The Benefits of Calorie RestrictionbenaGene contains a key intermediate in the Kreb's cycle which has beenshown to mimic the beneficial effects of a caloric restriction diet. Caloricrestriction has been associated with an increased average and maximallife span in several species, along with reductions in weight and glucoselevels.

Longevity GenesThe benefits of caloric restriction involve the increased expression oflongevity genes. benaGene has been shown to mimic the changes inexpression of over 350 genes in a similar fashion to caloric restriction. Italso increases the conversion of the cellular factor NADH to its oxidizedform NAD. NAD is critical to producing cellular energy, and stimulatesthese beneficial genes while NADH inhibits them.

Extended Health, Extended LifeThe genetic shifts mediated by beneGene help to delay the onset orreduce the incidence of several age-related diseases including cancer,diabetes, cardiovascular disease and neurological disease. Human trialshave found that benaGene reduces glucose levels and improves glucoseuptake. benaGene is formulated to be very stable and easily absorbedby the body, improving chances for a long and healthy life.

Life and HealthExtension

• Mimics a caloric restriction diet• Increases expression of longevity genes

• Reduces glucose levels• Helps reduce the incidence of age-

related disease

benaGene™

30 v-caps

Serving Size: 1 CapsulebenaGene™ 100 mg(3-carboxy-3-oxopropanoic acid)

Key Features: Calorie restriction mimetic

Suggested Use: One capsule daily with food or asdirected by a qualified healthpractitioner.

Main Indications: Life extension

Cautions: Do not use during pregnancy andlactation.

Source:Pharmaceutical Synthesis

Complementary Products: Acta Resveratrol, Benfotiamine,Carnosine

www.aor.caAdvancedOrthomolecular Research

Innovative Research& Scientific Integrity

AOR™ 3900 – 12th Street NE, Calgary, AB T2E 8H9

While aging can never be stopped, life extension is a realistic goal and a proven physiologicphenomenon in diverse organisms through various interventions.

There are several ways of extending life span but the key is to match the gain in years with acorresponding increase in vigour and vitality. In other words, adding years to life has to beconcurrent with adding life to years, ideally increasing both maximal life span and health span. Thelatter can be assessed by monitoring various disease-risk markers such as lowered blood glucoselevels, reactive oxygen and nitrogen species, lipid markers, age-amadori adducts, and differentinflammatory markers.

The process of aging has been ascribed to various mechanisms including: increased metabolismand thus increased production of reactive oxygen species, reduction of apoptosis (or programmedcell death), increased glucose/insulin, effect of longevity genes, and others.

Caloric restriction optimal nutrition (CRON) extends life and health span in a wide variety oforganisms and has been shown to delay the onset or reduce the incidence of many age-relateddiseases, including cancers, diabetes, cardiovascular diseases and neurological diseases (includingParkinson's and Alzheimer's). Furthermore, a significant improvement in various disease riskparameters has been conclusively shown in humans.

Thanks to the pioneering work of professors Leonard P. Guarente (of the Massachusetts Institute ofTechnology) and David A. Sinclair (of Harvard University), research has revealed that certainlongevity genes are activated during caloric restriction. Moreover, their work showed that this effectwas evident at any age; in other words, life extension could be achieved in older age groups as well.Gurante and other researchers believe that this effect may be related to the critical ratio of theubiquitous co-enzymes NAD+ (the oxidized form of NAD, or nicotinamide adenine dinucleotide)and its reduced form NADH. NAD is a niacin-derived coenzyme that is present in all living cells andis critical to the production of ATP - the body's primary source of all immediate energy. Higher NAD+levels are thought to have a stimulatory effect on the beneficial genes whilst a high NADHconcentration is thought to inhibit such genes. Hence a high NAD+/NADH ratio may prolong lifeand health span.

benaGene™ is a novel caloric restriction mimetic (CR mimetic). It mimics the changes in theexpression of over 350 genes in a similar fashion to caloric restriction and thus may be considereda true nutrigenomic compound. The resulting (and astonishing) increases in average and maximallife span, reduction in weight, and reduction in glucose levels have been observed in various species.

Human clinical trials have confirmed both reduction in glucose levels and an improved uptake ofglucose without negative side effects (and hence an effective hypoglycaemic agent). benaGene™works on a "biological diode" thereby increasing the conversion of NADH to NAD+ as well as onresulting changes in the electrical state and critical signaling molecules.

benaGene™ is the world's first novel and natural Krebs cycle intermediate compound that isspecifically formulated to be highly stable and bio-available so that a one-a-day dosage is all thatis required, offering the potential of life and health extension.

benaGene™

www.aor.caAdvancedOrthomolecular Research

Innovative Research& Scientific Integrity

AOR™ 3900 – 12th Street NE, Calgary, AB T2E 8H9