Trends in HIV incidence in Ontario based on the detuned assay: Update to October 2000
Assessing the Impact of National HIV Programs in Africa ......Presentation Outline ... Zambia....
Transcript of Assessing the Impact of National HIV Programs in Africa ......Presentation Outline ... Zambia....
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Jessica Justman, MDSenior Technical Director
ICAP at Columbia UniversityAssociate Professor of Medicine in Epidemiology
Mailman School of Public Health, Columbia University
Steven KinchenDeveloper, Apex Systems
Northrop Grumman CIMS Contractor Center for Global Health, CDC
May 7, 2019
Assessing the Impact of National HIV Programs in Africa through Population Surveys
ICAP Grand Rounds
PHIA Project Updates and Data Tools
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Presentation Outline
• Background• Global HIV epidemiology
• PHIA Project• Methods: survey design and lab• Results• Reports• Data visualization (video)• Public release dataset (video)
• Conclusions
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In 2017, 36.9 million people were living with HIV globallyN
umbe
r of P
eopl
e liv
ing
with
HIV
36.9 millionPLHIV
Source: UNAIDS 2018 estimates
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Global scale-up of antiretroviral therapy
0
5,000,000
10,000,000
15,000,000
20,000,000
25,000,000
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
*
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
Num
ber o
f peo
ple
on A
RT
People receiving antiretroviral therapy 21.7 millionPLHIV on ART
* Launch of the “3 by 5” initiative Source: UNAIDS /WHO estimates
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Global number of annual new HIV infectionsand targets for 2020 & 2030
36%↓
Source: UNAIDS /WHO estimates
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UNAIDS Global Targets
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Population-based HIV Impact Assessment (PHIA) Project
Goal: To conduct nationally representative, HIV-focused household surveys to assess the HIV epidemic and the impact of response programs in countries that have been heavily affected by the HIV epidemic
• 1o objectives: national HIV incidence andsubnational prevalence of viral loadsuppression among adults
• 2o objectives: HIV prevalence, 90-90-90cascades, detectable antiretrovirals, amongothers
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PHIA Project Methods: Survey Design, Sample Size, Eligibility & Data Collection
Survey Design Cross-sectional, two-stage cluster sample to achieve nationally representative cohorts
Sample size Powered for national HIV incidence and subnational VLS Approximately 30,000 participants, including 5,000 -10,000 children
Eligibility Household members who slept over the night beforeQuestionnaires Household, adult and adolescent
demographic, behavioral and clinical informationData collection Electronic data capture
Approximately six months of field workWeighting Sample weighted to adjust for selection probability, differences in non-
response and to achieve population representativeness
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PHIA Project: Lab Methods
Household • Venous blood draw; finger/heel stick for <2 years• HIV rapid testing per each national algorithm; CD4+ for HIV+• Return of results and counseling
Satellite Lab
• HIV confirmatory testing• Quality assurance testing
Central Lab(in-country)
• HIV RNA• HIV DNA (early infant diagnosis) for 0-18 month olds• HIV-1 limiting antigen (LAg)-avidity EIA• Incidence: LAg < 1.5 ODn, VL > 1000 c/mL and absence of detectable ARVs
Other Testing
• Qualitative ARV detection (HPLC tandem MS)• Genotyping and drug resistance
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Results
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Most eligible households and individuals participated
9283 85
91 93 9082
94 9789 84
9386 87 90 87 83 82
8994
80 82
9687 94 96 95 93 90
9398
9194
0
25
50
75
100
Cameroon Coted'Ivoire
Eswatini Ethiopia Lesotho Malawi Namibia Tanzania Uganda Zambia Zimbabwe
% in
terv
iewed
% households interviewed % men interviewed % women interviewed
https://phia.icap.columbia.edu/
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Most self-reported HIV-positive participantsconsented to provide blood
95 92 92 9488 87 85
9499
89 9095
9195 95
9187 90
9599
90 91
0
25
50
75
100
Cameroon Coted'Ivoire
Eswatini Ethiopia Lesotho Malawi Namibia Tanzania Uganda Zambia Zimbabwe
% co
nsen
ting
to b
lood
dra
w
Men Women
https://phia.icap.columbia.edu/
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High quality of biomarkers
99.2% 98.6% 99.8% 99.6%
questionnaires completed without errors
adult participants provided sample with expected blood volume
specimens with <24h arm-to-freezer time
specimens with no hemolysis or clotting
As of March 2019, a total of 375,000 blood samples were collected
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Annual HIV incidence among adults (15-49 years) without ARV adjustment
https://phia.icap.columbia.edu/
0.08
0.99
1.33
0.26 0.21 0.140.36 0.31 0.30
0.44
1.991.81
0.460.73
0.400.59
1.10
0.69
0.26
1.48
0.05
1.55
0.360.47
0.270.48
0.700.50
0
1
2
3
Cameroon Eswatini Ethiopia Lesotho Malawi Namibia Tanzania Uganda Zambia Zimbabwe
Annu
al H
IV In
cide
nce,
15-
49y
(%)
Male Female Total
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Annual HIV incidence among adults(15-49 years) without ARV adjustment
https://phia.icap.columbia.edu/
0
1
2
3
Cameroon Eswatini Ethiopia Lesotho Malawi Namibia Tanzania Uganda Zambia Zimbabwe
Annu
al H
IV In
cide
nce,
15-
49y
(%)
Male Female Total
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Annual HIV incidence incorporating ARV detection into the recent infection algorithm
https://phia.icap.columbia.edu/
0.22 0.14 0.280.44 0.34
1.00
0.33 0.240.64
00.5
11.5
22.5
Malawi Tanzania Zambia
Annu
al H
IV
Inci
denc
e, 1
5-49
ye
ars (
%)
Incidence with ARV adjustment
Male Female Total
0.26 0.14 0.310.46 0.40
1.10
0.36 0.270.70
0.00.51.01.52.02.5
Malawi Tanzania Zambia
Annu
al H
IV
inci
denc
e, 1
5-49
ye
ars (
%)
Incidence without ARV adjustment
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Viral load suppression (HIV RNA <1000 c/mL) among HIV-positive persons
43
28
68 67 6361
70
42
54 57 5446 46
7672 71 73
82
5763 60 64
45 40
73 70 68 6877
5260 59 60
0
20
40
60
80
100
Cameroon CoteD'Ivoire
Eswatini Ethiopia Lesotho Malawi Namibia Tanzania Uganda Zambia Zimbabwe
VLS
Prev
alen
ce (%
)
Male Female Total
73%
https://phia.icap.columbia.edu/
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Results: 90-90-90 among adults
https://phia.icap.columbia.edu/
72 71.460.6 55.6
37.2
98.6 87.193.6 93.1
88.1
89.6 89.2 8780.1
75.9
0
50
100
Ethiopia† Zambia Tanzania Cameroon Cote d'Ivoire†
Peop
le L
ivin
g w
ith H
IV
(%)
*Adjusted for ARVs unless otherwise specified; †Not adjusted for ARVs;Column labels indicate conditional proportions; Column heights indicate unconditional proportions
87 86 81 76.8 76.8 72.588.8 96.491.8 91.4 88.4 90.4
91.4 91.387.7 91.3 85.3 83.7
0
50
100
Eswatini Namibia Lesotho Malawi Zimbabwe Uganda
Peop
le L
ivin
g w
ith H
IV
(%)
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90-90-90 among adults by age(3-Country Combined)
46.4 64.877.8 70.4
82.380.7
90.1 87.0
79.388.1
89.8 88.6
0
20
40
60
80
100
15-24 25-34 35-59 15-59
Peop
le Li
ving
with
HIV
(%)
Diagnosed On Treatment Virally Suppressed
Column labels indicate conditional proportions; Column heights indicate unconditional proportions CROI #114 LB, 2016
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Pediatric 90-90-90Malawi and Zambia, 0-14 years
Adjusted for ARVs https://phia.icap.columbia.edu/
69.3
50.686.1
92.3
57.954.3
0
10
20
30
40
50
60
70
80
90
100
Malawi Zambia
Child
ren
Livi
ng w
ith H
IV (%
)
Diagnosed On treatment Virally suppressed
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HIV prevalence among adults in urban Ethiopia
https://phia.icap.columbia.edu/
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Viral load suppression (HIV RNA <1000 c/mL) among HIV-positive adults in urban Ethiopia
https://phia.icap.columbia.edu/
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90-90-90 among adults living with HIV inurban Ethiopia, by sex
https://phia.icap.columbia.edu/
Percentages shown in the graph refer to the conditional 90-90-90 targetsError bars represent 95% confidence intervals.
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Presentation Outline
• Background• Global HIV epidemiology
• PHIA Project• Survey design and weighting• Lab methods• Results• Reports• Data visualization (video)• Public release dataset (video)
• Conclusions
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Reports
• Available in“Resources” section
• Report types:• Summary sheets• First reports• Final reports
https://phia.icap.columbia.edu/
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11 PHIA Summary Sheets Available
Summary Sheets• PDFs• 4 to 6 pages• Tables, charts, maps
by sex, age, andregion
https://phia.icap.columbia.edu/
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Example: ZIMPHIA Summary Sheet
https://phia.icap.columbia.edu/
Summary Sheets include:• HIV incidence• HIV prevalence• Viral load suppression• UNAIDS 90-90-90
targets
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Example: ZIMPHIA Slides
https://phia.icap.columbia.edu/
PowerPoint slide sets include:• Charts• Maps• Descriptive
comments
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Example: Preliminary Summary Sheets
• Summary Sheets provide resultsquickly
• Some include preliminary findingsthat have not yet been adjustedfor the presence of antiretrovirals
• Preliminary findings are indicatedin the title
• Summary sheets with preliminaryfindings are replaced with finalsheets when they becomeavailable
https://phia.icap.columbia.edu/
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PHIA First Reports3 First Reports Available• Executive summary• More detailed presentation
of prevalence, incidence,90-90-90, and other resultsthan in the Summary Sheets
• Discussion of design andmethods
• Produced for earlier PHIAsurveys only
• All surveys have finalreports
https://phia.icap.columbia.edu/
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PHIA Final Reports
Final Reports include:• ARV-adjusted 90-90-90
estimates• Late HIV diagnosis (CD4+ cell
count)• Transmitted resistance to
ARVs• Retention on ART• TB (linkage, diagnosis and
treatment)• HIV knowledge and attitudes
https://phia.icap.columbia.edu/
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PHIA Final Reports (continued)
Final reports include detailed discussion of:• Sample frame and design• Implementation• Biomarker testing• Data processing• Response rates• HIV testing methodology• Estimates of sampling errors• Questionnaires• Consent forms
https://phia.icap.columbia.edu/
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Deliverables Forecast
https://phia.icap.columbia.edu/
Final Report Public DatasetFeb 2019 Mar 2019Oct 2018 Apr 2019
Jun 2019 Jul 2019Apr 2019 May 2019
May 2019 Jun 2019
Jun 2019 Jul 2019Jun 2019 Jul 2019
Jul 2019 Aug 2019
Jul 2019 Sept 2019Aug 2019 Oct 2019
Sept 2019 Oct 2019April 2020 May 2020Jan 2020 Feb 2020Aug 2020 Sep 2020
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PHIA Data Visualization Tool
• Allows detailed dataexploration without use ofstatistical software
• Available in “Data” section• Produces charts, tables,
and maps
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PHIA Data Visualization Tool
• Users can compare within and acrosscountries to explore spatial trends andvariations across contexts
• Supports customizing by:• Indicator• Country• Sub-national area• Stratifiers such as age, gender, income
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Video: Using the PHIA data visualization tool
Available at: https://youtu.be/mSUGJfdETjw
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PHIA Public-use Dataset Dissemination
Public-use datasets• Promote use and
dissemination of PHIAresults
• Support analysts inconducting their ownanalyses
• Require statistical softwareto analyze
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PHIA public-use dataset dissemination
Public-use datasets• Contain anonymized household, individual,
and biomarker data• Include technical documentation
• Are available in SAS, Stata, and CSV formats
• Available with Final Report for each country
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Video: Accessing PHIA documentation and datasets
Available at: https://www.youtube.com/watch?v=Wn5ZVnvu82g
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Data Requests
Request requirements• Title• Background/Context• Primary research question• Exposure/outcome variables
and covariates• Stat Methods• Collaborators• Where• Co-researchers
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Structure of PHIA datasets
• Each household record is associatedwith one or more individual records
• Each individual record may have anassociated biomarker record
• Separate datasets are provided forrecords at different levels of analysis
• Individual and biomarker tests areseparated for adults and children
• Geospatial data (masked locationdata) will be available upon request
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Getting started
After receiving the requested datasets:• Review PHIA data use manual• Review the survey-specific data use manual supplement• Note top count of replicate weights• Open datasets in a statistical package and compare record counts to
counts included in the survey-specific data use manual• Run unweighted frequencies and match some variables from the
codebooks and/or reports• Run weighted analyses and match some tables from the final report
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Video: Analyzing PHIA data in Stata
Available at: https://youtu.be/bAEhfdCz070
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Conclusions
• High participation in the PHIA surveys, with high qualitysamples and data from over 375,000 adults and children
• Data highlight achievements and gaps of national HIVresponse programs
• Remarkable progress toward 90-90-90 targets• Challenges among younger adults and children
• Datasets and visualization tools allow users to compare withinand across countries and explore spatial trends and variationsacross contexts
• Many final reports and datasets forthcoming
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Acknowledgements• Survey participants• Colleagues in CDC country offices, ministries of health and national statistical
bureaus in Cameroon, Cote D’Ivoire, Eswatini, Ethiopia, Haiti, Kenya, Lesotho,Malawi, Namibia, Rwanda, Tanzania, Uganda, Zambia and Zimbabwe
• CDC Atlanta colleagues• Laura Porter• Drew Voetsch• Kristin Brown
• ICAP colleagues• David Hoos• Elizabeth Radin• Getrude Makurumidze• Kay Yuengling
This project is supported by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) through CDC under the terms of cooperative agreement #U2GGH001226. The contents are the responsibility of ICAP and do not necessarily reflect the views of the United States Government.
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