ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref:...

29
ASYMMETRIC HYDROGENATION/ASYMMETRIC TRANSFER HYDROGENATION OF KETONES, IMINES AND ALKENES THROUGH NOYORI AND NOYORI TYPE CHIRAL RUTHENIUM CATALYSTS WITH REFERENCE TO PHARMA APPLICATIONS Dr.Sambasiva R Poreddy ENANTIOTECH CATALYSTS PVT LTD P.NO:22-B. Road No: 2 Venkataramana Colony, Vanasthalipuram Hyderabad-500070, India E-mail: [email protected] Ph: +91-9849601776 www.enantiotechcatalysts.com

Transcript of ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref:...

Page 1: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

ASYMMETRIC HYDROGENATION/ASYMMETRIC TRANSFER HYDROGENATION OF KETONES, IMINES AND ALKENES THROUGH

NOYORI AND NOYORI TYPE CHIRAL RUTHENIUM CATALYSTS WITH REFERENCE TO PHARMA APPLICATIONS

Dr.Sambasiva R Poreddy ENANTIOTECH CATALYSTS PVT LTD

P.NO:22-B. Road No: 2 Venkataramana Colony, Vanasthalipuram Hyderabad-500070, India

E-mail: [email protected] Ph: +91-9849601776 www.enantiotechcatalysts.com

mailto:[email protected]
http://www.enantiotechcatalysts.com/
Page 2: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

PREPARATION OF CHIRAL BUILDING BLOCKS THROUGH

ASYMMETRIC HYDROGENATION/ASYMMETRIC TRANSFER HYDROGENATION

Page 3: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 4: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 5: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 6: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 7: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 8: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

PHARMA APPLICATIONS

Page 9: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF KETONES

Page 10: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 11: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 12: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 13: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 14: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 15: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 16: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 17: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 18: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 19: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 20: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 21: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 22: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF IMINES

Page 23: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 24: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 25: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 26: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF ALKENES

Page 27: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 28: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e
Page 29: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e

THANK YOU


Iridium Catalysed Asymmetric Hydrogenation of Pyridines677724/FULLTEXT01.pdf · Iridium Catalysed Asymmetric Hydrogenation of Pyridines ... Iridium Catalysed Asymmetric Hydrogenation

Iridium Catalysed Asymmetric Hydrogenation of Pyridines677724/FULLTEXT01.pdf · Iridium Catalysed Asymmetric Hydrogenation of Pyridines ... Iridium Catalysed Asymmetric Hydrogenation

Asymmetric key

Asymmetric key

Unbiased, Accurate Yield Testing, Every Time FIRST Yield Guide.pdf · Corn and Soybean Yield Guide ND 2018 SD NE KS MO IA MN WI MI IL IN OH PA MD DE farmers’ independent research

Unbiased, Accurate Yield Testing, Every Time FIRST Yield Guide.pdf · Corn and Soybean Yield Guide ND 2018 SD NE KS MO IA MN WI MI IL IN OH PA MD DE farmers’ independent research

Reactions of Monosaccharides Monosaccharides - …szolcsanyi/education/files/Chemia... · Reactions of Monosaccharides Oxidation - Reduction OH O OH OH OH H OH OH O OH OH OH H OH

Reactions of Monosaccharides Monosaccharides - …szolcsanyi/education/files/Chemia... · Reactions of Monosaccharides Oxidation - Reduction OH O OH OH OH H OH OH O OH OH OH H OH

ALL RELEVANT ARCHITECTS AND ENGINEERS DRAWINGS M6 · 2021. 1. 13. · OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH CUTLINE CUTLINE M6 A49

ALL RELEVANT ARCHITECTS AND ENGINEERS DRAWINGS M6 · 2021. 1. 13. · OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH OH CUTLINE CUTLINE M6 A49

University of Groningen New approaches in asymmetric ...Asymmetric Hydrogenation of Unsaturated Carboxylic Acids Using a Mixed Ligand Approach 117 O OH O O O O O O N CO 2NH 2 NH 2

University of Groningen New approaches in asymmetric ...Asymmetric Hydrogenation of Unsaturated Carboxylic Acids Using a Mixed Ligand Approach 117 O OH O O O O O O N CO 2NH 2 NH 2

Asymmetric Routing

Asymmetric Routing

Artificial Photosynthesis - Macmillan Group...Masamune & Sharpless, Science 1983, 220, 949 HO OH HO O H OH OH OH OH asymmetric epoxidation MeO O O OR OBn OAc + O HO OBn OAc OR R1 [4+2]

Artificial Photosynthesis - Macmillan Group...Masamune & Sharpless, Science 1983, 220, 949 HO OH HO O H OH OH OH OH asymmetric epoxidation MeO O O OR OBn OAc + O HO OBn OAc OR R1 [4+2]

Kinetics and OH yield measurements to constrain energy barriers in the CH 3 OCH 2 + O 2 reaction

Kinetics and OH yield measurements to constrain energy barriers in the CH 3 OCH 2 + O 2 reaction

Safeguarding Investments in Asymmetric Interorganizational ... · Safeguarding Investments in Asymmetric Interorganizational Relationships: ... Asymmetric Interorganizational Relationships:

Safeguarding Investments in Asymmetric Interorganizational ... · Safeguarding Investments in Asymmetric Interorganizational Relationships: ... Asymmetric Interorganizational Relationships:

Ready; Catalysis Hydroformylation - UT Southwestern …€¦ · Ready; Catalysis Hydroformylation Asymmetric Hydroformylation: under-developed OH OH 4 steps high Oyield PPh2 OH O

Ready; Catalysis Hydroformylation - UT Southwestern …€¦ · Ready; Catalysis Hydroformylation Asymmetric Hydroformylation: under-developed OH OH 4 steps high Oyield PPh2 OH O

Chapter 18 Asymmetric Informationfaculty.bcitbusiness.org/kevinw/6500/Perloff/18M_Perloff_8008884_02_Micro_C18.pdf18.1 Problems Due to Asymmetric Information •Asymmetric information

Chapter 18 Asymmetric Informationfaculty.bcitbusiness.org/kevinw/6500/Perloff/18M_Perloff_8008884_02_Micro_C18.pdf18.1 Problems Due to Asymmetric Information •Asymmetric information

Memory of Chirality: A Strategy for Asymmetric Synthesisorggroup/supergroup_pdf/DJRSGPresent… · Two Forms of Chirality Ph O OH H NH2 Absolute (Static) Chirality Ph O OH H H Ph

Memory of Chirality: A Strategy for Asymmetric Synthesisorggroup/supergroup_pdf/DJRSGPresent… · Two Forms of Chirality Ph O OH H NH2 Absolute (Static) Chirality Ph O OH H H Ph

soils.landcareresearch.co.nz · Ohao Pt Parengarenga Har Great Exhibition Bay c ouhora Karikari Rangaunu . Bay 10 Oh Oh Oh Oh Oh Oh Motunau Oh Oh Oh Oh O White I Oh Oh CEA Oh xxxx

soils.landcareresearch.co.nz · Ohao Pt Parengarenga Har Great Exhibition Bay c ouhora Karikari Rangaunu . Bay 10 Oh Oh Oh Oh Oh Oh Motunau Oh Oh Oh Oh O White I Oh Oh CEA Oh xxxx

Think asymmetric

Think asymmetric

Asymmetric Information

Asymmetric Information

Kem-4.450 Asymmetric · PDF fileKem-4.450 Asymmetric Synthesis ... Fraction 4 16.0 58.0 ... E.J. et al. J. Am. Chem. Soc. 1970, 92, 396. O O H N OPh Me Me H H H O O O OH Me H H H O

Kem-4.450 Asymmetric · PDF fileKem-4.450 Asymmetric Synthesis ... Fraction 4 16.0 58.0 ... E.J. et al. J. Am. Chem. Soc. 1970, 92, 396. O O H N OPh Me Me H H H O O O OH Me H H H O

First Total Synthesis of (-) - Lomaiviticin Aglycon · Sharpless Asymmetric Dihydroxylation Et OTIPS OH OH Pd(OAc)2, O2, DMSO Saegusa Oxidation Et O OH OH MesCH(OCH3)2 PPTS Et O O

First Total Synthesis of (-) - Lomaiviticin Aglycon · Sharpless Asymmetric Dihydroxylation Et OTIPS OH OH Pd(OAc)2, O2, DMSO Saegusa Oxidation Et O OH OH MesCH(OCH3)2 PPTS Et O O

2/Ni(OH)2/Co(OH)2 Electrodes Supercapacitors Based on … · 2018. 9. 6. · 1 Supporting information Flexible All-solid-state Ultrahigh-energy Asymmetric Supercapacitors Based on

2/Ni(OH)2/Co(OH)2 Electrodes Supercapacitors Based on … · 2018. 9. 6. · 1 Supporting information Flexible All-solid-state Ultrahigh-energy Asymmetric Supercapacitors Based on

Asymmetric Losses

Asymmetric Losses