Behavioral Interventions for HIV/AIDS Guest Lecture for Dr. Detels’ EPI 227 Dallas Swendeman,...
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Transcript of Behavioral Interventions for HIV/AIDS Guest Lecture for Dr. Detels’ EPI 227 Dallas Swendeman,...
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Behavioral Interventions for HIV/AIDS
Guest Lecture for Dr. Detels’ EPI 227
Dallas Swendeman, Ph.D., M.P.H.Co-Director, Global Center for Children and Families (GCCF)
Executive Director, Center for HIV Identification, Prevention & Treatment Services (CHIPTS)Assistant Professor, Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine at UCLAAffiliated Faculty, Department of Epidemiology, UCLA Fielding School of Public Health
[email protected]://chipts.ucla.edu/; http://www.uclacommons.com/
April 17, 2013
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Behavioral vs. Biomedical• Biomedical interventions– Vaccines, pharmaceutical treatments, & medical
devices to prevent & treat disease
• Behavioral interventions– Programs that help people change their behaviors
to prevent & manage disease
• Almost all biomedical interventions require behavior changes – by patients, providers, organizations, etc.
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Behavioral vs. Structural
• Behavioral Interventions– directly target people to change their behaviors• adoption & utilization of tools or services • adherence to treatments & lifestyle recommendations
• Structural Interventions – change in access, availability, or acceptability• Policies, prices, payers, laws• Physical & social environments (culture), organizations,
communities
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Behavioral vs. Structural
• Structural = change in access, avail, accept– Ex. Condom avail, Testing/Tx avail, N&S
Exchange/Sale, Policies – States, Orgs, Venues
• Behavioral = directly target people to change– Ex. Condom use, Reduce # Partners, Clean Equip.,
Service Util.
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Behaviorally Targeted Structural Interventions
• E.g., condom or clean syringe use, treatment util. & adherence
• 100% Condom use program – Top Down
• Community-led structural intervention (CLSI)– Mobilization of people and resources
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Evidence-Based Interventions (EBI) • Systematic programs to support behavior change– Typically a manual guides training & implementation– more structured than an “Evidence-based Practice”
• Adopted medical “product development” model – vaccines, pharmaceuticals, devices
• Rigorous evaluation of risks and benefits– At least one RCT, but gold standard is 2 RCTs – Some say must be “replicated” by other teams– Some say large-scale “effectiveness” trial needed
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A new “Adherence” Paradigm?• “Combination Prevention” of biomedical &
behavioral interventions is wave of future– maybe structural
• Examples– ART “Treatment as Prevention”, • reduce community viral load & infectio
– PrEP & PEP• Reduce susceptibility to HIV exposures
• Dependent on uptake & adherence behaviors
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What are the Ingredients of Behavioral Interventions?
• Not just information
• Information is necessary but insufficient for behavioral change
• Behavioral intervention design is a “black box”– Not well specified design principles– What are the “Core Elements”?
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Behaviors vs. Knowledge, Attitudes, Beliefs (KAB)
• Knowledge may be necessary but is often not sufficient for behavior changes
• Rational Actor Assumptions
• Health Education vs. Beh. Change (Psychology)
• Motivation, Information, Skills, Address Barriers, Support to Sustain change
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Behavior Change Theories• Health Belief Model (Becker)– Knowledge & beliefs
• Social Learning theory (Bandura)– Social norms & rewards
• Stages of Change (Prochaska & DiClimente)– Pre-contemplation, contemplation, ready, action,
relapse, maintenance• Diffusion of Innovations (Rogers)– Community-level– Innovators, early-, middle-, late- adopters
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CONSORT Intervention Reporting Domains – Pt. 1
• Content/Elements – Content & How Delivered (oral, written, video,
computer, text-message)• Providers – Physicians/Experts/Social Workers vs. Peer/Lay/CHW
• Format – Self-help, individual, group, telephone
• Setting – Clinic, CBO/NGO, school, classroom, workplace,
homes, venues (brothels, bars, clubs)
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CONSORT Intervention Domains Pt. 2• Recipients
– Target populations
• Intensity – # of contacts & total contact time
• Duration – Period of time & spacing of contacts
• Fidelity – Delivered as Intended & Monitored/Measured (M&E)
* Need a science of intervention design & delivery
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Recipient “Target Population” Risks:
• Diagnosed or Infected• High-Risk – Behavioral, genetic, & epidemiological risk factors
• At-Risk – Potential for high-risk or infection if there is shift
in behavior, environment, or epidemiology• Low-risk
* Address stigma & “victim blaming”
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Intensity & Duration:
• Brief vs. Comprehensive
• Sustaining Impact Generalizing Impact
• Duration of behavioral changes
• Breadth of behavioral changes
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Delivery Formats:
• Mass Media (inform vs. behavior change)• Community-level & Networks• Small Group• One-on-One • New Delivery Formats: – Mobile Phones & Internet
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Providers:
• Professionals (Physicians, Therapists) – vs.
• CHWs – Task Shifting • Self-directed? • Stigma
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Settings:
• Clinical vs. Community (CBO / NGO)
• Disease-Specific vs. Wellness & General Health • Age & Gender Segregated vs. Family
Focused
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Content/Elements:• Almost completely unspecified
– new work in this area
• Manuals scripted & sequenced
• Theory? – Explains hypothesized change process & targets– Rarely specifies the content or techniques– More in common than different (use multiple)
• Common Elements • Principles, Processes, Techniques, Practices,
• Common Factors• Standardized Functions
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Core Elements defined by researcher-developers are not
consistent in scopeTheoretical Concepts
Key SkillsSocial Support
Specific ActivitiesPopulation characteristics & challenges
Delivery formatsRecruitment & Outreach Strategies
Key Outcomes
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The common factors of EBI are:
• Frame issue to motivate change
• Apply health information to daily life
• Build feel, think, do skills
• Address environmental barriers
• Build sustainable social support
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“Framing to Motivate Change” for adolescent HIV prevention
Protecting oneself is a source of ethnic or gender pride
Protecting virginity demonstrates hope for marriage
Protecting partners demonstrates caring and loving relationship
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• Believe in your worth & right to future• Distinguish fact from myth• Evaluate options & consequences • Commit to change• Plan ahead & be prepared • Practice self-control • Know pleasurable alternatives• Negotiate verbally, not non-verbally• Choose to limit your own freedom• Act to help others protect themselves
Common Principles of EBI:
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BPBR 20 steps for condom use.
BART Practice purchasing condoms.
FK “Condom hunt” in store.SC Role play condom
conversation.SS $1 reward for condom in
pocket.
Plan Ahead and Be Prepared
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Common Processes of EBI:Highly Structured
Goals, Agendas, Teacher Role
Strategies for Group ManagementSupport, Cohesiveness, Self-disclosure,
Active Engagement, Cultural SensitivityBehavioral Management, Fun
Feel, Think, Do SkillsCognitive, Affective, & Behavioral
Developmental IssuesSocial identity, Sense of self, Set rules,
Promote morality, Focus on future
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Fidelity: • Fidelity to what?– Scripted manuals– Essential practices (i.e., Core Elements)– Common factors, processes, principles, practices
• Adaptation & Standards of Evidence – Multi-phase trial borrowed from biomedical– If adapted, is it still an EBI? New trial needed?
• M&E vs. CQI Feedback Systems
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Provider-level Intervention
• Behavior Change like any other
• Adopt new practices • Implement with fidelity • Adaptation?
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mHealth CHW System (from www.Mobenzi.com, also see www.dimagi.com )
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Technology – Mobile Phones
• 5 standardized functions for behavioral intv.– Inform – about disease risks, protection, services – Train - new health behaviors and routines– Monitor – behaviors and risks– Shape – behaviors over time with feedback– Support – from peers/family to sustain behaviors
• Also for care coordination, CHW support, M&E
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SMS “Text-Messaging” & IVR
• Text-messaging (SMS)• Interactive Voice Response (IVR) • Multi-media Messaging (MMS)
– universally available on all phones (except MMS)– only time-stamped data and time-based prompts – no GPS/location prompts or unobtrusive data– need SMS/IVR back-end system & programming
for anything but small-scale SMS applications
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Smartphone Apps• maximum options – time, location/GPS, unobtrusive/background, etc.
• more technically involved programming– especially for unobtrusive data, battery life, etc.
• App incompatibility across phones – even with same OS (Android) not all devices will work– most likely have to provide phones to participants
• Researcher/Clinician authorable web-interfaces– under development, e.g., Ohmage.org
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Fidelity Monitoring & Support for Intervention Deliverers (& Dose/Exp.)
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If we build it, will they come?
• Hard to reach populations (stigma)
• Engagement Strategies
• Costs & Cost-effectiveness
• Payers & Sustainability