Babycell India - Umbilical Cord Blood Stem Cell Banking

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Transcript of Babycell India - Umbilical Cord Blood Stem Cell Banking

Page 1: Babycell India - Umbilical Cord Blood Stem Cell Banking
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Who we are

*RMS has been rated BB (Stable) by India Ratings and Research – Fitch group*RMS financial practices are annually audited by Deloitte

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Reach : National and International

Internationally, we have operations in Dubai and Srilanka

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Milestones

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Stem Cell Banking

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The magic of regeneration has always been seen in nature.

We humans are discovering its powers NOW!

Regeneration can be seen perfectly in sea cucumbers. Their bodies can grow up to three feet long and if cut into pieces, each piece can REGROW into a new sea cucumber.

The White-tailed deer can REGROW their antlers and this is the most extreme example of regeneration!

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Lizards have the ability to REGROW their tail within nine months.

The starfish have the ability to REGROW their arms and sometimes their whole bodies. Even if the critter is down to one arm, as long as it has its central nerve ring intact, it can grow into an entirely new starfish.

The human body has so much to offer, we are exploring its capacity to the best!

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What are these magical cells?

“Basic unit of life”

Stem cells are the body's raw material — from which all other cells with specialized functions are generated.

How amazing is it that life begins with a single cell!

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Where do we find them?

• Umbilical Cord Blood

• Umbilical Cord Tissue

• Bone Marrow

• Peripheral Blood

• Other sources under research• Dental Pulp

• Adipose Tissue (Fat)

• Embryo

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Disease statistics1. Worldwide, the annual number of new cases of childhood cancer exceeds

200,000 and more than 80% of these are from the developing world.

2. Every year around 32,000 children with Thalassemia are born in India

3. Approximately 8,000 cases (4,400 males and 3,820 females) of Hodgkin's

Lymphoma are detected per year . In India, 21% of all Hodgkins disease was seen

in children with a marked male female ratio of 5.5:1

4. Each year approximately 300,000 children are born with sickle cell anaemia or

one of its variants and nearly 80 per cent of these births occur in poor socio-

economic countries

References: 1. http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2009;volume=46;issue=4;spage=264;epage=273;aulast=Arora2. http://jcnh.in/download/isse1/3.%20Amrita%20Panja.pdf3. http://www.lymphomainfo.net/hodgkins/incidence.html4. Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat Commun. 2010;1:104.[PMC free article] [PubMed]

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PM Narendra Modi speaking about stem cells

• PM Narendra Modi visited the Stem Cell Research facility at

Japan in Sep 2014.

• He had a conversation with Shinya Yamanaka, Japan’s stem

cell pioneer and a 2012 Nobel Prize winner

• Spoke about concerns regarding the prevalence of sickle

cell anaemia among Indians

• Along with Shinya Yamanaka, Hon PM Narendra Modi

discussed about remedy for sickle cell anaemia through

stem cells

Indian PM Narendra Modi (R) speaking to Japanese Nobel Prize-winning stem cell

researcher Shinya Yamanaka (L)

Click here to read more

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Umbilical Cord Stem Cells and upcoming uses

• Acquired Hearing Loss : 63 million people in India suffer of acquired hearing loss

• Cerebral Palsy : In India, it is estimated at around 3 cases per 1000 live births.

• Congenital Heart Disease : Every year 78,000 infants born with congenital heart disease in India die

• Juvenile Diabetes : India is home to an estimated 97,700 children with Type 1Diabetes Mellitus

• Pediatric Stroke : Prevalence of stroke in India range from 44 to 843 per 100,000 population.

• Traumatic Brain Injury : 1.5 – 2million persons are injured and 1million die every year in India.

• Autism : India is home to about 10million people with autism.

In a landmark decision, approval given by U.S. FDA for the following diseases. Approvals expected for commercial use as early as 2017

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Cord blood stem cells and future use

Acquired hearing lossAutism

Paediatric stroke Traumatic brain injury

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Umbilical Cord Blood Umbilical Cord Tissue

• Tissue of the umbilical cord (not the blood inside it)

• Contains Mesenchymal Stem Cells. These have the ability

to regenerate tissue, nerve cells and damaged organs.

• Repairs bone, cartilage and connective tissue. Future

treatment may include spinal cord injuries and strokes

• First clinical trial - 1995

• Is now being researched and explored with over 200

clinical trials under way (globally)

• Blood that flows in the umbilical cord and placenta

• Contains Hematopoietic Stem Cells. These have the

ability to regenerate all types of blood cells.

• Treats blood related diseases and cancers such as

leukemia, anemia, thalassemia and autoimmune

disorders.

• First case - 1988

• Is now being used to treat over 80 blood related diseases

with 30,000 successful transplants (globally)

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Why should we preserve Umbilical Cord Stem Cells when other sources are available?

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• Cell Concentration is almost 10%-20% higher

than other sources.

• Faster differentiation and multiplication

potential since they are immature cells unlike

adult stem cells from other sources.

• Less prone to rejection as they have less

developed features.

• Preserved only for your family’s use and no

queuing to find a matching donor.

• Requires only a 4/6 match

Case study: Stanford professor dies after long search for bone marrow donor

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Cord Blood Transplantation Success Story

The first successful cord blood transplant was done on Matthew farrow

Click here to read the success story

Obstetrician from UK with leukemia is helped by cord blood transplant

David Hall, 66, from UK, spent 33 years deliveringbabies and clamping umbilical cords, whichbecame the source of his second chance at life.

Click here to read the success story

In 1988, Matthew, a 6 year old then, was diagnosedof Fanconi Anaemia. Today, 26 years later, MatthewFarrow is alive and the lucky recipient of the world’sfirst cord blood transplant.

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India's first Cord Blood transplantation was for Acute Lymphoblastic Leukemia (ALL) at Tata Memorial Hospital in 1996, followed by many more…

A child from Mumbai, Thane becomes the first patient in India to be cured of thalassemia in

2008

Rishi Bhanushali, a thalassemic major child from Kutch, Gujarat, gets treated

in 2009

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1000 Cord blood transfusions were done in India

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Hospitals performing Umbilical Cord Blood Stem Cell transplants in India

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Transplant Specialist Panel Sr.no. Transplant specialists Hospital

1. Dr Sandip Shah Gujarat Cancer Research Institute, Ahmedabad

2. Dr. Revathi Raj Apollo Hospital, Chennai

3. Dr. Vijay Ramanan Ruby Hall Clinic, Pune

Dr. Adwaita A Gore1. Prince Aly Khan Hospital, Mazgaon

4 2. Kohinoor Hospital, Kurla5 Dr. Niranjan Rathod Kokilaben Hospital, Mumbai6 Dr. Tapan Saikia Kokilaben Hospital, Mumbai

Dr. Suparno Chakrabarti Dharamshila Hospital, Delhi78 Dr. Rahul Naithani Max Super speciality Hospital, New Delhi9 Dr. Neeraj Sidharthan Amrita Institute of Medical Sciences, Kerala

Dr. Rahul Bhargava10 Artemis Hospital, Gurgaon

11 Dr. Mahesh Rajashekaraiah BGS Global Hospital, Bangalore

Dr. Indranil Ghosh12 Apollo Hospital, Kolkata

Dr. Gaurav Kharya13 BLK Super Speciality Hospital, New Delhi

Dr. Suresth Advani14 Jaslok Hospital

Dr. Dharma Choudhary BLK Super Speciality Hospital, New Delhi15

Dr. Ashish Dixit16 Manipal Hospital, Bangalore

Dr.Kannan Subramanian17 Sahaydri Hospital, Pune

Dr Mammen Chandy18 Tata Medical Centre, Kolkata

Dr. Sunil Parekh19 Bombay Hospital, Mumbai

20 Dr.Abhay A. Bhave Lilavati Hospital and Research Centre

Dr. Vijay Ramanan, Pune

“Stem cells can be used to treat 80 blood disorders and many

more in near future. Babycell is an institution which you can

approach for your needs for stem cell purpose’’

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Doctors Speak

Past president: Federation of Obstetric and GynaecologicalSocieties of India (FOGSI)

“Stem cell preservation is a smart, affordable, and simple way of ensuring a good life and hope of saving your loved ones from health related problems in future. Umbilical Cord Blood Banking is the most optimum solution available to mankind today!”

Dr. Suchitra Pandit, Mumbai

Dr. Nayna Patel, Anand

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Doctor speaks

“Babycell services are excellent. They come on

time for deliveries. Stem cell banking is very useful for

your future family health.”

Dr. G. Sudha Rani, Hyderabad

“Best services are provided by your team and also patients are satisfied.”

Dr. B. Usha Rani, Hyderabad

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Meet and Receive

• Fill up the health questionnaire, personal details, understand the Client Benefits and sign up!

• Receive Collection Kit and follow instructions mentioned on it.

• On the day of delivery, carry kit and call us to arrange the collection and transportation.

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Collect and Transport• In case you have opted for our phlebotomist, they

will collect the sample and hand over to our logistics partner.

• A special cold chain arrangement with TNT is available 24 x 7 x 365 which handles our biological samples

• Temperature validated kits for 72 hours

• No X-Ray Certificate

Data logger report

Data logger

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Preserve and Retrieve

Strategically located CPC in non-seismic, flood-proof and non-

polluting environment

On-site engineering team monitors sample to ensure

temperature, humidity and pressure maintenance 24 x 7 x 365

Adherence to strict guidelines as per GMP, GCP, GLP, FDA, DCGI

and ISO; entry permissible only to authorized personnel

Stainless steel construction, fire proof storage area, systems

designed to sustain power cut

Global shipment to any doctor centre using cryoshipperTake a tour of our Cell Processing CentreTM right now!

View certificates

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Cord Blood Processing

Babycell uses ‘’Double sedimentation spin (DSS)

technology’’

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Cord Tissue Processing

Cord Collection KitUmbilical Cord is processed and

segmented into small pieces.

Cells obtained from enzymatic digestion of

Umbilical Cord Tissue are transferred into several

cryovials

The cells are frozen in the controlled-rate freezer, where

the temperature is lowered gradually to optimize

preservation of stem cells.

After the controlled-rate freezing process, the cryovials are transferred for long term

cryopreservation at -196°C.

Isolation of UCT to give Whole Cell Population (WCP) including MSCs,

Epithelial cells and fibroblasts

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Exclusive Tests• Total nucleated cell count

• Total mononuclear cell count

• Total CD 34+ stem cell count

• CD 34+ Stem cell viability

• Sterility testing

• Colony forming unit (CFU) test for stem cells

• Blood grouping

• Infectious disease testing (HIV 1&2, HBsAg, Anti HBC, HCV, HTLV 1&2, CMVIgG, CMVIgM, Syphilis and malaria)

• Maternal Blood Test

• Tests for Cord Tissue – Cell count, cell viability, sterility testing and quality – visual check

(Babycell is the only cord blood bank that performs this test at the time of preservation. All accreditation authorities endorse CFU and strongly recommend it at the time of preservation and not retrieval)

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Colony Forming Unit Assay (CFU)

Ghee, Malai, Makhan, Kulfi, Rabdi, Basundi,

Burfi,

,

Gulabjamun, Paneer,

Dahi, Lassi, Shrikhand

Paneer, Raasgulla, Rasmalai,

Dahi, Lassi, Shrikhand

Dahi, Lassi,

Shrikhand

Standardized Milk - 4.5% Fat Content

Whole Milk - 3.25% Fat Content

Reduced Fat Milk - 2% Fat Content

Low Fat Milk - 1% Fat Content

Skimmed Milk - 0.5% Fat Content

CFU Video

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Power of 10

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A to Z Services

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‘’Babycell Processing Technology is superior to any other banks &

the value added services like CFU, HLA Typing, and

personalized ANC/PNC sessions are second to none. Thanks

Babycell!!’’

Speaking about CFU and HLA

Speaking about their visit to Babycell CPCTM Speaking about Logistics

Speaking about New born screening

Mr. and Mrs. Bhanushali (Mumbai) Mr. and Mrs. Mulchandani (Mumbai)

One of the most important factors to choose Babycell was that their storage facility is close to our city and they had the confidence to

invite us to visit the lab to see their operations if we wished. We

availed of their services for both our children and have been extremely satisfied till date!

Mr. and Mrs. Saini (Kota)

“The experience that we had with Babycell, at every phase was

superior, like the presentation, coordination done at the time of collection and post sales services. They have worked extremely hard to help us to know the minutest

details of the concept.”

Mr. and Mrs. Anand

“One of the best things about Babycell is their post sales services like the ‘New born

screening test’ that they had provided for our new born

babies, Aamya and Avin. The online post-natal sessions for mothers were helpful too. We

can completely rely on Babycellfor any advice in the future!!

Thank you Babycell.”

Client testimonials

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“In our case the delivery happened 5 weeks prior to the

predicted date! Babycellexceeded our expectations, with

the staff (Rajeshwari) immediately arriving at the hospital and

staying all night waiting for the delivery. She left only after she

had completed the collection of the cord. We are extremely happy

and grateful to Babycell.”

Speaking about on time collection

Speaking about easy plans

Speaking about entire process

“During the birth of my first child, I wasn’t very sure about the benefits of

stem cell banking, but during my second child’s birth, I had enough wisdom and the awareness of the

benefits of the banking. When I bought this from Babycell, in my view at that point in time, the offer from Babycell was best in comparison to

the other companies.

Babycell is reputed and professional and most important part for middle class people like

us. It was affordable and the instalment scheme helped us

preserve the baby’s stem cells as per our needs.

Staying away from India and delivering baby was not an easy

decision, whereas collecting stem cell and storing back in India was only in our dreams.

With the Babycell overall service from the case owner, supervisor,

logistics shipment, delivery, storing and testing cell the

entire process were Just in time (JIT) process 100%.

Client testimonials

Mr. and Mrs. Rajaram Kannan (Hyderabad)

Mrs. Sejal Bhavesh Malde, Thane Mr & Mrs. Sajid Golandaz, Mumbai

Mr. & Mrs. Bilwa

Speaking about Babycell vis a vis competition

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CSR ACTIVITIES

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Sibling Program

Babycell’s Sibling Program caters to expecting parents

who have a child that is diagnosed with a treatable

haematological condition. If assessed to be curable with

haematopoietic stem cell transplant, then Babycell will

provide cord blood collection, processing and storage

completely free of cost for 5 years for the upcoming baby

along with financial support up to 5Lacs

So far we have registered 15+ clients under our Sibling Program

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Donation to CARF

Babycell has extended a helping hand to the cancer

patients by contributing towards the cancer aid

and research foundation through every enrolment.

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Go Green initiative

This was an initiative with Mumbai

Obstetric and Gynecology Society to make a

positive contribution to the environment

starting at our facility in Lonavla.

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Spreading a smile

The objective of this program is to restore the normal development and active life of children born with cleft lip & palate. The CSR wing of RMS started to treat children with our innovative Tissue Engineered Collagen product free of cost.

https://www.youtube.com/watch?v=74s35emlwRU

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In the News!Click to view published articles of

Babycell Regrow

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Indications:

• Trauma

• Disease Condition

• Injury

Caused to the Cartilage in Joints

• Knee

• Ankle

• Shoulder

Prevents the progress to Osteoarthritis

Defected Cartilage

CHONDRON™Implantation

Complete Regeneration of Natural Cartilage

Regrow Your Cells. Rebuild Your Life.

Cell Therapy – Cartilage Implantation

Click here to view Chondron video

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Case 1 (30/M, OCD)

Case 2 (25/M, OCD)

Case 3 (41/F, Osteochondral Injury)

Relook ArthroscopyIntra-op DefectPre-op MRI

Intra-op DefectChondron Implant set Relook Arthroscopy

Post op recoveryChondron Implant setCartilage Defect

Case study:

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Indications:

• Avascular Necrosis

• Non-union Fractures

• Fibrous Displasia

• Bone Cyst/ Cavity

• Facial/ Oral Bone Gaps and Defects

Natural Alternate to Total Hip Replacement and Total Knee Replacement

Bone Gap

OSSRON™Implantation

Complete Regeneration of Natural Bone

Regrow Your Cells. Rebuild Your Life.

Cell Therapy – Bone Implantation

Click here to view the Ossron video

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Case 1 (58/F, Non-union)

Case 2 (37/M, AVN)

Post-op MRIIntra-op Defect

Pre-op MRI

Pre-op MRI Post-op MRI

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Case 3 (48/M, Maxillofacial)

Case 4 (38/M, Mandibular primordial cyst)

Post-op MRI

Ossron ImplantationPre-op MRI

Intra-op defectPre-op MRI Post-op MRI

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Cell Therapy – Skin Regeneration

Regrow Your Cells. Rebuild Your Life.

Burns

THERAFORM™Application

Complete Regeneration of Natural Skin

Diabetic Foot Ulcers

Maxillofacial Cleft palate (roof of mouth)- Birth defect

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Services• Cord Blood Collection

• Cord Tissue Collection

• Colony unit forming assay (CFU)

• HLA testing

• Testing, Processing, Preservation and Retrieval for 21 years

• Global Shipment

• Transplant Specialist

• New Born Screening

• Father’s Wellness Check Up

• Mummy & Tummy (Pre and Post Natal Care Sessions)

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Babycell’s Additional Support• Regrow Health Cover (clause 8.1)

• Loyalty Privilege (clause 8.2)

• Quality Assurance (clause 8.3)

• Philanthropy Programme (clause 8.4)

• Life Cover (clause 8.10)

• Right of Money Back (clause 8.11)

• Sibling Program (clause 8.5)

• Stem cell expansion as prescribed by transplant physician (clause 8.8)

• Collect and transport assist (clause 8.6)

• Stem cell xpert programme (clause 8.9)

• Tailor-made Package

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For those who want more!

Babycell™ Biocord

Haemoglobinopathy test

HLA typing

HLA cross matching

Full body screening

New Born Screening

Colony Forming Unit

Gift hamper

Data Logger facility

Maternity photo shoot

Home session for ante-natal care

Home session for post natal care

Quality Assurance upto 30 Lacs

Philanthropy program upto 30 Lacs

One Treatment Free under Regrow Health Cover

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Thank You

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