Introduction to Biochemistry Andy Howard Biochemistry, Spring 2008 IIT.
Biochemistry
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Transcript of Biochemistry
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BiochemistryBio I HonorsRupp
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WaterTwo hydrogens and
one oxygen bonded covalently
Electrons are not shared equally—oxygen is very electronegative
The uneven charge is known as polarity◦ Oxygen is negative◦ Hydrogens are
positive
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PolarityThe uneven
charge of water is what makes it good at dissolving other substances◦ Sugars◦ Proteins◦ Ionic compounds
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Water’s Physical PropertiesHigh surface
tensionHigh specific heatCohesion
◦ Attractive force between particles that are the same
Adhesion◦ Attractive force
between unlike particles
CapillarityUniversal solventNeutral pHHydrogen
bonding
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Water’s Physical Properties
Surface tension Cohesion
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Water’s Physical Properties
Adhesion Hydrogen bonds
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Carbon CompoundsCarbon has four outer electronsCarbon can form how many bonds?Types of bonds
◦Single◦Double◦Triple
Structures◦Straight chains◦Branched◦Rings
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Carbon Structure
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Carbon Structure
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Functional GroupsGroup Name Group Structure
Alcohol -OH
Aldehyde -CHO
Ketone -CO
Carboxylic acid -COOH
Amine -NH2
Phosphate -PO4
Sulfhydryl -SH
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PolymersMacromolecules or polymers are built
from single units called monomersDehydration synthesis or condensation
reaction joins two monomers◦Water is lost◦Building
Hydrolysis reactions break apart polymers into monomers◦Water is added◦Breaking
Energy used for both processes—ATP
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Dehydration Synthesis vs. Hydrolysis
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CarbohydratesComposed of
carbon, hydrogen, and oxygen
Sugars ◦ Monosaccharides◦ Disaccharides◦ Polysaccharides
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MonosaccharidesBasic formula is
C6H12O6Triose—3
carbonsPentose—5
carbonsHexose—6
carbons
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DisaccharidesBasic formula is
C12H22O11Two monosaccharides
have been linked and a water lost
The bond holding the sugars together is a glycosidic bond
Isomers—same chemical formula with different structures
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Polysaccharides
Storage Structural
StarchSimplest starch is
amylose, which is found in plants
Amylopectin is more complex with more branches
Glycogen is a highly branched animal starch
Cellulose and chitinCellulose is the most
abundant organic compound on Earth
Chitin is found in shells of crustaceans and insects
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Proteins Made of carbon,
hydrogen, and nitrogen
Monomers are amino acids linked through dehydration synthesis
Essential amino acids—need to be consumed because your body cannot make them
Lysine and tryptophan are two amino acids
Poorly represented in vegetarian diets
Lysine is found in chicken, turkey, potatoes, cheese, soy, eggs, milk, fish, and beef
Tryptophan is found in almonds, cabbage, kidney beans, lima beans, oats, pistachios, poppy seeds, spinach, and wheat
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Proteins con’t. Peptide bond is
the bond between amino acids
Many amino acids means many peptide bonds, hence proteins are referred to as polypeptides
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Proteins con’t.What are proteins good for?
◦Structural support◦Storage of food sources◦Transport proteins◦Hormones◦Antibodies◦Enzymes
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Proteins con’t.Different protein
shapes◦ Globular◦ Fibrous◦ Membranous
Enzymes◦ Special proteins
that speed up reactions; biological catalysts
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LipidsFatty acid chains
—referred to as acids because of the carboxylic acid functional group
Two subgroups◦ Saturated◦ Unsaturated
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Lipids con’t.
Saturated Unsaturated
Solid at room temperature
Found mostly in animals
No double bonds between carbons
Liquid at room temperature
Found mostly in plants
Double bonds between carbons
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Lipids con’t.Trans fatty acids
—also known as partially hydrogenated fats (check food labels)◦ Not good for you◦ Manufactured to
have more taste than unsaturated fatty acids
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Omega 3 Fatty Acids—Good LipidsHelp in cell
membrane formation—keeps them flexible
Deficiencies linked to:◦ Decreased mental
ability◦ Poor vision◦ Increased blood clots◦ Diminished immune
function◦ High blood pressure◦ Learning disorders◦ Growth retardation
Found in:◦ Walnuts◦ Pumpkin seeds◦ Brazil nuts◦ Avocados◦ Spinach◦ Collard greens◦ Salmon◦ Mackerel◦ Albacore tuna
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Omega 6 Fatty Acids—Good Lipids Help improve:
◦ Diabetic neuropathy
◦ Rheumatoid arthritis
◦ PMS◦ Skin disorders
such as psoriasis and eczema
Found in:◦ Grapeseed oil◦ Pumpkin seeds◦ Pinenuts◦ Pistachios◦ Raw sunflower
seeds◦ Olives◦ Chicken
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PhospholipidsVery similar to
fatty acids except there is a phosphate group attached
Polar phosphate group and non-polar fatty acids
Found in cell membranes
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WaxesA type of
structural lipidHighly waterproof
◦ Found on plant leaves to prevent water loss
◦ Also found on animals as a protective layer against microorganisms, Ex., earwax
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Nucleic AcidsDNA—deoxyribonucleic acid
◦ “deoxy” implies a certain sugar typeRNA—ribonucleic acid
◦ “ribo” implies a certain sugar typeBoth are composed of thousands of
monomers called nucleotidesThree parts to each
◦ Phosphate◦ Sugar◦ Nitrogenous base
Monomers are connected by phosphodiester bonds
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Nucleic Acids con’t.
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Nucleic Acids con’t.