B COLLAB 2014-#9 facing pages Layout 1 · 19 By Region: North America 20 By Region South America 21...

January 31, 2014

Focused Ultrasound A Global Perspective

Collaborative Network

1 . 3 1 . 2 0 1 4

2 Focused Ultrasound: A Global Perspective . Collaborative Network

F o c u s e d U l t r a s o u n d F o u n d a t i o n

About the Focused Ultrasound Foundation

The Focused Ultrasound Foundation is a medical technologyresearch, education and advocacy organization dedicated to improving the lives of millions of people with serious medicaldisorders by accelerating the development and adoption of focused ultrasound. The Foundation is unique in that it supports a platform technology that utilizes multiple mechanisms of action to treat a wide variety of diseases.

Positioned at the nexus of the large, diverse group of stakeholders comprising the ultrasound community, the Foundation functions as an independent, trusted and unbiased third party,aligning organizations into a cohesive ecosystem with a singlegoal: to make focused ultrasound technology available to patients in the shortest time possible. The Foundation works toestablish a patient centric culture, instill a sense of urgency in allstakeholders, and alleviate barriers to progress.

The Foundation catalyzes collaboration and partnerships, organizes and funds research, spearheads advocacy and patientsupport initiatives, and organizes meetings, symposia and workshops to create and disseminate knowledge and increaseawareness of focused ultrasound. Early-stage research funded by the Foundation “de-risks” subsequent investment, thus encouraging other funding sources such as disease-specific foundations, the NIH, and the biomedical industry to becomemore involved.

The Foundation is on the leading edge of the venture philanthropy and social entrepreneurship movements and is a model of how private philanthropy can work in concert with academia, industry and government to bridge the gap between research and commercialization of a high-impact medical technology.

Established in 2006 as a tax exempt organization, the Foundation is based in Charlottesville Virginia and has global activities.

About Focused UltrasoundFocused ultrasound is a revolutionary, noninvasive therapeutictechnology with the potential to transform the treatment ofmany serious medical disorders including tumors of the brain,breast, prostate, liver and other organs, Parkinson’s disease,epilepsy, and stroke. With ongoing research, focused

ultrasound could address unmet clinical needs and providetreatments which are superior to best current therapy, therebyimproving the quality of life and longevity for millions of patients around the world.

This breakthrough technology uses ultrasonic energy guidedby magnetic resonance or ultrasound imaging to treat tissuedeep in the body without incisions or radiation. Multiple intersecting beams of ultrasound are directed and concentratedwith on a target as small as a grain of rice, much like a magnifying glass can focus multiple beams of light on a single point.

A variety of profound biological effects result at the focal point where the beams converge; where individual beams pass unfocused through adjacent tissue on the way to their target, they exertno effect or damage. Integrated magnetic resonance and ultrasound imaging identifies and targets the tissue to be treated, guides and controls the treatment interactively, in real time, and provides immediate confirmation of the effectiveness of thetherapy. Because focused ultrasound offers many mechanisms of action, treatment of a wide variety of conditions is possible.

Focused ultrasound has the potential to be the ultimate in noninvasive surgery, an alternative or complement for radiation therapy, the means to dissolve blood clots and restore circulation through blocked vessels, and a way to deliver drugsin extremely high concentration to a precise point in the body, thus avoiding systemic toxicity.

Focused ultrasound is performed in an outpatient setting without general anesthesia. There are no incisions or scars, minimal pain and discomfort, and more rapid recovery. The technology has the potential to result in fewer complications such as infection or blood clots, avoid the toxic side effects of drugs and radiation therapy, and deliver treatment that issafer and more effective, costs less, and produces an immediateand verifiable effect.

Focused ultrasound is approved in the US and EU and a number of other countries for treatment of uterine fibroids and approved in the EU and other countries for treatment of bone metastasesand prostate cancer. In addition, extensive research is being conducted around the world on a number of clinical applications.

Focused Ultrasound: A Global Perspective . Collaborative Network 3


Charts by subjects

4 Manufacturers by Region

5 Research Sites 5 By Region

6 By Region: North America, South America

7 By Region: Europe

8 By Region: Asia, Oceania

9 Technical Research Sites9 By Region

10 By Region: North America

11 By Region: Europe

12 By Region: Asia

13 Pre-clinical Research Sites13 By Region



16 By Region: Asia

17 By Region: Oceania

The information in this report was provided by manufacturers and the focused ultrasound research community to the Focused Ultrasound Foundation. The FUS Foundation aims to provide themost accurate information, if you have more current or updatedinformation please send it to: [email protected].

18 Clinical Research Sites18 By Region


20 By Region South America21 By Region: Europe22 By Region: Asia23 By Region: Oceania

24 Commercial Treatment24 FUS Approvals by Region

25 By Region and Indications

26 By Country

27 By Region

28 By Region: North America, South America


30 By Region: Africa, Oceania

31 By Region: Asia



January 31, 2014

Manufacturers by Region■ MR guidance ■ US guidance ■ MR & US guidance ■ Visual guidance

7North America

10Europe

5Asia

■ FUS Instruments Inc.

■ Histosonics, Inc.

■ International Cardio Corporation, LLC

■ Kona Medical

■ Mirabilis Medica

■ Profound Medical Inc.

■ SonaCare Medical, LLC

■ Acublate

■ EDAP TMS S.A.

■ EyeTechCare

■ Image Guided Therapy (IGT)

■ InSightec LTD

■ Medsonic LTD

■ Philips Healthcare

■ Slender Medical LTD

■ Supersonic Imagine

■ Theraclion

■ Alpinion Medical Systems

■ Chongqing Haifu (HIFU) Medical Technology Co., LTD

■ Mianyang Sonic (SUONIKE) Electronic

■ Shanghai A&S Co., LTD

■ SITU SUNTEC



All Research Sites by Region

68North America

61Europe

1South America

37Asia

2Oceania

169Worldwide Total

Any FUS research site conducting technical, pre-clinical, or clinical FUS research.

January 31, 2014



January 31, 2014

Research Sites by Region

68North America

Artann LaboratoriesBoston UniversityBrigham and Women’s Hospital (BWH)Can-Am HIFU

CHI St. Luke’s HealthChildren's National HospitalCity of HopeCleveland ClinicCleveland Clinic CanadaColumbia UniversityDrexel UniversityDuke UniversityFox Chase Cancer CenterGrand Strand UrologyIndiana University Health, University HospitalIndiana University School of MedicineJewish General HospitalJohns Hopkins University School of MedicineLawson Health Research InstituteLondon Health Sciences Centre (LHSC)Mayo Clinic – MinnesotaMedical University of South Carolina (MUSC)Memorial Sloan-Kettering Cancer CenterMetropolitan UrologyMontefiore Medical CenterNational Institutes of Health (NIH)New York University (NYU) Langone Medical Center

and School of MedicineNYP – Weill Cornell Medical CenterOregon Health and Science UniversitySoutheast Urology NetworkSpecialists in Urology, PA

Stanford University Medical CenterSunnybrook Health Sciences CentreSwedish Neurosciences InstituteThe Hospital for Sick Children (SickKids)

The Methodist HospitalThunder Bay Regional Research InstituteTulane UniversityUCLA/BrainsonixUCLA Ronald Reagan Medical CenterUT SouthWesternUniversity Hospitals of Cleveland Case Medical CenterUniversity MRI & Diagnostic Imaging Centers – SouthUniversity of California, DavisUniversity of California at San DiegoUniversity of California San Diego (UCSD)

Thornton HospitalUniversity of California San Francisco (UCSF)University of ChicagoUniversity of CincinnatiUniversity of Illinois at Urbana-Champaign (UIUC)University of Kansas – KU Bioengineering Research

Center Mechanical EngineeringUniversity of Maryland School of MedicineUniversity of Michigan (UMich)University of MinnesotaUniversity of Texas MD Anderson Cancer CenterUniversity of UtahUniversity of Virginia (UVA) Health SystemUniversity of WashingtonUniversity of Wisconsin Carbone Cancer CenterUrologic Consultants of Southeastern PennsylvaniaUrology AssociatesUrology Centers of AlabamaUrology of San AntonioVanderbilt UniversityWake Forest University Baptist Medical CenterWalter Reed National Military Medical CenterWilliam Beaumont Health SystemsWinthrop University Hospital

1South America

Instituto do Cancer do Estado de Sao Paulo (ICESP)





61Europe

Amper KlinikAzienda Ospedaliera San PaoloBasingstoke and North Hampshire HospitalBrustzentrum Marienhospital BottropCareggi General HospitalCenter for Ultrasound Functional NeurosurgeryCentre Hospitalier Regional Universitaire de ToursCentre Léon BérardCharité Universitätsmedizin BerlinCHRU de Lille - Hôpital HuriezCHU de Bordeaux – Hôpital Saint-AndréCHU de Bordeaux – Hôpital du TonduCHU de Toulouse – Hôpital RangueilCisanello Hospital of University of PisaClinica oculistica Università – Ospedale oftalmicoCyprus University of TechnologyEindhoven University of TechnologyEuropean Institute of OncologyFondazione IRCCS Ca’ Granda Ospedale

Maggiore PoliclinicoFraunhofer Institut IBMT

German Cancer Research Center (DKFZ)Hôpital CochinHôpital Pitié-SalpêtrièreHôpitaux Universitaires de Genève (HUG)Hospices Civils de LyonHospital Clínico San CarlosHospital Universitario Marqués de Valdecilla (HUMV)Inserm LyonInstitute for Medical Science and Technology (IMSAT)Institut Gustave RoussyInstitut Langevin (ESPCI)Institut Mutualiste MontsourisInstituto CartujaJohn Radcliffe Hospital

Kantonspital WinterthurKlinikum FürthLaboratorio di Tecnologie Oncologiche (LATO) HSR Giglio –

Fondazione Istituto San Raffaele G. Giglio di CefalùMedical Center of Central Bank of Russian FederationN. N. Petrov Research Institute of OncologyNational Medical Surgery CenterNiguarda HospitalOspedale Generale Regionale “Francis Miulli’Research Center for Obstetrics, Gynecology and

Perintology of Russian Ministry of Health and Social Development

Rostov Scientific Research Institute of OncologyScuola Superiore Sant’AnnaSt. Mary’s HospitalThe Institute of Cancer Research (ICR)The Intervention Centre, Oslo University Hospital

RikshopitaletThomayer University HospitalUniversità degli Studi di ParmaUniversity Children's Hospital ZurichUniversity Hospital of EndocrinologyUniversity Hospital Schleswig-HolsteinUniversity Medical Center (UMC) UtrechtUniversity of GenevaUniversity of HeidelbergUniversity of HullUniversity of L’AquilaUniversity of MunichUniversity of Rome – La SapienzaUrologische Universitätsklinik Magdeburg


January 31, 2014



January 31, 2014


37Asia

307 Hospital of PLA

Apollo Specialty Hospital, ChennaiBreastopia Namba HospitalCentral Hospital of Shanghai Xuhui DistrictCHA Bundang Medical CenterChaim Sheba Medical CenterChaum HospitalChildren’s Hospital of Chongqing Medical UniversityFirst Affiliated Hospital of Medical College of

Xi’an Jiaotong UniversityFirst Affiliated Hospital of Zunyi Medical CollegeFirst Maternal and Child Health Hospital of ShanghaiFudan University Cancer HospitalGsl Medical CollegeHAIFU HospitalIndraprastha Apollo HospitalInstitute of Ultrasonic Engineering in Medicine and

Clinical Centre for Tumour TherapyJaslok Hospital and Research CentreKochi University HospitalNanyang Technological UniversityNational Medical Research Center

Peking Union Hospital, Chinese Academy of Medical Sciences

Peking University First HospitalPLA 301 Hospital (General Hospital of the

People’s Liberation Army)Queen Mary Hospital of the University of Hong KongRambam Medical CenterSamsung Medical CenterShinsuma General HospitalSRL Diagnostics – Jankharia ImagingSuining Central HospitalTaipei Medical University HospitalThe First Affiliated Hospital of Chongqing

Medical UniversityThe Second Artillery General Hospital of Chinese PLA

The Third Xiangya Hospital of Central South UniversityTokyo Women's Medical HospitalUniversity of Malaya (UMMC)YUCM Severance HospitalYUMC Gangnam Severance Hospital

2Oceania

Future Medical Imaging Group (FMIG)Royal Women's Hospital Melbourne




Technical Research Sites by Region

36North America

16Europe

3Asia

55 Worldwide Total

January 31, 2014



January 31, 2014

Technical Research Sites by Region and Areas

■ ■ ■ Boston University

■ ■ ■ ■ Brigham and Women’s Hospital (BWH)■ ■

■ ■ CHI St. Luke’s Health

■ ■ ■ ■ City of Hope

■ ■ ■ ■ Columbia University■

■ ■ ■ ■ Drexel University■

■ Duke University

■ ■ ■ ■ Indiana University School of Medicine

■ ■ ■ ■ Johns Hopkins University School ■ of Medicine

■ ■ Mayo Clinic – Minnesota

■ ■ Medical University of South Carolina (MUSC)

■ National Institutes of Health (NIH)

■ ■ ■ ■ Stanford University Medical Center■

■ ■ ■ ■ Sunnybrook Health Sciences Centre■ ■ ■ ■

■ ■

■ ■ Swedish Neurosciences Institute

■ ■ The Hospital for Sick Children (SickKids)

■ ■ ■ ■ Thunder Bay Regional Research Institute■

■ ■ ■ ■ Tulane University■

■ ■ ■ ■ UCLA/Brainsonix

■ ■ UCLA Ronald Reagan Medical Center

■ ■ ■ ■ University of California, Davis■ ■ ■ ■

■

■ ■ University of California at San Diego

■ University of California San Diego (UCSD) Thornton Hospital

■ ■ University of California San Francisco (UCSF)

■ ■ ■ University of Chicago

■ University of Cincinnati

■ ■ University of Kansas – KU Bioengineering Research Center Mechanical Engineering

■ ■ ■ ■ University of Maryland School ■ ■ ■ ■ of Medicine

■ ■ ■ ■ University of Michigan (UMich)

■ ■ ■ ■ University of Minnesota■ ■ ■

■ ■ ■ ■ University of Texas MD Anderson ■ ■ ■ ■ Cancer Center

■ ■

■ ■ ■ ■ University of Utah■

■ ■ ■ ■ University of Virginia (UVA) ■ ■ Health System

■ ■ ■ ■ University of Washington■ ■ ■ ■

■

■ ■ ■ ■ Vanderbilt University■ ■ ■ ■

■ ■ ■ Wake Forest University Baptist Medical Center

36North America

■ Amplification of cancer biomarkers

■ Clot lysis

■ Drug delivery

■ Drug activity enhancement

■ Focused Ultrasound Physics

■ Focused Ultrasound Transducer technology

■ Immunomodulation

■ MR imaging for FUS guidance

■ Neuromodulation

Radio sensitization

■ Sonodynamic therapy

■ Tissue destruction (Histotripsy)

■ Tissue destruction (Thermal Ablation)

■ Ultrasound imaging for FUS guidance

■ Vasodilatation



January 31, 2014


■ CHU de Bordeaux – Hôpital Saint-André

■ ■ ■ ■ Cyprus University of Technology■

■ Eindhoven University of Technology

■ ■ ■ ■ European Institute of Oncology

■ ■ Fraunhofer Institut IBMT

■ ■ ■ ■ Inserm Lyon■ ■ ■ ■

■ ■ ■ ■ Institut Langevin (ESPCI)■ ■

■ John Radcliffe Hospital

■ N. N. Petrov Research Institute of Oncology

■ ■ ■ ■ Scuola Superiore Sant’Anna■ ■ ■ ■

■ ■ ■ ■ St. Mary’s Hospital

■ ■ ■ ■ The Institute of Cancer Research (ICR)■

■ ■ ■ ■ University Children’s Hospital Zurich■

■ ■ ■ University Medical Center (UMC) Utrecht

■ ■ ■ ■ University of Heidelberg■ ■

■ University of Munich

16Europe


■ Clot lysis

■ Drug delivery






■ Neuromodulation

■ Radio sensitization





■ Vasodilatation



January 31, 2014


■ Breastopia Namba Hospital

■ ■ ■ Samsung Medical Center

■ ■ University of Malaya (UMMC)3Asia


■ Clot lysis

■ Drug delivery






■ Neuromodulation

■ Radio sensitization





■ Vasodilatation



January 31, 2014

Pre-Clinical Research Sites

44North America

22Europe

16Asia

84 Worldwide Total

Any FUS research site conducting animal research.

2Oceania



January 31, 2014

Pre-clinical Research Sites by Region

44North America

■ Artann Laboratories

■ ■ ■ Boston University

■ ■ ■ ■ Brigham and Women’s Hospital (BWH)■ ■ ■

■ CHI St. Luke’s Health

■ ■ City of Hope

■ ■ ■ ■ Columbia University■

■ ■ ■ ■ Drexel University

■ ■ Duke University

■ ■ Fox Chase Cancer Center

■ Indiana University Health, University Hospital

■ ■ ■ Johns Hopkins University School of Medicine

■ ■ ■ Lawson Health Research Institute


■ ■ Medical University of South Carolina (MUSC)

■ Memorial Sloan-Kettering Cancer Center

■ ■ ■ ■ National Institutes of Health (NIH)

■ ■ NYP – Weill Cornell Medical Center

■ ■ ■ ■ Stanford University Medical Center■ ■ ■

■ ■ ■ ■ Sunnybrook Health Sciences Centre■ ■ ■ ■■ ■ ■ ■

■ ■

■ ■ Swedish Neurosciences Institute

■ ■ ■ ■ The Hospital for Sick Children (SickKids)

■ ■ The Methodist Hospital

■ ■ ■ Thunder Bay Regional Research Institute

■ ■ ■ ■ Tulane University■

■ UCLA/Brainsonix

■ ■ UCLA Ronald Reagan Medical Center

■ ■ University MRI & Diagnostic Imaging Centers – South

■ ■ ■ University of California, Davis

■ University of California at San Diego

■ University of California San Diego (UCSD) Thornton Hospital


■ ■ ■ University of Chicago

■ ■ ■ University of Illinois at Urbana-Champaign (UIUC)

■ ■ ■ ■ University of Kansas –KU Bioengineering Research Center Mechanical Engineering

■ ■ ■ ■ University of Maryland School of Medicine

■ ■ ■ ■ University of Michigan (UMich)■ ■

■ ■ ■ ■ University of Minnesota■ ■

■ ■ ■ ■ University of Texas MD Anderson ■ Cancer Center

■ ■ University of Utah

■ ■ ■ ■ University of Virginia (UVA) Health System■

■ ■ ■ ■ University of Washington

■ Urology Centers of Alabama

■ ■ Vanderbilt University

■ Wake Forest University Baptist Medical Center

■ Alzheimer’s Disease■ Atherosclerosis■ Atrial fibrillation■ Back and neck pain■ Benign Prostatic

Hypertrophy■ Bladder tumors■ Bone Metastases ■ Brain Tumors■ Breast Cancer ■ Breast Fibroadenoma ■ Cancer pain■ Colon■ Epilepsy■ Essential Tremor■■ Glaucoma■ Hydrocephalus■ Hypertension■ Kidney Tumors■ Liver Tumor■ Neuropathic pain■ Obsessive-compulsive

Disorder■ Osteoarthritis■ Osteoid Osteoma■ Pancreatic Tumor■ Parkinson’s Disease■ Prostate Cancer■ Prostate Tumors■ Septal perforation■ Soft Tissue Tumors■ Stroke■ Thyroid & Parathyroid tumors■ Trigeminal neuralgia■ Uterine Fibroids■ Uterine Adenomyosis




January 31, 2014


■ ■ ■ Centre Léon Bérard

■ ■ CHU de Bordeaux – Hôpital Saint-André

■ ■ ■ ■ Cyprus University of Technology■ ■ ■ ■

■ ■ ■ Eindhoven University of Technology

■ European Institute of Oncology

■ ■ ■ German Cancer Research Center (DKFZ)

■ Hôpital Cochin

■■ Hôpitaux Universitaires de Genève (HUG)

■ Hospices Civils de Lyon

■■ Hospital Clínico San Carlos

■ ■ ■■ ■ Inserm Lyon■

■ ■ ■ ■ Institute for Medical Science and ■ ■ ■ ■ Technology (IMSAT)

■ ■ ■

■ ■ ■ ■ Institut Langevin (ESPCI)

■ ■ Instituto Cartuja

■ ■ ■ ■ John Radcliffe Hospital■ ■

■ Klinikum Fürth

■ Scuola Superiore Sant’Anna

■ The Institute of Cancer Research (ICR)

■ ■ ■ ■ University Medical Center (UMC) Utrecht

■ University of Geneva

■ ■ ■ ■ University of Heidelberg

■ ■ University of Hull




22Europe




January 31, 2014


16Asia


■ ■ ■ ■ Chaim Sheba Medical Center

■ ■ ■ Chaum Hospital

■ ■ ■ ■ Fudan University Cancer Hospital■ ■

■ Gsl Medical College

■ ■ ■ ■ HAIFU Hospital■ ■

■ Indraprastha Apollo Hospital

■ ■ ■ Jaslok Hospital and Research Centre

■ Kochi University Hospital

■ Nanyang Technological University

■ Peking Union Hospital, Chinese Academy of Medical Sciences

■ ■ ■ ■ PLA 301 Hospital (General Hospital of ■ ■ the People’s Liberation Army)

■ Rambam Medical Center

■ ■ ■ Samsung Medical Center

■ Taipei Medical University Hospital

■ ■ ■ University of Malaya (UMMC)







January 31, 2014


2Oceania

■ Future Medical Imaging Group (FMIG)

■ ■ ■ ■ Royal Women's Hospital Melbourne■ ■ ■







January 31, 2014

Clinical Research Sites by Region

52North America

50Europe

1South America

35Asia

2Oceania

140Worldwide Total

Any FUS research site treating patients as part of a clinical study.



January 31, 2014


■ ■ ■ ■ Brigham and Women’s Hospital (BWH)■

■ Can-Am HIFU

■ CHI St. Luke’s Health

■ Children’s National Hospital

■ ■ City of Hope

■ Cleveland Clinic

■ Cleveland Clinic Canada

■ Duke University

■ Fox Chase Cancer Center

■ Grand Strand Urology

■ Indiana University Health, University Hospital

■ Jewish General Hospital

■ Johns Hopkins University Schoolof Medicine

■ London Health Sciences Centre (LHSC)


■ Memorial Sloan-Kettering Cancer Center

■ Metropolitan Urology

■ ■ ■ Montefiore Medical Center

■ ■ ■ National Institutes of Health (NIH)

■ New York University (NYU) LangoneMedical Center and School of Medicine

■ ■ NYP – Weill Cornell Medical Center

■ Oregon Health and Science University

■ Southeast Urology Network

■ Specialists in Urology, PA

■ ■ ■ ■ Stanford University Medical Center■ ■

■ ■ ■ ■ Sunnybrook Health Sciences Centre

■ ■ ■ Swedish Neurosciences Institute

■ The Methodist Hospital

■ Thunder Bay Regional Research Institute

■ ■ ■ ■ Tulane University■ ■

■ ■ ■ ■ UCLA/Brainsonix

■ ■ ■ ■ UCLA Ronald Reagan Medical Center

■ UT Southwestern

■ University Hospitals of Cleveland Case Medical Center

■ ■ University MRI & Diagnostic Imaging Centers—South

■ ■ University of California San Diego (UCSD) Thornton Hospital


■ ■ University of Chicago

■ University of Cincinnati

■ University of Maryland School of Medicine

■ University of Michigan (UMich)

■ ■ ■ University of Texas MD Anderson Cancer Center

■ ■ ■ ■ University of Virginia (UVA) ■ Health System

■ University of Wisconsin Carbone Cancer Center

■ Urologic Consultants of Southeastern Pennsylvania

■ Urology Associates

■ Urology Center of Alabama

■ Urology of San Antonio

■ ■ ■ Vanderbilt University Medical Center

■ Walter Reed National Military Medical Center

■ William Beaumont Health Systems

■ Winthrop University Hospital




52North America




January 31, 2014





1South America

■ ■ ■ ■ Instituto do Cancer do Estado de ■ Sao Paulo (ICESP)




January 31, 2014


■ ■ ■ ■ Amper Klinik

■■ Azienda Ospedaliera San Paolo

■ Basingstoke and North Hampshire Hospital

■ ■ ■ ■ Brustzentrum Marienhospital Bottrop

■ ■ ■ ■ Careggi General Hospital ■ ■ ■ ■

■ ■ ■ ■ Center for Ultrasound Functional Neurosurgery

■ Centre Hospitalier Regional Universitaire de Tours

■ ■ ■ ■ Centre Léon Bérard ■

■ ■ ■ Charité Universitätsmedizin Berlin

■ CHRU de Lille - Hôpital Huriez

■ CHU de Bordeaux - Hôpital du Tondu

■ CHU de Bordeaux—Hôpital Saint-André

■ CHU de Toulouse - Hôpital Rangueil

■ ■ ■ ■ Cisanello Hospital of University of Pisa■ ■

■■ Clinica oculistica Università –Ospedale oftalmico

■ ■ ■ ■ European Institute of Oncology ■ ■ ■ ■

■ Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

■ Hôpital Pitié-Salpêtrière

■ Hospices Civils de Lyon

■■ Hospital Clînico San Carlos

■ ■ Hospital Universitario Marqués de Valdecilla (HUMV)

■ Inserm Lyon

■ Institut Gustave Roussy

■ Institut Mutualiste Montsouris

■ Instituto Cartuja

■ ■ ■ John Radcliffe Hospital

■ ■ Kantonspital Winterthur

■ Klinikum Fürth

■ ■ Laboratorio di Tecnologie Oncologiche (LATO) HSR Giglio – Fondazione Istituto San Raffaele G. Giglio di Cefalù

■ ■ ■ ■ Medical Center of Central Bank of ■ ■ Russian Federation

■ ■ N. N. Petrov Research Institute of Oncology

■ ■ ■ ■ National Medical Surgery Center ■ ■

■ ■ Niguarda Hospital

■ Ospedale Generale Regionale “Francis Miulli”

■ Research Center for Obstetrics, Gynecology and Perintology of Russian Ministry of Health and Social Development

■ ■ Rostov Scientific Research Institute of Oncology

■ ■ ■ ■ St. Mary’s Hospital■ ■

■ The Institute of Cancer Research (ICR)

■ ■ ■ The Intervention Centre, Oslo University Hospital Rikshopitalet

■ Thomayer University Hospital

■■ Università degli Studi di Parma

■ ■ ■ ■ University Children’s Hospital Zurich■

■ ■ University Hospital of Endocrinology

■ University Hospital Schleswig-Holstein

■ ■ ■ ■ University Medical Center (UMC) Utrecht

■ University of Heidelberg

■ ■ ■ ■ University of L’Aquila

■ ■ ■ ■ University of Munich

■ ■ ■ ■ University of Rome – La Sapienza■ ■

■ Urologische Universitätsklinik Magdeburg




50Europe




January 31, 2014


■ ■ ■ ■ 307 Hospital of the ■ ■ People's Liberation Army

■ Apollo Specialty Hospital, Chennai


■ Central Hospital of Shanghai Xuhui District

■ ■ CHA Bundang Medical Center

■ ■ Chaim Sheba Medical Center

■ ■ Chaum Hospital

■ ■ ■ ■ Children’s Hospital of Chongqing ■ ■ Medical University

■ First Affiliated Hospital of Medical College of Xi’an Jiaotong University

■ ■ ■ ■ First Affiliated Hospital of Zunyi ■ ■ Medical College

■ ■ ■ ■ First Maternal and Child Health■ ■ Hospital of Shanghai

■ ■ ■ ■ Fudan University Cancer Hospital■ ■

■ GSL Medical College

■ ■ ■ ■ HAIFU Hosptial■ ■

■ Indraprastha Apollo Hospital

■ ■ ■ ■ Institute of Ultrasonic Engineering in ■ ■ Medicine and Clinical Centre for

Tumour Therapy

■ ■ ■ ■ Jaslok Hospital and Research Centre

■ ■ ■ ■ National Medical Research Center■ ■

■ Peking Union Hospital, Chinese Academy of Medical Sciences

■ Peking University First Hospital

■ ■ ■ ■ PLA 301 Hospital (General Hospital■ ■ of the People’s Liberation Army)

■ ■ ■ ■ Queen Mary Hospital of the ■ ■ University of Hong Kong

■ Rambam Medical Center

■ ■ Samsung Medical Center

■ ■ Shinsuma General Hospital

■ SLR Diagnostics – Jankharia Imaging

■ ■ ■ ■ Suining Central Hospital■ ■

■ ■ Taipei Medical University Hospital

■ ■ ■ ■ The First Affiliated Hospital of ■ ■ Chongqing Medical University

■ ■ ■ ■ The Second Artillery General Hospital ■ ■ of Chinese PLA

■ ■ ■ ■ The Third Xiangya Hospital of ■ ■ Central South University

■ Tokyo Women's Medical Hospital

■ ■ ■ ■ University of Malaya (UMMC)■ ■ ■ ■

■ ■ ■ YUCM Severance Hospital

■ ■ ■ YUMC Gangnam Severance Hospital




35Asia




January 31, 2014





2Oceania

■ ■ ■ ■ Future Medical Imaging Group (FMIG)■ ■

■ ■ The Royal Women’s Hospital Melbourne




January 31, 2014

FUS Approvals by Region

Medical Condition United States Canada Europe Asia Latin America Middle East

Adenomyosis ✓Bone ✓ ✓ ✓ ✓ ✓ ✓Breast Cancer ✓ ✓Breast Fibroadenoma ✓ ✓Essential Tremor ✓ ✓Facet Rhizotomy ✓Hyperparathyroidisim ✓Kidney Cancer ✓ ✓Liver ✓ ✓Neuropathic Pain ✓ ✓Osteoid Osteoma ✓ ✓Pancreatic Cancer ✓ ✓Parkinsonian Tremor ✓ ✓Prostate Cancer ✓ ✓ ✓ ✓ ✓Thyroid Nodules ✓ ✓Uterine Fibroids ✓ ✓ ✓ ✓ ✓ ✓



January 31, 2014January 31, 2014

Commercial Treatment Sites by Indications and Regions

North America■ 7 Bone Metastases ■ 1 Breast Cancer ■ 1 Kidney Tumors■ 1 Liver Tumors ■ 1 Osteoid Osteoma■ 11 Prostate Cancer■ 1 Soft Tissue Tumors■ 15 Uterine Fibroids

South America■ 4 Prostate Cancer■ 1 Uterine Fibroids

Europe■ 9 Bone Metastases ■ 14 Breast Cancer ■ 6 Breast Fibroadenoma ■ 14 Kidney Tumors■ 14 Liver Tumors■ 14 Osteoid Osteoma■ 162 Prostate Cancer■ 14 Soft Tissue Tumors■ 37 Uterine Fibroids

Asia■ 1 Bone Metastases■ 89 Breast Cancer ■ 1 Essential Tremor ■ 88 Kidney Tumors■ 88 Liver Tumors■ 1 Multiple Myeloma ■ 88 Osteoid Osteoma■ 22 Prostate Cancer■ 91 Soft Tissue Tumors■ 109 Uterine Fibroids

Africa■ 1 Prostate Cancer

Oceania■ 2 Uterine Fibroids

Any site with a focused ultrasound system and regulatory approval from the respective country and charging for procedures.



January 31, 2014

Commercial Treatment Sites by Country

North AmericaBahamas

Bermuda

Canada

Costa Rica

Cuba

Dominican Republic

Mexico

United States

South AmericaBolivia

Brazil

Ecuador

Poland

Repubblica di San Marino

Romania

Russia

Spain

Switzerland

Ukraine

United Kingdom

AsiaChina

India

Israel

Japan

Kazakhstan

Kingdom of Saudi Arabia

Lebanon

Pakistan

Phillipines

Republic of Korea

Singapore

Syria

Taiwan

United Arab EmiratesAfricaSouth Africa

OceaniaAustralia

EuropeAustria

Belgium

Bulgaria

Denmark

France

Germany

Italy

Monaco

The Netherlands

Norway




January 31, 2014

Commercial Treatment Sites by Region

31North America

211Europe

5South America

144Asia

2Oceania

394Worldwide Total

1Africa




January 31, 2014


Brigham and Women’s Hospital (BWH)Can-Am HIFU

Center for Advanced MedicineCity of HopeCleveland Clinic CanadaClinica Union MedicaDoctors HospitalDon Mills Surgical UnitDuke Health Center at SouthpointFocused Ultrasound NorthwestFox Chase Cancer CenterGalenia HospitalHospital CIMA San JoseHospital Medical Surgical Research Center (CIMEQ)Imagen Por ResonanciaKing Edward VII Memorial HospitalLes Cours Medical CentreMayo Clinic – MinnesotaMedica Sur TlalpanMemorial Sloan-Kettering Cancer Center

Riverside Methodist HospitalSan Javier Hospital MarinaStanford University Medical CenterStanford University School of MedicineSunnybrook Health Sciences CentreThunder Bay Regional Research InstituteUCLA Ronald Reagan Medical CenterUniversity MRI & Diagnostic Imaging Centers – SouthUniversity of California San Diego (UCSD)

Thornton HospitalUniversity of California San Francisco (UCSF)University of Virginia (UVA) Health System

31North America

Centro de urología avanzada de la Clínica IncorHospital AC Camargo de São PauloHospital Carlos Andrade MarínHospital Policia Nacional GuayaquiInstituto do Cancer do Estado de Sao Paulo (ICESP) 5

South America




January 31, 2014


211Europe

CHU de BâleCHU de Bordeaux – Hôpital du TonduCHU de Bordeaux – Hôpital Saint-AndréCHU de GenêveCHU de Limoges – Hôpital DupuytrenCHU de Nancy – Hôpital de BraboisCHU de Nice – Hôpital PasteurCHU de Reims – Hôpital Robert DebréCHU de RennesCHU de Rouen – Hôpital Charles NicolleCHU de Toulouse – Hôpital RangueilCHU de Tours – Hôpital BretonneauCHU Nord Saint EtienneCHUv de LausanneCisanello Hospital of University of PisaClínica Virgen Blanca S.A.Clinical Diagnostis Center ZdorovieClinique d’AlembertClinique Beau SoleilClinique De MontchoisiClinique des GrangettesClinique du PalaisClinique Generale BeaulieuClinique Mutualiste Eugène AndréClinique Saint GeorgesClinique Saint-MichelClinique Universitaire Saint-Luc (UCL)Clinique urologique Nantes AtlantisCROB IRCCS RioneroDiakonie-Klinikum StuttgartDiakonie Krankenhaus Kreuznacher DiakonieDRK-Seepark Klinik Debstredt GmbHDTL MedicaEuropean Institute of OncologyEv. Jung-Stilling-KrankenhausEv. Krankenhaus Göttingen-Weende e.V.Foligno HospitalFranciscus ZiekenhuisFranziskus-KrankenhausGemeinschaftspraxis für urologieGPR Gesundheits-und Pfegezentrum

Rüsselsheim gGmbH-KlinikumGroupe Hospitalier Diaconesses Croix Saint-SimonHIFU Clinic – AMEDS CentrumHIFU Terramed Conformal CentreHôpital Edouard HerriotHôpital FochHôpital Jeanne de FlandreHôpital Pitié-SalpêtrièreHôpital TenonHospital Gral. Universitario Gregorio MaranonHospital of Mutua De Terrassa UniversityIMEXINI Divisione CanistroINI Divisione GrottaferrataInstitut Jules BordetInstitut Mutualiste MontsourisInstituto Cartuja

John Radcliffe HospitalKantonspital WinterthurKantonsspital FrauenfeldKatholisches Klinikum Essen GmbHKiev City Oncology HospitalKlink für Prostata-Therapie GmbHKlinikum FürthKlinikum ItzehoeKlinikum KonstanzKlinikum NürnbergKlinik und Poliklinik für Urologie der Universität

Regensburg am Caritaskrankenhaus St. JosefKrankenhaus der Barmherzigen Brüder WienKrankenhaus Dresden-FriedrichstadtKrankenhaus HietzingKrankenhaus NordwestLaboratorio di Tecnologie Oncologiche (LATO)

HSR Giglio – Fondazione Istituto San Raffaele G. Giglio di Cefalù

Loretto-KrankenhausMain Military Clinical Burdenko’s HospitalMarienhospital Arnsberg GmbHMarien-Hospital MarlMedical Center of Central Bank of Russian FederationMilitary Medical Academy St. PetersburgMonikiMoscow City Clinical Hospital BotkinMoscow Regional Rehabilitation Center of RoszdravMount Alvernia HospitalN. N. Petrov Research Institute of OncologyNational Medical Surgery CenterNiguarda HospitalNII of UrologyNottingham University City Hospital NHS TrustNuova Villa ClaudiaOrenbourg Oncology CenterOspedale “Cardinal Massaia” di AstiOspedale “Misericordia e Dolce” di PratoOspedale di GoriziaOspedale di MassaOspedale di Nocera Inferiore Umberto IOspedale San Bartolomeo di SarzanaOspedale San Raffaele Giglio di CefalùOspedale Sant’ Anna di ComoP.O. di CastellanzaP.O di EsteParacelsus Klinik GolzheimParacelsus Klinik Reichenbach GmbHPoliclínica San AntonioPoliclinico GemelliPolyclinique Bordeaux Nord AquitainePolyclinique du Parc RambotPolyclinique Jean VillarPrincess Grace HospitalRadiologische GemeinschaftspraxisRamsay Springfield HospitalResearch Center for Obstetrics, Gynecology and

Perinatology of Russian Ministry of Health and Social Development

ResoFus – Centre Medic AlomarRome American HospitalRostov Scientific Research Institute of OncologyRotkreuzklinikum MünchenSaint Marina HospitalSamara Oncoly CentreSankt Katharinen KrankenhausSaratov City Medical AcademySegeberger KlinikenSora Cancer CentreSpire Parkway HospitalSt. Antonius-HospitalSt. Barbara HospitalSt. Elisabethen-Krankenhaus der Katharina-Kasper

gGmbHSt. Elisabeth-Krankenhaus Köln-HohenlindSt. Elisabeth-Krankenhaus LeipzigSt.-Josefs-Hospital GmbHSt. Mary’s HospitalStädtisches Klinikum MünchenStepping Hill NHS HospitalSt. Petersburg Oncology DispanserSussex Nuffield HospitalThe Community Foundation Serving Richmond

and Central VirginiaThe Essex NuffieldThe HIFU Clinic Spire Gatwick Park HospitalThe I. M. Sechenov Moscow Medical Academy (MMA)The Intervention Centre, Oslo University HospitalRikshopitaletThe King George Hospital NHS TrustThe Princess Royal Hospital NHS TrustTheresienkrankenhaus MannheimThe Priory HospitalThe Royal Free NHS Trust HospitalThe Royal Surrey County Hospital NHS TrustThe Wellington HospitalThe Winterbourne HospitalThomayer University HospitalTILAK Unternehmen GesundheitUfa Oncology CenterUniversitätsklinikum Bonn (University Hospital Bonn)Universitätsspital BaselUniversitatsspital NordUniversity Children’s Hospital ZurichUniversity College London HospitalsUniversity Hospital, MR CenterUniversity Hospital of EndocrinologyUniversity Hospital Schleswig-HolsteinUniversity Medical Center (UMC) UtrechtUniversity Medical Center LubeckUniversity of L’AquilaUniversity of OxfordUniversity of Rome – La SapienzaUniversity of ViennaUrologisches ZentrumUrologische Universitätsklinik HeidelbergZaans Medisch Centrum

Aarhus University HospitalAgaplesion Diakonieklinikum HamburgAkademisches Lehrkrankenhaus der Universitat

FreiburgAlgemeen Ziekenhuis MiddelheimAlliance Medical, ItalyAmper KlinikAmphia ZiekenhuisAsklepios Kliniken Weißenfels-Hohenmölsen GmbHAsklepios Klinik UckermarkAsklepios Paulinen KlinikAz. Osp. San Giovanni Battista – Le MolinetteAzienda Ospedaliera ‘Di Venere – Giovanni XXIII’Azienda Ospedaliera A. CardarelliAzienda Ospedaliera Sant’AndreaAzienda Ospedaliera S.Maria degli AngeliAzienda Ospedaliera Universitaria Tor VergataAzienda Sanitaria Locale 21BMI Goring Hall HospitalBMI Highfield HospitalBMI The Kings Oak HospitalBrighton and Sussex University HospitalBrustzentrum Marienhospital BottropCareggi General HospitalCasa di Cura Abano TermeCasa di Cura Candela SpACasa di Cura ColumbusCasa di Cura Villa SerenaCEMEDIDiagnostico por imagenCenter for Ultrasound Functional NeurosurgeryCenter of Family Planning & Reproduction (CFPR)Central Bank Medical CenterCentral Institute of Traumatology and OrthopedicsCentre Hospitalier de ChambéryCentre Hospitalier de La Rochelle – Hôpital Saint LouisCentre Hospitalier de SaintongeCentre Hospitalier Grace de MonacoCentre Hospitalier Nord de Marseille – CHU

Centre Hospitalier Régional Universitaire de LilleCentre Hospitalier Regional Universitaire de ToursCentre Hospitalier Universitaire de CaenCentro Hospitalario QuirónCharité Universitätsmedizin BerlinCHRU de Guadeloupe – Hôpital les AbymesCHRU de Lille – Hôpital HuriezCHRU de Strasbourg – Hôpital Civil




January 31, 2014


Christiaan Barnard Memorial Hospital INTAMED

1Africa


Future Medical Imaging Group (FMIG)The Royal Women’s Hospital Melbourne2

Oceania



January 31, 2014


144Asia

307 Hospital of PLA

Affiliated Hospital of Armed Police's Medical CollegeAffiliated Hospital Of Chuanbei Medical CollegeAffiliated Hospital of Qinghai Medical CollegeAffiliated Hospital Of Xinxiang Medical CollegeAffiliated Hospital of Yokohama UniversityAizu Chuo HospitalAl Zahra HospitalBaoji Maternal and Child Health HospitalBeijing Cancer HospitalBeijing HospitalBharat Scans Private LimitedBreastopia Namba HospitalCentral Hospital of Shanghai Xuhui DistrictCHA Bundang Medical CenterChaim Sheba Medical CenterChang Gung Memorial Hospital (Chiayi)Chang Gung Memorial Hospital (Kaohsiung)Chang Gung Memorial Hospital (Keelung)Chang Gung Memorial Hospital (Linkou)Chang Gung Memorial Hospital (Taipei)Changhua Christian HospitalChaum HospitalChengdu Maternal and Child Health Center HospitalChengdu Shuangnan HospitalChildren’s Hospital of Chongqing Medical UniversityChina Medical University Beigang HospitalChongqing Three Gorges Central HospitalCity Hospital of Bincheng District in Binzhou CityClinical E.T.Clumax DiagnosticsConcept Medicare (India) Pvt Ltd.Dalian Friendship HospitalDar al Shifaa HospitalDaxian People’s HospitalDengfeng People’s HospitalEkaterinburg Regional Hospital N1/URAL Medical

Univercity Central Ural RegionFifth People’s Hospital of Nanchong CityFirst Affiliated Hospital, Zhengzhou UniversityFirst Affiliated Hospital of Guangxi Medical UniversityFirst Affiliated Hospital of Kunming Medical University

First Affiliated Hospital of Zunyi Medical CollegeFirst Maternal and Child Health Hospital of ShanghaiFortis HospitalFudan University Cancer HospitalFujian Provincial HospitalFukuoka Tokushukai HospitalFukuoka Tokushukai Medical CenterFuling Center Hospital of ChongqingGazprom medical centre, OMSK West Siberia RegionGuangzhou First Municipal People’s HospitalGuantao People’s Hospital of HebeiHAIFU HospitalHaifu Hospital of Tangshan Transportation Group Co. Ltd.Haikou Municipal HospitalHokuto HospitalHong-Kong Sanatorium & hospitalHôpital Sacré CœurHuainan Eastern HospitalHuabei Oil Field general hospital groupHuanggang Center HospitalHubei Maternal and Child Health HospitalIncheon Christian HospitalIncheon St. Mary’s Hospital of the Catholic UniversityInstitute of Ultrasonic Engineering in Medicine

and Clinical Centre for Tumour TherapyIseikai hospitalItabashi Chuo Medical Center, TokyoJapan Affiliated Hospital of Chiba UniversityJaslok Hospital and Research CentreJiangmen Wuyi Traditional Chinese Medicine HospitalJiangsu Armed Police Corps HospitalJiangsu Cancer HospitalJilin Center HospitalJiugang HospitalJiujiang Maternal and Child Health HospitalJixi People’s HospitalKaixian People’s HospitalKaoshiung Veterans General Hospital Khanty-Mansysk Regional hospital North SiberiaKing Fahad Medical CityKing Khalid University HospitalKK Women and Children’s HospitalKochi University HospitalLianyungang Orient HospitalLiaoning Fushun Cancer HospitalLuoyang Center HospitalMaternal and Child Health Hospital of Yubei DistrictNanshi HospitalNational Kidney and Transplant InstituteNational Medical Research CenterNo. 91 Central Hospital of the Liberation ArmyNong Ken HospitalObstetric Hospital of Changchun


Peking Union Hospital, Chinese Academy of Medical SciencesPeking Union Medical CenterPeople's Hospital of Hunan ProvincePeople’s Hospital of Nanchuan DistrictPeople’s Hospital of XingtaiPLA 301 Hospital (General Hospital of the

People’s Liberation Army)Primus Super Specialty HospitalQueen Mary Hospital of the University of Hong KongRamayya Pramila Urology HospitalRambam Medical CenterRussian Railways (RZD) Hospital Central SiberiaSamsung Medical CenterSapporo Toho hospitalShaanxi Maternal and Child Health HospitalShandong Cancer HospitalShandong Guangrao Traditional Chinese Medicine HospitalShandong Qianfoshan HospitalShanxi Traditional Chinese Medicine HospitalShenzhen Maternal and Child Health Center HospitalShinsuma General HospitalSindh Institue of Urology and TransplantationSingapore General HospitalSRL Diagnostics – Jankharia ImagingSt. Peter’s HospitalSuining Central HospitalSuining Hospital of Traditional Chinese MedicineSun Yat-Sen University Cancer CenterSunrise HospitalTaipei Medical University HospitalThe 452nd PLA HospitalThe Daqing Oil Field General Hospital GroupThe First Affiliated Hospital of Chongqing Medical UniversityThe First Affliated Hospital of Wannan Medical CollegeThe First People’s Hospital of ShijiazhuangThe Fourth People’s Hospital of ShenzhenThe Second Affiliated Hospital of Hebei Medical UniversityThe Second Artillery General Hospital of Chinese PLA

The Sixth People’s Hospital of NeijiangThe Tenth People’s Hospital of ShanghaiThe Third Xiangya Hospital of Central South UniversityTung’s Taichung MetroHarbor HospitalUniversity of Malaya (UMMC)Women’s Center IndiaXiaoshan Birth Control StationXijing Hospital of The Fourth Military Medical UniversityYamanashi University Medical HospitalYanbian Tianquan HospitalYongchuan Maternal and Child Health HospitalYonsei University College of MedicineYUMC Gangnam Severance HospitalZibo Municipal Maternal & Children Health Hospital


January 31, 2014

1230 Cedars Court, Suite F

Charlottesville, VA 22903

www.fusfoundation.org

Contact

Heather Huff-Simonin, MBA

Director, Global Business Development

434.326.9829 OFFICE

[email protected] EMAIL

The information in this report was

provided by manufacturers and the

focused ultrasound research community

to the Focused Ultrasound Foundation.

The FUS Foundation aims to provide

the most accurate information,

if you have more current or updated

information please send it to:

[email protected].

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