Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis...

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Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia Kosta Kostov Military Medical Academy, Sofia [email protected] [email protected]

Transcript of Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis...

Page 1: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

Asthma & Allergic Rhinitis

Epidemiology in Bulgaria

T. A. PopovMedical University, Sofia

Kosta KostovMilitary Medical Academy, Sofia

[email protected]

[email protected]

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womenNOBEL PRIZE

WINNER for

Physiology and

Medicine 2004 г.

LINDA BUCK !

She is the 7-th female

winner in the

history!

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Europe

& the

Balkan

countries RO

MC

BG

HRSL

BA

AL

SB

&MNTR

RU

UA

GR

BY

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Demografic / health indicators

• Total population: 7.866.000

• GDP per capita (Intl $): 5.021

• Life expectancy at birth m/f (years): 68.4/74.8

• Healthy life expectancy at birth m/f (years): 60.8/65.2

• Child mortality m/f (per 1000): 18/16

• Adult mortality m/f (per 1000): 221/99

• Total health expenditure per capita (Intl $): 198

• Total health expenditure as % of GDP: 3.9

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Basic Statistics of the Bulgarian

Scientific Community:

• Number of research staff

(lecturers and scientists) - 24.200

• Research staff only - 17.000

% of active population - 0.7%

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Physicians:

• Total number of physicians: 33.300

• GPs: 5.600

• Allergologists / Clinical Immunologists:

- certified specialist: 71

• Pulmonologists:

- certified specialist: 340

- engaged in pulmonary medicine: 541

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•ACI exists for 38 years

• PD exists for 37 years

• Independent specialities

• Pending on 4 main specialties:

�Internal Medicine (PD and ACI)

� Pediatrics (PD and ACI)

� Otorhinolaryngology (only for ACI)

� Dermatology (only for ACI)

Allergology and Clinical Immunology (ACI)

and Pulmonary Diseases (PD) in Bulgaria

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Epidemiological Study on Asthma

& Allergies in BG

• Cohort study (20-44 yrs)

• Questionnaires

• Even territorial distribution

• Random selection (voting rolls)

Mileva J et al., 2001

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Questionnaires:

• Translation of the ECRHS original

• Asthma diagnosis: if positive answers

were given to the questions:

Q 5. Have you had asthma attacks in the past 12

months?

Q 6. Are you presently using any asthma

medication?

• Additional questions

Mileva J et al., 2001

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Mileva J et al., 2001

Epidemiological study of asthma & allergic diseases in BG

Page 11: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

3.8 3.9

8.3

mountains lowlands sea coast

% %

%

p < 0.001

Asthma prevalence in Bulgaria

according to geographic regions

Mileva J et al., 2001

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asthma rhinitis

seasonal

perennial

15.8%

4.7%

6.4%

9.4%

Prevalence of Asthma and Rhinitis in Bulgaria

Mileva J et al., 2001

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New Studies:

A Study on the Relation of Allergy / Asthma

and Indoor Air Quality in Homes in Bulgaria

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Mustakov et al., in preparation

ALLOHOME epidemiological study

350 km

12.816 parents

6,520 6,296

Sofia

Burgas

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Mustakov et al., in preparation

ALLOHOME epidemiological study

Wheezing and asthma symptoms in Sofia

& Burgas

0

5

10

15

20

25

30

35

40

45

Sofia Burgas

%

Asthma symptoms Diagnoased asthma

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Mustakov et al., in preparation

ALLOHOME epidemiological study

Asthma, Allergic Rhinitis and Eczema in Sofia &

Burgas

0

5

10

15

20

25

Sofia Burgas

%

Diagnoased asthma Diagnosed Allergic rhinitis Eczema

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Mustakov et al., in preparation

ALLOHOME epidemiological study

Causes for wheezing in Sofia & Burgas

0

5

10

15

20

25

30

Sofia Burgas

%

Common cold Exercise Laughing & weeping Playing outdoors

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Mustakov et al., in preparation

ALLOHOME epidemiological study

Conclusion:

The higher prevalence of asthma and

rhinitis in Burgas (at the see) is probably

due to specific environmental factors,

which need to be identified.

Page 19: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

Multicenter multinational epidemiological

study of the prevalence of asthma, allergic

rhinitis and atopic dermatitis on the basis

of unified written and video questionnaire

in children aged 6-7 and 13-14 years.

I nternational

S tudy of

A sthma and

A llergy in

C hildren

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ALLHOME compared with ISAAC

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ISAAC phases:

International

Study of

Asthma and

Allergy in

Children

Phase 1: 1992(questionnaire)

Phase 2: 1997

(questionnaire + objective assessments)

Phase 3: 2002

(questionnaire)

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ISAAC Phase 1:

Results for

prevalence of

asthma symptoms

InternationalStudy ofAsthma and Allergy in Children

56 countries

5 continents

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Bulgaria in ISAAC – phase 3:

n = 2780

524

828

567

861

0

100

200

300

400

500

600

700

800

900

1000

6-7 yrs 13-14 yrs

n

Boys

Girls

21 schools in SofiaMustakov et al., in preparation

Page 24: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

ISAAC Phase 3 methods:

• Written questionaire:

• 3 parts:- asthma

- allergic rhinitis

- eczema

• Parents administered

(6-7 year-olds)

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ISAAC Phase 3 methods:

• Written questionaire:

• 4 parts:

- asthma

- allergic rhinitis

- eczema

- video questionnaire

• Children administered

(13-14 year-olds)

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Summary:

0

5

10

15

20

25

30

35

40

Asthma All. Rhinitis Eczema

%

6-7 yrs symproms

6-7 yrs diagnose

13-14 yrs symptoms

13-14 yrs diagnose

SymptomSymptom--based disease prevalence was 4based disease prevalence was 4--6 time higher than 6 time higher than

doctordoctor--based prevalence of asthma and allergic rhinitis:based prevalence of asthma and allergic rhinitis: this this

did not apply to did not apply to atopicatopic dermatitis / eczema, where symptom / dermatitis / eczema, where symptom /

doctor prevalence were basically the same.doctor prevalence were basically the same.Mustakov et al., in preparation

Page 27: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

Conclusion:

With asthma prevalence of With asthma prevalence of

4.7%4.7%

((doctordoctor’’s diagnosed asthmas diagnosed asthma) )

Bulgaria positions itself in Bulgaria positions itself in

close to the other Balkan close to the other Balkan

countriescountries

((Greece, Greece, RoumaniaRoumania and Albaniaand Albania))

on the ISAAC world list. on the ISAAC world list.

Bulgaria

Mustakov et al., in preparation

Page 28: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

SUCCESS FOR GARD

“ We dance round in a ring and suppose,

but the secret sits in the middle and knows”

Robert Frost

Page 29: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

Thank you Poland for:

• Your proud and praiseworthy position during the II World War

• Your long-standing striving for democracyand the wisdom of Karol Wojtyla.

• The historical example of distinguished kings Mieszko I (966), Stefan Batory and Jagiello

• Fryderyk Shopen (1810-1849)

• Writers and Nobel prize winners HenrykSienkiewicz (1846-1916), Wladislaw Rejmont(1867-1925) and WislawaSzymborska (1923)

• Filmmakers R. Polanski, A. Wajda (1926, Oscar 2000), K. Kieshlowski and K. Zanussi

Page 30: Asthma & Allergic Rhinitis Epidemiology in Bulgaria BG Kosta... · Asthma & Allergic Rhinitis Epidemiology in Bulgaria T. A. Popov Medical University, Sofia KostaKostov Military Medical

Thank you for

the attention!

[email protected]

Mobile: +359 888231921