Baseline topographic optic disc measurements are associated with the development of POAG: The CSLO Ancillary Study to the OHTS Linda M Zangwill Robert N Weinreb Julie Beiser Chuck C Berry George A Cioffi Anne L Coleman Gary Trick Jeffrey M Liebmann James D. Brandt Jody R Pitz-Seymour Keri A Dirkes Suzanne Vega Michael A Kass Mae O Gordon and the OHTS CSLO Ancillary Study Group Financial Disclosures Linda M Zangwill: (F) Heidelberg Engineering, Carl Zeiss Meditec Robert N Weinreb: (F) Heidelberg Engineering, Carl Zeiss Meditec Julie Beiser: None Chuck C Berry: None George A Cioffi: None Anne L Coleman: None Gary Trick: (C,R) Heidelberg Engineering Jeffrey M Liebmann: (F,C) Heidelberg Engineering James D. Brandt: None Jody R Pitz-Seymour: None Keri A Dirkes: None Suzanne Vega: None Michael A Kass: None Mae O Gordon: None Grant Support NEI EY11158 NEI EY09341 and EY09307 and the National Center on Minority Health and Health Disparities, Merck Research Laboratories Unrestricted grants from Research to Prevent Blindness CSLO Ancillary Study to the OHTS Objectives: To determine the effectiveness of HRT to objectively and quantitatively detect glaucomatous changes of the optic disc in ocular hypertensive patientsTo determine the effectiveness of HRT to objectively and quantitatively detect glaucomatous changes of the optic disc in ocular hypertensive patients To describe racial differences in optic disc topography in ocular hypertensive patientsTo describe racial differences in optic disc topography in ocular hypertensive patients To assess the effect of ocular hypotensive treatment on optic disc topographyTo assess the effect of ocular hypotensive treatment on optic disc topography To determine whether optic disk topographic measurements are an accurate predictor of glaucomaTo determine whether optic disk topographic measurements are an accurate predictor of glaucoma CSLO Ancillary Study to the OHTS Objectives: To determine the effectiveness of HRT to objectively and quantitatively detect glaucomatous changes of the optic disc in ocular hypertensive patientsTo determine the effectiveness of HRT to objectively and quantitatively detect glaucomatous changes of the optic disc in ocular hypertensive patients To describe racial differences in optic disc topography in ocular hypertensive patientsTo describe racial differences in optic disc topography in ocular hypertensive patients To assess the effect of ocular hypotensive treatment on optic disc topographyTo assess the effect of ocular hypotensive treatment on optic disc topography To determine whether optic disk topographic measurements are an accurate predictor of glaucomaTo determine whether optic disk topographic measurements are an accurate predictor of glaucoma Devers Eye InstituteDevers Eye Institute PI: Jack A. Cioffi, MD Coordinator: Kathryn Sherman Henry Ford Medical CenterHenry Ford Medical Center PI: Gary Trick, PhD Coordinator: Melanie Gutowski Jules Stein Eye Institute, UCLAJules Stein Eye Institute, UCLA PI: Anne L. Coleman, MD, PhD Coordinators: Tina Gonzales, Jackie Sanguinet New York Eye and Ear InfirmaryNew York Eye and Ear Infirmary PI: Jeffrey M. Liebmann, MD Coordinator: Jean Walker CSLO Ancillary Study: 7of the 22 OHTS Study Centers Participating Scheie Eye Institute, U. of PennsylvaniaScheie Eye Institute, U. of Pennsylvania PI: Jody R. Piltz-Seymour, MD Coordinator: Jane Anderson University of California-Davis,University of California-Davis, PI: James D. Brandt, MD Coordinators: Ingrid Clark, Vickie Jaicheum University of California-San DiegoUniversity of California-San Diego PI: Robert N. Weinreb MD Rigby Slight, MD Coordinators: Valerie Lepper, R.N. Eva Kroneker, Rivak Hoffman UCSD CSLO Reading Center Robert N. Weinreb, MD, Primary Investigator Linda M. Zangwill, PhD, Co-investigator Chuck C Berry, PhD, Biostatistician Keri L. Dirkes, MPH, Supervisor Suzanne Vega, MPH, Coordinator Amanda Policastro, Coordinator Amanda R. Smith, MPH, Coordinator Michelle Cambou, MPH, Coordinator Chris Asvar, Coordinator Isabela Niculae, MPH, Coordinator Image Acquisition Methods Heidelberg Retina Tomograph (HRT1) images acquired annually at dilated exam Both eyes: 10-degree field of view images OD: An additional 15 degree field of view 3 scans taken for each field of view K-values used to correct for magnification error Image series exported to CSLO Reading Center No processing at study centers Standardized, centralized image processing at CSLO Reading Center (UC San Diego) Quality Assurance Data CompletenessData Completeness Image QualityImage Quality Only Certified Operators Acquire ImagesOnly Certified Operators Acquire Images Image Processing Creation of Mean TopographiesCreation of Mean Topographies Outlining of Disc MarginOutlining of Disc Margin Exporting Data to OHTS Data Coordinating CenterExporting Data to OHTS Data Coordinating Center CSLO OHTS Ancillary Study Participants Demographic Characteristics African-AmericanOther Total Number of subjects* 75 (17%)376 (83%)451 Gender (% male) 29%45%42% Mean Age (years) 54.4 9.3 * With informed consent Conclusions HRT topographic measurements are strongly correlated with stereophotographic assessment of horizontal and vertical cup disc ratios - even in OHTS participants with normal appearing optic discs These results suggest that the HRT optic disc measurements describe features that are reflected in standardized assessment of cup-to-disk diameter ratios from stereophotographs AJO 2004 ;137: CSLO Ancillary Study to the OHTS Conclusions African-Americans have significantly larger optic discs, cups, neuroretinal rims and cup-to-disc ratios, and smaller rim-to-disc ratios than other OHTS CSLO Ancillary Study participants After adjusting for the difference in disc area, none of the differences in optic disc topography between African-Americans and other participants remained statistically significant These results highlight the need to consider race and optic disc size when evaluating the appearance of the optic disc in glaucoma Arch Ophthalmol 2004;122:22-28 CSLO Ancillary Study to the OHTS Racial Differences in Optic Disc Area (both eyes) p=