AUC - Past & Present Stephen Harding. Thé Svedberg 1884-1971.
Transcript of AUC - Past & Present Stephen Harding. Thé Svedberg 1884-1971.
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AUC - Past
& Present
Stephen Harding
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Thé Svedberg
1884-1971
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Svedberg oil-turbine ultracentrifuge
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“Evolution” of the AUCNumbers of papers in the Biochemical
Journal, per annum
0
10
20
30
40
50
60
1925 1935 1945 1955 1965 1975 1985 1995 2002
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1920’s: “Thé: I see a new dawn! ”
• Svedberg & Nichols: oil turbine u/c
• Optical system• Rinde: sector shape
cell
• Hemoglobin - Svedberg & Fåhraeus
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1926: 1st AUC paper on sedimentation equilibrium
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1930’s: “Proteins are molecules”
• Philpott/Svensson Schlieren optics
• Proteins as molecules• Concept of subunits• Perrin: Frictional
ratio calculations and shapes of molecules: TMV
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1930’s: “Proteins are molecules”
• Philpott/Svensson Schlieren optics
• Proteins as molecules• Concept of subunits• Perrin: Frictional
ratio calculations and shapes of molecules: TMV
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1930’s: “Proteins are molecules”
• Philpott/Svensson Schlieren optics
• Proteins as molecules• Concept of subunits• Perrin: Frictional
ratio calculations and shapes of molecules: TMV
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1948: Discovery of electricity is taken
into account
Spinco Model E (Pickels)Beckman Model E (Pickels)
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1948: Analysis of
Mixtures
A.G. “Sandy” Ogston
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“Evolution” of the AUCNumbers of papers in the
Biochemical Journal
0
10
20
30
40
50
60
1925 1935 1945 1955 1965 1975 1985 1995 2002
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Yphantis Schachman
Williams van Holde
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“Evolution” of the AUCNumbers of papers in the
Biochemical Journal
0
10
20
30
40
50
60
1925 1935 1945 1955 1965 1975 1985 1995 2002
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1980’s: “Take our advice and switch to more useful techniques
like NMR”
• “Advice” from the Biochemical Journal
• Garcia de la Torre: bead models
• National Centres in the USA and UK
• 1989 – news of another “new dawn”
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April 1991