Autophagy mechanism

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Autophagy

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This is a small presentation on the Mechanism and proteins involved in the autophagy

Transcript of Autophagy mechanism

Page 1: Autophagy mechanism

Autophagy

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Progression of Autophagy, Apotosis and Necrosis

Kim I, Rodriguez-Enriquez S, & Lemasters JJ (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462(2):245-253

/Autophagy

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Autophagy and Apoptosis Crosstalk

Yonekawa T & Thorburn A (2013) Autophagy and cell death. Essays Biochem 55:105-117

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Gallagher LE & Chan EY (2013) Early signalling events of autophagy. Essays Biochem 55:1-15

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Initiation

Elongation FusionGanley IG (2013) Autophagosome maturation and lysosomal fusion. Essays Biochem 55:65-78.

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Lippai M & Low P (2014) The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed Res Int 2014:832704

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Russell RC, et al. (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 15(7):741-750.

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Sinha S & Levine B (2008) The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27 Suppl 1:S137-148

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Induction of autophagy.

Dieter A. Kubli, and Åsa B. Gustafsson Circulation Research. 2012;111:1208-1221

Copyright © American Heart Association, Inc. All rights reserved.

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Mechanisms of mitochondrial membrane permeabilization.

Dieter A. Kubli, and Åsa B. Gustafsson Circulation Research. 2012;111:1208-1221

Copyright © American Heart Association, Inc. All rights reserved.

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Regulation of mitophagy.

Dieter A. Kubli, and Åsa B. Gustafsson Circulation Research. 2012;111:1208-1221

Copyright © American Heart Association, Inc. All rights reserved.

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Removal of mitochondria via autophagy adaptors or autophagy receptors.

Dieter A. Kubli, and Åsa B. Gustafsson Circulation Research. 2012;111:1208-1221

Copyright © American Heart Association, Inc. All rights reserved.

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Balance between life and death during stress.

Dieter A. Kubli, and Åsa B. Gustafsson Circulation Research. 2012;111:1208-1221

Copyright © American Heart Association, Inc. All rights reserved.

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Ganley IG (2013) Autophagosome maturation and lysosomal fusion. Essays Biochem 55:65-78.

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Induction of Autophagy by Cystatin C: A Mechanism That Protects …cdr.rfmh.org/Publications/PDFs_Nixon/Tizon 2010 PLoS One.pdf · 2020. 12. 9. · Induction of Autophagy by Cystatin

Induction of Autophagy by Cystatin C: A Mechanism That Protects …cdr.rfmh.org/Publications/PDFs_Nixon/Tizon 2010 PLoS One.pdf · 2020. 12. 9. · Induction of Autophagy by Cystatin

Autophagy - EMBOmeetings.embo.org/files/posters/17-autophagy.pdf · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy ORGANIZER Ivan

Autophagy - EMBOmeetings.embo.org/files/posters/17-autophagy.pdf · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy ORGANIZER Ivan

Autophagy in renal diseases - Home - Springer · Autophagy in renal diseases ... In the healthy kidney, autophagy plays an im-portant role in the homeostasis and viability of renal

Autophagy in renal diseases - Home - Springer · Autophagy in renal diseases ... In the healthy kidney, autophagy plays an im-portant role in the homeostasis and viability of renal

Matrine-induced autophagy regulated by p53 through AMP ... · in human hepatoma cells through a novel mechanism, which is p53/AMPK signaling pathway involvement in matrine-promoted

Matrine-induced autophagy regulated by p53 through AMP ... · in human hepatoma cells through a novel mechanism, which is p53/AMPK signaling pathway involvement in matrine-promoted

Autophagy: A Novel Mechanism Involved in the Anti ... · hydrochloride (Sigma, USA) under anaerobic conditions using anaerobic generator packs (GENbaganaer, Biomérieux, France).

Autophagy: A Novel Mechanism Involved in the Anti ... · hydrochloride (Sigma, USA) under anaerobic conditions using anaerobic generator packs (GENbaganaer, Biomérieux, France).

Mechanism of Cargo Recognition During Selective Autophagy · 2018. 9. 25. · 16 Mechanism of Cargo Recognition During Selective Autophagy Yasunori Watanabe 1,2 and Nobuo N. Noda

Mechanism of Cargo Recognition During Selective Autophagy · 2018. 9. 25. · 16 Mechanism of Cargo Recognition During Selective Autophagy Yasunori Watanabe 1,2 and Nobuo N. Noda

Phosphatidylethanolamine Regulates Autophagy and Longivity

Phosphatidylethanolamine Regulates Autophagy and Longivity

Rottlerin induces autophagy and apoptosis in prostate ... Induces Autophagy and... · Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling

Rottlerin induces autophagy and apoptosis in prostate ... Induces Autophagy and... · Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling

Autophagy - EMBOmeetings.embo.org/files/posters/17-autophagy-last.pdf · 2017. 2. 8. · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy

Autophagy - EMBOmeetings.embo.org/files/posters/17-autophagy-last.pdf · 2017. 2. 8. · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy

Autophagy Precedes Apoptosis in Angiotensin II-Induced ... · apoptosis [10, 11]. Many stimuli can cause simultaneous apoptosis and autophagy. Ang II induces autophagy, which is further

Autophagy Precedes Apoptosis in Angiotensin II-Induced ... · apoptosis [10, 11]. Many stimuli can cause simultaneous apoptosis and autophagy. Ang II induces autophagy, which is further

Autophagy-Derived Alzheimer s Pathogenesis - InTech - Opencdn.intechopen.com/...Autophagy_derived_alzheimer_s_pathogenesis.pdf · Autophagy-Derived Alzheimer s Pathogenesis ... homeostasis

Autophagy-Derived Alzheimer s Pathogenesis - InTech - Opencdn.intechopen.com/...Autophagy_derived_alzheimer_s_pathogenesis.pdf · Autophagy-Derived Alzheimer s Pathogenesis ... homeostasis

Deeper Understanding of Autophagy and pseudo-Autophagy ... · Deeper Understanding of Autophagy and pseudo-Autophagy through Latent-Space Analysis Sigurjón Ísaksson Clare Hall AdissertationsubmittedtotheUniversityofCambridge

Deeper Understanding of Autophagy and pseudo-Autophagy ... · Deeper Understanding of Autophagy and pseudo-Autophagy through Latent-Space Analysis Sigurjón Ísaksson Clare Hall AdissertationsubmittedtotheUniversityofCambridge

Autophagy In Life and Disease

Autophagy In Life and Disease

Autophagy as a Defence Mechanism

Autophagy as a Defence Mechanism

Regulation of autophagy by cytoplasmic p53 - … · Regulation of autophagy by cytoplasmic p53 ... p53 was able to repress the enhanced autophagy of p53–/ ... 4Università degli

Regulation of autophagy by cytoplasmic p53 - … · Regulation of autophagy by cytoplasmic p53 ... p53 was able to repress the enhanced autophagy of p53–/ ... 4Università degli

Evolving Insights on Metabolism, Autophagy, and ... et al. Liver Myofibroblasts: Metabolism, Autophagy and Epigenetics FIGURE 1 | A schematic model of metabolism, autophagy, and epigenetics

Evolving Insights on Metabolism, Autophagy, and ... et al. Liver Myofibroblasts: Metabolism, Autophagy and Epigenetics FIGURE 1 | A schematic model of metabolism, autophagy, and epigenetics

Review Article Role of the Crosstalk between Autophagy and ...Journal of Oncology. . e Crosstalk between Autophagy and Apoptosis. Since both autophagy and apoptosis play multiple,

Review Article Role of the Crosstalk between Autophagy and ...Journal of Oncology. . e Crosstalk between Autophagy and Apoptosis. Since both autophagy and apoptosis play multiple,

Apoptosis, Necroptosis & Autophagy - Novus Biologicals · PDF fileApoptosis, Necroptosis & Autophagy APOPTOSIS NECROPTOSIS AUTOPHAGY Key Targets in Apoptosis Initiator Caspases (-2,

Apoptosis, Necroptosis & Autophagy - Novus Biologicals · PDF fileApoptosis, Necroptosis & Autophagy APOPTOSIS NECROPTOSIS AUTOPHAGY Key Targets in Apoptosis Initiator Caspases (-2,

Autophagy - EMBO · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy ORGANIZER Ivan Dikic University of Frankfurt , DE

Autophagy - EMBO · Autophagy 25 – 29 September 2017 | Cavtat-Dubrovnik, Croatia meetings.embo.org/event/17-autophagy ORGANIZER Ivan Dikic University of Frankfurt , DE

Autophagic Processes in Yeast: Mechanism, Machinery and … · 2013-06-11 · Autophagy can be divided into two main types, micro-autophagy and macroautophagy (Figure 1), and both

Autophagic Processes in Yeast: Mechanism, Machinery and … · 2013-06-11 · Autophagy can be divided into two main types, micro-autophagy and macroautophagy (Figure 1), and both