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NIH SupportsBiomedical and Behavioral Research Around the Globe

Including Scientists at Institutions in over 90 Countries!

ARGENTINAAUSTRALIABELGIUMBOTSWANABRAZILCAMBODIACANADACHILECHINACOLUMBIACZECH REPUBLICDENMARKDOMINICAN REPUBLICEGYPTESTONIAFINLANDFRANCEGERMANYHAITIHONG KONGHUNGARYICELANDIRELANDISRAELITALYJAPAN

KENYALEBANON

MALAWIMEXICO

NETHERLANDSNEW ZEALAND

NIGERIAPAKISTAN

PERUPOLANDRUSSIA

SENEGALSINGAPORE

SOUTH AFRICASPAIN

SWEDENSWITZERLAND

THAILANDTURKEY

UNITED KINGDOMURAGUAY

ZIMBABWEAND MORE…

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U.S. Dept. of Health & Human Services

Administration forChildren and Families

(ACF)

Food and DrugAdministration

(FDA)

Health Resourcesand Services

Administration(HRSA)

Secretary of Health and

Human Services

Administration onAging(AoA)

Center for Medicare &

Medicaid Services

(CMS)

Indian HealthServices

(IHS)

National Institutesof Health

(NIH)

Agency for Healthcare

Research and Quality(AHRQ)

Centers for Disease Controland Prevention

(CDC)

Substance Abuse andMental Health Services

Administration(SAMHSA)

Agency for ToxicSubstances andDisease Registry

(ATSDR)

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National Institutes of Health

National Instituteon Alcohol Abuseand Alcoholism

National Instituteof Arthritis and

Musculoskeletaland Skin Diseases

National CancerInstitute

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National Instituteof Allergy and

Infectious Diseases

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National HumanGenome Research

Institute

National Heart,Lung, and Blood

Institute

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof General

Medical SciencesNational Institute

of Nursing Research

National Libraryof Medicine

National Centerfor Complementary

and AlternativeMedicine

FogartyInternational

Center

National Centerfor ResearchResources

National Instituteof Biomedical Imaging and

Bioengineering

No funding authority

NIHClinical Center

Centerfor Information

Technology

Center for Scientific

Review

National Center on Minority Health

and Health Disparities

Office of the Director Office of Extramural Research

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Applicant Institution

Authorized Institutional

Official

Principal Investigator

Sponsored Research

Administrator

The Research Partnership

NIH

Review Administrator

ProgramAdministrator

Grants Management Administrator

The NIH Extramural Team

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NIH Initiatives and Hot Topics

• NIH Themes

• The B Word: NIH Budget and the impact of ARRA

• Focus on New Investigators

• Directions for Peer Review

• Stem Cell Research

• Assuring Objectivity in Research

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Looking to the Future with theNew NIH Director

1. NIH Director as of August 17, 20092. Former Director of the National Human Genome

Research Institute, NIH3. Leader of the Human Genome Project4. Dr. Collins’ own lab discovered a number of important

genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's disease and more.

5. New York Times best selling book author6. Interest in the interface of science and faith.7. Musician and Rock Star of Science8. Believes the value of the NIH community is one where

hard work, laughter, and compassion allow the imagination to soar.

Francis S. Collins, Ph.D., MD

To better understand the direction of NIH, here’s some known (and little known) facts about the leader of NIH:

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Opportunity 1: Using high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases

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• NextGen DNA sequencing and beyond• Nanotechnology• Small molecule screening• New imaging modalities • Emphasis on comprehensive approaches

– All of the genes, all of the proteins, all of the common variations, all of the pathways for signal transduction, all of the patterns of gene expression, all of the steps in early development, all of the components of the immune system…

• Computational biology is critical• Examples that are ripe for expanded effort

– Cancer– Autism– Microbiome– Many more….

Opportunity 1: Using high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases

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Opportunity #2: Translating basic science discoveries into new and better treatments

Basic Research Drugs

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• Stage is set for NIH to play a greatly expanded role in translation– New discoveries about the fundamental basis of disease– Resources empowering academic investigators to

develop lead compounds and “de-risk” projects– Opportunity for public-private partnerships

• Stem cells (including hESC and iPSC)– Explosion of new information likely with new NIH policy

– 64 cell lines now approved for federal funding– Therapeutic uses still uncertain but urgent to pursue

• Small molecules– Roadmap provides high throughput screening (HTS)

capabilities that now match that of many pharmaceutical companies

– More on this theme later in the talk

Opportunity #2: Translating basic science discoveries into new and better treatments

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Opportunity #3: Putting science to work for the benefit of health care

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• Comparative effectiveness research• Prevention and personalized medicine

– Behavioral research• Health disparities research• Pharmacogenomics• Large scale prospective studies

– National Children’s Study– Study of adult onset diseases?

• Health IT• Health research economics

– Going beyond clinical trials to studying health care delivery in the real world?

– What payment incentives actually work to reduce costs and improve outcomes?”

Opportunity #3: Putting science to work for the benefit of health care