Australia-New Zealand Marine Biotechnology Network: … · 19/11/2012 1 Australia-New Zealand...

19/11/2012

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Australia-New Zealand Marine

Biotechnology Network:

Our treasure in the Sea

Oceania Biodiscovery Forum 2012

Eskitis Institute, Griffith University 19 November 2012

Professor Wei Zhang. Director CMBD

Raymond Tham. Manager, CMBD

The Australian Government

DSEWPaC, SPREP

Centre for Marine Bioproducts Development

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The Flinders Centre for

Marine Bioproducts Development

A cross-faculty Centre for innovation, education

and commercialisation in

Marine Bioproducts

Project Title

Australia-New Zealand Marine

Biotechnology Network (ANZMBN) Professor Joseph Baker

Professor Chris Battershill

Professor Wei Zhang

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Project Title

Australia-New Zealand Marine Biotechnology Network (ANZMBN)

An active forum in which to exchange ideas and

develop collaborations between researchers,

technologists, industry and Government colleagues

and other interested parties towards the

advancement of marine biotechnology in Australia

and New Zealand.

Australia-New Zealand Marine Biotechnology Network

Currently ~150 members

Research collaborations

A Network of capabilities, facilities and knowledge

Funding opportunities

Creating discovery and development pathways

Publicising and sharing marine biotechnology “wins”

Commercialisation of marine bioproducts

Influencing policy on marine biotechnology

Intellectual Property & Benefit Sharing

A vision for the future

An Australia-New Zealand Agreement on Marine Biotechnology:

Paving the way for an Oceania Agreement?

Regular research symposia at AMSA/NZMSS conferences

Developing solid ‘platform’ for the above eg CRC & ARC CoE

Complement DSEWPaC and SPREP Oceania engagement

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How Will ANZMBN Work? Hosted by the Centre for Marine Bioproducts Development (CMBD) at

Flinders University with a Steering Committee of key representatives from ANZ.

Initially it will consist of a database of interested persons and organizations,

with their affiliations and expertise.

Specific collaboration projects by interest groups

Quarterly newsletter will be developed to disseminate information about

Marine Biotechnology issues and events

Regular research symposia will be organized at AMSA/NZMSS conferences

Events

Resources

Student

profiles

Jobs

Recent

publications

LinkedIn

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Sponge

Team Flinders

University

+ SARDI (Jason Tanner, Alex Dobrovolskis)

9 The Network in action!

Marine Biotechnology Industry: a rapidly growing sector

for RD&E Collaborations

Functional

Bioactive

Compounds

Harvest from

the Sea

Transgenic

Production

Chemical

Synthesis

Mariculture

Cell Culture

Commercial

Production

New Products

New Industry

Marine

Discovery

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Why is Marine Biotechnology important

to science and industry?

Zhang and Tham, Adapted from

Baker, 2011 in comms, QLD DEEDI

Collaborations • AIMS, MISA, Griffith Uni, CSIRO and Australian Antarctic Division

ANZ marine biotechnology R&D & Industry Platform:

• Marine biodiscovery (focus on species) to

• Marine bioproducts development (focus on functional products and

applications) to

• Marine bioproducts commercialization (focus on benefits to the

society such as economic return, new industry and job growth)

Our speciality to complement Eskitis:

• Licensed access to Southern Waters biological megadiversity

• Extraction and fractionation technologies: High & low molec. Wt.

• Sustainable & amplified cell culture / aquaculture production

• End-user product targets: non-pharmaceutical / alternatives

• R&D clients in SA, NZ, China and USA.

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ANZ

Marine

Biotechnology

Network

Flinders University

SARDI

Uni. Adelaide

SA Herbarium

MISA

WAMSI

ASEAN & Pacific Islands

AIMS

Griffith / Eskitis

Qld Museum

AMSA

SIMS

CSIRO

Australian

Antarctic Division

Waikato University

NZMSS

USA, S. Americas,

Japan, Korea, China

NT Museum,

CDU ABS Capacity

Development

Initiative /

Nagoya Protocol

(Source: WoRMS discovery of marine species

http://www.marinespecies.org/aphia.php?p=stats)

Exponential Speed of New Marine

Species Discovery

(Slide Courtesy of Prof John Hooper)

20-50

years

?

http://www.marinespecies.org/aphia.php?p=stats

http://www.cbd.int/doc/publications/gti-brochure-en.pdf

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Publications of Marine Natural Products 1971-2010

-4-

No of publications on marine natural products in ISI database

(Topic=‘marine natural products’).

No of publications

Year 2010

20-50

years?

0

100

200

300

400

500

600

700

800

900

1000

1100

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009

Nu

mb

er

of

co

mp

ou

nd

s/y

ea

r

Year

New Marine Natural Product Discovery

2000-2009

2032….2062

20-50

years

?

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Strategic positioning, literally.

Baker, 2011 in comms, QLD DEEDI

NERM, 2012

•70,000km continental

coastline

•8.6 million km2

continental marine

territory

The world’s

least explored

region

•16.1 million km2

oceanic jurisdiction

An exclusive resource

Phylum No. of

species

%

endemic

References

Algae Chlorophyta 124 30 Womersley (1990)

Phaeophyta 231 57 Womersley (1990)

Rhodophyta ~1140 75 Womersley (1990)

Sponges >800 58 Hooper & Lévi (1994)

Bryozoans ~850 38 Barnes & Griffiths (2008)

Molluscs 19 000 95 Poore (1994)

Brachiopods 23 87 Richardson (1997)

Echinoderms 347 56 O’Hara & Poore (2000)

Crustaceans

~800

40 Poore (2004)

Cnidarians jellyfishes 38 Southcott (1982)

hydrozoans ~250 30 JE Watson pers. comm.

Pycnogonids 71 30? D Staples pers. comm.

Ascidians 368 93 Kott (2005, 2006)

Fishes 612 78 Gomon et al. (2008)

Endemic species of Southern Australia Waters – courtesy of Scoresby Shepherd (in press, 2012)

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CMBD Board of Advisors

The Centre is privileged to have a Board of Advisors made up of luminaries in industry, science and government,

who support the strategic efforts of the Centre in establishing a Marine Biotechnology industry in Australia and

towards Flinders University as a focal point for research and industry engagement. The Board convenes three

times a year and advises on management on the international, national and State viewpoints on science and

industry, strategic activities and pathways, and industry and government engagement of the Centre.

The Board is supported by a secretariat in the Centre and can be contacted at [email protected]

Programs of the CMBD

© 2011 Flinders University

Marine Bioproduct Discoveryand Development

Education, Trainingand Commercialisation

Marine Bioprocessing andBiorefinery Development

Analysis & Characterisat ion

Extraction & Fractionat ion

ProductCommercialisation

SustainableProduction Processes

Industry Needs

CMBDFlinders

BioactiveCompoundDiscoveries

Bioactive Product Development

Industryuptake / upscaling

BioprocessDevelopment








Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders












Industry Needs

CMBDFlinders





Compounds

Library

Development

• Compatible

Systems

• Shorten lead

Times

• Increase

Access

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Bioprocess Innovation & System Integration

Specialist services in a one-stop shop

Marine Bioresources: Sponges

Sponge Biodiscovery and Functional Applications @ Flinders University, SARDI

2010 Flinders University and SARDI

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HeLa human cell line Dr Jenny Jing Jing Wang

Antibiotics & Antifungal agents

PhD Mohammad Mehbub

Cultures grown on agar media tested for antifungal activity and showing antifungal

activity against Fusarium

A52 crude extracts showing activity against Staphylococcus aureus

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3

4

9

16

31

33

34

36

38

39

43

46

52

53

61

67

68

69

74

Act 4, 9, 16, 33, 34,

39, 52, 67, 69

showed activities

against

Staphylococcus

aureus

Act 33, 36 and 68

were found to be

active against

both fungus,

Fusarium and

Rhizoctonia

Act 52, 39 and 33

showing the

highest level of

inhibition.

Marine Bioresources: Microalgae

NCRIS / Alge & Biofuels Facility @ SARDI West Beach

Biorefinery optimisation @ Flinders University


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Marine Biofuels and Biorefinery

Pioneer of the BioRefinery Concept Some of Australia’s largest Microalgae Biofuels projects

Producing high value co-products not just fuels

The Biorefinery Concept

2011 Tham

Marine

Bioresources

Aquaculture

/ Mariculture

Seafood

Processing

Novel

Sources (eg.

Cell Culture)

METABOLITES

Primary

Proteins

Carbohydrates

Lipids

Secondary

Small molecule

compounds

(Alkaloids,

Terpenoids,

phenols)

Enzymes

Peptides

Food

Non-

Food

General

Nutrition

Supplements

Plant / animal

agricultural

chemicals

Pharma-

ceuticals

Cosmeceu-

ceuticals

Biofuels Fuel energy for

agriculture

operations and food

transport and

storage

Therapeutic /

preventative

medicine /

topical applications

Pest / Disease

control and

prevention

Soil conditioning

Plant and animal

nutrition

Food

Ingredients

BIO-

PRODUCTION

Novel

sustainable

methods for

large scale

production

BIO-

PROCESSING

Novel

sustainable

methods for

greater yield

and quality

Biorefinery Process Pathway

© Flinders University, Australia

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Marine Bioresources: Macroalgae

Macroalgae Biodiscovery Product Development @ Flinders University

Australian Kelp Products Pty Ltd, Beachport / Millicent


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Red Algae

Pretreatment

Buffer extraction

Crude protein Algal residue

Fractional precipitation

Ion exchange

Chromatography

Residues

micronutrients & minerals

Bromo-peroxidase

DEAE- Sepharose chromatography

R-Phycoerythrin

Molecular Sieve

Chromatography

Alkaline reaction

Agar

Photo-bleaching

Agar extraction

Post-purification

Pre

-trea

tme

nt

Fra

ctio

na

tion

Animal feeds

Na2O MgO Al2O3 SiO2 P2O5 SO3 K2O CaO MnO2Fe2O3 NiO ZnO SrO Cl Br I0

10

20

30

40

50

Algal materials of Gracilaria lemaneiformis

Residues after comprehensive utilization

Co

mp

on

en

ts

of in

org

an

ic e

le

me

nts (%

)

Marine Kelp–Based Bioprocessing &

Bioproducts

$15,000/g

$10,000/g $100/kg $1-5/kg

© 2010 Flinders University

Seafood Bioproducts Innovation for Health

“Seafood for Seafood” technologies Turn seafood co-products into high value functional foods

Enhance quality and reduce spoilage

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Result:

Demonstrable pathway to product output and value

creation

BIOREFINERY CONCEPT: Seafood

2007 – 2009 Zhang and Tham © Flinders University, Australia

Recent Media Coverage

National TV, Radio, Press and online news

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Acknowledgements

South Australian Premiers Science and Research

Fund (PSRF) and the Office of the Chief Scientist

Board of Advisors

DVC (Research) & RSO

Faculties & Schools executives

FCIC, Neuroscience, Proteomics, FAL, LMSC

Flinders Partners & Industry Partners

Australian Seafood CRC

Marine Innovation South Australia

Bio-Innovation SA / Ausbiotech

Australian Marine Science Association

SARDI Aquatic Sciences; Food Innovation

Media partners: SAPRO, Elsevier, Springer,

FSG, CRC Press, SSA

The Flinders Centre for

Marine Bioproducts Development

Talk to us today to find out what you can

do with

marine bioprocessing and

bioproducts [email protected]

Australia-New Zealand Marine Biotechnology Network: … · 19/11/2012 1 Australia-New Zealand...

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