Bioassay with cultured ganglia. Transport of NGF.

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Bioassay with cultured ganglia

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Transcript of Bioassay with cultured ganglia. Transport of NGF.

Page 1: Bioassay with cultured ganglia. Transport of NGF.

Bioassay with cultured ganglia

Page 2: Bioassay with cultured ganglia. Transport of NGF.

Transport of NGF

Page 3: Bioassay with cultured ganglia. Transport of NGF.

Structure of neurotrophins

Page 4: Bioassay with cultured ganglia. Transport of NGF.

Structure of neurotrophin receptors

Page 5: Bioassay with cultured ganglia. Transport of NGF.

Neurotrophin receptor specificity

Page 6: Bioassay with cultured ganglia. Transport of NGF.

Tyrosine kinaseReceptor activation:

Page 7: Bioassay with cultured ganglia. Transport of NGF.

Tyrosine kinaseReceptor activation:

Page 8: Bioassay with cultured ganglia. Transport of NGF.

Distribution of brain neurotrophins

Page 9: Bioassay with cultured ganglia. Transport of NGF.

SignalingPathways:

Page 10: Bioassay with cultured ganglia. Transport of NGF.

MAP kinase cascade:

Page 11: Bioassay with cultured ganglia. Transport of NGF.

“Caretaker” neurotrophins during outgrowth

Page 12: Bioassay with cultured ganglia. Transport of NGF.

Growth factors in the CNS

Page 13: Bioassay with cultured ganglia. Transport of NGF.

Depolarization and Ca influx enhances growth

factor expression

Page 14: Bioassay with cultured ganglia. Transport of NGF.

Diffusible factor from mouse sarcoma

Page 15: Bioassay with cultured ganglia. Transport of NGF.

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