Biodegradable Poly-d,l-Lactic Acid-Polyethylene Glycol Block Copolymers as a BMP Delivery System for Inducing

Bone

by Naoto Saito, Takao Okada, Hiroshi Horiuchi, Narumichi Murakami, Jun Takahashi, Masashi Nawata, Hiroshi Ota, Shimpei Miyamoto, Kazutoshi Nozaki, and

Kunio Takaoka

J Bone Joint Surg AmVolume 83(1 suppl 2):S92-S98

April 1, 2001

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1: A: Structural formula of poly-d,l-lactic acid homopolymer (PLA). m: number of units.

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1: A: Structural formula of poly-d,l-lactic acid homopolymer (PLA). m: number of units.

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Classification of six types of poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA-PEG) with plastic properties into four groups according to the calculated molecular weight of the PLA

segment and PEG segment.

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3: A and B: A soft radiograph and light micrograph of the new bone formed 3 weeks after implantation in the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000)

implant with 10 g of recombinant human bone morphogenetic protein (...

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3: A and B: A soft radiograph and light micrograph of the new bone formed 3 weeks after implantation in the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000)

implant with 10 g of recombinant human bone morphogenetic protein (...

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4: A and B: The swelling characteristic of the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000) is thought to be beneficial when considering the practical

application of polymer/bone morphogenetic protein (BMP) composites to...

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4: A and B: The swelling characteristic of the poly-d,l-lactic acid-polyethylene glycol block copolymer (PLA6,500-PEG3,000) is thought to be beneficial when considering the practical

application of polymer/bone morphogenetic protein (BMP) composites to...

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.

An example of bone induction on the surface of a block of porous hydroxyapatite (HA) combined with bone morphogenetic protein-2 and the plastic and swelling carrier polymer.

Naoto Saito et al. J Bone Joint Surg Am 2001;83:S92-S98

©2001 by The Journal of Bone and Joint Surgery, Inc.