BiODX - Antimicrobial Technology Presentation
-
Upload
grahampoultney -
Category
Technology
-
view
144 -
download
0
Transcript of BiODX - Antimicrobial Technology Presentation
An industrial biotech company situated in the CSIR Mining Innovation Centre, with over 6 years already dedicated to R&D in conjunction with the Council for Science and Industrial Research (CSIR) to develop sustainable biocides.
Based on the development of DECONT-X, a mild organic biocidal active ingredient, BiODX products have gained popularity due to its non-corrosive properties and non-toxicity surrounding microbial decontamination.
Industrial Formulations
Food and Beverage
Health
Agricultural
Copyright BiODX 2013 All Rights Reserved
Who We Are?
Copyright BiODX 2013 All Rights Reserved
• BiODX’s research was based upon a principal which assumed that triggering an action on sensory parameters of citrus would yield high dosages of biological yield from the target gene.
• BiODX’s innovative processes use the natural enzyme reaction occurring from the time of picking the fruit, where degradation of the antimicrobial component starts as the fruit converts all resources (sugars, bioflavonoids, antimicrobials etc.) in order to stay alive.
• Innovation is also seen in the formation of two active compounds that do not exist in the raw fruit; these two compounds are formed by virtue of the digestion process that converts citric acid and vitamins.
• Formulating preservative into the juice is a stoichiometric reaction. With reference to the formation of vitamin C, a citrus oxidation-reduction system has electron donating and electron accepting properties.
The Technology
Copyright BiODX 2013 All Rights Reserved
Active Citrus Extract
GC (gas chromatography) analysis identified active peak in citrus extract.
Bioflavonoids which is a main component of citrus has previously been reported as having a growth inhibitory effect on bacteria such as colibacillus, Staphylococcus aureus or methicillin-resistant Staphylococcus aureus.
Copyright BiODX 2013 All Rights Reserved
GC (gas chromatography) analysis of DECONT-X showing activity compounds and newly formed sub compounds post digestion.
Stabilised Citrus Extract
The reaction between the citrus extract and QAC is a stoichiometric reaction causing an ion exchange between the two compounds allowing the big molecule (citrus extract) to digest certain sugars and other elements into newly formed compounds.
Copyright BiODX 2013 All Rights Reserved
Regulatory Compliance
Originating in response to pollution laws in the USA, organic chemists use all the tools and training of traditional chemistry to create non-hazardous chemicals and processes
that are "benign by design".
SABS SPECIFICATION NUMBER
DESCRIPTION FDA & EPA (United States of America) Regulation
SANS 636 Disinfectants based on Quaternary Ammonium Compounds
400ppm
SANS 1615 Detergent-Disinfectants based on Glutaraldehyde
400ppm
SANS 1828 Cleaning Chemicals for the Food Industry
400ppm
SANS 1853 Disinfectants and Detergent Disinfectants for use in the Food
Industry
400ppm
SABS MARK Quality Management System ISO Accredited
KOSHER Certification Eco-Friendly Disinfectant
HALAAL Pending
Copyright BiODX 2013 All Rights Reserved
Product Comparative Safety Matrix
Ingredient Toxicity Environmental
ConcernsHandling
Sensory Effect
Corrosion Natural
Alcohols N N Y N N N
Aldehydes Y N N N N N
Paracetic Acid Y N Y Y Y N
Phenols Y Y N Y N N
Hypochlorite Y Y Y N Y N
Hydrogen Peroxide
N N Y N Y N
DECONT-X N Genopole N N N N
Organic chemistry describes a way of carrying out industrial activities from start (design) to finish (production), it is driven by overwhelming consumer demands, regulatory and
economic factors.
Copyright BiODX 2013 All Rights Reserved
BiODX Products VS. Conventional Chemicals
Chlorine, Heavy Metals, Solvents, Paracetic Acid, Caustic Soda, Aldehydes
Conventional 60% Natural 80% Natural
Pollution, effluent fines, corrosive, toxic waste, kills enzymes, damage to the environment
Earth Friendly, biodegradable, non-corrosive, non-toxic, harmless to the environment
Bring innovation to your customers to have differentiation from competition.
Copyright BiODX 2013 All Rights Reserved
About the Product
• All South African
• Earth friendly and fully biodegradable.
• Bactericidal, fungicidal and virucidal.
• Pleasant characteristic fragrance due to citrus content.
• Has characteristic detergent properties.
• Unaffected by ammonia & nitrates.
• Not reactive with organic matter (no THM).
• Fast kill kinetics on both sessile and planktonic bacteria.
Properties of DECONT-X:
Copyright BiODX 2013 All Rights Reserved
• Non-irritant at normal use levels
• Non-carcinogenic
• Non-mutagenic
• Non-embryotoxic
• Non-teratogenic
• Contains no alcohol, formaldehydes or other harmful chemicals.
• Chloride Free - does not generate any induced chemical corrosion regardless
the residence or contact time.
Safety Characteristics
SS
Copyright BiODX 2013 All Rights Reserved
Compatibility, Solubility & Stability
• DECONT-X is miscible with water and polar organic solvents.
• Stable in acid and alkaline pH environments from pH 2 up to pH 11.
• Compatible with a wide range of additives and auxiliary products including
surfactants, flocculants, dispersants, corrosion inhibitors and other biocides.
• In common with other non-oxidising biocides, strong reducing and oxidising
agents should be avoided.
• A potent antimicrobial with broad spectrum activity against Gram negative and
Gram positive bacteria, SRB’s, APB’s, anaerobes, yeasts and fungi.
• Possible anion replacement for stabilization under acid condition.
Copyright BiODX 2013 All Rights Reserved
The “intelligence” of DECONT-X kills 99.9 % of pathogenic micro-organisms & MIC’s (microbials influencing corrosion).
Product Performance
• Escherichia coli sp.
• Pseudomonas sp.
• Staphylococcus sp. + Streptococcus sp.
• Listeria sp.
• Effective against legionella at as low as 30 ppm.
• Black, green & brown moulds (Stachybotrys)
• SRB’s, ARB’s & Anaerobes (MIC’s)
• Remarkably effective against Pseudomonas, Stachybotrys and MIC’s.
Copyright BiODX 2013 All Rights Reserved
Performance on Hard Surfaces
Mic
rob
ial
Co
un
t
The following results show the microbial control obtained at the beginning, during and completion of a 3 month trial.
Copyright BiODX 2013 All Rights Reserved
DECONT-X Benchmarking VS. Conventional Chemicals
The number of internal failures related to MIC and chemical corrosion issues degrease by 80% with the use of DECONT-X.
Am
ou
nt
of
Ba
cter
ia c
fu/m
L
Copyright BiODX 2013 All Rights Reserved
Comparative MIC Agent Corrosion Rates
DECONT-X allows long residence time without generating any induced chemical corrosion and offers a technical alternate to reduce dependency on Glut and THPS.
MPY
Autoclave Corrosion Results on 1018 Steel
Copyright BiODX 2013 All Rights Reserved
• Oil / Petroleum (fuel additive)
• Fracking
• Pulp / Paper Mill Industry
• Water Treatment / Cooling Towers
• Biofilm Control
• Disinfectant Formulation
• Preservation / Coatings / Paint
• Printing Chemicals / Ink
Markets for DECONT-X
BiODX have positioned DECONT-X selectively in these markets where a sustainable biocide will have a competitive advantage due to end-user concerns related to the environment, product performance and toxicity.
Copyright BiODX 2013 All Rights Reserved
Toxicity & Corrosion Matrix
Conventional chemicals as demonstrated pose harmful risks to the labour force promoting absenteeism and corrosive properties leads to equipment damage
resulting in huge financial losses.
Conventional Chemicals
Toxicity /Corrosion
Max Paracetic AcidPhenols
HypochloriteHydrogen Peroxide
Aldehydes
Min
Natural
Sustainable Chemicals
Natural
Health / Financial Losses
Copyright BiODX 2013 All Rights Reserved
Product Advantages
One of many comparative examples of sustainable VS. conventional chemicals as applicable to cooling towers and there affect on water chemistry.
DECONT-X CHLORINE
Unaffected by ammonia & nitrates Affected by ammonia and nitrates
Non-toxic, no health & safety concerns Major health & safety concerns
pH Neutral Affects water pHPerceived as a protein/food - no resistance Bacterial strains can resist it
Non-corrosive Highly corrosive
Outstandingly effective against biofilm No efficacy against biofilm
No reaction to organic matter Produces trihalomethanes / carcinogens
Stand alone product Require extra chemicals
Stable at 5°c to 112°c Unstable
At 15-25 ppm (in water) is cheaper than chlorine Higher costs
Copyright BiODX 2013 All Rights Reserved
Time in Hours
- Control
- DECONT-X
Mic
rob
ial
Lo
ad (
cfu
/cm
2)
Total Bacteria Control in
Cooling Tower Water
The water sample was taken directly from a cooling tower that had undergone standard treatment of a two ton shock treatment of chlorine added every two weeks. The control did not get treated with any additional biocide during the 72 hours.
Copyright BiODX 2013 All Rights Reserved
• Stronger chemical concentrations
• Increased chemical costs
• Increased water / rinse costs
• Increased electricity / heating costs
• Increased process costs
• Increased labour / absenteeism costs
Bacteria do not identify DECONT-X as a poison and therefore do not imitate development of resistance.
Bacterial Resistance
Bacteria learn to acquire immunity to conventional chemicals, which means:
Copyright BiODX 2013 All Rights Reserved
The Knock-On Effect - slide 1 of 2
ConventionalChemicals
Sustainable Products
Sustainable Product VS. Conventional Chemicals
The Knock-on Effect
Water Electricity Effluent Corrosion Absenteeism
Pro
du
ct C
ost
Savings to a companies bottom-line are accrued by using sustainable chemicals, this is the responsibility of the CEO as it influences many knock-on effects.
Copyright BiODX 2013 All Rights Reserved
The Hidden Costs to the Knock-On Effect
slide 2 of 2
Conventional chemicals require heat, rinsing, water chemistry and affect the pH, this mixture of chemicals is harmful to the environment, human health and is
highly corrosive thus affecting the companies bottom-line!
Cost Conventional DECONT-X
Product Cost € 3.00 € 7.50
Electricity € 0.40 € 0.00
Water € 0.20 € 0.00
Effluent € 1.00 € 0.00
Stabilising Chemicals € 2.50 € 0.00
Corrosion € 0.50 € 0.00
Absenteeism € 2.00 € 0.00
Total € 9.60 € 7.50
Copyright BiODX 2013 All Rights Reserved
Marketing green & overcoming green-washing.
Are you Green or Green-washed?
Become an authority!
Copyright BiODX 2013 All Rights Reserved
Drop the Sentiment!
Time for green sentiment to get out of the boardroom!
Tree huggers out!
Green business is about making profits greener – with Industrial Ecology
Bunnies go home!
Copyright BiODX 2013 All Rights Reserved
An economy based on the intelligence of natural systems!
What are we really selling?
Copyright BiODX 2013 All Rights Reserved
Graham Poultney
Tel: 011 358-0052Cell: 082 447 [email protected]
Contact Us
Tel: 011 [email protected]
CSIR – Mining Innovation Centre Building 2Cnr. Carlow & Rustenburg RdMelville, JohannesburgSouth Africa