Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target by...
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Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
by Francis Mussai, Sharon Egan, Joseph Higginbotham-Jones, Tracey Perry, Andrew Beggs, Elena Odintsova, Justin Loke, Guy Pratt, Kin Pong U, Anthony Lo,
Margaret Ng, Pamela Kearns, Paul Cheng, and Carmela De Santo
BloodVolume 125(15):2386-2396
April 9, 2015
©2015 by American Society of Hematology
AML blasts are auxotrophic for arginine.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology
BCT-100 arginine depletion reduces the number of viable AML blasts in vitro and in vivo.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology
BCT-100 is cytotoxic against primary blasts from patients.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology
BCT-100 depletes arginine intracellularly.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology
BCT-100 halts proliferation and cell cycle arrest.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology
BCT-100 induced cell cycle arrest leads to necrotic cell death.
Francis Mussai et al. Blood 2015;125:2386-2396
©2015 by American Society of Hematology