus arteriosus in extremely-low-birth-weight neonates. J Perinatol, 30: 535-539, 2010.

171.Khan L, Rosenfeld CR, Liu X, Magness RR. Regulation of the cGMP-cPKG pathway and large- conductance Ca2+-activated K+ channels uterine arteries during the ovine ovarian cycle. Am J Physiol Endocrin Metabol, 298: E222-E228, 2010. PMCID: PMC2822482. PMID 19920217

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172.Ang JY, Lua JL, Asmar BI, Shankaran S, Heyne RJ, Schelonka RL, Das A, Li L, Jackson DM, Higgins RD, D'Angio CT and for the NICHD Neonatal Research Network. Nasopharyngeal carriage of Streptococcus pneumoniae in very low-birth-weight infants after administration of heptavalent pneumococcal conjugate vaccine. Arch Pediatr Adolesc Med. Dec;164(12):1173-5, 2010 (NICHD Network).

173.Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Laptook AR, Shankaran S, Walsh MC, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Survival and morbidity outcomes for very low birth weight infants with Down syndrome. Pediatrics. 126(6):1132-40, 2010 (NICHD Network).

174.Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, Kennedy KA, Poindexter BB, Finer NN, Ehrenkranz RA, Duara S, Sánchez PJ, O'Shea TM, Goldberg RN, Van Meurs KP, Faix RG, Phelps DL, Frantz ID 3rd, Watterberg KL, Saha S, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 126(3):443-56, 2010 (NICHD Network).

175.Duncan AF, Heyne RJ, Morgan JS, Ahmad N, Rosenfeld CR. Elevated blood pressure in very-low-birth-weight infants in the first 3 years of life. Pediatr Nephrol, 26:1115-1121, 2011.

176.Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, Tyson JE, Goldberg R, Donovan EF, Fanaroff AA, Das A, Poole WK, Walsh M, Higgins RD, Welsh C, Salhab W, Carlo WA, Poindexter B, Stoll BJ, Guillet R, Finer NN, Stevenson DK, Bauer CR and for the NICHD Neonatal Research Network. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. Jul;128(1):e112-20, 2011 (NICHD Network).

177.Laughon MM, Langer JC, Bose CL, Smith PB, Ambalavanan N, Kennedy KA, Stoll BJ, Buchter S, Laptook AR, Ehrenkranz RA, Cotten CM, Wilson-Costello DE, Shankaran S, Van Meurs KP, Davis AS, Gantz MG, Finer NN, Yoder BA, Faix RG, Carlo WA, Schibler KR, Newman NS, Rich W, Das A, Higgins RD, Walsh MC and for the NICHD Neonatal Research Network. Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants. Am J Respir Crit Care Med. Jun 15;183(12):1715-22, 2011 (NICHD Network).

178.Hintz SR, Kendrick DE, Wilson-Costello DE, Das A, Bell EF, Vohr BR, Higgins RD and for the NICHD Neonatal Research Network. Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age. Pediatrics. Jan;127(1):62-70, 2011 (NICHD Network).

179.Ambalavanan N, Walsh M, Bobashev G, Das A, Levine B, Carlo WA, Higgins RD; NICHD Neonatal Research Network. Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants. Pediatrics. Jan;127(1):e106-16, 2011 (NICHD Network).

180.Rosenfeld CR, DeSpain K, Xiao-tie L. Defining the differential sensitivity to norepinephrine and angiotensin II in the ovine uterine vasculature. Am J Physiol Regul,Integrat,Compar Physiol. 302: R59-R67, 2012. PMC Journal – In Process. PMID: 22031783

181.Rosenfeld CR, DeSpain K, Word RA, Liu X-t. Differential sensitivity to angiotensin II and norepinephrine in human uterine arteries. J Clin Endocrinol Metab. 97: 138-147. PMC Journal – Indexed for MedLine. PMID: 22031522

182.Thankavel PP, Rosenfeld CR, Ramaciotti C. Echocardiographic Prediction of Ductus Arteriosus Closure in Neonates ≤30 Weeks of Gestation. J Perinatol, In press.

183.Eckman DM, Gupta R, Rosenfeld CR, Charles SM, Mertz H, Moore LG. Pregnancy increases Myometrial artery pressure-induced constriction via NOS- or COX- independent mechanisms. Am J Physiol-Regul,Integrat,Compar Physiol, In press.

184.Miao D, Roy T, Rosenfeld CR. Mechanisms contributing to blood pressure regulation and angiotensin II- mediated pressor responses in conscious newborn sheep. Pediatr Res, in preparation.

185.Frankfurt JA, Duncan AF, Heyne RJ, Rosenfeld CR. Renal function and systolic blood pressure in very- low-birth-weight infants at 1-3 years of age. Pediatr Nephrol, (DOI) 10.1007/s00467-012-2265-y.

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186.Rosenfeld CR and Roy T. Large Conductance Ca2+-Activated and Voltage-Activated K+ Channels Contribute to the Maintenance of Uterine Vasodilation and Blood Pressure After Estrogen Treatment. Endocrinology, submitted.

MANUSCRIPTS IN PREPARATION:1. Rosenfeld CR, Ramacker F, Liu X-t. Regulation of smoothelin expression in myometrium and bladder

smooth muscle during development and pregnancy.2. Rosenfeld CR, Ramacker F, Liu X-t. Differential expression of smoothelin in vascular and bladder smooth

muscle during development. 3. Brown S, Kamm KE, Liu X-t, Rosenfeld CR. Smooth muscle maturation in ovine ductus arteriosus. 4. Rosenfeld CR, Chen T, Liu X-t, Roy T. Expression and regulation of estrogen receptor subtypes in uterine

endothelium and vascular smooth muscle.5. Rosenfeld CR, Liu X-t, McMillan C. Fetal growth restriction causes precocious alterations in vascular

angiotensin receptor subtype expression. 6. Bomela H, Rosenfeld CR. Prevalence and effects of neonates with congenital anomalies on neonatal care in

the ICU.7. Ennis B, Christy L, Rosenfeld CR. Antenatal steroids down regulate postnatal adrenal function in neonates

<1500 gm birth weight.8. Afolabi F, Salhab W, Ahmad N, Rosenfeld CR. Characterization of nosocomial infection and neutrophil

responses in the neonate. Pediatrics.

TEXTBOOK CHAPTERS: 1. Rosenfeld CR and Fixler DE. Cardiovascular changes and heart disease in pregnancy. In: Clinical

Cardiology (3): The Science and Practice of Clinical Medicine. Willerson JT and Sanders CA, Editors. Grune and Stratton, New York, 1976, pp. 477-482.

2. Rosenfeld CR. The renin-angiotensin system and regulation of uteroplacental blood flow. In: Uterine and Placental Blood Flow. Moawad AH and Lindheimer MD, Editors. Masson Publishing Co., Inc., New York, 1982, pp. 133-138.

3. Rosenfeld CR, Tyson JE, and Engle MD. Neonatology. Therapy in Pediatrics. Stroder J and Eichenwald HF, Editors. The CV Mosby Co., St. Louis, 1985.

4. Rosenfeld CR, Metze H, Fricke G, and Laptook AR. Neonatology. In: Current Therapy in Pediatrics - 2. Eichenwald HF and Stroder J, Editors. BC Decker Incorp. Philadelphia, 1989, Neonatal hypoglycemia pp. 38-40, Periventricular-intraventricular Hemorrhage pp. 46-49, Intrauterine growth retardation pp 50-54, Infant of the drug addict pp. 54-56, Necrotizing enterocolitis pp. 59-62.

5. Magness RR and Rosenfeld CR. Eicosanoids and the regulation of uteroplacental hemodynamics. In: Eicosanoids in Reproduction. MD Mitchell, Editor. CRC Press, Inc., Boca Raton, 1990, pp. 139-162.

6. Rosenfeld CR. Regulation of the Placental Circulation. In: Neonatal and Fetal Medicine - Physiology and Pathophysiology. Polin RA and Fox W, Editors. WB Saunders Co., Philadelphia, 1992, Chapter 5, pp 56-61.

7. Rosenfeld CR, et al. In: Pediatric Therapy - 3rd Edition. Eichenwald HF and Stroder J, Editors. Mosby-Year Book, Inc., St. Louis, 1993. Part Two, Neonatology: Neonatal Hypoglycemia pp 28-30, Periventricular-intraventricular Hemorrhage pp 37-40, Intrauterine Growth Retardation pp 41-44, Infant of the Drug Addict pp 45-47, Necrotizing Enterocolitis, pp 51-53.

8. Magness RR and Rosenfeld CR. Maternal Cardiovascular Alterations during Pregnancy. In: Perinatal and Pediatric Pathophysiology: A clinical Perspective. Gluckman PS and Heymann MA, Editors. Edward Arnold Publisher, London, 1993, pp 532-540.

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9. Rosenfeld CR. Regulation of the Placental Circulation. In: Fetal and Neonatal Physiology, 2nd Edition. Polin RA and Fox WW, Editors. WB Saunders Co., Philadelphia, 1998, Chapter 6, pp70-77.

10. Rosenfeld CR, Regulation of the Placental Circulation, In: Fetal and Neonatal Physiology, 3rd Edition.Edition. Polin RA and Fox WW, Editors. WB Saunders Co., Philadelphia, in preparation.

Polin RA, Fox WW, and Abman SH, Editors. W.B. Saunders Co., Philadelphia, 2004. Chapter 11, pp 97-

103. 11. Rosenfeld CR, Regulation of the Placental Circulation, In: Fetal and Neonatal Physiology, 4th Edition.Edition. Polin RA and Fox WW, Editors. WB Saunders Co., Philadelphia, in preparation.

Polin RA, Fox WW, and Abman SH, Editors. W.B. Saunders Co., Philadelphia, 2004. Chapter 11. In Press.

BOOKS: 1. The Uterine Circulation. Charles R. Rosenfeld, Editor. Perinatology Press. Ithaca, NY, 1989. Chapter VIII

pp 135-156, Chapter XII pp 208-238, and Chapter XIII, pp 239-271.

INVITED PAPERS: 1. Rosenfeld CR. Consideration of the uteroplacental circulation in intrauterine growth. Seminars in

Perinatology 8:42-51, 1984. 2. Rosenfeld CR, Porter JC. Arginine vasopressin in the developing fetus. In: Research in Perinatal

Medicine (IV). Perinatal Endocrinology. Albrecht E and Pepe GJ, Editors. Perinatology Press, Ithaca, NY, pp 91-103, 1985.

3. Lawrence S, Rosenfeld CR. Fetal pulmonary development and abnormalities of amniotic fluid volume. In: Seminars in Perinatal Medicine; Dynamics of Amniotic Fluid in Health and Disease, CR Rosenfeld, Guest Editor. 10(2):142-153, 1986.

4. Rosenfeld CR. Hemodynamically significant patent ductus arteriosus in low-birth-weight infants: Fact or fiction. In: Current Perinatology, Monohar Rathi, Editor. Springer-Verlag, New York, NY, pp 238-246, 1988.

5. Rosenfeld CR. Diagnosis of neonatal infection: Utilization of the absolute neutrophil count. In: Current Perinatology, Monohar Rathi, Editor. Springer-Verlag, New York, NY, pp 146-156, 1988.

6. Lawrence S, Yomens E, Rosenfeld CR. Intrauterine growth retardation: Pediatric Aspects. In: Current Therapy in Neonatal/Perinatal Medicine-2. NM Nelson, Editor. Decker Inc., Philadelphia, PA, pp 285-288, 1990.

7. Magness RR, Rosenfeld CR. Eicosanoids and the regulation of uteroplacental hemodynamics. In: Eicosanoids in Reproduction. Editor: MD Mitchell. CRC Uniscience Series, CRC Press, Inc., Boca Raton, F, pp 139-167, 1990.

8. Gant NF, Spitz B, Magness RR, Cox SM, Rosenfeld CR, and Cox K. The pathophysiology of pregnancy-induced hypertension: Clues from low-dose aspirin therapy. In: The Journal of the Bellevue Obstetrical and Gynecological Society. Editor: JR Snyder. The Bellevue Obstetrical and Gynecological Society, New York, NY, pp 47-52, 1991.

9. Magness RR and Rosenfeld CR. Steroid Control of Blood Vessel Function. In: Steroid Hormones and Uterine Bleeding, Alexander NJ and d'Arcangues C, Editors, American Association for the Advancement of Science, Washington, DC, Chapter 10, pp 107-120, 1992.

10. Rosenfeld CR. Vascular aspects of the renin-angiotensin system in the fetus. In: Local Systems in Reproduction. Serono Foundation Symposia, Magness, RR and Naftolin F (Eds), Raven Press, New York, NY, pp 303-315, 1993.

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11. Rosenfeld CR. Mechanisms controlling uteroplacental blood flow. Kumamoto District Journal of the Japanese Obstetrical and Gynecological Society 38:9-16, 1994.

12. Rosenfeld CR. Blood pressure in low birth weight infants after dexamethasone. Commentary. Eur J Pediatr 152:354-356, 1994.

13. Timmermans PBMWM, Inagami T, Saavedra JM, Ardaillou R, Rosenfeld CR, and Mendelsohn FAO. Angiotensin receptor subtypes and their pharmacology. In: Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990's. AC Cuello and B Collier, eds, Birkhauser Verlag, Basel, Switzerland, pp 37-58, 1995.

14. Rosenfeld CR. The Dilemmas of Managed Care: How does it impact care of the high-risk pregnancy and neonate? American Academy of Pediatrics, Perinatal Section Newsletter, 21:1-2, 1996.

15. Rosenfeld CR. Commentary: The Year Book of Pediatrics, Mosby - Year Book, Publisher, January 2002.

16. Dyer JS, Rosenfeld CR. Metabolic imprinting by prenatal, perinatal and postnatal overnutrition; A review. In Early Life Origins of Adult Diseases. Ed. Hardy DB, Sem Reprod Med 29: 266-276, 2011.

17. Rosenfeld CR. Role of estrogen in the regulation of uterine blood flow. (Reproductive Sciences, In preparation)

CASE REPORTS:1. Kapadia V, Embers D, Wells E, Lemmler M, Rosenfeld CR. Prenatal Closure of the Ductus Arteriosus and

Maternal Ingestion of Anthocyanins. J Perinatol, 30:291-294, 2010.2.

LETTERS:1. Rosenfeld CR. Band neutrophil counts in neonates. J Pediatr 126:504-505, 1995.

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