*04BIBLIOGRAPHY

O F

GERMFREE RESEARCH

1885-1963

M96 SUPPLAEM

BA. TEAH

Reproduced by the

for Federal Scientific & TechnicalInformaion Springfield VIa. 22151

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Best Available COPY

1966 SUPPLEMENT

BIBLIOGRAPHY

OF

GERMFREE RESEARCH*By

B. A. TEAHLobund Laboratory-

University of Notre Dcame

Notre Dame, Indiana

%Ppcdetd by funds from the Office of Ncivcai peea

Gr~zt No. N ONR 1823(15)

9 ~cop~yrqht 1967

I

I

To

JAMES A. REYNIERS

Tke outstanding pioneer in tke development of ihe germfree technique.

Tke fruits of his jorisigkt and efforts are attested herein and

previous bibliographies. May I simply say tkank you.

ta-.,-

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1. Abrams, 0. D.: "Symposium on rtcent advances !n germfre animal s-pea-:mentatlon." Amer. Inst. Biol. Scd., 1963 (Abe).

2. Abrams, G. D. and Bishop, J. E.: Effect of the normal microbial flora onthe resistance of the small intestine to infection. J. Bact., 92:1604, 1966.

. Abstracts of Symposium on Gnotoblotic Research, UniverWity of NotreDame, Notre Damm, Indiana, 1966.

4. Araujo, W. C.: Experimental dental caries In aseptic, gnotobioUc andnormal animas. (Por.) Rev. Brazil Odont, 25:275, 1966.

5. Ash, W. K.: R-,t submaxillar ghnd (RSMG) virus hemagglutinin andanti-hemagglutinin in gnotobiotic and convenhonal rats. Fed. Proc.,23:615, 1966 (Abs.).

6. Asofsky, R., Ikarl, N.S. and Hylton, M.B.: Immunoglobulln syntheis inimmunized germfree mice. Fed. Proc., 25:547, 1W6 (Abs.).

7. Auerbach, R., The development of immunity in tissue culture. Ann. N.Y.Acad. QcL, 139:270, 1966.

8. Axenlc cultures and defined media. Ann. N.Y. Acad. Set., 139, 272 pg.,1966.

9. Azar, M. M.: Termination of tolerance to human gamma globulin usinga related globulin. Fed. Proc., 25:473, 1966.

10. Baer, P. N. and Fitzgerald, F. J.: Periodontal disease in the 18-month-oldgermfree rat. J. Dental Res., 45:406, 1966.

11. Baker, D. E. J.: The commercial production of mice with a specifled flora.Nat. Cancer Inst Mono. No. 20, Viruses of Lab. Rodents, p. 161, 1966.

.12. Baker, D. E. J.: The influence of cage environment and diet upon mouseproductivity. 17th Ann. Animal Care Panel Meetg., Chicago, Illinois, 1968(Abs. No. 55).

13. Balish, E. and Phillips, A. W.: Growth and virulence of Candida albicansafter oral inoculation in the chick with a monoflora of either Escherichlacoil or Streptococcus faecal J. Bact., 91:1744, 1966.

14. Balish, E. and Phillips, A. W.: Growth, morphogenesisn, and virulence ofCandida albicans after oral inoculation in the germfree and conventionalchick. J. Bact., 91:1736, 1966.

15. Barry, T. A., Silber, R. IL and Wilson, R.: A bioassay for !xcterial endo-toxins based on the induction of hypcferremia in rodents. Fed. Proc., 25:733, 1966 (Abs.).

16. Bauer, H., Paronetto, F., Burns, W. and Einheber, A.: The enhancingeffect of the microbial flora on macrophage function and the immune re-sponse. J. Lxp. Med., 123:1013, 1966.

17. Bealmear, P. M.: Comparative study of tWe thymus of germfree and con-ventional CFW mice. PhD. Thesis, University of Notre Dame, NotreDame, Indiana, 1965.

18. Bealnear, P. M. and Wilson, R.: Histological comparison of the thymusof germ-free (axenic) and conventional CFW mice. Anat. Rec., 1":261,1966.

19. Beck, W. S. and Frey, L. 0.: Part II. The surgeon views contaminationcontrol. Contamination Control, V:13, 1966.

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20. van Bekkuni V W., de Vries, M. J. and van der WaaiJ, D.: Secondarydisease in germfree heterologous radiation chlmeras. Radloblological LUtTNO. Ann- Report for 198, p.40.

21. Bengson M. H. and Thomae, F. W.: Gnotobiotic implications of spacetravel. In Symp. IX Intc:. Congr. Microblol., Moscow, July 1966.

22. Bengson. M. H. and Thcmae, F. W.: In future cosmic fUghts (Rus.) Na-ture, 113:29, 1966.

23. Berkley, C.: Potentials for automatic control methods In defined mediastudies. Ann. N.Y. Acad. ScL, 139:234, 1966.

24. FX rntzen, A. K.: A controlled "'ulture environment for axenic growth ofparasites. Ann. N. Y. Acad. Sc., 139:175, 1966.

25. Betts, A. 0., Lamont, P. H. and Kelly, D. F.: Porcine enteroviruses otherthan the virus of Teschen disease. Ann. N. Y. Acad. ScL, 101:428, 1962.

26. Bornside, G. H. and Cohn, I.: Tne normal microbial flora: Comparativebacterial flora of anLals and man. Amer. J. Dig. Dis., 10:844, 1965.

27. Bosma, M. J., Makinodan, T. and Walburg, H. E.: A comparative st.dyof the immune potential of germfree and conventional mice. Fed. Proc.,25:547, 1966 (Abs.).

28. Brick, J. 0., Serrano, L. J. and Ensor, N.L.: Variation in breeding prcduc-tion among colonies of RFM mice under conditions of germfree, barrier,SPF, and convenftional housing. 17th Ann. Animal Care Panel Meetg.,Chicago, Illinois, 1966 (Abs. No. 92).

29. Brody, GI., Bishop, J. E. and Abrams, G. D.: Normal flora and collagenproduction. Arch. Path., 81:263, 1966.

30. Bryant, J. C.: Mammalian cells In chemically defined media in suspensioncultures. Ann. N.Y. Acad. Sc., 139:143, 1966.

31. Camden, R. W., Poole, C. M. and Flynn R. J.: Medroxyprogesterone ace-tate to delay labor in gravid mice and resulting effect on reproductiveability in cesarean-derived progeny. 17th Ann. Anila Care Panel Meetg.,Chicago, Illinois, 1966 (Abs. No. 74).

32. Carter, D.: Intestinal scihemic shock in germfree animals. Surg. Gynec.Obstet., 122:68, 1966.

33. Carter, D., Einheber, A. and Bauer, H.: The role of the microbial flora inuremia. I. Uremic colitis, cardiovascular lesions, and biochemical observ-ations. J. Ex. Med., 123:251, 1966.

4. Casey, R. H.: Can the SPF program benefit from a central testing sta-tion? Proc. George A- Young Conf. Vetcr. Adv. Swine Repopulatlon andNebr. Sixth Ann. SPF Swine Conf., Lincoln, Nebraska, p.11, 1966.

35. Caster, P., Garner, R. and Luckey, T.D.: Antigen-induced morphologicalchanges in germfree mice. Nature, 209:1202, 1966.

36. Christie, R. J., Johnson. D. J. and Whitney. R, A.: Techniques used in theestablishment of a deitned-flora mouse breeding colony. 17Wh Ann. AnimalCare Panel Meetg., Chicago, Illinois, 1966 (Abs. 68).

37. Cohn, I. and Bornslde, G. IL: Imbalance of the normal microbial flora:Influence of strangulation obstruction upon the bacterial ecology of thesmall intestine. Amer. J. Dig. Dis., 10:873, 1965.

38. Combs, E. and Sacquet, E.: Influence de l'etat axenique sur divers com-poses azotes contenus dams le caecum de rats albinos recevant des quan-tites variables de proteines. (Fr.) C.R. Acad. Sc., Paris, 262:685, 1968.

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39. Connell, M. S. J.: Response of x-lrradiated germfree CFW and C3H miceto treatment with isologous and homologous bone marrow. J. Exp. Hem-atol., 8:3, 1965.

40. Counce, S. 3.: Culture of insect embryos in vitro. An=. N.Y. Acad. Scd.139:65, 1966.

41. Coupe, R. E., Welch, L. C., Olson, K. C. and Nippert, L. E.: Annual SPFreport and reckgnition of outstanding producers. Proc. George A. YoungCon!. Veter. Adv. Swine Repopulatlon and Nebr. Sixth An&. SPF SwineCon!., Lincoln, Nebraska, p. 14, 1960.

42. Cumming, E. L. W., Cumnming, C. N. W.: Carworth quarterly letter. No.

43. Curt'as, P- Jones, R. T., Allen, R. C. and Harris, P. E.: Geneticallymarked Eso.,hertchla coil strains for studies on intestinal flora in mice.Bact. Proc., p. 38, 1966.

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44. Dalbow, M. H., Crosby, R. C. and Thonard, 3. C.: Splenic stimulation inaxenic mice following intra-gingival injection of endotoxin. Intern. Assoc.Dental Res., 44th Gen. Meetg., Miami Beach, Florida, 1960 (Abe.).

45. Damn, R. and Norris, L. C.: Studies of the effect of some antibacterial andantifungal agents on growth and egg production of chickens. PoultrySci., 41:78, 1962.

46. Dardas, G. F. and Smith, C. K.: Serum protein studies in germfree andconventional chickens. Symp. Gnotobiotic Res., Unlevralty of Notre Dame,Notre Dame, Indiana, p. 23, 1966 (Abs.).

47. Del Favero, J. E. and Farrell, R. L.: Experimental histoplasmosis in gno-tobiotic dogs. Amer. 1. Veter. Res., 27:60, 1966.

48. Dielachnieder. W.: Role of the national SPF accrediting agency. Proc.George A. Young Con!. Veter. Adv. Swine Repopualatk~n and Nebr. SixthAnn. SPF Swine Con!., Lincoln, Nebraska, p.22, 1966.

4 49. Dobbelaar, M. J. and van der Gulden, W. J. I.: De dierenarts en het dier-experirnent III. Tijdscltr. Diergeneesk., Nederl., 89:15, 1964.

50. Dolowy, W. C. and Cooper, M. R.: Cost analyses of production of germ-free chickens and guinea pigs. Proc. Animal Care Panel, 12:196, 1962(Abs.).

51. Downey, R. J. and Pisano, J. C.: A pbagocytosls-promoting globulin from134 inflammatory exudate. Life Sd., Pergamon Press, Great Britain, 5:1325,

1966

52. Downey, R. 3. and Pisano, J.C.: Effect of bacitracin on In. vitro phagocy-tosis. Nature, 210:654, 1966.

53. Downey, R. J. and Pisano, J. C.: Incorporation of acetate-C1 , to cellu-lar lipid du-ing phagocytosis. Fed. Proc., 25:538, 1966 (Abs.).

54. Dropkin, V. H.: Physiology of nematodes of the soil. Ann. N.Y. Acad. Sci.,139:39, 1966.

55. Dubos, R.: Adaptability for survival and growth. Values and Ideals ofAmerican Youth. (Eli Ginzberg, ed.) Columbia University Press, New

58. Dubos, FL: Environmental biology. BioScL, 14:11, 1V A.

57. Dubos, FL: Man and his envirornment-biornedical knowledge and socialaction. Perspectives in Bio. and Med., IXK:523, 1966.

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58. Daicluzeau. R_ Raibaud, P. and Dickinzon, A.B.: Hydrolyse de l'uree envitro et en vivo dans le caecum de rats gnotobiouqv !s, par differentessouches bacterlennes isolees du tube digestif de rats c'onventionneI& (Fr.7 )C.,I. Acad. Sci., Paris, 282:944, 1H6.

59. Dupont,. 3. RL, Jervis, H. R. and Sprinz, H.: Auerbach's plexus of the ratcecurn in i-elation to the germfree state. J. Comp. Neurol., 125:11, 198.

80. Durbin. C. G.: Comparative toxicology and current research needs in agri-culture and medicine. Ann. N.Y. Acad. Scd., 139:6, 1963.

81. Dymsza, H. A., Stoewsand, G. S., Enright, 3. 3. and Amnent, D.: Diet andintestinal microflora interrelationships in the gnotobiotlc rat. Fed. Proc.,2,5:482, 1966 (A~ls.).

62. Dymsza, H. A., Stoewsand, G. S., Enright, 3. 3., Trexler, P. C. and Gall,L C.: Human indigernous microilora !n gnotobiotic rats. Nature, M0:1236,19435.

63. Dynisza, H. A., Stoewsand, G. S., Enright J. J. and Trexier, P. C.: Inter-relationship between diet and Intestinal microflora in gnotobiotes. Abs.Papers, VII Int. Congr. Nutr., Hamburg, Pergaxnon Press, 1966.

64. Dymsza, H. A., Stoewsand, G. S., Enright, 3. 3., Ament, D. and Trexier.P. C.: Interrelationship between diet and intestinal microflora in gnoto-biotes. Proc. 7th Inter. Congr. Nutr. (In press).

65. Elnheber, A. and Carter, D.: The role of the microbial flora In uremnia.I. Survival times of germfree, limited flora and conventionalized ratsafter bilateral nephrectomy and fasting. J. Exp. Med., 123:239, 1966.

66. Einheber, A., Rosen. H., Wren. R. E. and Beaudry, N. N.: The role ofmicrobial flora in the hepatotLoxicity of chlor tetracycline In Vivo: A studywith germfree mice. Biochem. Pharmacol., England, Pergamnon Press,15:1093, 1966.

67. Eyssen, H.: Metabolism of lipids and sterols In germifree and conven-tional rats and chicks. In Syrnp. IX inter. Congr. Microbial., Moscow, p.329, 1966.

68. £lyssen, H., Evrard, E. and van den Bosch, J.: Cholesterol lowering effectof neomycin and n-methylated neomycin in germfree chicks. Life Sd.,Pergamon Press, Great Britain, 5:1729, 1966.

69. Fauve, a. M. and Delaunay, A.: Etablissement 'Vune colonie pilate desouris N.C.S., Annales de l'Institut Pasteur, 110,283, 1966.

70. Fitzgerald, R. J., Jordan, H. V. and Archard, H. 0.: Dental caries In gno-tobiotic rats infected with a variety of Lactobadlllus acidophilus. Arch.Oral Biol., Pergamon Press, Great Britain, 11:473, 1966.

71. Foster, H. L., Foster, S. 3. and Pfat', E. S.: The large scale production ofcaesarean-derived mice. Proc. Animval Care Panel, 12:196, 1962 (Abs.).

72. Foster, H. L. and Trexler, P. C.: Stanidardization of gnotobiotlc rat andmouse production. Syrnp. Gnotobiotic Res., University of Notre Dame,Notre Dame, Indiana, p.4, 19,66 (Abs.).

73. Foster, H. L., Trexier, P. C. and Rumsey, G.: A canned, sterile shippingdiet for small laboratory animals. 17th Ann. Animal Care Panel bleetg.,Chicago, Illnois, 1966 (Abs. No. 36).

74. Geever, E. F. arnd Levenson, S. M.: Iron pigmentation of the gut of germ-free and convfntionahized guinea-pigs. Experlentla, 20:391, 1964.

75. Gibbons, R. J., Berman, K. S., Kneettner, P. and Kapsimalis, B.: Dentalcaries and alveolar bone loss in giiotobiotic rats infected with capsuleforming streptococci of human origin. Arch. Oral Biol., 11549, 1966.

76. Gibbons, R. J. and Socransky, S. S,: Enhiancement of alveolar bone loss ingnotobiotic mice harbouring human gingival bacteria. Arc-h. Oral Biol.,Pergamon Press, Great Britin, 11:847, 1966.

77. Giddens, W. E., Pleasants, J. R_. Wostiann, B. S. and Whitehair, C. K.:Morphological findings in germfree rats fed antigen-free, water-solublediets. Symp. Gnotobiotic Research, University of Notre Dame, NoiiiDame, Indiana, p. 17, 1966 (Abs.).

78. Gilbey, J. G. and Pollard. M.: Search for mycoplasma (PPLO) in "germ.free" leukemic mice. Fed. Proc.. 25:292, 1966 (Abs.).

79. Ginsberg, M. K. and LaConte, M. L.: Reverse isolators. Amer. J. Nursing.64:88. 1964.

80. Glaser, D. A. and Wattenburg, WV. H.: An automated system for thegr owth and analysis of large numbers of bacterial colonies usixig an en-vironmental chamber and a comDiete controlled flying spot scanner. Ann.N.Y. Acad. Sci., 139:243, 1966.

81. Goodman. N. S. and Rozoff. M. H.: Defined media for the study of bacillipathogenic to insec. Ann. N.Y. Acad. Sci., 139:16, 1966.

82. Gordon, H. A.: Germfree animals in research: an extension of the pureculture concept. (Triangle) The Sandoz J. Med. Sci., 7:108, 1965 (Eng.,Fr., Ital., Ger, Dutch).

83. Gordon, H. A.: Germfree animals in the study of microbial effects ovaging. Persp. Exper. Gerontol., Shock, Chapter 23, Charles C. Thomaspub~., p. 295, 1936.

84. Gordon. H. A., Germfreo animals in research on aging. 7th Int. Congr.Gerontol., Vienna, Austria, No. 116, p.50, 1966 (Abs.).

85. Gordon, H. A.: Recent advances on bioactive substances in intestinalcontents of germfree animals. Symp. Gnotobiotic R-learch, University ofNotre Dame, Notre Dame. Indiana, p.25, 1966 (Abs.).

86. Gordon, H. A., Bruckner-Kardoss, E. and Abbott, C. J.: Separation ofmusculo-active and toxic agents in cecal contents of germifree animals.Fed. Proc., 24:689, 1965.

87. Gordon, H. A., Bruckner-Kardoss, E., Staley, T. E., Wagner, M. andWostmann, B. S.: Characteristics of th- germfree rat. Acta Anat., 64:301,1966.

88. Gordon, H. A., Bruckner-Ka-doss, E. and Wostmann, B. S. Aging ingermfree mice: Life tables and lesions observed at natural death. J. Ge-ront., 21:3,S0, 1966.

89. Grabar, P.: Anticorps et "globuliies-transporteurs". In "Protides of theBiological Fluids." (H. Peeters, ed.) Elsevier Publ. Co., Netherlands, Ji4,1963.

90. Grabar, P.: Immunological study of cellular components. Proc. FourthCongr. Hungarian Assoc. Microbiologists, Budapest, p. 107. 1964.

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91. Grabar, P.: The hypothesis of "carrer-glcbulins. In "Molecular andCellular Basis of Antibody Formation". (J. Sterzl, ed.) Proc. Symp.,Prague, p.621, 1964.

92. Graber, C. D., Moore, R. W., Suzuki, M, Redmond, W. E., O'Neal. R. M.and Lockhart. B. M.: Autochthonous intestinal flora and cholesterol levelsin rpecific pathogen free swine fed high-lipid and high-sucrose diets. J.Bact., 92:1290, 1966.

93. Graber, C. D., O'Neal, R. M. and Rabin, E. R.: Effect of high fat dietzintestinal microflora and serum cholesterol in rats. 3. Bacterol., 89:47,196.5.

94. Greenber-g, B.: Bacterial interactions in gn.otobiotic flies. In Symp. IXInter. Cone, Microbiol., Moscow, July 1966.

95. Griesemer, It. A.: Control of disease with germfree methods. Swine Blo-med. Res., p.747, 1965.

96. Grlesemer, R. A.: Methods for rearing large germfree mammals. In Symp.IX Inter. Congr., Microbiol., Moscow, July 1963.

97. Griesemer, R. A.: Raising of germfree mammals. (Rus.) Nature, 113:27,1966.

98. Griesemer, R. A.: The response of germfree dogs, cats, pigs and monkeysto irfectious agents. Symp. Gnotobiotic Research, University of NotreDame, Notre Dame, Indiana, p.18, 1966 (Abs.).

99. Gustafsson, B. E.: Bakteriefria forsckadjur, Sartyrck ur "20 ars medi-cinsk forsknlng," Statens MediInska Forskningsrad, p.468, 1945-1965.

100. Gustafason, B. E., Mldtvedt, T. and Norman, A.: Isol.ted fecal microor-ganisms capable of 7 alpha-dehydroxylating bile acids. J. Excper. Med.,

123:413, 1968.

101. van der Gulden, W. J. I. and Dobbelaar, M. J.: De dierenarts en het dier-experiment IV. Tijdschr. Diergeneesk, Nederl., 89:26, 1964.

102. Gwatklnr R.B.L.: Defined media and development of mammalian eggs invitro. Ann. N.Y. Acad. Scd., 139:79, 1966.

103. Hajek, P. and Mandel. L.: Antibody response c; young animals to bacteri-ophages of different immunological behaviours: Phi Chi 174 and T2. Fol.Microbiol., 11:282, 1966.

104. Hammarstrom, S.: Immunological studies in ulcerativa c-litls II "Colon"antigen and human blood group A and H like antigens !n germfree ratz.J. Exp. Med., 122:1075, 1965.

105. Hansen, C.T.: Genetic aspects of the breeding of gnotobiotes. Symp. Gno-tobiotic Research, University of Notre Dame, Notie Dame, Indiana, p.14,1966 (Ab)s.).

106. Harper, S. M. and Johnson, R. M.: The relaUon of selected nutritionalfactors to anaphylaxis and antibody formation in gnotobiote and conven-tional mice. Fed. Proc., 25:564, 1968 (Abs.).

107. Hedlund, H. E.: Role of the practicing veterinarian in the health of SPFherds. Proc. George A. Young Conf. for Veter. on Advances in Swi.e Re-population and Nebr. Sixth Ann. SPF Swine Conf., Lincoin, Nebraska,p.13, 1966.

108. Heine, W.: About planning and designing of barrier type animal labora-tories for research. Zschr. Versuchstierk. Bd., 8:335, 1966.

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109. Heins, E. R. and Myrvik, Q. N.: Levels of lysosomal hydroisses in alveolarand peritoneal macrophages from conventional and germfree rats. Fe&Proc., 25:439, 1966 (Abs.).

le. Heneghan, J. B.: Expearimental surgery in germfree animal. Symp. onGnotobiotic Research, University of Notre Dame, Notre Dame, Indiana,p.19, 1966 (Abs.).

111. Heneghan, J. B., Floyd, C. E. and Cohn, I.: Gnotobiotic dogs for surgicalresearch. J. Surg. Res., 6:24, 1966.

112. Heneghan J. B. and Gates, D. F.: Effects of peracetic acid used in gnot-obiotics on experimental animals. Lab. Animal Care, 16:96, 1966.

113. Hoag, W. G.: Specific requirements of inbred mice. Symp. on GnotobloticResearch, University of Notre Dame, Notre Dame 'ndiana, p. 15, 1966(Abs.).

114. Hobby, G. L., Lenert T. F., Maier-Engallena, J., Wa. ly, C., Keblish, M.,Manty, A. and Auerbach, 0.: Experimental tuberculo. and the immuno-genic effect of BCG in germfree mice. Amer. Rev. Resp )is., 93:396, 1968.

115. Holzinger, E. A. and Griesemer, R. A.: Effects of reoviru'w Iype I, on germ-free and disease free dogs. Amer. J. Epidem., 84:426, 1966.

118. Hook, W. A., Toussaint, A. J. and Simonton., L. A.: Appearance of naturalantibodies in young rabbits. Nature, 210:543, 1966.

117. Horoszewlcz, J. S., Mirand, E. A., Walker, M. J. and Jividen, J.: Experi-mental PPLO infection in gernfree HaM/ICR Swiss mice. Symp. onGnotobiotie Research, University of Notre Dame, Notre Dame, Indiana,~p. 12, 1966 (Abe.).

118. Horowitz, R. E.: Cellular and humoral defence mechanisms in germfreeanimals. In Symp. IX Inter. Congr. Microbiol, Moscow, July 1966.

119. Huempfner, H. R. and Deuschle, K. W.: Experimental tuberculosis ingermfree and conventional mice. Amer. Rev. Resp. Dis., 93:46t, 1966.

120. Huovienen, J. A. and Gustafsson, B. E.: Utilization of inorganic sulphate,sulphite and sulphide for sulphur amino acid biosynthesis in germfreeand conventional rats. XLL Scandinavian Congr. Physiol., Turku 1966,Acta Physiol. Scand., p. 81, 1966 (Suppl. 277).

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121. Ingle, D. J.: Scientific and ethical responsibilities associated with the useand care of animals. Fed. Proc., 25:1465, 1966.

122. Jackson, G. J.: Heminth Physiology: Stage and species differences inculture. Ann. N.Y. Acad. Sl., 139:91, 1966.

123. Jervis, H. R., Johrson, C. R. and Evans, C. B.: The rate of absorption ofintraperitoneally injected erythrocytes in germfree and conventional miceand its possible relationship t malaria. Milit. Med., 131:891, 1966 (Suppl.).

124. Julien, P.: Lea animaux san gerraes. (Fr.) Concours Med., 87:7790, 1965.

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125. Kajima, M. and Pollard, M.: Distribution oi .umor viruses in germfreerodents. Sixth Inter. Congr. Electron Microscopy, Kyoto, Japan, p.215,

1966.126. Kairta, M. and Pollard, M.: Tumor virus-like particles in germfree ro-

dents. Proc. IX Inter. Cancer Congr., Tokyo, 196 (Ab&).

127. KaJ!ma, M. and Pollard, M.: Virus detection in germfree rodents by elec-tron microscopy. Symp. on Gnotobiotic Res., University of Notre Dame,Notre Dame, Indiana, p. 11, 1966 (Abs.).

128. Kaneuchl, C., Mitsuoka, T., Yamamoto, S. and Sega, T.: Studies on therearing of germfree chickens: I. A new germfree chicken cage, (Jap.)Japan. J. Veter. Sci., 28:1, 1966.

129. Kasting, R. and McGinnis, A. 3.; Radioisotopes and determination of nu-trient requirements. Ann. N. Y. Acad. Sci., 139:98, 1966.

130. Kellogg, T. F.: A new fixed formula stock diet for germfree rodents.Syrnp. on Gnotobiotic Res., University of Notre Dame, Notre Dame, In-diana, p. 6, 1966 (Abs.).

131. Kellogg, T. F. and Wostmain, B. S.: The effect of carbohydrate digesti-bility on fecal steroids. Biochem. Biophys. Acta., 125:617, 1966.

132. Kim, Y. B., Bradley, S. G. and Watson, D. W.: Immune response to andelimination of particulate and soluble antigens in immunologically virginpiglets. Fed. Proc., 25:547, 1966 (Ab&).

133. Kim, Y. B., Bradley, S. G. and Watson, D. W.: Ontogeny of the immuneresmpnse. I. Development of inununoglobulins in germfree and conven-tional colostrum-deprived piglets. J. Immun., 97:52, 1966.

134. King, T. K.: Measurement of functional residual capacity in the rat. J.Appl. Physiol., 21:233, 1966.

135. King, T. K.: Mechanical properties of the lungs in the rat. 3. Appl. Phy-siol., 21:259, 1966.

136. King, T. K. and Bell, D.: Arterial blood gases in specific-pathogen-freeand bronchitic rats. J. AppL Physiol., 21:237, 1966.

137. Kl!ne, B. E., Lattuada, C. P., Schmidt, A. R.: Experience with rats andmice reared in isolators. Proc. Animal Care Panel, 12:195, 1962 (Abe.).

138. Knight. S. G.: Transformation: A unique enzymatic activity of moldspores and mycelium. Ann. N.Y. Acad. ScL, 139:8, 1966.

139. Kohler, E. M. and Bohl, E. H.: Studies of Escherichia coll in gnotobioticpigs. III. Evaluation of orally administered specific antisera. Canad. J.Comp. Med. Veter. Sci., 30:233, 1966.

140. Kokas, E.: Spontaneous villous motility in vivo: A model for testing NO-active substances. Symp. on Gnotobiotic Research, University of NotreDarme, Notre Dame, Igdiana, p. 26, 1.966 (Abs.).

141. Kokas, E. and Gordon, H. A.: Effect of bioactive substances in cecal con-tents of germfree animals in spontaneous villous motility. Fed. Proc.,25:199, 1966. (Abs.).

142. Kranz, P.: Jet stream ventilation for extreme air cleanliness. AS-TRAEJ., 4:37, 1962.

143. Kranz, P.: Calculating human comfort. ASEIRAE J., 6:68, 1964.

144. Kranz, P.: Jet stream ventilation tested. ASHRi._E J., 7:40, 1965.

145. Kranz, P., Levenson, S. M. and Laduke, M.: Designing for germfree en-vironments. ASHRAE J., March 1966.

146. Labrecque, A. D.: Parabiosis of CH. 129, and F hybrid mice in germ-

free and conventional environments. The Anatom. Record, 1.54:372, 1966.

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147. Lagercrantz. R., Hammarstrorn. S., Perlmann, P. and Gustafason.B.Inimunolog-ical studies in ulcerative colittab. III. Incidence of antibodies tocolon-antigen in ulcerative colitis and other gastro-intetilfll di-eases.Cliii. Exp. Immunol., 1:263, 1966.

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291. Trexler, P. C.: Germicides as a step in the elimination of mnicrobic con-tamination. Soap and Chemicals Spechties, 32, 1956.

292. Trex'er, P. C.: Isolators for the gnotobiotic rearing and use of large ani-mals. Proc. Animal Care Panel, 12:194, 1962 (Abs.).

293. Trexier, P. C.: The transportation of gnotobiotic animals. Proc. AnimalCare Panel, 12 196, 1962 (Abs.).

294. Trexler, P.C.: Gnotobiotics Newsletter. (P. C. Trexier, ed.). Assoc. Appi.Gnotobiotics, 1, 1963.

295. Trexler, P. C.: Gnotobiotlcs Newsletter. (P.C. Trexler, ed.). Assoc. Appi.Gnotobiotics, 1, 1964.

296. Trexlpr, P. C.: Gnotobiotics Newsletter. (P.C. Trexler, ed.). Assoc. Appi.Gnotobiotics, 1, (3, 4) 1965.

297. Trexler, P. C.: Gnotobiotics Newsletter. (P. C. Trexler, ed_). GnotobioticsRes. Found., 2, (1, 2, 3) 1966.

298. Trexler, P. C.: Recent developments in instrumentation and contamina-tion control. Symp. on Gnotobiotics Res., University of Notre Dame, NotreDame, Indiana, p.1, 1966 (Abs.).

299. Tuleckes, WV.: Continuous cultures of higher plant cells in liquid media:Th-e advantages and potential use of phytostat. Ann. N.Y. Acad. Sci.,139):162, 1966.

_V

300. Valencia, R. and Cong., H. N'G.: Gestation and viability of ti'e litter inamicrohial and conventional rats submitted to a vitamin B1 , de~ficientdiet. (Fr.) C.R. Acad. Sdi., Paris, 263:290, 1966.

301. Van Hoosier, G. L., Trentin, J. J., Shields, J., Stephens, K., Stertback, W.A. and Parker, J. C.: Effect of caesarean-derivation, g-notobiote fosternursing and barrier maintenance of an inbred mouse colony on enzooticvirus status. Lab. Animal Care, 16:119, 1966.

302. van der Waaij, D.: Bacteriological decontami~nation of the digestive tractof mice anti its effect on survival following whole body irradiation. Ra-diobiological institute TNO. Ann. Report for 1966. p. 4 5.

303. van der Waaij, D. ind Zimmentnan, W. M. Th.: Problems in the sanitationof monkeys for whole-bedy irradiation experiments. Proc. Inter. Symp.Bone Marrow Therapy and Chem. Protection Irrad. Pruuates, Rljswijk,p.2 3 1. 1962.

304. van der Waaij, D. and van Bekkum, D. W.: Experiences wqth germfreeand "disease-free" animals and their significance for clinical medicine.(Dut.) Nederl. T. Geneesk., 109:2342, 1965.

305. Wagner, M.: Germnfree methods. In Symp. X Inter. Congr. Microbiol.,Moscow, July 1966.

306. n Wanr, M. td o h fets of specific immunization on experi-menual dental caries in the gnotobloti. rat. rissert. Abs., Purdue Univer-sity, XXVII, 1966.

307. Wagner, M. and Lattuada, C. P.: Microbiological monitoring of gnotob!-otic animals. Symp. on Gnotobiotic Res., University of Notre Dame, NotreDame, Indiana, p.8, 1966 (Abs.).

308 Waibel, P. E., Rao, B. S., Dunkelgod, K. E., Siccardi, F. J. and Pomeroy,B. S.: A chemically defined liquid diet for the chick. J. Nutr., 88:131, 1966.

309. Walburg, H. E., Mynatt, E. I. and Robie, D. M.: The effect of strain anddiet on the thirty day mortality of x-irradiated germfree mice. Rad. Res.,27:616, 1966.

310. Waxier, G. L.: Specific-pathogen-free and germfree animals in research.Agii. Sci. Rev., 4:28, 1966.

311. Waxler, G. L., Schmidt, D. A. and Whitehair, C. K.: Technique for rearinggnotobiotic pigs. Amer. J. Veter. Res., 27:300, 1966.

312. Wiech, N. L. and Hamilton, 3. G.: Absorption and metabolism of dietarytriglycerides in the germfree rat Fed. Proc., 25:231, 1966 (Abs.).

313. Williams, F. P., Christie, R. J. and Johnson, D. J.: A new autoclave sys-tem for sterilizing vitamin-rortifled commercial rodent diets with lowernutrient loss. 17th Ann. Animal Care Panel Meetg., Chicago, Illinois, 1966(Abs. No. 67).

314. Wilson, R.: Thymectomy and radlosensitivity in germfree mice. Symp. onGnotobiotic Res., University of Notre Dame, Notre Dame, Indiana, p.21,1966 (Abs.)

315. Wilson, R., Bealmear, M. and SJodin. K.: A technique for thymectomizinggermfree mice .T. Appl. Physlol., 21:279, 1966.

316. Wilson, R. and Bealmear, M.: Homograft rejection by neonatally thymec-

tomized germfree mice. Exp. Hematol., 9:27, 1966.

317. Wolfe, L., Griesemer, R. and Rohovsky, M.: Germfree cynomolgus mon-keys. Lab Animal Care, 16:364, 1966.

318. Wostmann, B. S. and Bruckner-Kardoss, E.: Oxidation-reduction poten-tials in cecal contents of germfree and conventional rats. Proc. Soc. Exp.Biol. Med., 121:1111, 1966.

319. Wostmann, B. S. and Olson, G. B.: Antibody response in germfree chick-ens. Sy np. on Gnotobiotic Res., University of Notre Dame, Notre Dame,Indiana, p.22, 1966 (Abs.).

320. Wostmann, B. S., Wiech, N. L. and Kung, E.: Catabolism and eliminationof cholesterol in germfree rats. J. Lipid Res., 7:77, 1966.

321. Wright, R. A., Hiatt, E. P. and Weiss, H. S.: Mortality and histopathol-ogy of germfree rats and mice exposed to 100% oxygen. Proc. Soc. Exp.Biol. Med., 122:446, 1966.

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322. Yale, C. E. and Altemeier. W. A.: Intestinal obstruction in germfree rats.Arch. Surg., 91:241, 1965.

323. Yamashita, S.: V. Flowering of Lemna and nucleic acid metabolism. In"Nutritional Studies on the Flower Formation in Higher Plants". Res.Report No. 1 Lab. of Plant Nutr. and Lab. of Fertilizer. School of Agri.,Nagoya University, Japan, p.43, 1964 (Eng. Summary).

324. Young, G. A. and Underdahl, N. R.: A diet and technic for starting pigswithout colostrum. Arch. Biochem. Biophysics., 32:449, 1151.

325. Young, G. A.: Plastics, gnotobiotes and asepsis. Correspondence, J. Amer.Veter. Med. Assoc., 193:4, 1961.

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326. Young, F. B., Sharon, W. S axid Long, R. B.: Preparation and uae of drypowder tissue culture media. Ann. N.Y. Acad. Sci., 139:1M8 196CG

327. Zuckerman, A.: Propagation of parasitic protozoa in tlsue culture 'Idavian embryos. Ann. N.Y. Ajcad Sci., 139:24, 1988.

Anonymous

323. Anonymous: Bone marrow transplanijon in irradiated animals. EUJRA-TOM, Eur 3607.e, p.3, Presses Academiques Europeenes, Brussel 1964.

329. Anonymous: Caesarean-originated, barrier-sustained vs. conventional an-lxnsls in researe.. Charles River Digest, V, 1966.

330. Anonymous: Cholesterol catabo "'m in germfree rats. Nutr. Rev., 24:278,1966.

3U1. Ancnyinous: Current research with germfree animals. Charles RiverDigest, MII 1964.

332. Anonymous: Onotoblotic animals. Charles River Digest 1. 1962.

333. Anonymous: Production and application of pathogen free animals in rad-iation experiments. EUJRATOM, Eur 1607.e, p.7, Presse" AcademiquesEuropeenres, Brussels, 1964.

334. Anionyincus: Hospital use of sterile patient isolators. CAontain. Control,5:40, 1966.

335. Anonymous: Sterilization processes. Charles River Digest, V, 16.

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-INDEX-

Antibiotics - 162, 184, 263

Apparatus -- 8, 23, 24, 30, 79, 80, 96, 97, 142, 143, 144, 145, 172, 183, 186, 203,231, 249

Bloactive Agent* - 85, 86, 89, 90, 91, 100, 103, 131, 138, 140, 141, 202, 275

Blood - 5, 6, 9, 16, 51, 52, 53, 109, 189, 190, 198, 216, 217, 218, 250, 264,268, 269, 270, 271, 273

Calves- 277

Cats - 98, 241

Chickens - 13, 14, 45, 46, 50, 67, 68, 128, 178, 256, 262, 319

Controlled Yomra - 11, 13, 29, 36, 65, 69, 115, 152

Dental lygi n e -- 4, 10, 70, 75, 243, 244, 245, 246, 306

Dieta - 12, 38, 61, 63, 64, 73, 77, 92, 93, 129, 130, 153, 175. 178, 191, 207,226, 227, -28, 229. 700, 308, 309, 313

Diseams --- 2, 15, 26, 33, 37, 47, 95, 104, 117, 147, 156, 163, 187, 174. 176, 182,191, 192, 208, 233, 247, 266

Dog- 47, 98, 111, 115, 232

Endotoxin.s - 194, 195

Establiqhnient & Maintenance - 8, 12, 23, 24, 28, 36, 40, 6b, 71, 72, 96, 108, 121,137, 170 171, 172, 232, 248, 284, 285, 290, 292

Flies - 94

Fish - 236

Gernifree Applications - 1J, 124, 149 164, 166, 206, ) .9, 210 211, 239, 286, 305,329, 331, 333

Genetics - 105, 146Gerontology - 83, 84. 38

Guinea Pig - 50, 74, 150, :75, 134, 200

Helminths - 122, 260

Horneostagis-- 168

Insects-- S1Intestinal Tract --- 222, 223, 224, 225, 280, 302

Media - 81, 102 122, 197, 299, 326

Metazoa - 1 iSMouse---

Bacterial - 27, 42, 43, 66, 76, 114, 119, 167, 173, 174, 188, 189, 192, 193,199, 221. 247, 252, 276

Blood - 6, 106, 123, 173, 188; 190, 198, 205, 218

Chemnical - 31, 66, 106, 155, 180, 212, 233, 321

Intestinal - 302

Irradiation - 59, 274, 302, 309

Maintenance - 113, 137, 154, 248, 252, 301

Morphology - 35, 44, 48

Thymus - 17, 18, 314, 315, 318

Viral - 78, 125, 126, 127, 155, 161, 182, 188, 191, 215, 220, 221, 301

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......

Nun~oes -54, 287Parabios -146

Patogen F -re- -34 107, 136, 15, 26 251, 253, 25, S0 o. 33VPatient Ca, - 158. 160, 255. 257, 25&, 25. 2593

Philsopy- 5, 5, W7, 6, 82 t

Phytalagellat. - 196, 234 235, 236Plants - 323

Primates - 98, 176, 303, 317abbit.s- 116

Amino Acid - 120Bacteria - 58, 62, 63, 64, 93, 243, 246Bloactiv Agents - 85, 86, 275Blood -104, 109, 136, 261, 320, 330Dent..i Hygiene - 70. 75, 243, 244, 246, 306

'w Diet- 61, 63, 64, 77, 93, 226, 228, 229, 300HLatology- 118, 214I Immunology - 104Intestine - 61. 141, 157, 181, 228, 229, 230, 264, 275, 318, 322-Leukemia - 216MaIntenance - 137, 151Metabollsm- 67, 187, 243, 279, 312Morphology - 87, 179Neurological - 59Parasltc- 174Respiration - 134, 135, 321Surgery - 65

I-" Tumors - 240Wound Healing - 159, 242

Shock - 32

Space Travel - 21, 22, 165

Sterilization - 112, 153, 201, 219, 237, 238, 278, 291, 313, 325, 335

Surgery - 110, 111

Swine - 25, 92, 98, 132, 133, 139, 148, 160, 172, 185, 231, 251, 253, 254, 267,272, 311, 324

Symposia -1, 3, 41, 48

Testing - 307

Thymus- 17, 18, 42, 169, 117, 261, 314, 315, 316

Tissue Culture - 7, 148

Transplantation - 316, 327, 328

Transportation - 293Tumor - 125, 126, 127, 180, 204, 212, 213, 240

Viral - 5, 25, 115, 125, 126, 127, 160, 161, 182, 188, 191, 211, 215, 220, 221

Wound Iealing-245, 288

~; -23-