Babycell India - Umbilical Cord Blood Stem Cell Banking
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Transcript of Babycell India - Umbilical Cord Blood Stem Cell Banking
Who we are
*RMS has been rated BB (Stable) by India Ratings and Research – Fitch group*RMS financial practices are annually audited by Deloitte
Reach : National and International
Internationally, we have operations in Dubai and Srilanka
Milestones
Stem Cell Banking
The magic of regeneration has always been seen in nature.
We humans are discovering its powers NOW!
Regeneration can be seen perfectly in sea cucumbers. Their bodies can grow up to three feet long and if cut into pieces, each piece can REGROW into a new sea cucumber.
The White-tailed deer can REGROW their antlers and this is the most extreme example of regeneration!
Lizards have the ability to REGROW their tail within nine months.
The starfish have the ability to REGROW their arms and sometimes their whole bodies. Even if the critter is down to one arm, as long as it has its central nerve ring intact, it can grow into an entirely new starfish.
The human body has so much to offer, we are exploring its capacity to the best!
What are these magical cells?
“Basic unit of life”
Stem cells are the body's raw material — from which all other cells with specialized functions are generated.
How amazing is it that life begins with a single cell!
Where do we find them?
• Umbilical Cord Blood
• Umbilical Cord Tissue
• Bone Marrow
• Peripheral Blood
• Other sources under research• Dental Pulp
• Adipose Tissue (Fat)
• Embryo
Disease statistics1. Worldwide, the annual number of new cases of childhood cancer exceeds
200,000 and more than 80% of these are from the developing world.
2. Every year around 32,000 children with Thalassemia are born in India
3. Approximately 8,000 cases (4,400 males and 3,820 females) of Hodgkin's
Lymphoma are detected per year . In India, 21% of all Hodgkins disease was seen
in children with a marked male female ratio of 5.5:1
4. Each year approximately 300,000 children are born with sickle cell anaemia or
one of its variants and nearly 80 per cent of these births occur in poor socio-
economic countries
References: 1. http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2009;volume=46;issue=4;spage=264;epage=273;aulast=Arora2. http://jcnh.in/download/isse1/3.%20Amrita%20Panja.pdf3. http://www.lymphomainfo.net/hodgkins/incidence.html4. Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat Commun. 2010;1:104.[PMC free article] [PubMed]
PM Narendra Modi speaking about stem cells
• PM Narendra Modi visited the Stem Cell Research facility at
Japan in Sep 2014.
• He had a conversation with Shinya Yamanaka, Japan’s stem
cell pioneer and a 2012 Nobel Prize winner
• Spoke about concerns regarding the prevalence of sickle
cell anaemia among Indians
• Along with Shinya Yamanaka, Hon PM Narendra Modi
discussed about remedy for sickle cell anaemia through
stem cells
Indian PM Narendra Modi (R) speaking to Japanese Nobel Prize-winning stem cell
researcher Shinya Yamanaka (L)
Click here to read more
Umbilical Cord Stem Cells and upcoming uses
• Acquired Hearing Loss : 63 million people in India suffer of acquired hearing loss
• Cerebral Palsy : In India, it is estimated at around 3 cases per 1000 live births.
• Congenital Heart Disease : Every year 78,000 infants born with congenital heart disease in India die
• Juvenile Diabetes : India is home to an estimated 97,700 children with Type 1Diabetes Mellitus
• Pediatric Stroke : Prevalence of stroke in India range from 44 to 843 per 100,000 population.
• Traumatic Brain Injury : 1.5 – 2million persons are injured and 1million die every year in India.
• Autism : India is home to about 10million people with autism.
In a landmark decision, approval given by U.S. FDA for the following diseases. Approvals expected for commercial use as early as 2017
Cord blood stem cells and future use
Acquired hearing lossAutism
Paediatric stroke Traumatic brain injury
Umbilical Cord Blood Umbilical Cord Tissue
• Tissue of the umbilical cord (not the blood inside it)
• Contains Mesenchymal Stem Cells. These have the ability
to regenerate tissue, nerve cells and damaged organs.
• Repairs bone, cartilage and connective tissue. Future
treatment may include spinal cord injuries and strokes
• First clinical trial - 1995
• Is now being researched and explored with over 200
clinical trials under way (globally)
• Blood that flows in the umbilical cord and placenta
• Contains Hematopoietic Stem Cells. These have the
ability to regenerate all types of blood cells.
• Treats blood related diseases and cancers such as
leukemia, anemia, thalassemia and autoimmune
disorders.
• First case - 1988
• Is now being used to treat over 80 blood related diseases
with 30,000 successful transplants (globally)
Why should we preserve Umbilical Cord Stem Cells when other sources are available?
• Cell Concentration is almost 10%-20% higher
than other sources.
• Faster differentiation and multiplication
potential since they are immature cells unlike
adult stem cells from other sources.
• Less prone to rejection as they have less
developed features.
• Preserved only for your family’s use and no
queuing to find a matching donor.
• Requires only a 4/6 match
Case study: Stanford professor dies after long search for bone marrow donor
Cord Blood Transplantation Success Story
The first successful cord blood transplant was done on Matthew farrow
Click here to read the success story
Obstetrician from UK with leukemia is helped by cord blood transplant
David Hall, 66, from UK, spent 33 years deliveringbabies and clamping umbilical cords, whichbecame the source of his second chance at life.
Click here to read the success story
In 1988, Matthew, a 6 year old then, was diagnosedof Fanconi Anaemia. Today, 26 years later, MatthewFarrow is alive and the lucky recipient of the world’sfirst cord blood transplant.
India's first Cord Blood transplantation was for Acute Lymphoblastic Leukemia (ALL) at Tata Memorial Hospital in 1996, followed by many more…
A child from Mumbai, Thane becomes the first patient in India to be cured of thalassemia in
2008
Rishi Bhanushali, a thalassemic major child from Kutch, Gujarat, gets treated
in 2009
1000 Cord blood transfusions were done in India
Hospitals performing Umbilical Cord Blood Stem Cell transplants in India
Transplant Specialist Panel Sr.no. Transplant specialists Hospital
1. Dr Sandip Shah Gujarat Cancer Research Institute, Ahmedabad
2. Dr. Revathi Raj Apollo Hospital, Chennai
3. Dr. Vijay Ramanan Ruby Hall Clinic, Pune
Dr. Adwaita A Gore1. Prince Aly Khan Hospital, Mazgaon
4 2. Kohinoor Hospital, Kurla5 Dr. Niranjan Rathod Kokilaben Hospital, Mumbai6 Dr. Tapan Saikia Kokilaben Hospital, Mumbai
Dr. Suparno Chakrabarti Dharamshila Hospital, Delhi78 Dr. Rahul Naithani Max Super speciality Hospital, New Delhi9 Dr. Neeraj Sidharthan Amrita Institute of Medical Sciences, Kerala
Dr. Rahul Bhargava10 Artemis Hospital, Gurgaon
11 Dr. Mahesh Rajashekaraiah BGS Global Hospital, Bangalore
Dr. Indranil Ghosh12 Apollo Hospital, Kolkata
Dr. Gaurav Kharya13 BLK Super Speciality Hospital, New Delhi
Dr. Suresth Advani14 Jaslok Hospital
Dr. Dharma Choudhary BLK Super Speciality Hospital, New Delhi15
Dr. Ashish Dixit16 Manipal Hospital, Bangalore
Dr.Kannan Subramanian17 Sahaydri Hospital, Pune
Dr Mammen Chandy18 Tata Medical Centre, Kolkata
Dr. Sunil Parekh19 Bombay Hospital, Mumbai
20 Dr.Abhay A. Bhave Lilavati Hospital and Research Centre
Dr. Vijay Ramanan, Pune
“Stem cells can be used to treat 80 blood disorders and many
more in near future. Babycell is an institution which you can
approach for your needs for stem cell purpose’’
Doctors Speak
Past president: Federation of Obstetric and GynaecologicalSocieties of India (FOGSI)
“Stem cell preservation is a smart, affordable, and simple way of ensuring a good life and hope of saving your loved ones from health related problems in future. Umbilical Cord Blood Banking is the most optimum solution available to mankind today!”
Dr. Suchitra Pandit, Mumbai
Dr. Nayna Patel, Anand
Doctor speaks
“Babycell services are excellent. They come on
time for deliveries. Stem cell banking is very useful for
your future family health.”
Dr. G. Sudha Rani, Hyderabad
“Best services are provided by your team and also patients are satisfied.”
Dr. B. Usha Rani, Hyderabad
Meet and Receive
• Fill up the health questionnaire, personal details, understand the Client Benefits and sign up!
• Receive Collection Kit and follow instructions mentioned on it.
• On the day of delivery, carry kit and call us to arrange the collection and transportation.
Collect and Transport• In case you have opted for our phlebotomist, they
will collect the sample and hand over to our logistics partner.
• A special cold chain arrangement with TNT is available 24 x 7 x 365 which handles our biological samples
• Temperature validated kits for 72 hours
• No X-Ray Certificate
Data logger report
Data logger
Preserve and Retrieve
Strategically located CPC in non-seismic, flood-proof and non-
polluting environment
On-site engineering team monitors sample to ensure
temperature, humidity and pressure maintenance 24 x 7 x 365
Adherence to strict guidelines as per GMP, GCP, GLP, FDA, DCGI
and ISO; entry permissible only to authorized personnel
Stainless steel construction, fire proof storage area, systems
designed to sustain power cut
Global shipment to any doctor centre using cryoshipperTake a tour of our Cell Processing CentreTM right now!
View certificates
Cord Blood Processing
Babycell uses ‘’Double sedimentation spin (DSS)
technology’’
Cord Tissue Processing
Cord Collection KitUmbilical Cord is processed and
segmented into small pieces.
Cells obtained from enzymatic digestion of
Umbilical Cord Tissue are transferred into several
cryovials
The cells are frozen in the controlled-rate freezer, where
the temperature is lowered gradually to optimize
preservation of stem cells.
After the controlled-rate freezing process, the cryovials are transferred for long term
cryopreservation at -196°C.
Isolation of UCT to give Whole Cell Population (WCP) including MSCs,
Epithelial cells and fibroblasts
Exclusive Tests• Total nucleated cell count
• Total mononuclear cell count
• Total CD 34+ stem cell count
• CD 34+ Stem cell viability
• Sterility testing
• Colony forming unit (CFU) test for stem cells
• Blood grouping
• Infectious disease testing (HIV 1&2, HBsAg, Anti HBC, HCV, HTLV 1&2, CMVIgG, CMVIgM, Syphilis and malaria)
• Maternal Blood Test
• Tests for Cord Tissue – Cell count, cell viability, sterility testing and quality – visual check
(Babycell is the only cord blood bank that performs this test at the time of preservation. All accreditation authorities endorse CFU and strongly recommend it at the time of preservation and not retrieval)
Colony Forming Unit Assay (CFU)
Ghee, Malai, Makhan, Kulfi, Rabdi, Basundi,
Burfi,
,
Gulabjamun, Paneer,
Dahi, Lassi, Shrikhand
Paneer, Raasgulla, Rasmalai,
Dahi, Lassi, Shrikhand
Dahi, Lassi,
Shrikhand
Standardized Milk - 4.5% Fat Content
Whole Milk - 3.25% Fat Content
Reduced Fat Milk - 2% Fat Content
Low Fat Milk - 1% Fat Content
Skimmed Milk - 0.5% Fat Content
CFU Video
Power of 10
A to Z Services
‘’Babycell Processing Technology is superior to any other banks &
the value added services like CFU, HLA Typing, and
personalized ANC/PNC sessions are second to none. Thanks
Babycell!!’’
Speaking about CFU and HLA
Speaking about their visit to Babycell CPCTM Speaking about Logistics
Speaking about New born screening
Mr. and Mrs. Bhanushali (Mumbai) Mr. and Mrs. Mulchandani (Mumbai)
One of the most important factors to choose Babycell was that their storage facility is close to our city and they had the confidence to
invite us to visit the lab to see their operations if we wished. We
availed of their services for both our children and have been extremely satisfied till date!
Mr. and Mrs. Saini (Kota)
“The experience that we had with Babycell, at every phase was
superior, like the presentation, coordination done at the time of collection and post sales services. They have worked extremely hard to help us to know the minutest
details of the concept.”
Mr. and Mrs. Anand
“One of the best things about Babycell is their post sales services like the ‘New born
screening test’ that they had provided for our new born
babies, Aamya and Avin. The online post-natal sessions for mothers were helpful too. We
can completely rely on Babycellfor any advice in the future!!
Thank you Babycell.”
Client testimonials
“In our case the delivery happened 5 weeks prior to the
predicted date! Babycellexceeded our expectations, with
the staff (Rajeshwari) immediately arriving at the hospital and
staying all night waiting for the delivery. She left only after she
had completed the collection of the cord. We are extremely happy
and grateful to Babycell.”
Speaking about on time collection
Speaking about easy plans
Speaking about entire process
“During the birth of my first child, I wasn’t very sure about the benefits of
stem cell banking, but during my second child’s birth, I had enough wisdom and the awareness of the
benefits of the banking. When I bought this from Babycell, in my view at that point in time, the offer from Babycell was best in comparison to
the other companies.
Babycell is reputed and professional and most important part for middle class people like
us. It was affordable and the instalment scheme helped us
preserve the baby’s stem cells as per our needs.
Staying away from India and delivering baby was not an easy
decision, whereas collecting stem cell and storing back in India was only in our dreams.
With the Babycell overall service from the case owner, supervisor,
logistics shipment, delivery, storing and testing cell the
entire process were Just in time (JIT) process 100%.
Client testimonials
Mr. and Mrs. Rajaram Kannan (Hyderabad)
Mrs. Sejal Bhavesh Malde, Thane Mr & Mrs. Sajid Golandaz, Mumbai
Mr. & Mrs. Bilwa
Speaking about Babycell vis a vis competition
CSR ACTIVITIES
Sibling Program
Babycell’s Sibling Program caters to expecting parents
who have a child that is diagnosed with a treatable
haematological condition. If assessed to be curable with
haematopoietic stem cell transplant, then Babycell will
provide cord blood collection, processing and storage
completely free of cost for 5 years for the upcoming baby
along with financial support up to 5Lacs
So far we have registered 15+ clients under our Sibling Program
Donation to CARF
Babycell has extended a helping hand to the cancer
patients by contributing towards the cancer aid
and research foundation through every enrolment.
Go Green initiative
This was an initiative with Mumbai
Obstetric and Gynecology Society to make a
positive contribution to the environment
starting at our facility in Lonavla.
Spreading a smile
The objective of this program is to restore the normal development and active life of children born with cleft lip & palate. The CSR wing of RMS started to treat children with our innovative Tissue Engineered Collagen product free of cost.
https://www.youtube.com/watch?v=74s35emlwRU
In the News!Click to view published articles of
Babycell Regrow
Indications:
• Trauma
• Disease Condition
• Injury
Caused to the Cartilage in Joints
• Knee
• Ankle
• Shoulder
Prevents the progress to Osteoarthritis
Defected Cartilage
CHONDRON™Implantation
Complete Regeneration of Natural Cartilage
Regrow Your Cells. Rebuild Your Life.
Cell Therapy – Cartilage Implantation
Click here to view Chondron video
Case 1 (30/M, OCD)
Case 2 (25/M, OCD)
Case 3 (41/F, Osteochondral Injury)
Relook ArthroscopyIntra-op DefectPre-op MRI
Intra-op DefectChondron Implant set Relook Arthroscopy
Post op recoveryChondron Implant setCartilage Defect
Case study:
Indications:
• Avascular Necrosis
• Non-union Fractures
• Fibrous Displasia
• Bone Cyst/ Cavity
• Facial/ Oral Bone Gaps and Defects
Natural Alternate to Total Hip Replacement and Total Knee Replacement
Bone Gap
OSSRON™Implantation
Complete Regeneration of Natural Bone
Regrow Your Cells. Rebuild Your Life.
Cell Therapy – Bone Implantation
Click here to view the Ossron video
Case 1 (58/F, Non-union)
Case 2 (37/M, AVN)
Post-op MRIIntra-op Defect
Pre-op MRI
Pre-op MRI Post-op MRI
Case 3 (48/M, Maxillofacial)
Case 4 (38/M, Mandibular primordial cyst)
Post-op MRI
Ossron ImplantationPre-op MRI
Intra-op defectPre-op MRI Post-op MRI
Cell Therapy – Skin Regeneration
Regrow Your Cells. Rebuild Your Life.
Burns
THERAFORM™Application
Complete Regeneration of Natural Skin
Diabetic Foot Ulcers
Maxillofacial Cleft palate (roof of mouth)- Birth defect
Services• Cord Blood Collection
• Cord Tissue Collection
• Colony unit forming assay (CFU)
• HLA testing
• Testing, Processing, Preservation and Retrieval for 21 years
• Global Shipment
• Transplant Specialist
• New Born Screening
• Father’s Wellness Check Up
• Mummy & Tummy (Pre and Post Natal Care Sessions)
Babycell’s Additional Support• Regrow Health Cover (clause 8.1)
• Loyalty Privilege (clause 8.2)
• Quality Assurance (clause 8.3)
• Philanthropy Programme (clause 8.4)
• Life Cover (clause 8.10)
• Right of Money Back (clause 8.11)
• Sibling Program (clause 8.5)
• Stem cell expansion as prescribed by transplant physician (clause 8.8)
• Collect and transport assist (clause 8.6)
• Stem cell xpert programme (clause 8.9)
• Tailor-made Package
For those who want more!
Babycell™ Biocord
Haemoglobinopathy test
HLA typing
HLA cross matching
Full body screening
New Born Screening
Colony Forming Unit
Gift hamper
Data Logger facility
Maternity photo shoot
Home session for ante-natal care
Home session for post natal care
Quality Assurance upto 30 Lacs
Philanthropy program upto 30 Lacs
One Treatment Free under Regrow Health Cover
Thank You
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