AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise •...
Transcript of AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise •...
![Page 1: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/1.jpg)
AVIAN INFLUENZA AND
THE IZSVE BIOBANKMaria Serena Beato, Isabella Monne, Calogero Terregino
EU-NRLs Annual Meeting, Padova, 21 June 2019
![Page 2: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/2.jpg)
SCIENTIFIC COLLECTIONS
![Page 3: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/3.jpg)
Biological Resource Centres (BRCs)
BRCs are an essential part of the infrastructure underpinning biotechnology. Theyconsist of service providers and repositories of the living cells, genomes of organism,and information relating to heredity and the functions of biological systems. BRCscontain collection of culturable organism, replicable parts of these, viable but not yetculturable organism cells and tissues, as well as data bases containing molecular,physioligical and structural information relevant to these collecions and relatedbioinformatics. BRCs must meet the high standards of quality and expertisedemanded by the international community of scientist and industry for the delivery ofbiological information and materials. They must provide access to biological resourceson which R&D in the life sciences and the advancement of biotechnology depends.
Organisation for Economic Co-operation and Development (OECD/OCSE) Best Practice guidelines for BRC
BiotechnologyMaterials
DataService
Expertise
![Page 4: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/4.jpg)
• Professional repositories of biological samples (Paskal et al., 2018)
• Long term storage and conservation facility for biological specimens to support future investigations (EC, 2006)
• Essential research tool, Web
• Functional units
• Scientific community service (Morente et al., 2008)
• Service tool (Morente et al., 2008)
• Long-term storage of biological samples for research or clinical purposes (Hallmans and Vaught, 2011)
HOW DO OTHERS DEFINE BIOBANKS?
![Page 5: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/5.jpg)
FUNCTIONS
ACCESS INNOVATION
![Page 6: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/6.jpg)
• POPULATION-BASED BIOBANKS: VOLUNTEERS• DISEASE ORIENTED BIOBANKS: INCLUSION AND EXCLUSION CRITERIA• TISSUE BIOBANKS: CANCER• MULTIPLE PURPOSES BIOBANKS: COMBINATIONS USING NOVEL AND WELL REGULATED TOOLS
TYPES OF BIOBANKS
From Paskal et al., 2018
![Page 7: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/7.jpg)
WHO IS INTERESTED IN BIOBANKS?
![Page 8: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/8.jpg)
EVERYONE, THE SOCIETY
![Page 9: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/9.jpg)
![Page 10: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/10.jpg)
6.Gene drive7.Advanced reproductive technologies8.Double-stranded RNA9.Syntetic alternatives to wildlife products
2. Ancient DNA3.Genome sequencing4. Bioinformatics5.Genome editing
![Page 11: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/11.jpg)
PNAS, 2016
BIOBANKS AND INFECTIOUS DISEASES: a successful story
![Page 12: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/12.jpg)
THE ROLE OF BIOBANKS FOR INFECTIOUS DISEASES: a less successful story
• 2008: Ebola positive sera• 2009: Ebola antibodies detected in
Ghanaian bats (2012 report)• 2016: Ebola outbreaks
• 1.6 billion dollars mobilized by the World Bank for Ebola
Could the Ebola outbreak havebeen different if small investiments
had been made to collect fieldsamples after the intial report?
![Page 13: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/13.jpg)
• 50% of published research cannot be replicated
• In 2000-2010, 80,000 patients took part in studiesthat were later retracted beacuse of mistakes or
improperties
BIOBANKS AND RESEARCH
![Page 14: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/14.jpg)
-Only 0.95% of the 20,200 strains includedin the 2008 issues of 8 EuropeanMicrobiology Journal were deposited in public collections
-Only 0.03% of 12,000 strains included in 2 2009 issues of the Journal of Clinical Microbiology are deposited in public collections
WHO IS INTERESTED IN BIOBANKS?
![Page 15: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/15.jpg)
DEPOSITING IN A BIOBANK IS WORTHWILE!!!!
PAPERS ASSOCIATED TO A BIOBANK CODE HAVE A CITATION RATE 220% HIGHER THAN OTHERS PAPERS
![Page 16: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/16.jpg)
TO TAKE VETERINARY MEDICINE TO A NEW LEVEL
BRINGING THE BIOBANKING TOOL TO REFERENCE LABORATORIES ACTIVITIES
WHY A VETERINARY BIOBANK
HOW
![Page 17: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/17.jpg)
OUR PREDECESSORS
![Page 18: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/18.jpg)
IZSVE BIOBANKCollection, storage of diagnostic biological resources by the IZSVe
reference laboratories
UNIQUE
EPIDEMICS
EMERGENT DISEASES
SCIENTIFICALLY RELEVANT
![Page 19: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/19.jpg)
SAMPLETISSUE
ORGAN
LAB TEST HOMOGENATE
Modification
PATHOGEN ISOLATION
VIRUS
BACTERIA
Modifications
TEST RESULTS
TEMPORARY STORAGE DURING LAB TESTS
LAB REPOSITORY
BIOBANK
Modification(quality controls)
![Page 20: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/20.jpg)
2014 – Involvement of the AI and ND National and OIE/FAO RL
2015 - Involvement of the National and FAO Rabies RL
2016 - nowadays – Strenghthening the activities for RL and for non RL at the IZSVe
CHRONICLE
![Page 21: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/21.jpg)
THE ITALIAN NETWORK OF VETERINARY BIOBANKS
2013 –Set-up of the network
COORDINATOR: The Lombardy and Emilia Romagna Experimental Institute(IZSLER) , software development
OTHER EXPERIMENTAL INSTITUTES (II.ZZ.SS) INVOLVED: IZSVe, IZSSICILIA, IZSPLV, IZSAM
IZSLER HAS BEEN APPOINTED AS:OIE COLLABORATING CENTRE FOR VETERINARY BIOLOGICAL BIOBANK
![Page 22: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/22.jpg)
Biological
materials
Data
Expertise
AvianInfluenza Biobank
ARE WE READY FOR BIOBANKING?
![Page 23: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/23.jpg)
From the 1° report of the Multidisciplinary workshop on EID, Sci Coll, 2015
HOW WE WOULD LIKE TO USE THE AVIAN INFLUENZA BIOBANK
![Page 24: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/24.jpg)
WHAT DO WE ALREADY HAVE?
![Page 25: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/25.jpg)
WHAT DO WE ALREADY HAVE?
![Page 26: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/26.jpg)
WHAT DO WE ALREADY HAVE?
![Page 27: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/27.jpg)
ON LINE CATALOGUE
![Page 28: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/28.jpg)
ON LINE CATALOGUE
![Page 29: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/29.jpg)
Emerging Diseases
Environmental change
Food security
Human migration
![Page 30: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/30.jpg)
![Page 31: AVIAN INFLUENZA AND THE IZSVE BIOBANK...Biotechnology Materials Data Service Expertise • Professional repositories of biological samples (Paskal et al., 2018) • Long term storage](https://reader033.fdocuments.in/reader033/viewer/2022050102/5f4134cb5e326525e6583493/html5/thumbnails/31.jpg)
DURING THE NEXT OUTBREAK……
KEEP CALM
AND
DEPOSIT