Artificial Enteral Nutrition & Time-limited Trials
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Artificial Enteral Nutrition & Time-limited Trials
Kyle P. Edmonds, MD
Assistant Clinical ProfessorDoris A. Howell, MD, Palliative Care ServiceUC San Diego Health System
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Informed consent Series
• The problem
• What is likely
• Benefits & burdens
• Medically-appropriate options
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Ethical Principles
• Withdrawing = withholding
• Autonomy allows for pt refusal of medical care
• Clinicians balance benefit & harm
Ganzini M. 2006.
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Legal principles
• US case law: artificial nutrition is a medical intervention & can be refused (Cruzan)
• Specific requirements will vary state-to-state
Ganzini M. 2006.
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Case86 year old woman with FAST 7D Alzheimer-type dementia is on her third admission from her board & care in six months for sepsis of
urinary origin. Her infection has improved and she is nearing discharge.
As you are leaving the room early in the morning on her final day the daughter says “oh, doc, she’s not eating very much and when she does, she coughs. Oh and she’s
been losing weight…”
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AD Likely course
• Eating problems develop in 86% w advanced dementia39% die w/in 6 mos2/3 of NH residents don’t want a FT
Teno, 2011.
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AD Likely course
Mitchell SL. 2009.
No dysphagia
Dysphagia
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AD Last 3 Months: morbidity
•Pneumonia (37%)
•Fever (32%)
•Eating problems (90%)
Mitchell SL. 2009.
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Physiology in Dying
• Constitutional Weakness Fatigue
• GI: Loss of ability to swallow Dehydration Ileus Symptoms: anorexia; nausea; dry mouth
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What are pt / family goals?
• Desire to Improve strength Avoid “starvation”
• Meaning of food / eating
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Patient/Family Meaning
•“Food” = ?
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Patient/Family Meaning
•No! “Food” =
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Patient/Family Meaning-Making
Johnson et al., 2011.
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Specific Disease States
• Artificial nutrition may be a “Bridge” therapy in:
• Severe mucositis (H&N CA, BMT)
• Acute stroke with dysphagia
• Early ALS (before Resp Failure)
• Obstructions (H&N CA or GI CA)
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Burden of ANH
• Breathlessness
• Edema
• Ascites
• Nausea / vomiting
• Polyuria
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Outcomes…
Ganzini M. 2006.; Teno J. 2011.
• IncreasedMortality
• IncreasedTime in restraints
• IncreasedIn-hospital mortality
• IncreasedComplication rate
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…Outcomes
Ganzini M. 2006.
• IncreasedAspiration PNA
• Same (worse?)
Skin integrity
• Same (worse?)
Wound healing
• Same (worse?)
Symptom control
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Case
86 yoF with advanced dementia & recurrent infections now with weight loss and anorexia
Found by SLP to have aspiration with all consistencies.
Diagnosis?
Options?
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Decreasing food intake•Fear: Starvation
•ManagementNormalize & ReframeFood for comfortAspiration risk
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Role of the team
1. Diagnose dying
2. Use “not medically appropriate”
3. Assure comfort, non-abandonment
4. Discuss alternatives
5. Develop clear time-limited trials
6. Involve, inform other members (RN, SLP)
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Potential Goals of Care
Restorative or Cure
Return to Baseline
Improve Survival
Improve Function
Relieve Symptoms
Allow Natural Death
Adapted from Mulkerin, 2011.
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Decision-making Pendulum
Paternalism Autonomy
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Values
Hopes
Wishes
Personhood
Lifestory
Goals of Care
Medical Options
Patient/Family Clinicians
Ventilator
Pressors
Code Status
Antibiotics
Disposition
The Plan of Care
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Time-Limited Trials• A structured medical intervention
• Gather all parties
• Agree on: Exact length of time Specific goals (reasons to continue) Specific burdens (reasons to stop) What will happen if goals not met
• Reevaluation
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Evidence conclusion
Destination therapy with artificial enteral nutrition is a burdensome intervention with very limited medical-appropriateness. In cases
where family is resistant to this recommendation, a structured time-limited trial would be appropriate.
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Palliative Care is…
• A team that can help your patients and families manage the pain, symptoms, and stress of serious illness.
• Available at any age and at any stage in a serious illness and can be provided along with curative treatment.
• Expert communication for challenging situations.
• Partnering with you for better outcomes by helping your patients tolerate curative treatment.
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References• Finucane TE, Christmas C, Travis K. Tube feeding in patients with advanced
dementia: A review of the evidence. JAMA 1999;282:1365–1370.
• Ganzini, Linda. "Artificial Nutrition and Hydration at the End of Life: Ethics and Evidence."Palliative and Supportive Care 4 (2006): 135-43. PMID: 16903584
• Koretz, Ronald L., MD. "Do Data Support Nutrition Support? Part I: Intravenous Nutrition."Journal of the American Dietetic Association 107 (2007): 988-96. PMID: 17524720
• Koretz, Ronald L., MD. "Do Data Support Nutrition Support? Part II: Enteral Artificial Nutrition."Journal of the American Dietetic Association 107 (2007): 1374-1380. PMID: 17659905
• Mitchell, SL et al (2009). The Clinical Course of Advanced Dementia. NEJM. 361 (16). 1529-1538.
• Teno JM et al. (2011). Decision-making and outcomes of feeding tube insertion: A five-state study. J Am Geriatr Soc. 59: 881-886.