ASPECTS REGARDING THE ETIOLOGY AND CLINICAL MATTERS OF THE FEBRILE SEIZURES IN CHILDREN First...
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ASPECTS REGARDING THE ETIOLOGY AND CLINICAL MATTERS OF THE FEBRILE SEIZURES IN CHILDREN
First Author: Iulia Laura GavrilaAuthor: Alina Grama, Adriana Craciun, Diana Lapusneanu, Maria Magdalena AlojeCoordinator: Asist. Univ. Dr. Alina Grama
INTRODUCTION
Febrile seizures are the most common seizure disorder in childhood. They are a benign epileptic manifestation of infancy occurring between 6 months and 5 years of age, accompanied by fever and affecting an estimated 2-5 % of children with no neurological history.
Purpose: Was the evaluation of febrile seizures on children hospitalized in Pediatric 1 Clinic of Targu Mures.
Material and method: A retrospective study was performed on 195 patients diagnosed with Febrile Seizures, between January 2009- December 2012.
RESULTS OBTAINED AFTER GROUPING FS BY SEX AND ENVIRONMENTAL ORIGIN
Male
Female
114
81
Rural environment
Urban environment
103
92
Number Number
Results obtained from the clustering of cases by age
Age of patients Minim Average Maxim
Age group < 6 months6 months to
5 years> 5 years
Percentage in the number of
cases5,1 % 91,3 % 3,6 %
THE NUMBER OF PATIENTS WITH SIMPLE/COMPLEX FS BY AGE
Simple FS Complex FS0
20
40
60
80
100
120
140
4 6
133
46
3 4
< 6 months
6 months - 5 years
> 5 years
Simple FS = generalized seizures, lasting less than 15 minutes, and without recurrence within 24 hours
Complex FS = have focal semiology, last more than 15 min and have more than one episode during the same febrile event
THE DISTRIBUTION OF CASES IN EACH OF THE 4 YEARS (INCLUDED IN THIS STUDY)
Series1
0.00%5.00%
10.00%15.00%20.00%25.00%30.00%35.00%
2009
2010
2011
2012
19.50%
20.50%
25.10%
34,9
2009201020112012
TYPE OF SEIZURE FREQUENCY ACCORDING TO
GENDER
Simple FS Complex FS0
20
40
60
80
100
120
140
Female
Male
Total58
23
82
32
140
55
TYPE OF MANIFESTATIONS
Tonic-clonic seizures
Tonic seizures
Atonic seizures
Clonic seizures
0.00% 20.00% 40.00% 60.00%
56.40%
20.50%
12.30%
8.20%
FREQUENCY OF DISEASES RELATED TO FEBRILE SEIZURES
Series10%
10%
20%
30%
40%
50%
60%
70%
80% 80%
24.10%
8.20%9.70%3.60%2.60%
Superior Airway in-fectionsInferior Airway in-fectionsUrinary infectionsEruptive diseases Vaccination reac-tionAcute enterocolitis
ETIOLOGY RESULTING FROM THE STUDY
Bacterial infection Viral infection0.00%
20.00%
40.00%
60.00%
80.00%
100.00%
120.00%
97.40%
2.60%
BACTERIAL INFECTION/TYPE OF SEIZURES/SEASONS
Complex FS Simple
FS Total FS - bact inf Total FS
- viral inf
0
10
20
30
40
50
60
70
20
41
61
0
10
3646
2
720 27
2
16
40
56
1
SpringSummerAutumnWinter
Results: Family history of seizures and epilepsy
Frequency (number)
Percent
Seizures 11 5,6
No Seizures 184 94,4
Epilepsy 13 6,7
No Epilepsy 182 93,3
THE RISK OF RECURRENT FS / AGE <1 YEAR OF THE FIRST FS
020406080
100120140160180200
2228
50
27
118
145
49
146
195
recurrent FSnon-re-current FSTotal
p=0,01Value
95% Confidence Interval
Lower Upper
Odds Ratio for Age of 1st FS< 1 year (da / nu)
3,434 1,709 6,898
For cohort Recurrent FS = yes
2,341 1,485 3,690
For cohort Recurent = no
,682 ,523 ,888
N of Valid Cases
195
CONCLUSIONS As in the literature, this study proves that simple febrile seizures, with tonic-clonic manifestations are most frequently seen especially in male children between 6 months and 5 years old.
In addition to this, I have determined that: The risk of recurrent FS is 3,4 times higher for patients where 1st F.S. occurred at the age of under 1 year compared to those where it occurred at an age of more than 1 year. The number of cases is higher in the rural environment In the 4 study years, the number of cases increased The bacterial etiology is predominant Superior airway infections were frequently associated with F.S Both simple and complex FS appeared more often in spring
and winter.
BIBLIOGRAPHY http://www.ncbi.nlm.nih.gov/pubmed/24477659# http://www.medscape.com/viewarticle/769023 http://www.ncbi.nlm.nih.gov/pubmed/7594268 Togănel R.: Puericultură, Litografia UMF, Târgu-Mureș, 2009 Baghiu M.D: Lecţiuni de pediatrie, Târgu-Mureş, 2009, vol. II Baumann RJ. Technical report: treatment of the child with simple febrile
seizure. Pediatrics 1999;103:e86.www.pediatrics.org/cgi/content/full/ 103/6/e86 (accessed 19 June
Butnariu A., Badiu I., Boros E. : Puericultura şi Pediatrie, Ed. 4, Editura Medicala Universitara Iuliu Hateganu, Cluj Napoca, 2011
Bui T, Delgado C, Simon H – Infant seizures not so infantile: first-time seizures în children under six months of age presenting to the ED. Am J Emerg Med, 2002
Friedman MJ, Sharieff GQ – Seizures în children. Pediatr Clin N Am, 2006 Man C. Sorin, Manulescu V. Mircea: Pediatrie Pediatrica, Editura
Risoprint Cluj Napoca, 2006 Popescu V – Convulsiile febrile. Revista Română de Pediatrie, 2006, LV
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