Atcheson dn areplicationmodel
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DNA Replication
Mackenzie Atcheson
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DNA Replication begins in the Origin of
Replication.This is Called the Replication Fort.
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Adenine
5’
5’
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Adenine
Thymine
5’
5’
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Adenine
Thymine
Cytosine
5’
5’
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Adenine
Thymine
Cytosine
Guanine
5’
5’
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
AdenineA purine base,
that is the constituent involved in
base pairing with thymine in DNA and
with uracil in RNA.
A
A
A
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
Thyminea pyrimidine base that is one of the four bases
coding genetic
information in the
polynucleotide chain of DNA
A
A
A
T
T
T
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
Cytosinea pyrimidine
base that codes genetic information in
the polynucleotide chain of DNA
or RNA
A
A
A
T
T
T
C
C
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
Guaninea purine base
that codes genetic
information in the
polynucleotide chain of DNA
or RNA
A
A
A
T
T
T
C
C
G
G
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3’
3’
5’
5’
Adenine
Thymine
Cytosine
Guanine
DNA Polymerase
Reads DNA
In The 3’-5’
Direction.
A
A
A
T
T
T
C
C
G
G
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Helicase
The first step of DNA replication is unwinding or unzipping the DNA. Helicase is the enzyme that unzips the DNA.
A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C Hydrogen Bonds between the base pairs are broken.
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
A molecule of DNA Polymerase attaches to one strand of the DNA and moves in the 3’ to 5’ direction.
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
A molecule of DNA Polymerase attaches to one strand of the DNA and moves in the 3’ to 5’ direction.
This is used as a template for assembling a leading strand of nucleotides and reforming the double helix.
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
DNA synthesis can only occur in a 5’ to 3’ direction.
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
DNA synthesis can only occur in a 5’ to 3’ direction.
Another form of DNA polymerase binds to the other strand.
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
This molecule must synthesize discontinuous segments of polynucleotides
5’
5’
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A
A
A
A
T
T
T
T
G
G
G
G
C
C
C
C
This molecule must synthesize discontinuous segments of polynucleotides
These are called Okazaki Fragments.
5’
5’
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There are now two identical copies of the DNA.
Thymine—Adenine
Guanine—Cytosine
BASE PAIRSSugar Phosphate Backbone
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Thymine—Adenine
Guanine—Cytosine
BASE PAIRSSugar Phosphate Backbone
DNA Replication occurs in the “S” phase of the interphase in mitosis.
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THE END