Assessing the exposome in occupational cancer the exposome in occupational cancer Lode Godderis1,2,...
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Assessing the exposome in occupational cancer Lode Godderis 1,2 , Steven Haenen 1 , Katrien Poels 1 , Jeroen Vanoirbeek 1 1 KULeuven, Occupational, Environmental and Insurance Medicine Lab Occupational and Environmental Hygiene 2 IDEWE, Knowledge, Information and Research
Transcript of Assessing the exposome in occupational cancer the exposome in occupational cancer Lode Godderis1,2,...
Assessing the exposome in occupational cancer
Lode Godderis1,2, Steven Haenen1, Katrien Poels1, Jeroen
Vanoirbeek1
1 KULeuven, Occupational, Environmental and Insurance Medicine
Lab Occupational and Environmental Hygiene 2 IDEWE, Knowledge, Information and Research
Outline
• Introduction
• Omics Exposomics
• Approaches
• Critical windows of exposure
• Conclusions
Introduction
Cancer Treatment
Genes 10%
GWAS
Introduction
Prevention Cancer
Environment 10%
EWAS
Mechanism: GEWAS
Introduction
Prevention Cancer Treatment
Genes 10%
Environment 10% 80%
Introduction
Environment
Outline
• Introduction
• Omics Exposomics
• Approaches
• Critical windows of exposure
• Conclusions
Omics Exposomics
Omics Exposomics
Omics Exposomics
Rappaport and Smith. Science 2010
Omics Exposomics
Genomics Exposomics Responsomics
Outline
• Introduction
• Omics Exposomics
• Approaches
• Critical windows of exposure
• Conclusions
Approaches
Bottom-up approach Top Down approach
Measure agents in air, water & food
Test for associations with cancer case
Identify important exogenous exposures
Identify all important exposures
Test for associations with cancer case
Measure agents in blood
Adapted from: Rappaport Journal of Exposure Science and Environmental Epidemiology 2011
Genetic and epigenetic mechanisms
Approaches
Cancer
Solvent exposure
Approaches
Bottom-up approach
Measure agents in air, water & food
Test for associations with cancer case
Identify important exogenous exposures
Bottom-up approach
Bottom-up approach
Bottom-up approach
Carcinogen
Bottom-up approach • Layer Chemical
Agents • Effective search
Carcinogen
Bottom-up approach
Approaches
Top Down approach
Identify all important exposures
Test for associations with cancer case
Measure agents in blood
Top Down approach
Top Down approach
Godderis et al. Plos One 2012
Results: Top Down approach
Godderis et al. Plos One 2012
Top Down approach
Godderis et al. Plos One 2012
Top Down approach
Godderis et al. Plos One 2012
Top Down approach
McHale et al. Mutat Res. 2010,
Top Down approach
Top Down approach
Tabish et al. Plos One 2012
Top Down approach
Godderis et al. Epigenomics 2012
Outline
• Introduction
• Omics Exposomics
• Approaches
• Critical windows of exposure
• Conclusions
Mother Umbilical cord
Critical windows of exposure
Mother Father
Preconception
Adulthood
Puberty Childhood
Fetal
Outline
• Introduction
• Omics Exposomics
• Approaches
• Critical windows of exposure
• Conclusions
Conclusion
• Technological challenges
• Small volumes
• GIS
• “omic”s
– “molecular signature”
– mechanisms
• EWASGEWAS
Conclusion
Thank you-omics
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