1st ITALIAN MEETING

ON RESEARCH IN ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD)

25th FEBRUARY 2017, 9:00 am – 18:30 pm.

Paolo VI auditorium, via Gezio Calini 30, 25121 Brescia (Italy)

9:00 am Introduction: Nuccia Gatta (chief of the association), Maria Novella Luciani (health

minister delegate), Ottavio Di Stefano (local order of physician's chief )

Basic research - Discussants: Ilaria Ferrarotti, Annamaria Fra, Elena Miranda

9:15 am Not only S, not only Z - I. Ferrarotti, Pavia

9:45 am AAT pathologic polymers – E. Miranda, Rome

10:15 am AAT not classics polymers: a multidisciplinary challenge A. Fra, Brescia and M. Manno, Palermo

10:45 am Induced stem cells in the study of AATD

R. Ronzoni, London and F. Michielin, Padova

11:15 am COFFEE BREAK

11:30 am Pathogenetic mechanisms in hepatic illness caused by Z mutationN. Brunetti-Pierri, Naples, and P. Piccolo, Naples

12:00 am Hepatocytes, chaperons e chaperon-therapy: models of study F. Cappello, Palermo

12:30 am LECTURE – hepatic and extrahepatic AAT – F. Callea, Rome

1:15 pm LUNCH

Clinical research - Discussants : Claudio Tantucci e Angelo Corsico

2:00 pm What a physician asks to the researchers - L. Corda and F. Benini, Brescia

3:45 pm Microbiome project – B. Balbi, Veruno

4:15 pm AATD and bronchiectasis – S. Aliberti, Milan

4:45 pm AATD and vascular pathology: is there any association?

L. Pini and G. Gregorini, Brescia

5:15 pm AATD: pediatric characteristics – M. Fuoti, Brescia

6:00 pm Conclusions – L. Corda and N. Gatta