Artemisina. Malaria Quinina Cloroquina Artemisina Artemisina: Nuevas armas contra la malaria.

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Transcript of Artemisina. Malaria Quinina Cloroquina Artemisina Artemisina: Nuevas armas contra la malaria.

Page 1: Artemisina. Malaria Quinina Cloroquina Artemisina Artemisina: Nuevas armas contra la malaria.

Artemisina

Page 2: Artemisina. Malaria Quinina Cloroquina Artemisina Artemisina: Nuevas armas contra la malaria.

Malaria Quinina

H

O HH

N

N

MeO

Cloroquina

Artemisina

Artemisina: Nuevas armas contra la malaria

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GUERRA DEL VIETNAM (1955-1975)

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Artemisia annua Tu Youyou

Terapia combinada con artemisina (ACT)

Artemisina

Mefloquina

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Science, 2010, 330, 1355

Semisíntesis

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OZ439Roche-Medicines and Malaria Venture-Single dose-Low cost of goods-High oral bioavailability-phase IIIPNAS 2011, 108, 11, 4400

O

OOO N

O

Cl Cl

Cl

NHO

O

OH

H

OO

OMe

Artemether /Lumefantrina

Análogos

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Síntesis total

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Reacción de Shapiro

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Oxidación de Wacker-Tsuji

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Formación de oxígeno singlete


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