11 Predisposing Factors:Genetics, Age, Gender, RacePeripheralVascular ReninBloodVolumeSodium andWaterRetentionAngiotensinproduction ofcatecholamineRAAS!sfunctionAtherosclerosisVascular changesGlucose"nsulinresistance#eart RateVascularResistance$%er&acti%it! ofS'SPrecipitating Factors:Stress, $(esit!, 'utrients, Su(stance a(use, ), *idne! +hronic"n,ammation#!pertension-issue "schemia.nd $rgan!sfunctionPeripheral VascularResistanceAngiotensin ""Wea/ (lood%esselsAtherosclerosisendomethelin0%asoconstrictor12nitric o3cidePlateletaggregation.ndotheliald!sfunctionVascularremodelling#!pertroph! ofm!ocardiumassociated toh!pertensionSodium andWaterRetention Pain4actic Acid fomationAnaero(icmeta(olism-issue "schemiaSmooth musclecontractioneathStro/e,-ransientischemicattac/, Acute(raininfarction,+ere(ralthrom(osis,RetinalVascularsclerosis, 4ossof Vision+hronic*idne!isease)a!ocardialischemia, )"Gangrene25rine output +hest pain+laudication, painful sensation, Blurring of %ision, dou(le %ision, and other %isual #ead ache, di66iness, fatigue, changes in mentation, sensorium and Arterial %essels of lo7ere3tremities.!es Brain *idne! #eart