Bakersfield, California March 15, 2019 Sudden Infant Death ... · 5/3/2019 · Chair, California...
Transcript of Bakersfield, California March 15, 2019 Sudden Infant Death ... · 5/3/2019 · Chair, California...
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Thomas G. Keens, M.D. Chair, California SIDS Advisory Council
Professor of Pediatrics, Physiology and Biophysics
Keck School of Medicine of the University of Southern California
Division of Pediatric Pulmonology and Sleep Medicine
Children’s Hospital Los Angeles
No Conflicts of Interest to Disclose
Sudden Infant Death
Syndrome and
Safe Infant Sleep
7th Annual Kern County Perinatal Symposium
Bakersfield, California March 15, 2019
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“And this woman's son
died in the night ...”
1 Kings 3: 19
(950 B.C.)
Antoon Claeissens, The Judgment of Solomon, ~1600.
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Figure Courtesy of Doctor Maria Valdes-Dapena
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4
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5
Sudden
Death
of an Infant
Emergency
Responders
Coroner's
Investigation
Autopsy
Determination
of the Cause
of Death
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The sudden unexpected death of an infant,
under one-year of age, with onset of the fatal
episode apparently occurring during sleep, that
remains unexplained after a thorough
investigation, including performance of a
complete autopsy, and review of the
circumstances of death and the clinical history.
Krous, H.F., J.B. Beckwith, R.W. Byard,
T.O. Rognum, T. Bajanowski, T, Corey, E. Cutz,
R. Hanzlick, T.G. Keens, and E.A. Mitchell.
Pediatrics, 114: 234-238, 2004.
Sudden Infant
Death Syndrome
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In this presentation, the
following terms are considered
synonymous:
• SIDS
• SUID
• SUDI
• Undetermined
They all mean the same thing;
that the infant’s death is
unexpected and unexplained.
Sudden Infant
Death Syndrome
Cutz, E. JAMA Pediatr., 170: 315-316, 2016.
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8
0.0
0.5
1.0
1.5
2.0
1980 1985 1990 1995 2000 2005 2010 2015
SID
S R
ate
per 1
,000 L
ive B
irth
s
California
USA
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Erck Lambert, A.B., et al. Pediatrics, 141: doi:10.1542/peds.2017-3519 , 2018.
Combined SUID
SIDS
Unknown Cause
ASSB
1990 1995 2000 2005 2010 2015
Year
2.0
1.5
1.0
0.5
0
Infa
nt
Mo
rta
lity
(De
ath
s p
er
10
00
Liv
e B
irth
s)
doi: 10.1542/peds.2017-3519
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Guntheroth, W.G., and P.S. Spier. Pediatrics, 110: 110;e64, 2002.
14
13
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https://www.cdc.gov/sids/data.htm https://www.cdc.gov/sids/data.htm
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Infant Deaths by Gestational Age
Ostfeld, B.M., et al. Pediatrics, 140: e20163334, 2017.
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SIDS Autopsy Findings
• No identifiable cause of
death.
• No signs of severe illness.
• No signs of significant
stress.
• Diagnosis of exclusion
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With the perseverance
of Trojans ...
• Faithful.
• Scholarly.
• Skillful.
• Courageous.
• Ambitious.
“Here are provided seats of meditative joy,
Where shall arise again the destined reign of Troy.”
Virgil, Aeneid
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Modified after Professor Jacopo P. Mortola. McGill University.
Imagine a car driving up
a steep mountain road.
The car has stopped.
Why can’t the car
continue up the hill?
How Are We to Understand SIDS?
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Imagine a car driving up a steep mountain
road. The car has stopped.
Why can’t the car continue up the hill?
Medical Model.
• There is a flat tire.
• Identify the problem.
• Find a solution to the problem.
• Fix the problem.
Modified after Professor Jacopo P. Mortola. McGill University.
How Are We to Understand SIDS?
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• Cardiac causes.
• Respiratory causes.
• Arousal disorders.
• Metabolic disorders.
• Infections.
• Vitamin deficiency.
• Environmental toxins.
Medical Model
of SIDS
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A New Way of Thinking.
• There are too many passengers.
• The engine is not powerful enough.
• The road is too rocky.
• The road is too steep.
Modified after Professor Jacopo P. Mortola. McGill University.
How Are We to Understand SIDS?
Imagine a car driving up a steep mountain
road. The car has stopped.
Why can’t the car continue up the hill?
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Kinney, H.C., and B.T. Thach. N. Eng. J. Med., 361: 795-805, 2009.
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiatory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Hannah Kinney
Infant
Vulnerability
Environment Development
SIDS
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiatory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Hannah Kinney
Infant
Vulnerability
Environment Development
SIDS
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22
0
10
20
30
40
50
60
70
30 35 40 45 50 55 60
PCA (weeks) at beginning of 4-week observation period
SIDS
Ramanathan, R., and CHIME. J. Amer. Med. Assoc., 285: 2199-2207, 2001.
Ra
te o
f a
t le
as
t 1
ex
tre
me
ev
en
t
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Neuman, M.R., et al., and CHIME. Physiol. Meas., 22: 267-286, 2001.
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Is SIDS a Catastrophic
Physiologic Crisis?
• If normal infants do not precisely
control breathing, heart rate, and
oxygenation …
• Then SIDS may not have to be a
catastrophic physiological crisis.
• Maybe it just needs to be a small
problem which nudges or pushes
a vulnerable infant over the edge.
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiratory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Hannah Kinney
Development Environment
Infant
Vulnerability
SIDS
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Kinney, H.C., and B.T. Thach. N. Eng. J. Med., 361: 795-805, 2009.
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Kinney, H.C., and B.T. Thach. N. Eng. J. Med., 361: 795-805, 2009.
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Panigrahy, A., et. al. J. Neuropath. Exp. Neurol., 59: 377-384, 2000.
Kinney, H.C., et al. J. Neuropath. Exp. Neurol., 60: 228-247, 2001.
Kinney, H.C., et al. J. Neuropath. Exp. Neurol., 62: 1178-1191, 2003.
Paterson, D.S., et al. J. Amer. Med. Assoc., 296: 2124-2132, 2006.
Duncan, J.R., et al. J. Amer. Med. Assoc., 303: 430-437, 2010.
Randall, B.B., et al. Pediatrics, doi: 10.1542/peds.2013-0700. 2013.
Goldstein, R.D., et al. Pediatrics, 137: e20154661, 2016.
Hannah Kinney, M.D.
Neuropathologist.
Harvard Medical School.
Brainstem Neurotransmitters
in SIDS
• Brainstem is the life support
portion of the brain.
• Autopsy studies found decreased
serotonin (5-HT) and serotonergic
neurotransmitter receptor binding
activity in brainstems of SIDS vs
controls infants.
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32 Duncan, J.R., et al. J. Amer. Med. Assoc., 303: 430-437, 2010.
Hannah Kinney
0
20
40
60
80
100
Raphe
Obscurus
PGCL
Bra
ins
tem
Se
roto
nin
Co
nc
en
tra
tio
n
(pm
ol/
mg
)
SIDS (n=35)
Controls(n=5)
Hospitalized(n=5)
P <0.05 P <0.04
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Paterson, D.S., et al. J. Amer. Med. Assoc., 296: 2124-2132, 2006.
5-HT1A Receptor Binding Density
in the SIDS Mid-Medulla
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Randall, B.B., et al. Pediatrics, doi: 10.1542/peds.2013-0700. 2013.
Sudden death without Asphyxia
Sudden death with Asphyxia
Known Cause of Death
p<0.001
p<0.001
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35
Randall, B.B., et al. Pediatrics, doi: 10.1542/peds.2013-0700. 2013.
Goldstein, R.D., et al. Pediatrics, 137: e20154661, 2016.
Accidental
Asphyxia or
Suffocation
Sudden Death
without
Asphyxia
Sudden
Death with
Asphyxia
Brain Abnormality Small Intermediate Severe
Asphyxial Insult Severe Intermediate Small
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiratory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Development Environment
Infant
Vulnerability
SIDS
Infant Vulnerability may have Many Causes
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A New Way of Thinking:
Modified after Professor Jacopo P. Mortola. McGill University.
How Are We to Understand SIDS?
Imagine a car driving up a steep mountain
road. The car has stopped.
Why can’t the car continue up the hill?
• Some cars are
Ferrari’s.
• Some cars are
Jeep’s.
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiratory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Hannah Kinney
Infant
Vulnerability
Development
SIDS
Environment
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Ostfeld, B.M., et al. Pediatrics, 125: 447-453, 2010.
0
5
10
15
20
25
30
0 1 2 3 4 5 6 7
SID
S V
icti
ms (%
)
Number of Risk Factors (modifiable and nonmodifiable) present per case
244 SIDS victims
from New Jersey,
1996-2000.
The majority of SIDS victims have ≥1 Risk Factor
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Trachtenberg, F., et al. Pediatrics, 129: 630-638, 2012.
The majority of SIDS victims have ≥1 Risk Factor
2.1 2.1
0
1
2
3
Nu
mb
er o
f M
od
ifia
ble
Ris
k F
acto
rs
Modifiable Risk Factors per Case
91.7
64.5
89.3
68.7
0
20
40
60
80
100
1 or More 2 or More
SID
S V
icti
ms
(%)
Pre-BTS 1991-1993 (n=169) BTS 1996-2008 (n=307)
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How can we, as a
population, reduce the
risks of SIDS?
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• Most infants with risk factors will not
die from SIDS.
• Some infants without risk factors will
die from SIDS.
• However, infants with risk factors are
at increased risk of dying from SIDS.
= Causes / Risk
Factors
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Babies Should Sleep on their Backs
for Every Sleep
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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Vennemann, M.M., et al. Pediatrics, 123: 1162-1170, 2009.
Blair, P.S., et al. B.M.J., 339: b3666, 2009.
Li, D-K, et al. Am. J. Epidemiol., 157: 446-455, 2003.
Mitchell, E.A., et al. Arch. Pediatr. Adolesc. Med., 153: 1136-1141, 1999.
Mitchell, E.A., et al. Pediatrics, 100: 835-840, 1997.
Oyen, N., et al. Pediatrics, 100: 613-621, 1997.
0 5 10 15 20
Oyen, 1997
Mitchell, 1997
Mitchell, 1999
Li, 2003
Blair, 2009
Vennemann, 2009
Prone Sleeping and SIDS (Odds Ratios vs Non-Prone Sleeping)
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0%
20%
40%
60%
80%
100%
1992 1995 1998 2001 2004 2007
Supine
Side
Prone
Willinger, M., et al. J. Amer. Med. Assoc., 280: 329-335, 1998.
Colson, E.R., et al. Arch. Pediatr. Adolesc Med., 163: 1122-1128, 2009.
M. Willinger
National Infant Sleep Position Study
(U.S.A.)
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0.5
1.0
1.5
0
M. Willinger, et al. J. Amer. Med. Assoc., 280: 329-335, 1998.
Colson, E.R., et al. Arch. Pediatr. Adolesc Med., 163: 1122-1128, 2009.
0
20
40
60
80
1990 1992 1994 1996 1998 2000 2002 2004 2006
U.S. Prone Sleeping and SIDS Rate
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47
0
5
10
15
20
25
Mitchell Oyen
SID
S R
isk O
dd
s R
ati
o v
s S
up
ine
Sle
ep
P
osit
ion
Prone
Side
Mitchell, E.A., et al. Pediatrics, 100: 835-840, 1997.
Oyen, N., et al. Pediatrics, 100: 613-621, 1997.
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SIDS Risk Reduction: Curriculum for Nurses, NICHD, 2006.
NIH Publication No. 06-6005.
Supine Prone
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California
Infants
Placed on
the Back to
Sleep:
76.1%
Maternal and Infant Health Assessment Survey Prepared by: Maternal, Child and Adolescent
Health Program, Center for Family Health, California Department of Public Health
http://www.cdph.ca.gov/data/surveys/MIHA/MIHAComparisonMaps/CompareRegSleepPos2012.pdf
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Use a Firm Sleep Surface.
Firm Crib Mattress and Fitted Sheet
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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Sitting Devices are Not
Recommended for Routine Sleep
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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Roomsharing, Without Bedsharing,
is Recommended.
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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• In 1892, a Scottish police surgeon, Templeman,
first drew attention to the potential role of
excessive alcohol consumption and overlaying.
• 258 cases of suffocation in infants.
• More than half of deaths occurred Saturday
night.
• Postulated that intoxication impaired arousal
responses of parents sleeping with infants,
thus increasing the risk of accidental
suffocation.
Templeman, C. Edinburgh Med. J., 38: 322-329, 1892.
Early Study of Maternal Overlaying
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California
Infants
Who
Always or
Often
Bedshare:
39.3%
Data Source: Maternal and Infant Health Assessment Survey Prepared by: Maternal, Child and Adolescent Health
Program, Center for Family Health, California Department of Public Health
http://www.cdph.ca.gov/data/surveys/MIHA/MIHAComparisonMaps/CompareRegBedshare2011.pdf
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Richard, C., et al. Sleep, 19: 685-690, 214-219, 1996.
McKenna, J.J., et al. Pediatrics, 100: 214-219, 1997.
Mosko, S., et al. Am. J. Physical Anthropol., 103: 315-328, 1997.
Richard, C.A., et al. J. Appl. Physiol., 84: 1374-1380, 1998.
McKenna, J.J., and T. McDade. Paediatr. Respir. Rev., 6: 134-152, 2005.
Ball, H.L., et al. Arch. Dis. Child., 91: 1005-1010, 2006.
• Increased breastfeeding, but not when
compared to room-sharing.
• No decrease in apnea.
• No stimulation of breathing.
• Increased arousals (baby wakes mother).
• Decrease in deep sleep.
• No apparent physiological protection.
Bedsharing, Breathing,
and Infant Sleep
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56 McGarvey, C., et al. Arch. Dis. Child., 88: 1058-1064, 2003.
0
5
10
15
20
25
Any
Bedsharing
Bedhsaring
Last Sleep
Maternal
Smoking
Age >20
weeks
Supine Sleep
Od
ds
Ra
tio
Be
ds
ha
rin
g v
s N
ot
Be
ds
ha
rin
g
203 SIDS.
622 controls.
4.31
16.47
21.84
2.63 1.07
Bedsharing and SIDS in Ireland, 1994-1998
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57 Tappin, D, et al. J. Pediatr., 147: 32-37, 2005.
• 123 SIDS.
• 263 controls.
0
10
20
30
40
50
60
70
All Couch <11 weeks
old
>11 weeks
old
Separate
Room
Od
ds
Ra
tio
SID
S v
s C
on
rols
2.89
10.20
1.07 3.26
66.90
123 SIDS.
263 controls.
Bedsharing and SIDS in Scotland, 1996-2000
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58 Blair, P.S., et al. Br. Med. J., 319: 457-462, 1999.
0 10 20 30 40 50
Separate Room
Bedshare on
Sofa
Bedshare
Whole Night
Bedshare, but
return to cot
SIDS = 325
Controls = 1300
P. Fleming & P. Blair
Bedsharing and SIDS Risk: CESDI Study (Odds Ratios vs did not sleep with an adult)
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59 Blair, P.S., et al. PLoS ONE 9(9): e107799. doi:10.1371, 2014.
• 123 SIDS.
• 263 controls.
3.9
18.3 18.3
8.9
1.1
0
5
10
15
20
All Couch With
Parent
Who Drank
EtOH
With
Parent
Who
Smoked
Absence of
Other
Hazards
Od
ds
Ra
tio
SID
S v
s C
on
rols
400 SIDS.
1,386 controls.
P. Fleming & P. Blair
Bedsharing and SIDS in the U.K.
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• Infant’s crib or bassinet
should be placed in the
parents’ bedroom close
to the parents’ bed.
• Infant can be brought
to bed for
breastfeeding, but then
returned to the crib.
• Devices promoted to
make bedsharing
“safe” are not
recommended.
Roomsharing
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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• Infant <3-months of age.
• Parent cigarette smoking.
• Parent is excessively tired; such as sleep
deprivation (<4-hours sleep the previous night).
• Parent depressant medication or alcohol use.
• With non-parent or multiple persons.
• Soft or unsafe bed.
• Duvets, pillows, or soft covers.
• Sleeping on a sofa, armchair, or couch.
Bedsharing is
Especially Unsafe with:
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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• Roomsharing, with the infant in a crib in the
parents’ room next to the adult bed, is safest,
and is safer than bedsharing.
• Infants brought to bed for breastfeeding should
return to a separate crib.
• Do not bedshare if parents smoke cigarettes.
• Do not bedshare if the parents’ arousal is
depressed (alcohol, drugs, sleep deprived <4-
hours sleep the night before).
• Do not sleep with an infant on a sofa or chair.
SIDS AAP Recommendations
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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Keep Soft Objects and Loose
Bedding Out of the Crib
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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Consider Offering a Pacifier
at Nap Time and Bedtime
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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Avoid Cigarette Smoke Exposure
During Pregnancy and After Birth
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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67
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Avoid Overheating and Head Covering;
Infants should not feel hot to touch.
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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Infants Should be Immunized
according to AAP and CDCP Advice.
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://healthlevelup.com/vaccinations-and-children/
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Avoid Alcohol and Illicit Drug Use
During Pregnancy and After Birth.
AAP Policy Statement. Pediatrics, 138: e20161889, 2016.
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Avoid Use of Commercial Devices
Inconsistent with Safe Infant Sleep
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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Encourage Tummy Time when the
Infant is Awake and Observed.
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
http://www.medscape.com/features/slideshow/safe-sleep-principles?
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No Evidence to Recommend
Swaddling to Reduce the Risk of SIDS
AAP Policy Statement. Pediatrics, 138: e20162938, 2016.
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Infant Swaddling
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Infant Swaddling
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Pease, A.S., et al. Pediatrics, 137: e20153275, 2016.
Swaddling and SIDS
SIDS 760
Controls 1759
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• Prone sleeping position.
• Thick blankets.
• Face covered.
• For infants older than 3-
months. There is a danger when infants begin to
roll from supine to prone, the swaddled
infant can not regain the supine position.
Ponsonby, A.L., et al. N. Eng. J. Med., 329: 377-382, 1993.
Wilson, C.A., et al. J. Paed. Child Health, 30: 506-512, 1994.
L’Hoir, M.P., et al. Eur. J. Pediatr., 157: 681-688, 1998.
Van Sleuwen, B.E., et al. Pediatrics, 210: e1097-e1106, 2007.
Pease, A.S., et al. Pediatrics, 137: e20153275, 2016.
AAP Policy Statement. Pediatrics, 138: e20161889, 2016.
Avoid Swaddling if …
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78
0.0
0.5
1.0
1.5
2.0
1980 1985 1990 1995 2000 2005 2010 2015
SID
S R
ate
per 1
,000 L
ive B
irth
s
California
USA
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79
73
28
65
3853
0
20
40
60
80
100
Items inCribs
Prone Sleep BedshareEver
BedshareRoutine
Bedshare onCouch
Pro
po
rtio
n o
f M
oth
ers
(%
) n = 4,547
Dreisbach, S. American Baby Magazine, March, 2014, issue. http://www.parents.com/baby/safety/nursery/how-safe-is-your-babys-sleep/?page=3
Parents Ignore Safe Infant Sleep
Recommendations
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Varghese, S., et al. J. Perinatol., doi:10.1038/jp.2015.111, 2015.
22
9
3
18
20
22
0 5 10 15 20 25
Put Soft Items in Crib
Do Not Immunize
Smoke Cigarettes
Do Not Breastfeed
Do Bedshare
Prone or Side Sleep
Parents of Newborn Infants (%)
Many Parents Do Not Follow
Safe Infant Sleep Recommendations
n = 121 parents
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Eron, N.B., et al. Health Promot. Pract., 10: 1-9. 2009.
0 20 40 60 80 100
Give Written Material
Do Discuss SIDS Risk
Should Discuss SIDS Risk
Knows Back Sleep Safest
Behavior Can Reduce SIDS
N = 214
Primary Care Physicians Do Not
Discuss SIDS Risk Reduction
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Eisenberg, S.R., et al. Pediatrics, 136: DOI: 10.1542/peds.2015-0551, 2015.
Mothers Commonly Receive No Advice
on Infant Care Practices
Advice from Physicians
0% 20% 40% 60% 80% 100%
Pacifier Use
Sleep Location
Sleep Position
Breastfeeding
Immunizations
AAP Advice Against AAP Advice No Advice
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Eisenberg, S.R., et al. Pediatrics, 136: DOI: 10.1542/peds.2015-0551, 2015.
Mothers Commonly Receive No Advice
on Infant Care Practices
Advice from Nurses
0% 20% 40% 60% 80% 100%
Pacifier Use
Sleep Location
Sleep Position
Breastfeeding
Immunizations
AAP Advice Against AAP Advice No Advice
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Supine
Alone
Firm mattress
Empty crib
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85
0.0
0.5
1.0
1.5
2.0
1980 1985 1990 1995 2000 2005 2010 2015
SID
S R
ate
per 1
,000 L
ive B
irth
s
California
USA
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• Safe infant sleep recommendations
create a safer infant sleep environment.
• Should reduce accidental infant deaths
during sleep.
• Triple Risk Hypothesis suggests SIDS
is an interaction between age, intrinsic
vulnerability, and environment.
• The only thing we can affect is the
environmental stress.
Are We Reducing
SIDS or Suffocation?
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WARNING The cause of SIDS is not yet known.
This information has not been
proved to be the cause of SIDS.
However, I have attempted to give
you some idea about some current
directions of SIDS research.
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brainstem serotonin:
Autonomic Dysfunction Disrupting Cardiorespiratory Control
Filiano, J.J., and H.C. Kinney. Biol. Neonate, 65: 194-197, 1994.
Hannah Kinney
Infant
Vulnerability
Development Environment
SIDS
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• Most common cause of sudden infant
death between the ages of 1-month
and 1-year.
• Cause remains unknown.
• Can not be predicted in infants prior
to death.
• Reduction in SIDS in populations
through public health intervention.
• SIDS has not been eliminated.
Sudden Infant
Death Syndrome
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