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TH4 +TH4 +

Bactericidal, virucidal and fungicidal disinfectant

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4 Quaternary ammoniums

g Octyl dicyldimethyl ammoniumchloride

37,50 g/l

g Dioctyl dimethyl ammoniumchloride 18,75 g/l

g Glutaraldehyde 62,50 g/l

1 Aldehyde

g Alkyl dimethyl benzyl ammonium chloride 50,00 g/l

g Didecyl dimethyl ammonium chloride 18,75 g/l

TH4 +: TH4 +: A patent formulaA patent formula

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g Pine oil

2 Terpenic Derivatives

g Terpineol

20 g/l

20 g/l

TH4 +: TH4 +: PhysicochemicalPhysicochemical characteristicscharacteristics

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g Green limpid solution with a light pine smell

g Density at 20°C = 1

g pH = 3.85 (non diluted product)

pH = 4.70 (solution at 0.5%)

APPEARANCE

The synergistic action between quaternary ammonium and glutaraldehyde

4QA

Lipophilic action

Glutaraldehyde

Hydrophilic action

g Act on cell membrane

g Permeability of themembrane

g Act on nucleic acidof virus

g Combinaison with metabolic enzymeof bacteria and fungi

TH4 + : TH4 + : PropertiesProperties

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TH4 + : TH4 + : PropertiesProperties

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These components have a light disinfecting property.

Moreover :

• Terpineol is an effective insect repellent (insects are potential vectorsof microorganisms).

• Pine oil, thanks to its «stickness» allows the final solution of TH4+ tostay longer on vertical surfaces. It also evaporates very slowly and increases the remanence of TH4+.

TERPINE DERIVATIVES

Ministry of Agriculture HomologationMinistry Ministry of Agriculture Homologationof Agriculture Homologation

TH4 +TH4 +

Ministry of agriculture homologationBactericidal and fungicidal 0,5 %Virucidal 0,5% to 2%

Effective in presence of interferent substancesEffective towards GUMBORO diseasesApprouved in case of contagious diseases:

- Brucellosis 0.5%- Tubercullosis 1%- FMD 3%

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The ideal disinfectant for your breeding farm.

TH4 +: TH4 +: TheThe ReferenceReference

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g Virucidal, Bactericidal,fungicidal

Bacteria Poultry Swine Cattle DilutionBacillus anthracis Anthrax Antrax 1 : 200Bordetella bronchiseptica Bordetella Infections Atrophic rhinitis 1 : 200Campylobacter Vibrionic hepatitis Enteritis 1 : 400

P.I.AClamydia Psittacosis 1:200Clostridium Botulism 1:200

Necrotic enteritis Necrotic enteritisCorynebacterium Mastitis; suppurative diseases 1 : 200E.Coli Colibacillosis Colibacillosis Colibacillosis 1: 200

Swollen Head; septicemia Bowel edemaErysipelothrix Erysipelas Erysipelas 1 : 200Haemophilus Infectious coryza Pneumonia 1: 200

Pleuro-pneumoniaKlebsiella Mastitis; Rhinitis 1 : 200

Suppurative diseasesLeptospira Leptospirosis Leptospirosis 1 : 1000Listeria monocytogenes Listeriosis 1 : 400Mycobacterium Tuberculosis Tuberculosis 1 : 100Mycoplasma spp CRD; Mycoplasmosis Swine enzootic pneumonia 1 : 500

Infectious synovitis ArthritisPasteurella spp Avian cholera Pneumonia; Pasteurellosis Pneumonia 1 : 200

Pasteurellosis Atrophic rhinitisProteus spp Suppurative diseases Suppurative diseases 1 : 200Pseudomonas aeruginosa Pseudomonas infections cystitis Mastitis 1 : 200

pyelonephritis Suppurative diseasesRickettsia spp Q fever; Anaplasmosis 1 : 200Salmonella spp Salmonellosis Salmonellosis salmonellosis 1 : 200Staphyllococcus spp Staphyllococcosis Meningitis; Arthritis Mastitis; suppurative diseases 1 : 400

Mastitis; suppurative diseasesStreptococcus spp Streptococcosis Meningitis; Arthritis Mastitis; suppurative diseases 1 : 200

Mastitis; suppurative diseasesCondition d'essai: Eau distilée - Albumine 1% - Extrait de levure 1% 08

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Bactericidal activityBactericidal activity

Virus Poultry Swine Cattle DilutionAdenovirus Avian cholera Porcine adenovirus Bovine Adenovirus 1 : 100(DNA, Naked) EDS 76

Haemorragic enteritisQuail bronchitis

Arterivirus Bordetella Infections Blue ear (PRRS) 1 : 400(RNA, Naked)Birnavirus IBG (Gumboro) Enteritis 1 : 200(RNA, Naked)Calicivirus Vesiculous exanthema 1 : 200Coronavirus Avian IB TGE Neonatal calf diarrhea 1 : 2000(RNA, Coated) Blue comb disease (turkey) Vomiting & wasting disease

Hemagglutinating encephalomyelitisPorcine epidemic diarrhea

Herpesvirus Mareks Aujeszky IBR 1 : 5000(DNA, Coated) Infectious Laryngo Tracheitis Inclusion body rhinotracheitis Bovine herpes

Duck plague Porcine cytomagelovirus Epstein BarrIridovirus African swine fewer 1 : 200(DNA, Naked)Orthomyxovirus Avian influenza Swine influenza Influenza 1 : 200(RNA, Coated) Fowl plaguePapovavirus Bovine papillomatosis 1 : 200(DNA, Naked)Paramyxovirus Avian PMV Blue eye Rinderpest 1 : 500(RNA, Coated) Newcastle disease

Swollen Head (SHS)Parvovirus Chicken anaemia Porcine parvovirus Calf enteritis 1 : 50(DNA, Naked) Derszy (Reproduction disorders)

Virucidal activityVirucidal activity

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Virus Poultry Swine Cattle DilutionPicornavirus Duck virus hepatitis FMD FMD 1 : 50(RNA, Naked) Infectious avian Teschen-Talfan Bovine enterovirus

encephalomyelitis Swine vesicular disease(epidemic tremor) SMEDI

Porcine enterovirus infectionEncephalomyocarditis

Poxvirus Avian pox Swine pox Cow pox 1 : 500(DNA, Coated) Lumpy skin diseaseReovirus Runting & stunting Porcine rotavirus (diarrhea) Rotavirus of calves 1 : 1000(RNA, Naked) Avian diarrhea Reovirus infection Ibaraki

TenosynovitisViral arthritisDuck rotavirus

Retrovirus Avian cholera Leukosis 1 : 200(RNA, Coated) Rous sarcoma Sarcoma

Reticulo endotheliosis Bovine syncitialRhabdovirus Rabies Rabies 1 : 200(RNA, Coated) Vesicular stomatitis Vesicular stomatitis

Hemorragic septicemia Ephemaral feverTogavirus Classical swine fever Bovine viral diarrhea 1 : 500RNA, Coated) (Hog choléra)

Virucidal activityVirucidal activity

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g With no formol and no phenol

g Its biodegradability > 90% after use

g Low toxicity: LD 50 = 3 ml / kg = (3 g/ kg) (rat)Irritating test in rabbit = index 2.8 = lightly irritating

g 15 years of experience in France = 15 years of satisfaction

A safe product...A A safe productsafe product......TH4 +TH4 +

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g No sensitive to the variation of pH, Th

g Density at 20°C: 1

g Stability: 3 ans

g Effective even at low temperature

Chemically stableChemicallyChemically stablestable

TH4 +TH4 +

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TH4+ is used at the dosage of 0,5% à 2% according to the breeding conditions and specifics diseases

g In In sprayingspraying ::

0,3 litre of solution per square meter of surfacesto disinfect

g In In thermofoggingthermofogging: :

1,5 ml/cubic meters for a contact period of 6 hours2,5 ml/ cubic meters for a contact period of 4 hours

TH4+ is homologated in thermofogging

Low concentrationLow Low concentrationconcentrationTH4 +TH4 +

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A wide activity fieldAA wide activity fieldwide activity fieldTHE BREEDING:g Livestock housing: poultry, cattle…g Livestock feed preparation premisesg Livestock transport equipmentg..

THE FOOD PROCESSINGg Refrigerated meat warehousing, salteries, slaughterhousesg Brewing industry, ...

THE AGRICULTUREg Cereals, fruit, vegetables, potatoes storage premisesg Flowers storage premisesg...

TH4 +TH4 +

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The reference disinfectant The reference disinfectant Wide spectrum (bactericidal, virucidal, fungicidal) orTarget on specific diseases

Low concentration

No risk (users) - biodegradability

No corrosive - chemically stable

Efficient in presence of interferent substances

Homologated by the ministry of agriculture

TH4 +TH4 +

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TH4 +TH4 +

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ADVANTAGES AND DISADVANTAGES

Avantagesg Effective on Gram positive(Gram negative) and coated virusand fungi

g High detergent and wetting powder

g High stabilityg No corrosive

g Biodegradability

g Effective at various pHg Long actingg Foamg Fast acting

Disadvantagesg No effective on naked virus g Low activity on Gram negative andfungig Sensitive to organic matter

g No compatibility with anionic agent

The Quaternary AmmoniumsThe The Quaternary Quaternary AmmoniumsAmmoniumsTH4 +TH4 +

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Avantagesg Wide spectrum(Virucidal, bactericidal, fungicidal)

g Good efficacy in presence of interferentsubstances

g No corrosive

Disadvantagesg Slow action

g Odour

The GlutaraldehydeThe The GlutaraldehydeGlutaraldehydeTH4 +TH4 +

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Why to choose TH4+Why Why to to choose choose TH4+TH4+Comparison with chloride derivated products

+- Wide spectrum

- Low toxicity

- Deodorant action

-- Corrosive (Iron and steel)

- Low stability (light, storage,…)

-low efficacy on mould and virus

- High sensibility on interfering matters(organic matter and hard matter)

- The efficacy is linked with pH

- Irritating for eyes

- Escaping of cl2 in presence of acid

Chloride bleach: No homologated

TH4 +TH4 +

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Why to choose TH4+Why Why to to choose choose TH4+TH4+Comparison with Formaldehyde

+ -

TH4 +TH4 +

- Wide spectrum (B, F, V)

- Activity in various pH

- Adapted for the disinfection of hatcheries and incubator

- Slow action

- Toxic for the users

- Corrosive

- low wetting power

- 100% efficient at T = 25°C Hygrometry = 80- 90%

- Unpleasant odour

Formol: Not homologated

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Why to choose TH4+Why Why to to choose choose TH4+TH4+Comparison with phenolic derivated products

+ -

TH4 +TH4 +

Formol: Not homologated

- Good activity on bacteria

- Low sensitivity to organic matter

- Low virucidal activity

- Sensitive to hard water

- No compatibility with anionic - agents

- Low biodegradability

- Unpleasant odour

- Toxicity: Cutaneous lesions

- Efficient at 5>pH>7

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Why to choose TH4+Why Why to to choose choose TH4+TH4+Comparison with iodine derivated products (iodophore)

+ -

TH4 +TH4 +

- Wide spectrum (B, F, V)

- Surfactant property

- Efficient with low temperature

-Improvement of activity in an acid pH

- Stable in storage (in acid environment)

- Colouring of materials

- High sensibility to organic matter

- High sensibility to hard water

- Low stability at T>40°C

Pure iodine: toxic, corrosive, colour the materials,low solubility and …not homologated 08

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ACTIVITYOMOLOGATION IN BREEDING FIE TOXICITY BIODEGRA-SPECTRUM (Presence of organic matters) DABILITY

B F V at more than 90 %GENERIC PRODUCTSBleach B,F,V No homologation corrosive yesCresols and phenol B,F No homologation toxic few degradableFormol B,F,V No homologation very toxic yesSPECIFIC PRODUCTSPhenolassociations

B,F 0.4 to 1% 0.2 to 0.5% - toxic low

Associationscontaining formol

B,F,V 0.25 to 2.5% 0.7 to 6% 1 to 3 % toxic variable

TH4+ associationof quaternary ammoniumsand of aldehyde (without formol)

B,F,V 0.5% 0.5% 0.2 to 2 % no yes

Legend : *B : Bactericidal *F : Fungicidal * V : Virucidal *-No homologation

A disinfectant of choiceA A disinfectant disinfectant of of choicechoiceTH4 +TH4 +

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TH4+

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ACTIVITY DATAVirucidal (Naked Viruses) Yes No Yes No Yes Yes Some Some YesVirucidal (Coated Viruses) Yes Yes Yes Yes Yes Yes Yes Yes YesBactericidal Yes Yes Yes Yes Yes Yes Yes Yes YesFungicidal Yes Yes Yes Yes Yes Yes Yes Yes YesFast acting Yes No No Yes Yes No Yes Yes YesActive in Organic Matter Yes Yes Yes No No Yes No No No

A disinfectant of choiceA A disinfectant disinfectant of of choicechoiceTH4 +TH4 +

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TH4+

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ACTIVITY DATAActive in Hard Water Yes Yes Yes No Yes Yes No No NoStable in solution Yes Yes No Yes No Yes No Yes YesNo known resistance Yes No Yes Yes Yes Yes Yes No YesRemanent Yes Yes No Yes No No No No NoWetting - Cleaning Yes No No Yes No No No No NoUse in thermofogger Yes No No Yes No Yes No No No

A disinfectant of choiceA A disinfectant disinfectant of of choicechoiceTH4 +TH4 +

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TH4+

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SAFETY DATANon-toxic Yes No No Yes Yes Yes No Yes NoNon-irritant Yes No No Yes No No No Yes NoPleasant smell Yes No No Yes Yes No No Yes NoNon-corrosive Yes Yes No Yes No Yes No No NoBiodegradable Yes No Yes Yes Yes Yes Yes Yes YesNon-stainging Yes No Yes Yes Yes Yes No No Yes

A disinfectant of choiceA A disinfectantdisinfectant of of choicechoiceTH4 +TH4 +

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