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Aruni Bhatnagar.doc
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CURRICULUM VITAE July 2008 NAME: Aruni Bhatnagar PRESENT POSITION AND ADDRESS: Professor of Medicine Distinguished University Scholar Division of Cardiology Department of Medicine University of Louisville 580 S. Preston Street Baxter II Bldg. Rm. 421 Louisville, KY 40202 Tel: (502) 852-5966 Fax: (502) 852-3663 Email:[email protected] BIOGRAPHICAL: DATE & PLACE OF BIRTH: Dec. 17, 1960 - Lucknow, U.P. India CITIZENSHIP: Indian (Permanent Resident USA) HOME ADDRESS: 5614 Wolf Pen Trace Prospect, KY 40059 (502) 228-7793 EDUCATION: Institution Date Degree Subject University of Lucknow 1979 B.S. Chemistry, Botany, Zoology India University of Lucknow 1981 M.S. Biochemistry India University of Kanpur 1986 Ph.D. Chemistry India 1
Transcript of Aruni Bhatnagar.doc
CURRICULUM VITAE
July 2008NAME: Aruni Bhatnagar
PRESENT POSITION AND ADDRESS:
Professor of MedicineDistinguished University ScholarDivision of CardiologyDepartment of MedicineUniversity of Louisville580 S. Preston StreetBaxter II Bldg. Rm. 421Louisville, KY 40202
Tel: (502) 852-5966 Fax: (502) 852-3663Email:[email protected]
BIOGRAPHICAL:
DATE & PLACE OF BIRTH: Dec. 17, 1960 - Lucknow, U.P. India
CITIZENSHIP: Indian (Permanent Resident USA)
HOME ADDRESS: 5614 Wolf Pen Trace Prospect, KY 40059
(502) 228-7793
EDUCATION:
Institution Date Degree Subject University of Lucknow 1979 B.S. Chemistry, Botany, ZoologyIndia University of Lucknow 1981 M.S. BiochemistryIndia
University of Kanpur 1986 Ph.D. Chemistry India
PROFESSIONAL EXPERIENCE:
1981 - 1985 Research Fellow National Council of Education Research & TrainingCentral Drug Research Institute Lucknow, U.P. 226001 India
1985 - 1990 Postdoctoral Fellow Dept. of Human Biological Chemistry & GeneticsUniversity of Texas Medical Branch, Galveston, TX 77555
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1990 - 1995 Assistant Professor Dept. of Human Biological Chemistry & Genetics and Dept. of Physiology and Biophysics, University of Texas Medical Branch Galveston, TX 77555
1995 - 1998 Associate Professor Dept. of Human Biological Chemistry & Genetics and Dept. of Physiology and Biophysics, University of Texas Medical Branch Galveston, TX 77555
1998 - to date Professor Division of Cardiology, Department of Medicine, and the Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202
Teaching:
Member Graduate School, Department of Human Biological Chemistry and Genetics, UTMB, 1990-1998.
Special Member Graduate School, Department of Physiology and Biophysics, UTMB, 1991-1998.
Special Member Graduate School, UL, 1999 to date
School of Medicine (UTMB); 1990-1998:
Clinical Correlation; 1 lecture
Small Group Exercises (IFL) in Human Genetics: (1 week course)
Clinical Exercises (2 to 3 per year)
Graduate School
Citric Acid Cycle and Oxidative Phosphorylation-Cell Biology Course (4 lectures), 1992-1998.
Carbohydrate Metabolism: Department of Human Biological Chemistry and Genetics (6 lectures), 1992-1998.
Molecular Toxicology: Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, (3 lectures), 2005, 2006, and 2007.
Member, Reading and Examination Committee for the thesis by Sergey Chekmenev, Speed School of Engineering. Thesis title: Non-contact and passive computer vision methodology for measurement of arterial pulse using thermal IR imaging, April, 2008.
Member, Dissertation Committee, Immaculate Amunom, School of Medicine. Thesis title: Lipid aldehydes are substrates and transcriptional regulators of cytochromes P450, April 2008.
Students/Trainees
Past Trainees:
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1. Si-Qi Liu, Graduate Student, HBC&G (Co-Supervisor) UTMB, 1991–1995, Post Doctoral Fellow, 1997-1998, currently Assistant Professor, Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY.
2. Albert Zacarias, Ph.D., Post-Doctoral Fellow, Physiology and Biophysics, UTMB,1992 -1998. currently Physicist, Division of Radiation Oncology, University of Louisville Hospital, Louisville, KY.
3. Animesh Chandra, Ph.D., Post-Doctoral Fellow, HBC&G, UTMB, 1994-1997, currently Scientific Writer, General Clinic Research Center, University of Texas Medical Branch, University of Texas, Galveston TX.
4. Jeff Almrud, Student, Texas A&M, 1992–1994, currently Research Associate, Department of Chemistry and Biochemistry, University of Texas At Austin, Austin, TX.
5. Sanjay Srivastava, Ph.D., Post-Doctoral Fellow, HBC & G, UTMB, 1995-1998, currently Associate Professor, Division of Cardiology, University of Louisville, Louisville, KY.
6. Johannes Ruef, M.D., Fellow, Division of Cardiology, UTMB, 1996-1998, currently Professor of Medicine, Division of Cardiology, University of Heidelberg, Heidelberg, Germany.
7. Kota Ramana, Ph.D., Post-Doctoral Fellow , HBC&G, UTMB, 1999-2002, currently an Assistant Professor in Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX.
8. Ken Shinmura, M.D., Fellow, Division of Cardiology, University of Louisville, 1999-2000, currently Assistant Professor, Division of Geriatric Medicine, Dept. of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
9. Eitaro Kodani, M.D., Fellow, Division of Cardiology, University of Louisville, 2000-2001, currently Department of Internal Medicine, Nippon Medical School Tama-Nagayama Hospital, Tama-shi, Japan.
10. Michael Hill, Ph.D., Fellow, Division of Cardiology, University of Louisville, 1999-2001, currently an Assistant Professor Department of Physiology, Meharry Medical College, Nashville, TN.
11. Matthew B. West, Graduate Student, Department of Biochemistry, University of Louisville, 2002- to date. Currently AAAS Science Policy Fellow, National Institutes of Health, Washington, D.C.
12. Matthew Spite, Graduate Student, Department of Physiology and Biophysics, University of Louisville, 2003 to 2005. Currently, Postdoctoral Fellow, Brigham & Women’s Hospital, Harvard University, Boston, MA.
13. Sunday Awe, Post-doctoral Fellow, Currently, Physicist, Food & Drug Administration, Bethesda, Maryland.
14. Bradford G. Hill, Graduate Student, Department of Biochemistry, University of Louisville, 2003- 2007. Currently, Postdoctoral Fellow, University of Alabama at Birmingham, Alabama.
Current Trainees:
1. Aisha Isabelle Bagshaw, Graduate student, Department of Pharmacology, University of Louisville, 2005- to date.
2. Srinivas M. Tipparaju, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2003- to date.
3. Karin Kaiserova, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2003- to date.
4. Elena Vladykovskaya, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2005 – to date.
5. Evgeny Ozhegov, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2005 – to date.
6. Shahid Pervez Baba, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2005 – to date.
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7. Petra Haberzettl, Post-Doctoral Fellow, Division of Cardiology, University of Louisville, 2006-to date
8. Rachel Keith, Graduate Student, Department of Physiology and Biophysics, University of Louisville, 2006 – to date.
9. Laura Wheat, Graduate Student, Department of Physiology and Biophysics, University of Louisville, 2007- to date.
10. Jason Hellman, Graduate Student, Department of Physiology and Biophysics, University of Louisville, 2008- to date.
11. Alan Brooks, MD-PhD Student, Department of Biochemistry and Molecular Biology, University of Louisville, 2008-to date.
SERVICE Interview students and faculty for School of Medicine, University of Texas Medical Branch Member, Cardiology Fellows Selection Committee, University of Louisville Member, IRB, University of Louisville
Scientific Review: Biochemical PharmacologyAmerican Journal of Physiology
BiochemistryComparative Biochemistry and Physiology
Toxicology and Applied Pharmacology Journal of Molecular and Cellular Cardiology
Experimental and Clinical CardiologyProceedings of the National Academic of Sciences, USAJournal of Pharmacology and Experimental TherapeuticsCirculation ResearchCirculationBiochemistryAmerican Journal of PathologyLife Sciences Journal of the American College of CardiologyArteriosclerosis, Thrombosis and Vascular BiologyEnvironmental Health PerspectivesBasic Research in CardiologyDiabetesDiabetes CareEnvironmental Health PerspectivesMutation ResearchChemico-Biological InteractionsEnvironmental ResearchJournal of Free Radical in Biology and Medicine
Editorial Board: Journal of Pharmacology and Experimental Therapeutics. Aug, 1999 – 2004Circulation Research, Aug, 2004 – to date Guest Editor, Circulation, 2008-to date
Grant Review: Reviewer: Sealy Center Grants at the University of TexasReviewer: Jewish Heart and Lung Institute Grants Program, LouisvilleCharter member: ALTX-4 Study Section, National Institutes of Health, 1999-2003Ad-hoc Member: ALTX-4 Study Section, NIHMember, Environmental Protection Agency Review Panel, June 2002
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Member, Review Committee, Reynolds Foundation and AHA Peer Review Committee for the Cardiovascular Research Center grants, March 2003Member, Review Panel on Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and other Air Pollutants, EPA, November 5, 2003Chairman, NIEHS Special Emphasis Panel for RFA, “The Role of Air Pollutants in Cardiovascular Disease”, March 4-5, 2004.Member, Superfund Review, ZES1 JAB (S5), National Institutes of Environmental Health Sciences, October 4-7, 2004.Member, Review Panel for Program Project Grant 2P01 ES-00925-06, ZESI RAM-C (DG), NIEHS, November 3, 2004.Chairman, Review Panel for Program Project Grant PA-02-127, ZES1 LKB-A (K4), National Institutes of Environmental Health Sciences, February 28, 2005.Member, Review Panel ZES1 LKB-A (K7), National Institutes of Health, February 28, 2005. Member, Review Panel ZRG1 HEME-A 10, National Institutes of Health, March 18, 2005.Member, Review Panel ZES1-RAM-A-L4, National Institutes of Health, April 26, 2005.Member, Review Panel ZRG1 DIG F(02), National Institutes of Health, June 15, 2005.Chairman, Review Panel ZES1 LKB-C (K1), National Institutes of Health, August, 4, 2005.Member, Review Panel, Myocardial Ischemia and Metabolism, National Institutes of Health, October 26-27, 2005Chairman, NIEHS Special Emphasis Panel ZES1 LKB (K2), National Institutes of Health, April 4, 2006.Member, DHHS Special Emphasis Review Panel ZRG1 DIG-C, National Institutes of Health, May 10-11, 2006.Member, EPA ORD Nanotechnology Review Panel Two (06-F1-F7), May 17-19, 2006.Member, National Institutes of Health Myocardial Ischemia and Metabolism Study Section, June 19, 2006.Chairman, NIH Special Emphasis Review Panel ZRG1 DIG F (02) M, National Institutes of Health, June 27, 2006.Member, National Institute of Health, Myocardial Ischemia and Metabolism (MIM) Study Section, October 13, 2006.Chairman, NIH Special Emphasis Review Panel ZRG1 DIG-F 02 M XNDA, March 13, 2007.Chairman, K99/R00, K01/R13 Review, National Institutes of Health, March 19, 2007Member, NIEHS Nanomaterials Initiative Review, May 14-16, 2007Member, NIEHS ZES1 LKB-A (R5), July 11, 2007Chairman, NIEHS, Center Program – RFA ES-06-010, National Institutes of Health, July 12-13, 2007Chairman, NIEHS ZRG1 DIG-F(02) M, Special Emphasis Panel, National Institutes of Health, October, 25, 2007.Chairman, NIEHS Loan repayment applicationsChairman, Special Emphasis Panel, ZRG1 DIG-F02 M, National Institutes of Health, June 26, 2008.
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Member: Organizing Committee, XXII Annual Meeting of the American Section of the International Society for Heart Research, June 14-18, 2000
Organizing Committee, NIEHS Workshop on Cardiovascular Toxicology, Aug 6-7 2002
Jewish Hospital Heart & Lung Institute Scientific Affairs Committee, June 2004 to date
University of Louisville Institutional Review Board, 2005-to date
MEMBERSHIP IN SCIENTIFIC SOCIETIES:
International Society of Heart ResearchAmerican Heart AssociationSociety of ToxicologyAmerican Society for Biochemistry & Molecular BiologyAmerican Chemical Society
AWARDS AND HONORS:
Second Place, National Declamation Contest, New Delhi, India, 1973National Science Talent Award, India, 1976.Summer Fellowship, National Council of Educational Research and Training, India 1977, 1979, 1981University Scholar, University of Louisville, Louisville, KY 1998-2003Distinguished University Scholar, University of Louisville, Louisville, KY 2003Fellow of the American Heart Association (FAHA), 2005President’s Award for Outstanding Scholarship, Research and Creative Activity, 2007Partner in Healthcare Award – Contributing to Greater Louisville Healthcare Community, 2007
Ph.D. THESIS TITLE:
Biochemical and Electrophysiological Characterization of the Pacemaker Cells of the Sino-Atrial Node and its Relation to the Origin of Heart Beat.
RESEARCH ACTIVITIES
A. AREAS OF INTEREST:
Lipid Peroxidation in Heart DiseaseCardiovascular Complications of DiabetesRedox Regulation of Ion ChannelsOxidative Stress and AtherogenesisEnvironmental Cardiology
B. RESEARCH SUPPORT:
As Principal Investigator:
1. Detoxification and Toxicity of 4-Hydroxyalkenals in Heart
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National Institutes of Health, R01 HL55477-014/1/97-3/31/01 Current Annual Direct Costs $ 180,913
Total Direct Costs $ 636, 534National Institutes of Health, R01 HL55477-066/1/01-5/31/05 Current Annual Direct Costs $ 175,000
Total Costs $ 1,022,000National Institutes of Health 1 R01-HL55477-1010/01/2005-9/30/2010 Current Annual Direct Costs $250,000
Total Costs $1,837,500Status: Funded
2. Cardiac Metabolism of Enals
National Institutes of Health R01 HL/ES59378-01 12/01/97-11/30/02 Current Annual Direct Costs $145,873
Total Direct Costs $ 774,466National Institutes of Health R01 HL59378-0612/01/02-11/30/07 Current Annual Direct Costs $ 200, 000
Total Costs $ 1,171,667 Status: Funded
National Institutes of Health R01 HL59378-0606/01/08-05/30/13 Current Annual Direct Costs $ 250,000
Total Costs $ 1,850,000 Status: Pending (Score: 136; Priority 6.1 percentile)
3. Cardioprotective Effects of Ethanol
National Institutes of Health R21 AA1329909/01/01 - 08/30/04 Annual Direct Costs $ 100,000
Total Costs $ 438,000Status: Completed
4. Vascular Toxicity of Aldehydes
National Institutes of Health R01 ES-1206212/01/02 - 11/30/07 Annual Direct Costs $293,691
Total Costs $1,743,822
Status: Funded
5. Cardiovascular Toxicity of Environmental Aldehydes
National Institutes of Health 1 P01 ES-118607/01/03-6/30/08 Annual Direct Costs $ 924,033
Total Costs $ 6,989,060
Status: Funded
6. 2004 Symposium on “Pollutants and Heart Disease”
National Institutes of Health R13 ES013442-01
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06/01/04-05/31/06 Annual Direct Costs $ 10,000
Status: Completed
7. Evaluation of Cigarette Smoke and Fine Particle Exposure on Endothelial Cell Function
Philip Morris USA Inc.09/01/2005-08/31/2008 Annual Direct Costs $179,875
Total Cost $806,679Status: Funded
8. Atherothrombotic Effects of Particulate Matter
Environmental Protection Agency EM-8333670108/01/2007-07/31/2009 Annual Direct Cost $ 537,576
Total Costs $1,440,900Status: Funded
9. Center for Excellence in Diabetes and Obesity Research
NIH-NCRR 1 P20 RR0244897/01/08-6/30/2013 Annual Direct Cost $1,996,871
Total Costs $11,596,871Status: Pending (Priority Score: 131)
As Collaborator
1. PKCε and Src PTK signaling in preconditioning (P.I. PeiPei Ping)
National Institutes of Health RO1 HL63901 12/01/1999 - 11/30/2004 Annual Direct Costs $ 219,013
Total Direct Costs $ 1,193,851Status: Completed
2. Oxygen Radicals and Cardiac Adaptation to Ischemia (P.I. Roberto Bolli)
National Institutes of Health RO1 HL557574/1/00-3/31/10 Annual Direct Costs $ 286,445
Total Direct Costs $ 1,578,500Status: Funded
3. Molecular Basis of Preconditioning (P.I. Roberto Bolli) 5 % Effort
National Institutes of Health RO1 HL68088-017/01/01-6/30/06 Annual Direct Costs $ 359,890
Total Direct Costs $ 2,027,808Status: Completed
4. -Adrenergic Receptor Activity and Oxidative Stress in Heart Failure (P.I. Sumanth D. Prabhu)
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Department of Veterans Affairs06/01/02-05/31/07 Annual Direct Costs $ 150,000
Total Direct Costs $ 750,000Status: Funded
5. Protection of Ischemic Myocardium (P.I. Roberto Bolli)
National Institutes of Health P01 HL078825-01 Annual Direct Costs $1,656,25112/1/04-11/30/09 Total Costs $ 11,722,326
Status: Funded
As Consultant:
1. Contribution of Lipid Peroxidation Products to the Mitogenic Effects of Oxidized Low Density Lipoprotein (P.I. Sanjay Srivastava).
American Heart Association-Ohio Valley Affiliate Annual Direct Costs $ 35,000 07/01/2000 to 06/30/2002 Total Direct Costs $ 70,000
Status: Completed
2. Mitochondrial Metabolism of Aldehydes (P.I. Si-Qi Liu)
American Heart Association- National-Scientist Development Grant07/01/00-06/30/04 Annual Direct Costs $ 59,091
Total Direct Costs $ 236,364Status: Completed
3. Endothelial Metabolism of Atherogenic Aldehydes (P.I. Sanjay Srivastava)
National Institutes of Health R01 HL65618-018/01/2002-5/31/2006 Annual Costs $ 200,000
Total Costs $ 1,184,000Status: Funded
4. Metabolism of Base Propenals (P.I. Sanjay Srivastava)
National Institutes of Health RO1 ES11594-01 Annual Costs $ 225,0006/01/2003-5/31/2008 Total Costs $ 1,665,000
Status: Funded
As Mentor:
1. Diabetes Induced Changes in HDL (Student: Robert Morehead)
American Heart Association Undergraduate Summer Research Fellowship Program 06/01/2003 - 09/30/2003
Annual Direct Costs $2,500
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Total Direct Costs $2,500 Status: Completed
2. Diabetic Dysregulation pf Endothelial Glucose Metabolism: Role of Nitric Oxide (Student: Matthew West)
American Heart Association Predoctoral Fellowship Ref #0415128B 07/01/2004 - 06/30/2006
Annual Direct Costs $18,000 Total Direct Costs $36,000
Status: Completed
3. Ischemic modification of mitochondrial proteins in the heart (Student :Bradford G. Hill)
American Heart Association Predoctoral Fellowship Ref #0415165B 07/01/2004 - 06/30/2006
Annual Direct Costs $18,000 Total Direct Costs $36,000
Status: Completed
4. Redox Regulation of Voltage-sensitive K channels (Fellow: Srinivas M. Tipperaju)
American Heart Association (Ohio Valley Affiliate) Post-doctoral Fellowship 07/01/2004 - 06/30/2006
Annual Direct Costs $41,000 Total Direct Costs $82,000
Status: Completed
5. Cardiovascular Toxicity of Environmental Aldehydes – Project 5 (Fellow: Sunday Awe)
NIEHS Research Supplement for Underrepresented Minorities 3 P01 ES011860-03S1 08/12/2005 - 08/04/06
Annual Direct Costs $42,812 Total Direct Costs $42,812
Status: Completed
6. UofL Environmental Health Sciences Training Program (P.I. David W. Hein)
National Institute of Environmental Health Sciences 1 T32 ES011564-01 7/01/2004 - 6/30/2009
Annual Direct Costs $41,359 Total Direct Costs $697,188
Status: Funded
7. Role of Nitric Oxide in Regulation of Myocardial Substrate Metabolism (Fellow: Karin Kaiserova)
American Heart Association (Ohio Valley Affiliate) Post-doctoral Fellowship Ref # 0625357B 07/01/2006 – 06/30/2008 Annual Direct Costs $43,000
Total Direct Costs $86,000
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Status: Funded
8. Insulin Resistance and Cigarette Smoke (Fellow: Shahid Baba)
Phillip Morris Post-doctoral Fellowship 07/01/2007 – 06/30/2008 Annual Direct Costs $40,000
Total Direct Costs $40,000 Status: Funded
PUBLICATIONS:
1. Bhatnagar, A., Mehrotra, M. and Tripathi, O. Calcium efflux and spontaneous activity of frog sinus venosus in isotonic sucrose solution. Ind J Exp Biol 24, 389-394, 1986.
2. Awasthi, Y.C., Bhatnagar, A. and Singh, S.V. Evidence for the involvement of histidine at the active site of glutathione S-transferase from human liver. Biochem Biophys Res Comm 143, 965-970, 1987.
3. Bhatnagar, A., Das, B. and Srivastava, S.K. Diethyl pyrocarbonate inactivation of human placental aldehyde reductase II. Biochim Biophys Acta 916, 179-184, 1987.
4. Bhatnagar, A., Das, B., Gavva, S.R., Cook P.F. and Srivastava, S.K. The kinetic mechanism of human placental aldose reductase and aldehyde reductase II. Arch Biochem Biophys 261, 264-274, 1988.
5. Tripathi, O. and Bhatnagar, A. Extracellular fluid space in rabbit SA node and atria as studied by 14C-inulin and 14C-sucrose. Jpn J Physiol 37, 1057-1060, 1987.
6. Tripathi, O., Ray, M., Bajpai, V.K., Bhatnagar, A., Kumar, R., Singh, Y.K., Singh, C., Shipstone, A.C. and Dhawan, B.N. Effects of sodium deoxycholate on the mechanical and electrical activities and ultrastructure of guinea pig atria. Biomed Biochim Acta 9, 901-914, 1988.
7. Das, B., Bhatnagar, A., Liu, S-Q., Srivastava, S.K., Messmer, M., Ueno, N. and Chakrabarti, B. Spectral properties of human placental aldose reductase and aldehyde reductase II. Biochem Int 19, 497-504, 1989.
8. Srivastava, S.K., Ansari, N.H., Liu, S-Q., Izban, A., Das, B., Szabo, G. and Bhatnagar, A. The effect of oxidants on biomembranes and cellular metabolism. Mol Cell Biochem 91, 149-157, 1989.
9. Srivastava, S.K., Ansari, N.H., Bhatnagar, A., Hair, G., Liu, S-Q. and Das, B. Activation of aldose reductase by nonenzymatic glycosylation. In Maillard Reaction in Aging, Diabetes, and Nutrition. Publisher Alan R. Liss, Inc. pp. 171-184, 1989.
10. Liu, S-Q., Bhatnagar, A., Das, B. and Srivastava, S.K. Functional cysteinyl residues in human placental aldose reductase. Arch Biochem Biophys 275, 112-121, 1989.
11. Bhatnagar, A., Liu, S-Q., Das, B. and Srivastava, S.K. Involvement of sulfhydryl residues in aldose reductase-inhibitor interaction. Mol Pharmacol 36, 825-830, 1989.
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12. Bhatnagar, A., Liu, S-Q., Das, B., Ansari, N.H. and Srivastava, S.K. Inhibition kinetics of human kidney aldose and aldehyde reductases by aldose reductase inhibitors. Biochem Pharmacol 39, 1115-1124, 1990.
13. Bhatnagar, A., Srivastava, S.K. and Szabo, G. Oxidative stress alters specific membrane currents in isolated cardiac myocytes. Circ Res 67, 535-549, 1990.
14. Srivastava, S.K., Ansari, N.H. and Bhatnagar, A. Sugar induced cataractogenesis: A paradigm of oxidative tissue pathology? Lens Eye Toxic Res. 7, 161-171, 1990.
15. Bhatnagar, A., Liu, S-Q. and Srivastava, S.K. Structure-activity correlations in human kidney aldehyde reductase-catalyzed reduction of para-substituted benzaldehyde by 3-acetyl pyridine adenine dinucleotide phosphate. Biochim Biophys Acta 1077, 180-186, 1991.
16. Bhatnagar, A., Das, B., Liu, S-Q., and Srivastava, S.K. Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters. Arch Biochem Biophys 287, 329-336, 1991.
17. Ansari, N.H., Bhatnagar, A., Liu, S-Q., and Srivastava, S.K. Purification and characterization of aldose reductase and aldehyde reductase from human kidney. Biochem Int 25, 755-765, 1991.
18. Liu, S-Q., Bhatnagar, A. and Srivastava, S.K. Carboxymethylation-induced activation of bovine lens aldose reductase. Biochim Biophys Acta 1120, 329-336, 1992.
19. Bhatnagar, A. and Srivastava, S.K. Aldose reductase: Congenial and injurious profiles of an enigmatic enzyme. Biochem Med Metabol Biol 48, 91-121, 1992.
20. Bhatnagar, A., Liu, S-Q., Petrash, J.M. and Srivastava, S.K. Mechanism of inhibition of aldose reductase by menadione (Vitamin K3). Mol Pharmacol 42, 917-921, 1992.
21. Liu, S-Q., Bhatnagar, A. and Srivastava, S.K. Does sorbinil bind to the substrate binding site of aldose reductase? Biochem Pharmacol 44, 2427-2429, 1992.
22. Petrash, J.M., Harter, T.M., Devine, C.S., Olins, P.O., Bhatnagar, A., Liu, S-Q. and Srivastava, S.K. Involvement of cysteine residues in catalysis and inhibition of human aldose reductase: Site-directed mutagenesis of Cys-80, -298 and -303. J Biol Chem 267, 24833-24840, 1992.
23. Castro, G.J., and Bhatnagar, A. Effect of extracellular ions and modulators of calcium transport on survival of tert-butyl hydroperoxide exposed cardiac myocytes. Cardiovas Res 27, 1873-1881, 1993
24. Liu, S-Q., Bhatnagar, A., Ansari, N.H., and Srivastava, S.K. Identification of the reactive cysteine residue in human placenta aldose reductase. Biochim Biophys Acta 1164, 268-272, 1993
25. Bhatnagar, A., Ansari, N.H., Zacarias, A. and Srivastava, S.K. Digital image analysis of cultured rat lens during oxidative stress-induced cataractogenesis. Exp Eye Res 57, 385-391,1993.
26. Liu, S-Q., Bhatnagar, A. and Srivastava, S.K. Bovine lens aldose reductase: pH-Dependence of steady-state kinetic parameters and nucleotide binding. J Biol Chem 268, 25494-25499,1993.
27. Bhatnagar, A., Liu, S-Q., Ueno, N., Chakrabarti, B. and Srivastava, S.K. Human placental aldose reductase: Role of Cys-298 in substrate and inhibitor binding. Biochim Biophys Acta 1205, 207-214, 1994.
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28. Ansari, N.H., Bhatnagar, A., Fulep, E., Khanna, P. and Srivastava, S.K. Trolox protects hyperglycemia-induced cataractogenesis in cultured rat lens. Res Comm Chem Pathol Pharmacol 84, 93-104, 1994.
29. Bhatnagar, A. Biochemical mechanism of irreversible cell injury caused by free radical-initiated reactions. Mol Cell Biochem 137, 9-16, 1994.
30. Bhatnagar, A. Electrophysiological effects of 4-hydroxynonenal, an aldehydic product of lipid peroxidation, on isolated rat ventricular myocytes. Circ Res 76, 293-304, 1995.
31. Bhatnagar, A. Attenuation of reperfusion injury by the antioxidant n-propyl gallate. J. Cardiovasc Pharmacol 26, 343-347, 1995.
32. Bhatnagar A. Ansari N.H, Wang L-F, Khanna P, Wang C-S, Srivastava S.K. Calcium-mediated disintegrative globulization mimics cataractogenesis. Exp Eye Res 61, 303-310 1995.
33. Bhatnagar A. Metabolic dependence of free radical-induced hypercontracture of cardiac myocytes. Biochem Arch 11, 135-140, 1995.
34. Srivastava, S., Chandra A., Bhatnagar, A., Srivastava, S.K., Ansari, N.H. Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase. Biochem Biophys Res Comm 217, 741-746, 1995.
35. Wang, L.F., Bhatnagar, A., Ansari, N.H., Dhir, P., Srivastava, S.K. Mechanism of calcium-induced disintegrative globulization of rat lens fiber cells. Invest Ophthalmol Vis Sci 37, 915-922, 1996.
36. Srivastava, S.K., Awasthi, S., Wang L.F., Bhatnagar, A., Awasthi, Y.C., Ansari, N.H. Attenuation of 4-hydroxynonenal-induced catractogenesis in rat lens by butylated hydroxytoluene. Curr Eye Res 15, 749-754, 1996.
37. Srivastava, S.K., Wang L.-F., Ansari, N.H. and Bhatnagar, A. Calcium homoestasis in isolated single cortical fibers of rat lens. Invest Ophthalmol Vis Sci 38, 2300-2312, 1997.
38. Bhatnagar, A., Dhir, P., Wang, L.-F., Lo, W.-K., and Srivastava, S. K. Alterations in the light transmission through single lens fibers during calcium-mediated disintegrative globulization. Invest Ophthalmol Vis Sci 38, 586-592, 1997.
39. Bhatnagar A. Contribution of ATP to oxidative stress-induced changes in the action potential of isolated cardiac myocytes. Am J Physiol 272, H1598-H1608, 1997.
40. Chandra, A., Srivastava, S., Petrash, J.M., Bhatnagar, A., and Srivastava, S.K. Active site modification of aldose reductase by nitric oxide. Biochim Biophys Acta 1341, 217-222, 1997.
41. Wang, L.F, Dhir, P., Bhatnagar, A., Srivastava, S.K. Contribution of osmotic changes to disintegrative globulization of single cortical fibers isolated from rat lens. Exp Eye Res 65, 267-275, 1997.
42. Chandra, A., Srivastava, S., Petrash, M., Bhatnagar, A., Srivastava, S.K. Modification of aldose reductase by nitrosoglutathione. Biochemistry 36, 15801-15809, 1997.
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43. Bhatnagar, A., Hypercontracture of cardiac myocytes induced by the lipid peroxidation product, 4-hydroxynonenal: dependence on external calcium and energy source. Biochem Arch 13, 215-222 1997.
44. Reuf J., Rao, G.N., Li F.Z., Bode, C., Patterson, C., Bhatnagar, A., and Runge, M.S. Induction of aortic smooth muscle cell growth by the lipid peroxidation product, 4-hydroxy-2-nonenal. Circulation 97, 1071-1078, 1998.
45. Srivastava S, Chandra A, Ansari N.H, Srivastava S.K, Bhatnagar, A. Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation derived aldehyde - 4-hydoxynonenal. Biochem J 329, 469-475, 1998.
46. Srivastava S. Chandra A, Wang, L.-F., Seifert, W.E., DaGue, B.B., Ansari, N.H., Srivastava, S.K., Bhatnagar, A. Metabolism of the lipid peroxidation product, 4-hydoxy-trans-2-nonenal, in isolated perfused rat heart. J Biol Chem 273, 10893-10900, 1998.
47. Srivastava S., Harter, T.M., Chandra, A., Bhatnagar, A., Srivastava, S.K., and Petrash, J. M. Kinetic studies of FR-1, a growth factor-inducible aldo-keto reductase. Biochemistry 37, 12909-12917, 1998.
48. Bhatnagar, A., Srivastava, S., Wang, L., Chandra, A., Ansari, N.H., Srivastava, S.K. Cardiac metabolism of enals. Adv Exp Med Biol 463, 223-229, 1999.
49. Petrash, J.M., Harter, T.M., Srivastava, S., Chandra, A., Bhatnagar, A., Srivastava, S.K. Strucuture-Function studies of FR-1: A growth factor-inducible aldo-keto reductase. Adv Exp Med Biol 463, 435-443, 1999.
50. Srivastava, S.K., Chandra, A., Srivastava, S., Petrash, J.M., Bhatnagar, A., Regulation of aldose reductase by aldehydes and nitric oxide. Adv Exp Med Biol 463, 501-507, 1999.
51. Srivastava, S., Watowich, S.J., Petrash, J.M., Srivastava, S.K. and Bhatnagar, A. Structural and kinetic determinants of aldehyde reduction catalyzed by aldose reductase. Biochemistry 38, 42-54, 1999.
52. Bhatnagar, A., and Bolli, R. Modulation of KATP channels to protect the ischemic myocardium: Clinical implications. Exp Clin Cardiol. 4, 20-22, 1999.
53. Ruef, J., Liu, S.-Q., Bode, C., Tocchi, M., Srivastava, S., Runge, M., and Bhatnagar, A. Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation after arterial injury. Arterio Thromb Vasc Biol 20, 1745-1752, 2000.
54. Dixit, B.L., Balendiran, G.K., Watowich, S.J., Srivastava, S., Ramana, K.V., Petrash, J.M. Bhatnagar, A., and Srivastava, S.K. Kinetic and structural characterization of the glutathione binding site of aldose reductase. J Biol Chem 275, 21587-21595, 2000.
55. Shinmura, K., Tang, X-L, Wang, Y., Xuan, Y-T, Liu, S-Q, Takano, H., Bhatnagar, A., and Bolli, R. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. Proc Natl Acad Sci USA 97, 10197-10202, 2000.
56. Srivastava, S., Dixit, B.L., Cai, J., Sharma, S., Hurst, H., Bhatnagar, A., and Srivastava, S.K., Metabolism of lipid peroxidation product, 4-hydroxynonenal (HNE) in rat erythrocytes - Role of aldose reductase. Free Radic Biol Med 29, 642-651, 2000.
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57. Ramana K.V., Dixit, B.L., Srivastava, S, Balendiran G.K., Srivastava, S.K. and Bhatnagar, A. Selective recognition of glutathiolated aldehydes by aldose reductase. Biochemistry 39, 12172-12180, 2000.
58. Ramana K.V., Dixit, B.L., Srivastava, S.K., Balendiran G.K, Watowitch S.J., Petrash J.M., Bhatnagar, A., and Srivastava, S.K. Characterization of the glutathione binding site of aldose reductase. Chem-Biol Interact 130:537-548, 2001.
59. Wang, L.-F., Christensen, B.N., Bhatnagar, A., and Srivastava, S.K. Role of calcium-dependent protease(s) in globulization of isolated rat lens cortical fiber cells. Invest Ophthalmol Vis Sci. 42, 194-199, 2001.
60. Dixit, B., Kota R., Jackson, EB., Srivastava, S., Bhatnagar, A., and Srivastava, S.K., Metabolic regulation of AR activity by nitric oxide donors. Chem Biol Interact 131:573-581, 2001.
61. Bhatnagar, A., Ruef Johannes, Liu, S.-Q., Srivastava, S, and Srivastava, S.K. Regulation of vascular smooth muscle cell growth by aldose reductase. Chem Biol Interact 131:627-636, 2001.
62. Srivastava, S., Dixit, B. L., Ramana, K. V., Chandra, A., Chandra, D., Zacarias, A., Petrash, J. M, Bhatnagar, A., and Srivastava, S. K. Structural and kinetic modifications of aldose reductase by S-nitrosothiols. Biochem J 358:111-118, 2001.
63. Srivastava, S, Liu, S.-Q., Zacarias A., Srivastava, S, and Bhatnagar. A. Involvement of aldose reductase in the endothelial metabolism of atherogenic aldehydes. Chem. Biol Interact 131, 563-571, 2001.
64. Liu, S.-Q., Jin, H., Zacarias, A., Srivastava, S., and Bhatnagar, A. Binding of pyridine coenzymes to the β-subunit of the voltage-sensitive potassium channels. Chem-Biol Interact 132, 955-962, 2001.
65. Srivastava, S.K., Dixit, B.L., Srivastava, S., Ramana, K.V., Balendiran, G., and Bhatnagar, A., Aldose reductase efficiently detoxifies lipid-derived aldehydes. Pharmacol Therap New Millen. (Gupta, S.K., ed) pp 707-712, Narosa Publishing House, New Delhi, 2001.
66. Srivastava, S., Conklin, D.J., Boor, PJ, Liu, S.Q., Srivastava, S.K., and Bhatnagar, A. Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein-derived aldehyde - 4-hydroxy trans-2-nonenal in vascular smooth muscle cells. Atherosclerosis 18, 339-350, 2001.
67. Liu, S.Q., Jin, H., Zacharias, A., Srivastava, S., Bhatnagar, A. Binding of pyridine coenzymes to the β-subunit of the voltage-sensitive potassium channel. J Biol Chem 276, 11812-11820, 2001.
68. Ramana, K.V., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B.B., and Srivastava, S.K., Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem 277, 32063-32070, 2002.
69. Balafanova, Z., Bolli, R., Pass J.M., Wang, O., Bhatnagar, A., Tang, X.T., Cardwell, E., and Ping, P.P., Nitric oxide induces nitration of PKCε translocation via enhanced PKCε-RACK2 interactions: a novel mechanism of NO-triggered activation of PKCε. J Biol Chem 277, 15021-15027, 2002.
70. Chandra D., Ramana, K.V., Wang, L.F., Christensen, B.N., Bhatnagar, A., and Srivastava, S.K. Inhibition of fiber cell globulization and hyperglycemia-induced opacification by aminopeptidase inhibitor Bestatin. Invest Ophthalmol Vis Sci 43, 2285-2292, 2002.
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71. Shinmura, K., Bolli, R., Liu, S.-Q., Tang, X. L., Kodani, E., Xuan, Y.-T., Srivastava, S., and Bhatnagar, A., Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ Res 91, 240-246 2002.
72. Zacarias, A., Bolanowski, D., Bhatnagar, A. Comparative measurements of multicomponent phospholipid mixtures by electrospray mass spectroscopy: relating ion intensity to concentration. Anal Biochem 308, 152-159, 2002.
73. Srivastava, S., Chandrasekar, B., Bhatnagar, A., Prabhu, S.D. Lipid peroxidation derived aldehydes and oxidative stress in failing heart: role of aldose reductase. Am J Physiol 283, H2612-H2619, 2002.
74. West, M., Srivastava S., and Bhatnagar, A. The role of lipid peroxidation in myocardial ischemia. In Myocardial Ischemia and Preconditioning. Dhalla N.S., Takeda, N., Singh, M., Lukas A. Eds. Kluwer Academic Publishers, Boston, 2003 pp 465-480.
75. Chandra, D., Jackson, E.B., Ramana, K.V., Srivastava, S.K., and Bhatnagar, A., Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes 51, 3095-3101, 2002.
76. Ramana, K.V., Friedrich, B., Bhatnagar, A., and Srivastava, S.K. Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF- in human lens epithelial cells. FASEB J, 10. 1096.fj02-0568fje, 2002.
77. Ramana, K.V., Chandra, D., Srivastava, S., Bhatnagar, A., and Srivastava, S.K. Aldose reductase mediates the mitogenic signals of cytokines. Chem-Biol Interact 143-144, 587-596, 2003.
78. Wang, J., Wen, J., Li, J., Yin, J., Zhu, Q., Wang, H., Yang, Y., Qin, E., You, B., Li, W., Li, X., Huang, S., Yang, R., Zhang, X., Yang, L., Zhang, T., Yin, Y., Cui, X., Tang, X., Wang, L., He, B., Ma, L., Lei, T., Zeng, C., Fang, J., Yu, J., Wang, J., Yang, H., West, M.B., Bhatnagar, A., Lu, Y., Xu, N., and Liu, S. Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin Chem. 49, 1989-1996, 2003.
79. Srivastava, S.K., Ramana, K.V., Chandra, D., Srivastava, S., Bhatnagar, A. Regulation of aldose reductase and the polyol pathway activity by nitric oxide. Chem-Biol Interact 143-144, 333-340, 2003.
80. Chandra, D., Ramana, K.V., Friedrich, B., Srivastava, S., Bhatnagar, A., and Srivastava, S.K. Role of aldose reductase in TNF--induced apoptosis of vascular endothelial cells. Chem-Biol Interact 143-144, 605-612, 2003.
81. Bhatnagar, A., Kumar, R., Tipparaju, S.M., and Liu, S.-Q. Differential pyridine nucleotide binding to the -subunit of the voltage-sensitive K channel: A mechanism for redox regulation of excitability? Chem-Biol Interact 143-144, 613-620, 2003.
82. Liu, S.-Q., Yin, J., and Bhatnagar, A. Protein kinase C-dependent phosphorylation of the -subunit of the voltage-sensitive potassium channels (Kv2). Chem-Biol Interact 143-144, 597-604, 2003.
83. Varma T., Liu, S.-Q., West, M., Thongboonkerd V., Ruvolo, P. P., May, W.S., and Bhatnagar, A., Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase. FEBS Letts 534, 175-179, 2003.
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84. Ramana, K.V., Chandra, D., Srivastava, S., Bhatnagar, A., Srivastava, S.K. Nitric oxide regulates the polyol pathway of glucose metabolism. FASEB J, 17, 417-425, 2003.
85. Bhatnagar, A. Surviving Hypoxia: The importance of rafts, anchors, and fluidity. (Editorial) Circ Res 92, 821-823, 2003.
86. Tsakadze, N.L., Srivastava, S., Awe S.O., Adeagbo, A.S., Bhatnagar, A., and D’Souza, S.E. Acrolein-induced vasomotor responses in rat aorta. Am J Physiol 285, H727-H734, 2003.
87. Ping P, Baines CP, Gu Y, Prabhu S, Zhang J, Tsai LL, Cardwell E, Zong NC, Vondriska TM, Korge P, Bhatnagar A, Wang GW. Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways. J Cardiovasc Toxicol 3, 341-352, 2003.
88. Srivastava, S.K., Ramana, K.V., Srivastava, S, and Bhatnagar, A. Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates. In The Emerging Role of Aldo-Keto Reductases in the Metabolism of Toxic Substances. Penning T.M., J.M. Petrash Eds. ACS Symposium Series 865, 37-48, 2004.
89. Ramana, K.V., Chandra, D., Srivastava, S., Bhatnagar, A., and Srivastava, S.K. Aldose reductase regulates reactive oxygen species mediated inflammatory signals. In The Emerging Role of Aldo-Keto Reductases in the Metabolism of Toxic Substances. Penning T.M., J.M. Petrash Eds. ACS Symposium Series 865, 213-223, 2004.
90. Bhatnagar, A., Liu, S.Q., Srivastava, S., Ramana, K.V., and Srivastava, S.K. Aldose reductase and the stress response. In The Emerging Role of Aldo-Keto Reductases in the Metabolism of Toxic Substances. Penning T.M., J.M. Petrash Eds. ACS Symposium Series 865, 199-211, 2004.
91. Srivastava, S., Ramana, K.V., Srivastava, S.K., D’Souza, S.E., and Bhatnagar, A. Role of aldose reductase in the detoxification of oxidized phospholipids. In The Emerging Role of Aldo-Keto Reductases in the Metabolism of Toxic Substances. Penning T.M., J.M. Petrash Eds. ACS Symposium Series 865, 49-64, 2004.
92. Bhatnagar, A. Cardiovascular pathophysiology of environmental pollutants. Am J Physiol 286, H479-H485, 2004.
93. Wang, J., Xue, Y., Feng, X., Li, X., Wang, H., Li, W., Zhao, C., Cheng, X., Ma, Y., Zhou, P., Yin, J., Bhatnagar, A., Wang, R., and Liu, S-Q. An analysis of the proteomic profile of Thermoanerobacter tengcogenesis under optimal culture conditions. Proteomics 4, 136-150, 2004.
94. Ramana, K.V., Chandra, D., Wills, N.K., Bhatnagar, A., and Srivastava, S.K. Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic rats. J Diab Compl 18, 177-182, 2004.
95. Ramana, K.V., Bhatnagar, A., and Srivastava, S.K. Inhibition of aldose reductase attenuates TNF--induced expression of adhesion molecules in endothelial cells. FASEB J 18, 1209-1218, 2004.
96. Ramana, K.V., Bhatnagar, A., and Srivastava, S.K. Aldose reductase regulates TNF--induced expression of Bcl-2 family proteins in vascular endothelial cells. FEBS Letts 570,189-194, 2004.
97. Srivastava, S., Spite, M., Trent, J.O., West. M.W., Ahmed, Y., and Bhatnagar, A. Aldose reductase-catalyzed reduction of aldehyde phospholipids. J. Biol. Chem. 279, 53395-406, 2004
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98. Ramana, K.V., Friedrich, B., Srivastava, S., and Bhatnagar, A., and Srivastava, S.K. Activation of NF-B by hyperglycemia is regulated by aldose reductase. Diabetes 53, 2910-2920, 2004.
99. Bhatnagar, A. Beating Ischemia: A new feat of EETs? (Editorial) Circ Res 95, 443-445, 2004.
100.Tipparaju, S.M., Saxena, N., Liu, S.-Q., Kumar, R., and Bhatnagar, A. Differential regulation of voltage-gated K+ channels by oxidized and reduced pyridine coenzyme nucleotides. Am. J. Physiol 288, C366-C376, 2005.
101. Ramana, K.V., Friedrich, B., Tammali, R., West, M.B., Bhatnagar, A., Srivastava, S. K. Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and
formation of diacyglycerol in vascular smooth muscle cells. Diabetes 54, 818-829, 2005.
102. Srivastava, S., Ramana, K.V., and Bhatnagar, A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocrine Reviews 26, 380-392, 2005
103. Srivastava, S., Tammali, R., Chandra, D., Greer, D.A., Ramana, K.V., Bhatnagar, A., Srivastava, S.K. Regulation of lens aldose reductase activity by nitric oxide. Exp Eye Res 81, 664-672, 2005.
104. Amunom A., Stephens L.J., Conklin D.J., Srivastava S., Bhatnagar A., and Prough R.A. Several cytochrome P450 are monooxygenases. Enzymology and Molecular Biology of Carbonyl Metabolism 12 (Weiner H., Plapp B., Lindahl R., and Maser E edition, Perdue University Press) 118-123, 2005.
105. Spite M., Srivastava S., Trent J.O., West M.B., Ahmed Y., and Bhatnagar A. Metabolism of phospholipids aldehydes : role of aldose reductase. Enzymology and Molecular Biology of Carbonyl Metabolism 12 (Weiner H., Plapp B., Lindahl R., and Maser E edition, Perdue University Press) 256-265, 2005.
106. Ramana K.V., Friedrich B., Srivastava S., Bhatnagar A., and Srivastava S.K. Regulation of NF-B by aldose reductase in hyperglycemia. Enzymology and Molecular Biology of Carbonyl Metabolism 12 (Weiner H., Plapp B., Lindahl R., and Maser E edition, Perdue University Press) 284-293, 2005.
107. Awe S.O., Hill B.G., Hoetker D.J., Srivastava S., and Bhatnagar A. Metabolism of lipid peroxidation product-4,hydroxyl-trans-2-nonenal in the ischemic heart. Enzymology and Molecular Biology of Carbonyl Metabolism 12 (Weiner H., Plapp B., Lindahl R., and Maser E edition, Perdue University Press) 378-387, 2005.
108. Singh, R., White, M.A., Ramana, K.V., Petrash, J.M., Watowich, S.J., Bhatnagar, A., and Srivastava, S.K. Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins, 64:101-110, 2006.
109. Srivastava, S., Ramana, K.V., Tammali, R., Srivastava, S.K. and Bhatnagar, A. Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes 55, 901-910, 2006.
110. West, M.B., Hill, B.G., Xuan, Y-T., Bhatnagar, A. Protein glutathiolation by nitric oxide: An intracellular mechanism regulating redox protein modification. FASEB J 20, 1715-1717, 2006
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111. Hill B.G., Barski, O., Bhatnagar, A., Getting to the heart of pollution: is pollution a new risk factor for cardiovascular disease? Sustain, 13, 17-23, 2006.
112. Kaiserova, K., Srivastava, S., Hoetker, J.D., Awe, B.O., Tang X.-L., Cai, J., and Bhatnagar, A. Redox activation of aldose reductase in the ischemic heart. J. Biol. Chem., 281, 15110-15120, 2006.
113. Ramana, K.V., Bhatnagar, A., Awasthi, S., Srivastava, S., Yadav, U.C.S., Awasthi, Y.C., and Srivastava, S.K. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase-catalyzed reduction of HNE-glutathione conjugates in regulating cell growth. J. Biol. Chem. 281, No. 26, 17652-17660. 2006
114. Bhatnagar, A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res 99, 692-705, 2006.
115. Ramana, K., Willis, M., White, M., Horton, J., DiMaio, M., Srivastava, D., Bhatnagar, A., Srivastava, S. Endotoxin-induced cardiac myopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 114, 1838-1846, 2006.
116. Awe, S.O., Adeagbo, A.S.O., D’Souza, S.E., Bhatnagar, A., Conklin, D.J. Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism. Tox Appl Pharm. 217, 266-276, 2006.
117. Conklin, D.J., Bhatnagar, A., Cowley, H., Johnson, G.H., Wiechmann, R.J., Sayre, L.M., Trent, M.B., Boor, P. Acrolein stimulates hypercontraction in isolated human blood vessels. Tox Appl Pharm. 217 , 277-288, 2006.
118. Conklin, D., Prough, R., Bhatnagar, A. Aldehyde metabolism in the cardiovascular system. Mol BioSys 3, 136-150, 2007.
119. Srivastava, S.K., Ramana, K., Bhatnagar, A. Life without aldose reductase. Editor: Weiner/Henry H., Enzymology & Molecular Biology of Carbonyl Metabolism. Volume 13. Purdue University Press 2007. In Press.
120. Hill, B.G., Srivastava, S., Feldman, A., Bhatnagar, A. Metabolism of 4-hydroxy-trans-2-nonenal (HNE)-modified proteins in vascular smooth muscle cells. Editor: Weiner/Henry H., Enzymology & Molecular Biology of Carbonyl Metabolism. Volume 13. Purdue University Press 2007. In Press.
121. Spite, M., Barski, O., Ahmed, Y., Bhatnagar, A., Srivastava, S. Relative efficacy of aldo-keto reductases in catalyzing the reduction of phospholipid aldehydes. Editor: Weiner/Henry H., Enzymology & Molecular Biology of Carbonyl Metabolism. Volume 13. Purdue University Press 2007. In Press.
122. Tipparaju, S.M., and Bhatnagar, A. Pipette perfusion: methods and application. In Patch-Clamp Analysis: Advanced Techniques. Wolfgang W., Boulton, A.A., and Baker, G.B. editors, Humana Press, Totowa, New Jersey 2007.
123. Hill, B.G., and Bhatnagar, A. Role of glutathiolation in preservation, restoration and regulation of protein function. IUBMB Life 59, 21-26, 2007.
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124. Spite, M., Baba, S.P., Ahmed, Y., Barski, O., Nijhawan, K., Petrash, J.M., Bhatnagar, A. and Srivastava, S. Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem. J. 405, 95-105, 2007.
125. Ramana, K.V., Tammali, R., Reddy, A.B.M., Bhatnagar, A., Srivastava, S.K. Aldose reductase-regulated tumor necrosis factor- production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology. 148, 4371-4384, 2007.
126. Tipparaju, S.M., Liu, S.Q., Barski, O.A., and Bhatnagar, A. NADPH binding to -subunit regulates inactivation of voltage-gated K+ channels. Biochem. Biophys. Res. Comm. 359, 269-276, 2007.
127. Amunom, I., Stephens, L., Tamasi, V., Cai, J., Pierce, W., Conklin, D.J., Bhatnagar, A. , Srivastava, S., Martin, M.V., Guengerich, P., and Prough, R. Cytochromes P450 catalyze oxidation of α,β-unsaturated aldehydes. Arch. Biochem. Biophys., 464,187-196, 2007.
128. Luo, J., Hill, B.G., Gu, Y., Cai, J., Srivastava, S., Bhatnagar, A., and Prabhu, S.D. Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure. Am. J. Physiol. 293, H3673-H3684, 2007.
129. Hill, B.G., Haberzettl, P., Srivastava, S., Ahmed, Y., and Bhatnagar, A. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth muscle cells. Biochem J 410, 525-534, 2008.
130. Jones, S.P., Zachara, N., Nogh, G.A., Hill, B.G., Teshima, Y., Bhatnagar, A., Hart, G.A., and Marban, E. Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation 117, 1172-1182, 2008.
131. Kaiserova, K., Tang, X-L., Srivastava, S, and Bhatnagar, A. Role of nitric oxide in regulating aldose reductase activation in the ischemic heart. J. Biol. Chem. 238, 9101-9112, 2008.
132. Shi, L., Wang, Y., Tu, S., Li., Z., Sun, M., Srivastava, S., Xu, N., Bhatnagar, A., Liu,S.-Q. The responses of mitochondrial proteins in rat liver to the consumption of moderate alcohol: The possible roles of aldo-keto reductases. J. Proteome Res 7, 3137-3145, 2008.
133. Wang, G.-W., Guo, Y., Vondriska, T.M., Zhang, J., Zhang, S., Tsai, L.L., Zong, N.C., Bolli, R., Bhatnagar, A., and Prabhu, S.D. Acrolein consumption exacerbates myocardial ischemic injury and block nitric oxide-induced PKC signaling and cardioprotection. J. Mol. Cell. Cardiol. 44, 1016-1022, 2008.
134. Cai, J., Hill, B.G., Bhatnagar, A., Pierce, W.M., Prough, R.A. Bioactivation and protein modification reactions of unsaturated aldehydes. Adv Bioact Res (In Press), 2008,
135. Tipparaju, S.M., Barski, O.A., Srivastava, S., and Bhatnagar, A. Catalytic mechanism and substrate specificity of the -subunit of the voltage-gated (Kv) channel. Biochemistry 47, 8840-8854, 2008.
136. West, M.B., Ramana, K.V., Kaiserova, K., Srivastava, S.K., and Bhatnagar, A. L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Letts 582, 2609-2614, 2008.
137. West, M.B., Rokosh, G., Obal, D., Velayutham, M., Xuan, Y-T., Hill, B.G., Keith, R., Schrader, J., Guo, Y., Conklin, D.J., Prabhu, S.D., Zweier, J.L., Bolli, R., and Bhatnagar, A. Cardiac
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myocyte-specific expression of inducible nitric oxide synthase protects against ischemia-reperfusion injury by preventing mitochondrial permeability transition. Circulation (In Press) 2008.
138. Aramati, B.M., Ramana, K.V. Srivastava, S, Bhatnagar, A., and Srivastava, S.K. Aldose reductase regulates high glucose-induced ectodomain shedding of TNF- via PKC- and TACE in vascular smooth muscle cells. Endocrinology (In Press) 2008.
139. Barski, O.A., Tipparaju, S.M., and Bhatnagar, A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metabol Rev (In Press) 2008.
140. O’Toole, T.E., Conklin, D.J. and Bhatnagar, A. Environmental risk factors for heart disease. Enviorn. Rev (In Press) 2008.
ABSTRACTS:
1. Bhatnagar, A. Bioelectrochemical studies on the cardiac muscle. Proc. IIIrd Congress of Indian Association of College-Going-Scientists., Ind. Inst. Tech., Kanpur, India. 26-27, 1980.
2. Bhatnagar, A. and Tripathi, O.N. The contracture of frog ventricular strips in non-electrolytic sucrose solution. Ind. J. Heart Res., 1, 45, 1980.
3. Bhatnagar, A., Chowdury, A.R. and Tripathi, O.N. Relationship between the ion content and mechanical activity of frog ventricular strips soaked in ion-free sucrose solution. Ind. J. Pharmacol., 14, 50, 1982.
4. Bhatnagar, A., Mehrotra, M., Singh, C., and Tripathi, O.N. Altered response pattern of isolated auricles to vagosymapathetic nerve stimulation in the presence of deoxycholic acid. Ind. J. Pharmacol., 14, 54 , 1982
5. Bhatnagar, A., Kapoor, N.K., Singh, C., and Tripathi, O.N. Differential activity of calcium-ATPase in amphibian and mammalian myocardium and its modification by sucrose solution and deoxycholate. Ind. J. Pharmacol. 14, 49, 1982.
6. Mehrotra, M., Bhatnagar, A., Tripathi, O.N., and Dhawan, B.N. Effects of lanthanum on the response of isolated guinea-pig auricles to vagosympathetic stimulation. Ind. J. Pharmacol., 15, 25, 1983.
7. Bhatnagar, A., and Tripathi, O. Effects of nifedipine on the spontaneous electrical activity of rabbit SA node. Ind. J. Heart Res., 2, 27, 1984.
8. Bhatnagar, A., and Tripathi, O. Effects of A-23187 on the transmembrane electrical activity of the pacemaker cells of rabbit SA node. J. Mol. Cell. Cardiol., 18, 12, 1986.
9. Bhatnagar, A., and Tripathi, O. A change in the action potential duration does not underlie the negative chronotropic effect of acetylcholine on rabbit SA node. J. Mol. Cell. Cardiol., 18, 71, 1986.
10. Das, B., Ansari, N.H., Hair, G., Bhatnagar, A. and Srivastava, S.K., Role of aldose reductase in diabetic complications. Fed. Proc. 45, 1502, 1986.
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11. Bhatnagar, A., Das, B., Cook, P.F and Srivastava, S.K. Steady-state kinetics of aldose reductase reaction. Invest. Ophthalmol Vis Sci, 28, 281, 1987.
12. Song, H.P., Das, B., Bhatnagar, A., and Srivastava, S.K. Purification and properties of human brain, lens and placenta. Fed. Proc., 46, 1495, 1987.
13. Bhatnagar, A., Das, B., and Srivastava, S.K. Structure-activity studies on aldose reductase and aldehyde reductase II, Fed. Proc., 46, 1971, 1987.
14. Das, B., Bhatnagar, A., and Srivastava, S.K. Diethylpyrocarbonate inactivation of human placental aldehyde reductase II, Fed. Proc., 46, 2154, 1987.
15. Srivastava, S.K., Das, B., Liu, S-Q., Ansari, N.H. and Bhatnagar, A. Inhibition of human kidney aldose reductase and aldehyde reductase by aldose reductase inhibitors. Invest. Ophthalmol Vis Sci, 30, 1989.
16. Liu, S-Q., Bhatnagar, A., Das, B., and Srivastava, S.K. pH dependence of kinetic parameters of human liver aldehyde reductase. FASEB J, 4, A1164, 1990.
17. Srivastava, S.K., Ansari, N.H., Das, B., Liu, S-Q., and Bhatnagar, A. Induction of aldose reductase by glucose in bovine lens and the mechanism of enzyme reaction. Invest Ophthalmol Vis Sci, 31, 1990.
18. Srivastava, S.K., Liu, S-Q., Ansari, N.H. and Bhatnagar, A. Oxidative stress modulates inhibitor sensitivity of bovine lens aldose reductase. Invest Ophthalmol Vis Sci, 32, 1011, 1991.
19. Bhatnagar A., Liu, S-Q., and Srivastava, S.K. Approaches to increase selectivity of aldose reductase inhibitors. Transition state analogs and substrate enzyme complexes. U.S.-Japan Aldose Reductase Workshop; Kona, Hawaii, 1991.
20. Srivastava, S.K., Liu, S-Q., Bhatnagar, A. and Ansari, N.H. Mechanism of activation of human and bovine lens aldose reductase. U.S.-Japan Aldose Reductase Workshop; Kona, Hawaii, 1991.
21. Srivastava, S.K., Ansari, N.H., Liu, S-Q., and Bhatnagar, A. Regulation of aldose reductase activity and inhibitor sensitivity by sulfhydryl oxidation. FASEB J, 5, A1507, 1991.
22. Srivastava, S.K., Liu, S-Q., Bhatnagar, A. and Ansari, N.H. Activation of bovine lens aldose reductase by carboxymethylation. Int Cong Eye Res, 1992.
23. Bhatnagar, A., Liu, S-Q., Ueno, N., Chakrabarti, B. and Srivastava, S.K. Role of Cys-299 in catalysis and inhibition of human placental aldose reductase. FASEB J, 6, A1699, 1992.
24. Srivastava, S.K., Ansari, N.H., Liu, S-Q. and Bhatnagar, A. Carboxymethylation-induced activation of bovine lens aldose reductase. Invest Ophthalmol Vis Sci, 33, 1376, 1992.
25. Srivastava, S.K., Liu, S-Q., Bhatnagar, A., Ansari, N.H. and Petrash, J.M. Sorbinil and alcohol substrate bind at the same site on bovine lens aldose reductase. Invest Ophthalmol Vis Sci, 34, 758, 1993.
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26. Fulep, E., Ansari, N.H., Bhatnagar, A., Zacarias, A. and Srivastava, S.K. Digital image analysis of cultured rat lens during oxidative stress-induced cataractogenesis. Invest Ophthalmol Vis Sci, 34, 1297, 1993.
27. Bhatnagar, A. Hydrogen peroxide-induced alterations in the kinetics of the cardiac sodium current. Biophys J, 64, A91 1993.
28. Bhatnagar, A. Tertiary-butyl hydroperoxide (t-BHP)-induced alterations in the cardiac action potential, FASEB J, 7, A102, 1993.
29. Ansari, N.H., Bhatnagar, A., Zacarias, A. and Srivastava, S.K. Prevention of sugar-induced cataractogenesis in rat lenses by Trolox. FASEB J, 7, A848, 1993.
30. Liu, S-Q., Bhatnagar, A., Petrash, J.M. and Srivastava, S.K. Role of Cys-298 in inhibition of aldose reductase by menadione. FASEB J, 7, A848, 1993.
31. Zacarias A, Simon B, Bhatnagar A. Magnetic Field effects on metal-catalyzed reactions: Luminol radical recombination in solution. Biophys J, 66, A377, 1994.
32. Almrud JJ, Bhatnagar A. Activation of ATP-sensitive K channel in cardiac myocytes under oxidative stress: role of the DNA repair enzyme poly (ADP-ribose) polymerase. Biophys J, 66, A329, 1994.
33. Ansari, N.H., Bhatnagar, A. and Srivastava, S.K. Digital image analysis: A powerful tool for the quantitation of endogenous peroxides and lens opacity. Invest Ophthalmol Vis Sci, 35, 1810, 1994.
34. Bhatnagar, A. Aldehydic product of lipid peroxidation, 4-hydroxynonenal, inhibits inward rectifies K+ channels and depletes intracellular ATP in isolated rat ventricular myocytes. FASEB J, 8, A607, 1994.
35. Liu, S-Q., Bhatnagar, A., Ansari, N.H. and Srivastava, S.K. Catalytic reaction mechanism of aldose reductase. FASEB J, 8, A936. 1994.
36. Srivastava, S.K., Ansari, N.H., Wang, L. and Bhatnagar, A. Isolation and culture of single rat lens fiber cells: Effect of calcium. Int Cong Eye Res, 1994.
37. Srivastava, S. K., Ansari, N.H., Khanna, P., Wang, C., Bhatnagar, A. Calcium channel and Na+/ Ca++ exchanger and Ca++ -induced globulization of isolated lens fiber cells that mimic cataractogenesis. Invest Ophthalmol Vis Sci 36, S604, 1995.
38. Srivastava, S., Chandra, A., Ansari, N.H., Bhatnagar, A., Srivastava, S.K. Detoxification of lipid peroxidation product 4-hydroxynonenal by aldose reductase. FASEB J., 10, A272, 1996.
39. Bhatnagar, A. High intracellular ATP delays hydrogen peroxide mediated loss of excitability of cardiac myocytes but exacerbates proongation of the action potential. FASEB J., 10, A582, 1996.
40. Srivastava, S.K., Awasthi S., Bhatnagar, A., Awasthi, Y.C. Lens of curcumin fed rats are resistant to the catractogenic effects of 4-hydroxynonenal in organ cultures. Invest Ophthalmol Vis Sci 37, S882, 1996
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41. Reuf, J., Wu, Y., Bhatnagar, A., Bode, C., Runge, M.S., Rao, G.N. A role of 4-hydroxynonenal, a lipid peroxidation product in redox-sensitive vascular smooth muscle cell growth. Circulation Suppl 94, I637-638, 1996.
42. Srivastava, S.K., Wang, L.-F., Bhatnagar, A. Calcium homeostasis of isolated cortical fibers of rat lens. Invest Ophthalmol Vis Sci 38, S703, 1997.
43. Ansari, N.H., Khanna, P., Bhatnagar, A., Bhalla, P., Szweda, L. Protein-HNE adducts in human diabetic cataractous lenses. Invest Ophthalmol Vis Sci 38, S1171, 1997.
44. B. Dixit, S. Srivatava, S. Watowich, J.M. Petrash, A. Bhatnagar, and S.K. Srivastava. Reduction of glutathione conjugates of lipid-derived unsaturated aldehydes: A novel antioxidant role of aldose reductase FASEB J. 13, A1363, 1999.
45. Liu, S.-Q., Ruef, J., Srivastava, S., Bhatnagar, A. Reduction of intimal hyperplasia by inhibitors of aldose reductase. J. Mol. Cell. Cardiol. 32, A31, 2000.
46. Srivastava, S., Liu, S.-Q., Srivastava, S.K., Bhatnagar, A. Detoxification of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal (HNE) in smooth muscle cells. J. Mol. Cell. Cardiol. 32, A32, 2000.
47. Zacarias, A., Sobrattee, S., Srivastava, S., Liu, S.-Q., Bhatnagar, A. Involvement of aldose reductase in the synthesis of plasmalogen precursors in the heart. J. Mol. Cell. Cardiol. 32, A50, 2000.
48. Shinmura, K., Liu, S.-Q., Tang, X.-L., Kodani, E., Xuan, X.-T., Bhatnagar, A. Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circulation. 102, II-120, 2000.
49. Zacarias, A., Sobrattee, S., Srivastava, S., Liu, S.-Q., Bhatnagar, A. Metabolism of Base Propenals in the Heart : The role of aldose reductase in detoxifying mutagenic and cytotoxic products of oxidative DNA damage. J. Mol. Cell. Cardiol. Volume 33, Issue 6, A112, 2001.
50. Bhatnagar, A., West, M., Bolanowski, D., Liu, S.-Q., Prabhu, S. D., Srivastava, S. Acrolein exacerbates atherosclerosis in ApoE-null mice. FASEB. J. 16, A173, 2002.
51. Tsakadze, N., Srivastava, S., Adeagbo, A., Bhatnagar, A., D’Souza, S. αβ-Unsaturated aldehydes, 4-hydroxy-nonenal (HNE) and acrolein (Acr), modulate vasomotor responses in rat aortic rings. FASEB. J. A850, 2002.
52. Srivastava, S., Liu, S.-Q., D’Souza, S. E., Bhatnagar, A. The contribution of , unsaturated aldehydes to endothelial function and atherogenesis. FASEB. J. 16, A145, 2002.
53. Liu, S.-Q., Srivastava, S., Prough, R. A., Bhatnagar, A. The metabolic fate of 4-hydroxy trans-2-nonenal (HNE) in cardiac mitochondria. FASEB. J. 16, A144, 2002.
54. Srivastava, Satish; Ramana, K.; Chandra, D.; Srivastava, Sanjay; Bhatnagar, A. Regulation of the vascular activity of the poyol pathway by nitric oxide. FASEB. J. A913, 2002.
55. Srivastava, S.K, Ramana, K.V., Chandra, A and Bhatnagar A. Aldose reductase regulates the activation NF-B by lipid peroxidation-derived aldehydes. Intern. Soc. Free Radic Res 33 (S-1); S145, 2002.
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56. Bhatnagar, A., Shinmura, Liu, S.-Q., Xian-Liang Tang, Kodani, E., Xuan, Y.T., Srivastava, S., and Bolli R. Role of lipid peroxidation-derived aldehydes in ischemic preconditioning. Free Radic. Biol. Med. 33(S-1), S161, 2002.
57. Srivastava, S., Bhatnagar, A., Prabhu.S.D. Decreased aldose reductase expression and activity contributes to increased oxidative stress in the failing heart. Free Radic. Biol. Med. 33(S-1), S161, 2002.
58. Ramana K.V., Chandra, D., Srivastava S., Bhatnagar, A., Aggarwal B.B, and Srivastava, S.K. Aldose reductase interrupts reactive oxygen species mediated inflammatory signals. Amer. Chem. Soc. 224: U371-U371 062-TOXI Part 1 2002.
59. Srivastava, S., Ramana, K.V., Srivastava, S.K., and Bhatnagar A. Role of aldose reductase in the detoxification of oxidized phospholipids. Amer. Chem. Soc. 15 (12): 1666-1667 63 December 2002.
60. Bhatnagar, A., Srivastava, S., Hill, B., West, M., Gu, Y., Luo, J., and Prabhu S. Acrolein-induced myocardial dysfunction. J. Mol. Cell. Cardiol. 35 (6): A7-A7 L20 June 2003.
61. Hill, B., Srivastava, S., and Bhatnagar, A. Lipid peroxidation-derived protein modifications in the ischemic heart. J. Mol. Cell Cardiol. 35 (6): A45-A45 P104 June 2003.
62. Ping, P., Baines, C., Gu, Y., Prabhu, S., Zhang, J., Tsai, L., Cardwell, E., Zong, N., Vondriska, T., Korge, P., Bhatnagar, A., Wang, GW. Cardiovasc Toxicol. 2003;3(4):341-51.
63. Prough, R.A, West, M.B, Srivastava, S., and Bhatnagar, A. Metabolism of 4-hydroxy-trans-2-nonenal: role of cytochrome P450. EB 2003, FASEB J. 17 (4): A610-A610 Part 1 Suppl. S, March 14 2003.
64. Srivastava, S., Liu, S.-Q., and Bhatnagar, A. Cellular metabolism of base propenals. EB 2003, FASEB J. 17 (4): A175-A176 Part 1 Suppl. S, MAR 14 2003.
65. Kheirandish L, Gozal D, Bhatnagar A., and Row BW. Increased vulnerability to chronic intermittent hypoxia (CIH)-induced spatial learning deficits in apolipoprotein E-deficient mice. (Presented at: 18th Annual APSS Meeting, June 5-109, 2004, Philadelphia, PA) Abstracted in: Sleep 2004.
66. Tipparaju, S., Kumar, R., Liu, S.Q., Bhatnagar, A. Prydine Coenzyme Binding to Kv Proteins Imparts Redox-Sensitivity to Kv Channels. Circulation III-62. Vol 110 No 17, 286.
67. West, M.B., Hill, B., Conklin, D.J., and Bhatnagar, A. Nitric oxide-mediated glutathiolation of actin during acetylcholine-induced relaxation of aortic rings. Oxidative Post-Translational Modifications in the Cardiovascular System. Cardiovascular Proteomics p. 32, 2004.
68. Hill, B., Srivastava, S., Tang, L., and Bhatnagar, A., Formation of protein carbonyls in the ischemic heart. Oxidative Post-Translational Modifications in the Cardiovascular System. Cardiovascular Proteomics p. 84, 2004.
69. Conklin, D.J., Prough, R., Clark, D., Hill, B., Srivastava, S., Liu, S.Q., Bhatnagar, A. 2005. Acrolein-induced dyslipidemia in mice: A risk factor of cardiovascular disease. Toxicologist Volume 84:S-1, Abstract 1844.
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70. Prough R.A., West M., Srivastava S., and Bhatnagar A. Metabolism of 4-hydroxy-trans-2-nonenal: role of cytochrome P450. EB 2003, FASEB J. 17: A610, 2003.
71. Bhatnagar, A., Srivastava, S., Hill, B., West, M., Gu, Y., Luo, J., and Prabhu S. Acrolein-induced myocardial dysfunction. J. Mol. Cell. Cardiol. 35 (6): A7-A7 L20 June 2003.
72. West, M., Hill, B., and Bhatnagar, A. Induction of Reversible Protein Glutathiolation by Nitric Oxide. FASEB J. 18 (8): C276, #120.6, 2004.
73. West, M., Rokosh, G., Clark, D., Liu, S., Guo Y., Bolli, R., Bhatnagar, A. Nitric Oxide Prevents Mitochondrial Permeability Transition during Ischemia-Reperfusion: Implications for the Cardioprotective Effects of Late Preconditioning. Circulation:110:III-236, 2004
74. Spite, M., Srivastava, S., Trent, J.O., West, M.B., Ahmed, Y., Bhatnagar, A., Metabolism of Phospholipid Aldehydes: Role of Aldose Reductase Enzymology and Molecular Biology of Carbonyl Metabolism, 12th Symposium Burlington, VT 2004.
75. Spite, M., Srivastava, S., Trent, J.O., West. M.B., Ahmed, Y., Liu, S., and Bhatnagar, A. Aldo-Keto Reductases Catalyze the Reduction of Atherogenic Aldehydes. FASEB J. 19(4): A843, #517.11, 2005.
76. Spite, M., Srivastava, S., Trent, J., West. M., Ahmed, Y., Liu, S., and Bhatnagar, A. Aldo-Keto Reductases Catalyze the Reduction of Atherogenic Aldehydes. FASEB J. 19(4): A843, #517.11, 2005.
77. West, M., Xuan, Y., Rokosh, G., Guo, Y., Prabhu, S., Bolli, R., Bhatnagar, A. Constitutive overexpression of inducible nitric oxide synthase protects the ischemic heart by inhibiting mitochondrial permeability transition. Circulation 112: II-59, 2005.
78. Tipparaju, S., Liu, S., Barski, O., Bhatnagar, A. Redox Regulation of Voltage-Gated Potassium Channel Kv1.5 by β-subunits: Differential Effects of Kvβ1.3 and 2.1. Circulation 112: II-97, 2005.
79. Luo, J., Hill, B., Gu, Y., Cai, J., Bhatnagar, A., Prabhu, S. Acrolein, a Pervasive Environmental Pollutant and Ednogenous Lipid Peroxidation Product, Depresses Myofilament Calcium Responsiveness and Recapitulates the Phenotype of Stunned Myocardium. Circulation 112: II-119, 2005.
80. Kaiserova, K., Awe, B.O., Srivastava, S., Bhatnagar, A. Peroxynitrate-mediated Activation of Aldose Reductase in the Ischemic Heart. Circulation 112:II-283, 2005.
81. Conklin, D.J., Gozal, D., Row, B.W., Kheirandish, L., Uwamariya, C., Srivastava, S., Bhatnagar, A. 2005. Effect of chronic intermittent hypoxia on atherosclerosis in apoE-null mice: role of dyslipidemia. Experimental Biology. Abstract #387.4, 2005
82. Spite, M., Ahmed, Y., Bhatnagar, A., and Srivastava, S., Fibroblast Growth Factor regulated Protein-1 detoxifies phospholipid aldehydes and prevents atherosclerotic Lesion formation. Free Radic Biol Med 39:S131, 2005.
83. Tipparaju, S.M., and Bhatnagar, A. Pipette Internal Perfusion: Methods and Application. In Patch- Clamp Analysis: Advanced Techniques. Wolfgang, W., Boulton, A.A., and Baker, G.B. Editors, Humana Press, Totowa, New Jersey (In Press) 2006.
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84. Prough , A. Amunom, I. Stephens, L. Conklin, D.J. Bhatnagar, A. Induction of cytochrome P450 by Nrf2 activators: Implication for aldehyde metabolism. Abstract #7330. 2007.
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