Adichunchanagiri

Institute of Medical

Sciences

Chief Patron

Paramapoojya

Sri Sri Sri

Nirmalanandanatha

Mahaswamiji

Chief Advisor

Dr. Shivaramu M.G.

Principal A.I.M.S.

Chief Editor

Dr. Aliya Nusrath.

Professor & Head

Dept. of Biochemistry

Editorial Board

Dr. Rajeshwari A.

Assoc. Professor

Dr. Chikkanna D.

Assoc. Professor

Sri. Somashekar G.N.

Asst. Professor

Dr Maithri C.M.

Asst. Professor

Dr. N. Asha Rani

Asst. Professor

Members

Dr. Shilpashree Y.D.

Asst. Professor

Dr. Reshma D.

Asst. Professor

Mrs Rafiya Begum

Tutor

Dr Namitha D.

Tutor cum PG

Contact information:

biomedaims@gmail.com

Biochemistry - Medicine at molecular level

Biomed Dept of Biochemistry

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News letter VOLUME 1 ISSUE 5 JULY 2014

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From Editor’s Desk Greetings

CME Special Issue With great pleasure and pride we are releasing the fifth

issue of Biomed.

Another academic year has come to an end and a new

academic year is at our doorstep presenting with new challenges.

The academic year was highly successful with many research

publications to our credit, innovative teaching methods, student

seminars etc. The most highlighted event of the year was the

successful completion of our debutant State level CME on

“Biochemical Aspects of Cardiovascular Diseases –An

Update” on 11th

February 2014.

We are grateful to our beloved principal for his

encouragement and support and I am extremely thankful to my

team who have given more than cent percent in all our ventures.

We are also grateful to all the delegates from our institute,

various other institutions, medical practitioners, officers and

consultants for their active participation in making this CME a

successful one.

CME inaugration by diginitaries

Sitting from left to right: Mrs Rafiya Begum, Dr N Asha Rani, Dr Chikkanna D, Dr Anita R Bijoor (Guest

Speaker), Dr Aliya Nusrath, Dr Shaheena Banu (Guest Speaker), Dr Rajeshwari A, Dr Sunil kumar S(Guest

Speaker) and Mr Somashekhar GN. Standing from left to right: Dr prathibha K,

Dr Namitha D, Mr Mahalinge Gowda, Mr Krishne Gowda, Mr Mahalinge Gowda, Mr HongereGowda and Mr

ShankereGowda

Summary of the CME The programme started with the functioning of 10 registration counters at 8.30am. The inauguration

of the CME started at 9.30 am at Lecture Hall- 1 AIMS. The dignitaries present on the dais for the

inaugural function were Dr. M G Shivaramu – Principal, AIMS, Dr. Manohar T M – Medical

Superintendent, AH & RC, Dr. Shaheena Banu - Assoc Prof & HOD, Dept of Biochemistry, Sri

Jayadeva institute of Cardiovascular Sciences and Research, Dr. Anita R Bijoor - Prof & HOD, St

Johns Medical College, Dr. Sunil Kumar S – Assoc Prof, JSS Medical College and hospital, Dr.

Vijay Shankar Assoc Prof , Dept of Pathology, KMC Observer, Dr. Aliya Nusrath- Prof & HOD,

Dept of Biochemistry, Organizing Chairman

The function began with the invocation song by Ms Ashwini, MBBS Student. Welcome address

was given by Dr. Aliya Nusrath, Organizing Chairman. The dignitaries on the dais were felicitated.

Inauguration was done by lighting of the lamp by all the dignitaries. Dr. M G Shivaramu, Principal, AIMS chief guest of the function addressed the gathering. Following the inauguration scientific

session started at 10.30 am with the following topics delivered by the guest speakers.

Topic :- Biomarkers in Ischemic Heart Disease and Heart Failure

Speaker :- Dr. Shaheena B, Associate Professor & HOD, Dept of Biochemistry, Sri Jayadeva

Institute of Cardiology, Bengaluru.

Topic :- Markers of Acute Coronary Syndrome

Speaker :- Dr. Anita R Bijoor, Prof & HOD, Dept of Biochemistry, St. John’s Medical College,

Bengaluru.

Topic :- Vascular Biology and Cardiovascular Risk Factors

Speaker :- Dr. Sunil Kumar S , Associate Prof, Consultant Interventional Cardiologist, JSS

Medical College & Hospital , Mysore.

Topic :- Guidelines for the use of Biochemical Cardiac Markers and Risk Factors

Speaker :- Dr. Anita R Bijoor, Prof & HOD, Dept of Biochemistry, St. John’s Medical College,

Bengaluru. The session ended at 4.40 pm. CME programme was concluded by valedictory note.

Vote of thanks was delivered by Dr Rajeshwari Associate Professor, Dept of Biochemistry, AIMS.

Certificate were issued from 5.00 pm onwards.

Procalcitonin Procalcitonin (PCT) is a well-established biomarker for the diagnosis of sepsis. PCT reflects

the severity of bacterial infection and is in particular used to monitor progression of infection into

sepsis or septic shock, infectious diseases like pneumonia, bacterial meningitis and malaria It is

used to measure the activity of the systemic inflammatory response, in therapy and prognosis.

Experimental data have shown that PCT plays an important role during monocyte adhesion and

migration, and further has a stimulatory effect on inducible nitric oxide synthase gene expression in

patients with sepsis, representing key features of the atherosclerotic process. Studies have been

done on the impact of PCT on cardiovascular prognosis and levels were found to correlate with the

extent of atherosclerosis and were even associated with an adverse outcome.

Dr Reshma D, Asst. Professor, Dept. Of Biochemistry

Oxidative stress: Can it be the sole cause for disease progression Oxidative stress is the imbalance between free radical generation and scavenging of the

same in the body. Reactive oxygen species is a term used to define molecules with no free electron

but is very reactive, example hydrogen peroxide, nitric oxide, hypochlorous acid. In cardiovascular

disease oxidation of LDL in presence of several reactive oxygen species is known. This oxidative

modification of LDL is known to be a feature of atherosclerotic process. In diabetes mellitus,

hyperglycemia, atherogenic lipoproteins and advanced glycation end products are linked to

oxidative stress. Increased insulin level causes increased oxidative stress in response to which

recruitment of peroxisomes in hypothalamus will make neurons less susceptible to high levels of

circulating leptins. Regular exercise, healthy dietary habits and no alcohol and tobacco

consumption have been shown to reduce oxidative stress in healthy individuals and also help to

maintain blood glucose levels in diabetic individuals. Treatment with antioxidants have not shown

promising results after the onset of disease but healthy life style keeps in check oxidative stress can

surely help to prevent onset of disease

Mrs Rafiya Begum.Tutor, Dept. Of Biochemistry

FetuinA : A Novel marker for Type 2 Diabetes Mellitus Fetuin, a binding protein synthesized in the liver and is secreted into the bloodstream. It is

more abundantly found in fetal blood, hence the name "fetuin". It’s α2- HS glycoprotein (α2-

Heremans-Schmid glycoprotein) which plays an important role in vascular calcification, regulation

of bone metabolism, insulin resistance, protease activity control, keratinocytes migration, and

breast tumor cell proliferative signaling. Fetuin-A has also been identified as a biomarker for

neurodegenerative disease. Normal range is 0.5 – 1.5 g/L. Higher levels of Fetuin-A levels is found

in conditions of insulin deficiency and insulin resistance. Higher levels of Fetuin-A is associated

with incident diabetes mellitus in older persons regardless of sex, race, or prevalent cardiovascular

disease status. Dr Shilpashree Y D. Asst. Professor, Dept. Of Biochemistry

Research is to see what everybody else has seen, and to think what nobody else has thought.

Albert Szent-Gyorgyi.

Proud to present our debutant CME on 11th February 2014 few glimpses

Other Important Events - Two new staff Dr. Shilpa Y.D, Asst. Professor and Dr. Reshma D, Asst. Professor joined

our department. We extend them, a warm welcome to our family of Biochemistry.

- A student seminar was conducted on Heme Metabolism and Jaundice on 30th

April 2014.

- 05 original scientific papers were published in International journals in last six months

Hearty Congratulations

1. Our staff Dr. Chikkanna D is promoted as Associate

Professor. He is serving the institution since 1987. He is

also the warden for Boys Hostel. Congratulations Sir.

2. Our Post Graduate Dr. Prathibha K passed out with

excellent score of 70%. Hearty congratulations.

Dr Chikkanna D Dr PrathibhaK