Beginning of the chapterGluten intolerance and Genetics

(Gluten Sensor)

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SENSORS

GLUTEN SENSOR

Celiac disease / Gluten Intolerance

SENSORS

GLUTEN SENSOR

Gluten (Wheat protein)

Incorrect programming of the immune system (it fights against gluten)

digestive problemslactose intolerance9x higher ENT tumor risk80x higher lymphatic tumor risk

On average, 11 years until diagnosis

12% of the untreated cases are fatal12% of the untreated cases are fatal

Gluten-free dietGluten-free diet>>>Complete freedom from symptoms>>>Complete freedom from symptoms>>>Normalization of the other (tumor) risks>>>Normalization of the other (tumor) risks

GLUTEN INTOLERANCE

Receptors and infections

Bacteria

Receptor genesReceptor genes

Bacteria

The receptor presents The receptor presents bacterial proteinsbacterial proteins

Bacteria is Bacteria is absorbedabsorbed

The bacteria is The bacteria is broken upbroken up

The receptor is The receptor is built and the built and the

bacterial proteins bacterial proteins are integratedare integrated

T-cell

APC-cell

ALARM!!!ALARM!!!

DQ-A1

DQ-B1

GLUTEN INTOLERANCE

Receptors and infections

Receptor geneReceptor gene

Wheat protein Wheat protein (gluten) is (gluten) is absorbedabsorbed

Proteins are Proteins are broken upbroken up

The receptor The receptor cannot integrate cannot integrate

glutengluten

APC-cell

T-cell

Everything OK!Everything OK!

DQ-A1

DQ-B1

GLUTEN INTOLERANCE

Receptors and infections

Receptor geneReceptor gene

Wheat protein Wheat protein (gluten) is (gluten) is absorbedabsorbed

Proteins are Proteins are broken upbroken up

Gluten is Gluten is integrated into integrated into

the receptorthe receptor

APC-cell

The receptor contains GlutenThe receptor contains Gluten

T-cell

ALARM!!!ALARM!!!

DQ-A1

DQ-B1

GLUTEN INTOLERANCE

Receptors and infections

What can we find out from the genetic analysis? What can we find out from the genetic analysis?

NegativeNegative -> The probability of gluten intolerance = ~0%-> The probability of gluten intolerance = ~0%

PositivePositive -> The probability of gluten intolerance = up to 40%-> The probability of gluten intolerance = up to 40%

Pay attention to symptoms > immediate, correct diagnosis Pay attention to symptoms > immediate, correct diagnosis

Gluten Free Diet > absolute freedom from symptomsGluten Free Diet > absolute freedom from symptoms

GLUTEN INTOLERANCE

Counselling example

EARLY DETECTIONEARLY DETECTION

1)1)Pay attention to the symptoms when eating gluten containing Pay attention to the symptoms when eating gluten containing productsproducts

DIETARY ADJUSTMENTSDIETARY ADJUSTMENTS

1)1)Avoid gluten containing foodAvoid gluten containing food

Nutrition Sensor can helpNutrition Sensor can help

End of the chapterGluten intolerance and genetics

(Gluten Sensor)

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