1. A New Discovery in NanomedicineCelecoxCur A Safe And Fffective Nanomedicine For Arthritis

2. 1 234LOW DOSE BY IMPROVING SOLUBILITY MAY ANSWER TO MANY PROBLEMS 3. Although a wide range of drugs are available, the successful and cost effective treatment of inflammatory arthritis is still a major unmet medical need Celecoxib is not readily dissolved and dispersed for rapid absorption in the gastrointestinal tract when administered orally More generally, a need exists for orally deliverable formulations of cyclooxygenase-2 inhibitory drugs of low water solubility including celecoxib. Hence to use high dose to achieve the required efficacy Do we need to use 400mg of Celecoxib? Is the drug is a problem or the dosage ? FDA committee advised doctorsthreat to sale.lowest available doses of Celebrex Patent expired hence a to prescribe the The (200 mg/day) and Bextra (10 mg/day). But how sure are we that these dosages are safe? We know that 400 mg/day of Celebrex causes heart attacks and strokes; can we be sure that 200 mg doesn't? We know that 20 mg/day of Bextra causes heart attacks and strokes; can we be sure that 10 mg doesn't? No, we cannot be sure. More likely, even at these lower recommended dosages, some risk remains. 4. TNFPhospholipid PLA2G2A PLA2G4A NF-kBarachidonic acidIL6PTGS2CelecoxCurPTGS1IL6PGH2 ????? PGD2PGD2PGD2PGI2Inflammation Pain Fever Neoplasia CytoprotectionPGI2Allergy AasthmaPlatelet Aggregation Vasoconstriction 5. $1M INVESTED $3M NEEDED ( FOR ANALYTICAL TOOL, cGMP MANUFACTURING, PRE-CLINICAL, IND, etc) 6. PROOF OF CONCEPT ------------------ESTABLISHED R & D---------------------------------------- -MOSTLY ESTABLISHED PILOT SCALE MANUFACTURING---- ESTABLISHED IN-VITRO STUDY----------------------- - PRELIMINARY TESTING Pilot scale Production------------------- Established ANIMAL STUDIES----------------------- ON-GOING 7. Discovery/ Answer to Problem CELECOXCUR IS A HYBRID DRUG OF TWO MOLECULES CELECOXCUR IS WATER SOLUBLE (BIOAVAILABLE) CELECOXCUR IS SAFE FOR STOMACH CELECOXCUR IS PATENTED CELECOXCUR IS MORE POTENT CELECOXCUR IS NEW APPROACH CELECOXCUR WATER SOLUBILITY PROBLEM RESOLVED CELECOXCUR LOW DOSE TO ACHIEVE THE SAME RESULTS AS OF 400MG OF CELECOXIB No SDS, No T-20, No oil, No alcohol, No casein, No cellulose, No PEF and No lipid in CelecoxCur The present invention of CELECOXCUR is directed to a method of treating inflammatory arthritis in a cost effective manner BY LOW DOSE AND LOW COST OF MANUFACTURING.SHOULD BE FAFFER. 8. MILESTONES cGMPManufacturing Animal efficacy: Drug Interactions IND Phase I Phase II License submission(1st year) (1st year) (2nd year) (2nd year) (3rd year) (3rd and 4th year) 9. It is not micro It is Nano NO OIL, No detergent IT IS MORE POTENT LESS TOXIC AND COST EFFECTIVE ACT ON MULTIPLE SITENanomedicine is The Answer 10. Join us to take this Discovery to clinicCONTACT Mewa Singh, PhD 609-902-7128 mewasinghsandhu@hotmail.com www.nanomeda.com www.nanosgroup.comNanomedicine Is The Future Of Pharma