Asthma Market
Transcript of Asthma Market
Asthma Market: US
Currently $15 billion Projected to reach $17 billion by 2010 Major Players
GSK - Advair(Fluticasone/salmeterol) AstraZeneca – Symbicort(Budesonide/ Formoterol) Merck - Singulair(Montelukast) Cipla -Indian Market (56.9% share of the asthma
market)
Source: www.wikinvest.com/concept/Asthma_drug_marketBussiness Insight: The Indian Pharmaceutical Market Outlook to 2014
Asthma Drugs: US Market
Source: “Asthma & COPD-Clearing the air” 18 June 2007
Asthma Drugs: US Market
Source: GSK 2007 20-Fpg.11 , AZN 2007 20-F pg.1 MRK 2007 10-K pg.4
Asthma: India
2008 100,000 units of nebulizers sold at a total value of
Rs.10 crores 2009
Expected that 1,20,000 units will be sold in Indian market at a value of more than Rs.11 crores
CAGR(Compound Annual Growth Rate) Currently growing at 20% Future growth rate expected to be 25%
Source: www.medicalbuyer.co.in/2007/competitive-yet-growing-market-of nebulizers-1727
Asthma: India
Source: www.medicalbuyer.co.in/2007/competitive-yet-growing-market-of-nebulizers-1727-41.html
Prevalence in US & EU
Although UK stands out as the country which carries a greater disease burden related To asthma than any other country analyzed, prevalence of asthma is estimated to be Increasing in the other major markets, as there is less difference between pediatric prevalence rates for asthma between the UK & some of the other major markets
Asthma/COPD first/second-line brands by company & type-2004
World Top Ten Respiratory Drugs 2008
Generic Name Brands Companies Indications Sales
2006 2007 2008
Advair GSK Asthma 6.13 7 7.5
Montelukast Singulair Merck Asthma 3.56 4.3 4.3
Tiotropium Spriva COPD 1.74 2.5 1.9
Symbicort AstraZeneca Asthma 1.2 1.5 1.5
Budesonide Pulmicort AstraZeneca Asthma 1.3 1.4 1.2
Mometasone Nasonex Allergic rhinitis 0.94 1.1 1.3
Fluticasone Flovent, Flixotide GSK Asthma 1.22 1.25 1.2
Fexofenadine Allegra, Telfas Sanofi-Aventis Allergic rhinitis 0.86 0.99 1.1
Cetrizine Zyrtec Allergic rhinitis 2.4 2.2 1.9
Fluticasone Salmetrol
Boehringer Ingelheim, Pfizer
Budesonide + Formoterol
Schering-Plough Sanofi Aventis
Pfizer,UCB, Daiichi Sankyo
Source: Global Respiratory Market Review & World Top Ten Respiratory Drugs 2008
Top 10 Products
Top 10 Products
GSK AstraZeneca
GSK
Top 10 Products
Sanofi Aventis
Pfizer,UCB, Daiichi
Allergy Pipeline: July 1999-2009
Indication Phase Revision date
Omalizumab Genentech Allergic asthma June 2009
Allergy/ Asthma Preclinical Jan 2007
Allergic asthma Preclinical Jan 2007
Ragweed Allergy Vaccine Allergic rhinitis Pre-registration Mar 2009
Seasonal allergic rhinitis Phase III
Circassia (UK) Phase II May 2009
Seasonal allergic rhinitis Phase II Nov 2008
Curalogic (DK) Allergy Discontinued III Dec 2007
Molecule Company
Launched (AU, BR, CA, EU
unioin, NZ, CH USA)
Anti-IgE allergy vaccine
United Biomedical (USA)
Anti -C5 Mab therapy Alexion Pharmaceuticals
(USA)
Pollinex /Quattro (Allergy Vaccine)
Allergy Therapeutics Licensee:
Allerpharma Ragweed allergy
vaccine sublingual Greer Laboratories
(USA) June 2008
Ragweed Allergy Vaccine
Seasonal Allergic Rhinitis
Ragweed allergy vaccine tablet
ALK-Abello(DK) /Schering Plough
Microencapsulated ragweed pollen
extract
Allergy Pipeline: July 1999-2009Indication Phase Revision date
House dust mite allergy vaccine tablet Phase II April 2009
Phase II Mar 2008
Greer Laboratories Allergic rhinitis Phase I Mar 2009
Allergy vaccine subcutaneous Allergy Therapeutics Allergy Preclinical Feb 2007Anti allergy vaccine tablet ALK-Abello (DK) Preclinical Jan 2007
Phylogica (AU) Allergy Preclinical Sep 2005
Dust mite allergy vaccine Allergic asthma Preclinical Aug 2004
Allergy vaccine University of Edinburgh (UK) Allergy Mar 2007
Novozymes Allergy Nov 2005
Molecule Company
Oralair Mites (House dust mite allergy vaccine tablet )
Stallergens SA (FR)/Paladin Labs; Solvay
Pharmaceuticals
Perennial allergic rhinitis
ALK Mite tablet (House dust mite allergy
vaccine tablet )
ALK-Abello(DK) /Schering Plough
Allergic asthma/ Allergic rhinitis
House dust mite allergy vaccine
Allergic asthma/rhinitis
Phylogica (House dust mite allergy vaccine )
National University of Singapore
Discontinued Preclinical
House dust mite allergy vaccine Discontinued Preclinical
Allergy Pipeline: July 1999-2009Indication Phase Revision date
Others ALK-Abello (DK) Seasonal allergic rhinitis Mar 2009
Seasonal allergic rhinitis Pre-registration Jan 2009
Allergopharma (DE) Allergy Phase III April 2009
Allergopharma (DE) Allergy Phase III Mar 2003
Asthma Phase II May 2006
MEM 1414 Allergic asthma Phase II 2009
Allergic asthma Phase II 2009
Allergy Phase I Feb 2007
Perennial allergic rhinitis Phase I Dec 2005
Molecule Company
Grazax (Grass pollen allergy vaccine tablet)
Launched(DK, DE, NO, SE,
UK) Oralgen grasspollen (Grass pollen allergy
vaccine)
Fornix Biosciences (NL)
Wasp venom allergy vaccine
Bee venom allergy vaccine
MAP3K9 kinase inhibitors
DeCODE genetics (Iceland) Memory
Pharmaceuticals Mometasone/formoterol
Schering Plough/ Novartis
Sublingual allergy vaccine
Allergy Therapeutics (UK)
Cat allergy vaccine sublingual
Greer Laboratories (USA)
Allergy Pipeline: July 1999-2009
Indication Phase Revision date
Others HAE 1 Genentech Allergic asthma Phase I 2009
QAX 935 Idera Pharmaceuticals Allergic asthma Phase I 2009R 343 Rigel Pharmaceuticals Allergic asthma Phase I 2009
Allergy vaccine VLP Biotech (USA) Allergy Preclinical Dec 2004Allergy Preclinical Sep 2008
AFM 19 Allergy/ Asthma Preclinical July 2005
Asthma therapy Asthma Preclinical Oct 2007
NX 401 Novavax (USA) Allergy Preclinical July 2005Allery /Asthma Preclinical July 2003
Molecule Company
(E)-2-(3-(3-(3-Bromophenylamino)-2-cyano-3-oxoprop-1-
enyl)-1H-indol-1-yl)acetic acid
Actelion Pharmaceuticals (CH)
Affirmed Therapeutics (DE)
Schering Plough ; Oscient Pharmaceuticals
Allergy/Asthma therapy
Rigshospitalet; Santaris (DK)
Allergy Pipeline: July 1999-2009Indication Phase Revision date
Others 1217B Asthma Preclinical Aug 2007
PYM 60001 Phytopharm (England) Asthma Preclinical July 2007
PRS 060 Pieris (DE) Asthma Preclinical July 2007SRP312 SR Pharma (England) Asthma Preclinical May 2007
Tryptase inhibitirs Selecore (DE) Asthma Preclinical Sep 2005Targepeutics Allergic asthma Preclinical Sep 2005
Asthma therapy Asthma Preclinical May 2005
ME-108 Pharmexa (DK) Allergy Mar 2007
Unknown Food allergy Apr 2002
Allergy vaccine Food allergy Discontinued II July 1999
Allergy Mar 2008
Molecule Company
Medigreen Biotechnology Corp(CN)
TARG-ALLERG 1-200
Celestar Lexico Sciences (JP)
Discontinued Preclinical
Food Allergy DNA Vaccine
No development reported
University of Brimingham / GSK Acambis
Asthma/Allergy therapy Boehringer Ingelheim; J&J
Discontinued Preclinical
Allergy Pipeline: July 1999-2009Indication Phase
Other Allergy therapy Allergy Discontinued Preclinical Dec 2007
Allergy therapy Allergy Discontinued Preclinical Aug 2007
Maxy 320 Maxygen /ALK-Abello Allergic asthma Discontinued Preclinical Jan 2007
Allergy therapy & Diagnostics ImmavaRx (USA) Allergy No development reported Feb 2006
Asthma/Allergy therapy Amgen Allergy/asthma No development reported Aug 2001
E-CpG ODN CJ Corporation (SK) Allergic asthma Discontinued Preclinical Aug 2007
Asthma therapy Asthma Discontinued Preclinical Dec 2006
Asthma therapy OSI Pharmaceuticals Asthma No development reported June 2006
PLIVA ; PLR 8 PLIVA (Croatia) Asthma Discontinued Preclinical May 2006
Stress Protein allergy therapy Allergy/Asthma Discontinued Preclinical Oct 2002
VMR 001 Vernalis Group (UK) Asthma Discontinued Preclinical May 2001
Molecule Company Revision date
Kyorin Pharmaceuticals (JP); Infinity
Pharmaceuticals (USA) Katolinska Institute (SE)
; Maxygen (USA)
Sirna Therapeutics (USA)
Nventa Biopharmaceuticals
(USA)
Allergy Pipeline: July 1999-2009
Indication Phase Revision date
Allergic Rhinitis Allergy Vaccine Allergy Therapeutics Allergic rhinitis Phase III 2009
CP 118 Collegium Pharmaceuticals Allergic rhinitis Phase II 2009
Curalogic Allergy Phase II 2009
Z-207 Zeria Allergic rhinitis Phase I Aug 2008AVP 13358 Avanair Pharmaceuticals Phase I 2009
GSK 1004723 Boehringer Ingelheim Allergic rhinitis Phase I 2009Emisphere Allergy Phase I 2009
ALR 8 Topigen Pharmaceuticals Allergic rhinitis Preclinical Dec 2005
Allergic conjunctivitis Alcaftadine Vistakon Pharmaceuticals Allergic conjunctivitis Phase III 2009
Betotastine Ube Industries Allergic conjunctivitis Pre-registration 2009
K 123 Kowa Allergic conjunctivitis Phase II 2009
Fovea Pharmaceuticals Allergic conjunctivitis Phase II 2009
Molecule Company
Microencapsulated cat hair extract
Allergic rhinitis / asthma
Sodium cromoglicate oral
Prednisolone/ ciclosporin